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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NKX2-2
Full Name:
Homeobox protein Nkx-2.2
Alias:
Homeobox protein NK-2 homolog B
Type:
Mass (Da):
30133
Number AA:
273
UniProt ID:
O95096
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
S
L
T
N
T
K
T
G
F
S
V
K
Site 2
T8
M
S
L
T
N
T
K
T
G
F
S
V
K
D
I
Site 3
S11
T
N
T
K
T
G
F
S
V
K
D
I
L
D
L
Site 4
T21
D
I
L
D
L
P
D
T
N
D
E
E
G
S
V
Site 5
S27
D
T
N
D
E
E
G
S
V
A
E
G
P
E
E
Site 6
Y66
L
P
L
K
N
P
F
Y
D
S
S
D
N
P
Y
Site 7
Y73
Y
D
S
S
D
N
P
Y
T
R
W
L
A
S
T
Site 8
S79
P
Y
T
R
W
L
A
S
T
E
G
L
Q
Y
S
Site 9
T80
Y
T
R
W
L
A
S
T
E
G
L
Q
Y
S
L
Site 10
S86
S
T
E
G
L
Q
Y
S
L
H
G
L
A
A
G
Site 11
S99
A
G
A
P
P
Q
D
S
S
S
K
S
P
E
P
Site 12
S100
G
A
P
P
Q
D
S
S
S
K
S
P
E
P
S
Site 13
S101
A
P
P
Q
D
S
S
S
K
S
P
E
P
S
A
Site 14
S103
P
Q
D
S
S
S
K
S
P
E
P
S
A
D
E
Site 15
S107
S
S
K
S
P
E
P
S
A
D
E
S
P
D
N
Site 16
S111
P
E
P
S
A
D
E
S
P
D
N
D
K
E
T
Site 17
T118
S
P
D
N
D
K
E
T
P
G
G
G
G
D
A
Site 18
S136
R
K
R
R
V
L
F
S
K
A
Q
T
Y
E
L
Site 19
T140
V
L
F
S
K
A
Q
T
Y
E
L
E
R
R
F
Site 20
Y152
R
R
F
R
Q
Q
R
Y
L
S
A
P
E
R
E
Site 21
S154
F
R
Q
Q
R
Y
L
S
A
P
E
R
E
H
L
Site 22
S163
P
E
R
E
H
L
A
S
L
I
R
L
T
P
T
Site 23
T195
A
E
K
G
M
E
V
T
P
L
P
S
P
R
R
Site 24
S199
M
E
V
T
P
L
P
S
P
R
R
V
A
V
P
Site 25
Y237
A
G
I
P
F
S
A
Y
S
A
Q
S
L
Q
H
Site 26
S238
G
I
P
F
S
A
Y
S
A
Q
S
L
Q
H
M
Site 27
Y247
Q
S
L
Q
H
M
Q
Y
N
A
Q
Y
S
S
A
Site 28
Y251
H
M
Q
Y
N
A
Q
Y
S
S
A
S
T
P
Q
Site 29
S252
M
Q
Y
N
A
Q
Y
S
S
A
S
T
P
Q
Y
Site 30
S255
N
A
Q
Y
S
S
A
S
T
P
Q
Y
P
T
A
Site 31
T256
A
Q
Y
S
S
A
S
T
P
Q
Y
P
T
A
H
Site 32
Y259
S
S
A
S
T
P
Q
Y
P
T
A
H
P
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation