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Updated November 2019
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Protein Info
Short Name:
CEP152
Full Name:
Centrosomal protein of 152 kDa
Alias:
CE152
Type:
Unknown function
Mass (Da):
189071
Number AA:
1654
UniProt ID:
O94986
International Prot ID:
IPI00016653
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005829
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y19
V
Q
N
E
D
E
E
Y
D
E
E
D
Y
E
R
Site 2
Y24
E
E
Y
D
E
E
D
Y
E
R
E
K
E
L
Q
Site 3
T35
K
E
L
Q
Q
L
L
T
D
L
P
H
D
M
L
Site 4
S47
D
M
L
D
D
D
L
S
S
P
E
L
Q
Y
S
Site 5
S48
M
L
D
D
D
L
S
S
P
E
L
Q
Y
S
D
Site 6
S54
S
S
P
E
L
Q
Y
S
D
C
S
E
D
G
T
Site 7
T61
S
D
C
S
E
D
G
T
D
G
Q
P
H
H
P
Site 8
S83
N
E
Q
M
L
P
K
S
Q
S
V
N
G
Y
N
Site 9
S85
Q
M
L
P
K
S
Q
S
V
N
G
Y
N
E
I
Site 10
Y89
K
S
Q
S
V
N
G
Y
N
E
I
Q
S
L
Y
Site 11
Y96
Y
N
E
I
Q
S
L
Y
A
G
E
K
C
G
N
Site 12
S110
N
V
W
E
E
N
R
S
K
T
E
D
R
H
P
Site 13
T112
W
E
E
N
R
S
K
T
E
D
R
H
P
V
Y
Site 14
Y119
T
E
D
R
H
P
V
Y
H
P
E
E
G
G
D
Site 15
S130
E
G
G
D
E
G
G
S
G
Y
S
P
P
S
K
Site 16
Y132
G
D
E
G
G
S
G
Y
S
P
P
S
K
C
E
Site 17
S133
D
E
G
G
S
G
Y
S
P
P
S
K
C
E
Q
Site 18
S136
G
S
G
Y
S
P
P
S
K
C
E
Q
T
D
L
Site 19
Y144
K
C
E
Q
T
D
L
Y
H
L
P
E
N
F
R
Site 20
Y153
L
P
E
N
F
R
P
Y
T
N
G
Q
K
Q
E
Site 21
T154
P
E
N
F
R
P
Y
T
N
G
Q
K
Q
E
F
Site 22
Y190
S
C
Q
G
L
E
P
Y
N
K
V
T
Y
K
P
Site 23
T194
L
E
P
Y
N
K
V
T
Y
K
P
Y
Q
S
S
Site 24
S207
S
S
A
Q
N
N
G
S
P
A
Q
E
I
T
G
Site 25
S215
P
A
Q
E
I
T
G
S
D
T
F
E
G
L
Q
Site 26
T217
Q
E
I
T
G
S
D
T
F
E
G
L
Q
Q
Q
Site 27
S262
L
I
E
K
L
N
E
S
E
R
Q
I
R
Y
L
Site 28
Y268
E
S
E
R
Q
I
R
Y
L
N
H
Q
L
V
I
Site 29
T284
K
D
E
K
D
G
L
T
L
S
L
R
E
S
Q
Site 30
S286
E
K
D
G
L
T
L
S
L
R
E
S
Q
K
L
Site 31
S290
L
T
L
S
L
R
E
S
Q
K
L
F
Q
N
G
Site 32
S329
E
E
Q
M
I
K
K
S
R
T
T
E
M
A
L
Site 33
T332
M
I
K
K
S
R
T
T
E
M
A
L
E
S
L
Site 34
S351
V
D
L
H
H
S
E
S
L
Q
R
A
R
E
Q
Site 35
S361
R
A
R
E
Q
H
E
S
I
V
M
G
L
T
K
Site 36
T367
E
S
I
V
M
G
L
T
K
K
Y
E
E
Q
V
Site 37
Y370
V
M
G
L
T
K
K
Y
E
E
Q
V
L
S
L
Site 38
S376
K
Y
E
E
Q
V
L
S
L
Q
K
N
L
D
A
Site 39
T384
L
Q
K
N
L
D
A
T
V
T
A
L
K
E
Q
Site 40
S396
K
E
Q
E
D
I
C
S
R
L
K
D
H
V
K
Site 41
T417
E
A
I
K
L
E
K
T
E
I
I
N
K
L
T
Site 42
S426
I
I
N
K
L
T
R
S
L
E
E
S
Q
K
Q
Site 43
S430
L
T
R
S
L
E
E
S
Q
K
Q
C
A
H
L
Site 44
S482
T
E
L
K
D
E
I
S
L
Y
E
S
A
A
K
Site 45
Y484
L
K
D
E
I
S
L
Y
E
S
A
A
K
L
G
Site 46
S486
D
E
I
S
L
Y
E
S
A
A
K
L
G
I
H
Site 47
S495
A
K
L
G
I
H
P
S
D
S
E
G
E
L
N
Site 48
S497
L
G
I
H
P
S
D
S
E
G
E
L
N
I
E
Site 49
T506
G
E
L
N
I
E
L
T
E
S
Y
V
D
L
G
Site 50
Y509
N
I
E
L
T
E
S
Y
V
D
L
G
I
K
K
Site 51
S522
K
K
V
N
W
K
K
S
K
V
T
S
I
V
Q
Site 52
S526
W
K
K
S
K
V
T
S
I
V
Q
E
E
D
P
Site 53
S538
E
D
P
N
E
E
L
S
K
D
E
F
I
L
K
Site 54
S556
E
V
Q
R
L
L
G
S
N
S
M
K
R
H
L
Site 55
S558
Q
R
L
L
G
S
N
S
M
K
R
H
L
V
S
Site 56
S565
S
M
K
R
H
L
V
S
Q
L
Q
N
D
L
K
Site 57
S590
Q
V
K
K
D
E
K
S
I
E
V
E
T
K
T
Site 58
T595
E
K
S
I
E
V
E
T
K
T
D
T
S
E
K
Site 59
T597
S
I
E
V
E
T
K
T
D
T
S
E
K
P
K
Site 60
S600
V
E
T
K
T
D
T
S
E
K
P
K
N
Q
L
Site 61
S611
K
N
Q
L
W
P
E
