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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF15
Full Name:
Rho guanine nucleotide exchange factor 15
Alias:
Ephexin-5;Vsm-RhoGEF
Type:
Mass (Da):
91940
Number AA:
841
UniProt ID:
O94989
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
A
Q
S
L
P
A
A
T
P
P
Site 2
T10
A
Q
S
L
P
A
A
T
P
P
T
Q
K
P
P
Site 3
T13
L
P
A
A
T
P
P
T
Q
K
P
P
R
I
I
Site 4
S26
I
I
R
P
R
P
P
S
R
S
R
A
A
Q
S
Site 5
S28
R
P
R
P
P
S
R
S
R
A
A
Q
S
P
G
Site 6
S33
S
R
S
R
A
A
Q
S
P
G
P
P
H
N
G
Site 7
S41
P
G
P
P
H
N
G
S
S
P
Q
E
L
P
R
Site 8
S42
G
P
P
H
N
G
S
S
P
Q
E
L
P
R
N
Site 9
S50
P
Q
E
L
P
R
N
S
N
D
A
P
T
P
M
Site 10
T55
R
N
S
N
D
A
P
T
P
M
C
T
P
I
F
Site 11
T59
D
A
P
T
P
M
C
T
P
I
F
W
E
P
P
Site 12
S79
P
P
A
L
L
P
P
S
A
S
R
A
S
L
D
Site 13
S81
A
L
L
P
P
S
A
S
R
A
S
L
D
S
Q
Site 14
S84
P
P
S
A
S
R
A
S
L
D
S
Q
T
S
P
Site 15
S87
A
S
R
A
S
L
D
S
Q
T
S
P
D
S
P
Site 16
T89
R
A
S
L
D
S
Q
T
S
P
D
S
P
S
S
Site 17
S90
A
S
L
D
S
Q
T
S
P
D
S
P
S
S
T
Site 18
S93
D
S
Q
T
S
P
D
S
P
S
S
T
P
T
P
Site 19
S95
Q
T
S
P
D
S
P
S
S
T
P
T
P
S
P
Site 20
S96
T
S
P
D
S
P
S
S
T
P
T
P
S
P
V
Site 21
T97
S
P
D
S
P
S
S
T
P
T
P
S
P
V
S
Site 22
T99
D
S
P
S
S
T
P
T
P
S
P
V
S
R
R
Site 23
S101
P
S
S
T
P
T
P
S
P
V
S
R
R
S
A
Site 24
S104
T
P
T
P
S
P
V
S
R
R
S
A
S
P
E
Site 25
S107
P
S
P
V
S
R
R
S
A
S
P
E
P
A
P
Site 26
S109
P
V
S
R
R
S
A
S
P
E
P
A
P
R
S
Site 27
S116
S
P
E
P
A
P
R
S
P
V
P
P
P
K
P
Site 28
S124
P
V
P
P
P
K
P
S
G
S
P
C
T
P
L
Site 29
S126
P
P
P
K
P
S
G
S
P
C
T
P
L
L
P
Site 30
T129
K
P
S
G
S
P
C
T
P
L
L
P
M
A
G
Site 31
S145
L
A
Q
N
G
S
A
S
A
P
G
T
V
R
R
Site 32
T149
G
S
A
S
A
P
G
T
V
R
R
L
A
G
R
Site 33
T190
G
E
R
E
A
P
L
T
G
S
G
S
Q
E
N
Site 34
S194
A
P
L
T
G
S
G
S
Q
E
N
G
A
P
D
Site 35
S242
P
R
V
P
R
R
A
S
P
L
R
T
S
R
S
Site 36
T246
R
R
A
S
P
L
R
T
S
R
S
R
P
H
P
Site 37
S247
R
A
S
P
L
R
T
S
R
S
R
P
H
P
P
Site 38
S249
S
P
L
R
T
S
R
S
R
P
H
P
P
S
I
Site 39
S255
R
S
R
P
H
P
P
S
I
G
H
P
A
V
V
Site 40
T264
G
H
P
A
V
V
L
T
S
Y
R
S
T
A
E
Site 41
S265
H
P
A
V
V
L
T
S
Y
R
S
T
A
E
R
Site 42
T269
V
L
T
S
Y
R
S
T
A
E
R
K
L
L
P
Site 43
T291
T
R
V
R
Q
D
A
T
I
F
G
D
P
P
Q
Site 44
S305
Q
P
D
L
D
L
L
S
E
D
G
I
Q
T
G
Site 45
S314
D
G
I
Q
T
G
D
S
P
D
E
A
P
Q
N
Site 46
T322
P
D
E
A
P
Q
N
T
P
P
A
T
V
E
G
Site 47
T326
P
Q
N
T
P
P
A
T
V
E
G
R
E
E
E
Site 48
Y353
P
L
Q
D
E
P
L
Y
Q
T
Y
R
A
A
V
Site 49
S373
W
G
V
G
E
D
G
S
P
S
P
A
N
A
G
Site 50
S375
V
G
E
D
G
S
P
S
P
A
N
A
G
D
A
Site 51
T384
A
N
A
G
D
A
P
T
F
P
R
P
P
G
P
Site 52
T394
R
P
P
G
P
R
N
T
L
W
Q
E
L
P
A
Site 53
T410
Q
A
S
G
L
L
D
T
L
S
P
Q
E
R
R
Site 54
S412
S
G
L
L
D
T
L
S
P
Q
E
R
R
M
Q
Site 55
S421
Q
E
R
R
M
Q
E
S
L
F
E
V
V
T
S
Site 56
T427
E
S
L
F
E
V
V
T
S
E
A
S
Y
L
R
Site 57
S431
E
V
V
T
S
E
A
S
Y
L
R
S
L
R
L
Site 58
S435
S
E
A
S
Y
L
R
S
L
R
L
L
T
D
T
Site 59
T440
L
R
S
L
R
L
L
T
D
T
F
V
L
S
Q
Site 60
T452
L
S
Q
A
L
R
D
T
L
T
P
R
D
H
H
Site 61
T454
Q
A
L
R
D
T
L
T
P
R
D
H
H
T
L
Site 62
T460
L
T
P
R
D
H
H
T
L
F
S
N
V
Q
R
Site 63
S481
R
F
L
A
T
L
L
S
R
V
R
S
S
P
H
Site 64
S485
T
L
L
S
R
V
R
S
S
P
H
I
S
D
L
Site 65
S486
L
L
S
R
V
R
S
S
P
H
I
S
D
L
C
Site 66
S490
V
R
S
S
P
H
I
S
D
L
C
D
V
V
H
Site 67
Y507
A
V
G
P
F
S
V
Y
V
D
Y
V
R
N
Q
Site 68
Y510
P
F
S
V
Y
V
D
Y
V
R
N
Q
Q
Y
Q
Site 69
Y516
D
Y
V
R
N
Q
Q
Y
Q
E
E
T
Y
S
R
Site 70
T527
T
Y
S
R
L
M
D
T
N
V
R
F
S
A
E
Site 71
S532
M
D
T
N
V
R
F
S
A
E
L
R
R
L
Q
Site 72
S540
A
E
L
R
R
L
Q
S
L
P
K
C
E
R
L
Site 73
T574
L
Q
N
I
L
R
Q
T
E
E
G
S
S
R
Q
Site 74
S578
L
R
Q
T
E
E
G
S
S
R
Q
E
N
A
Q
Site 75
S579
R
Q
T
E
E
G
S
S
R
Q
E
N
A
Q
K
Site 76
S599
S
K
I
I
E
R
C
S
A
E
V
G
R
M
K
Site 77
T615
T
E
E
L
I
R
L
T
Q
R
L
R
F
H
K
Site 78
S632
A
L
P
L
V
S
W
S
R
R
L
E
F
Q
G
Site 79
S655
R
G
G
V
L
F
A
S
R
P
R
F
T
P
L
Site 80
T674
F
S
D
L
L
L
I
T
Q
P
K
S
G
Q
R
Site 81
Y687
Q
R
L
Q
V
L
D
Y
A
H
R
S
L
V
Q
Site 82
S691
V
L
D
Y
A
H
R
S
L
V
Q
A
Q
Q
V
Site 83
S702
A
Q
Q
V
P
D
P
S
G
P
P
T
F
R
L
Site 84
T706
P
D
P
S
G
P
P
T
F
R
L
S
L
L
S
Site 85
S710
G
P
P
T
F
R
L
S
L
L
S
N
H
Q
G
Site 86
S713
T
F
R
L
S
L
L
S
N
H
Q
G
R
P
T
Site 87
T720
S
N
H
Q
G
R
P
T
H
R
L
L
Q
A
S
Site 88
S727
T
H
R
L
L
Q
A
S
S
L
S
D
M
Q
R
Site 89
S728
H
R
L
L
Q
A
S
S
L
S
D
M
Q
R
W
Site 90
S730
L
L
Q
A
S
S
L
S
D
M
Q
R
W
L
G
Site 91
T741
R
W
L
G
A
F
P
T
P
G
P
L
P
C
S
Site 92
S748
T
P
G
P
L
P
C
S
P
D
T
I
Y
E
D
Site 93
T751
P
L
P
C
S
P
D
T
I
Y
E
D
C
D
C
Site 94
Y753
P
C
S
P
D
T
I
Y
E
D
C
D
C
S
Q
Site 95
S764
D
C
S
Q
E
L
C
S
E
S
S
A
P
A
K
Site 96
S766
S
Q
E
L
C
S
E
S
S
A
P
A
K
T
E
Site 97
T772
E
S
S
A
P
A
K
T
E
G
R
S
L
E
S
Site 98
S776
P
A
K
T
E
G
R
S
L
E
S
R
A
A
P
Site 99
S779
T
E
G
R
S
L
E
S
R
A
A
P
K
H
L
Site 100
T789
A
P
K
H
L
H
K
T
P
E
G
W
L
K
G
Site 101
S831
R
L
L
E
A
V
G
S
S
S
G
T
P
N
A
Site 102
S832
L
L
E
A
V
G
S
S
S
G
T
P
N
A
P
Site 103
S833
L
E
A
V
G
S
S
S
G
T
P
N
A
P
P
Site 104
T835
A
V
G
S
S
S
G
T
P
N
A
P
P
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation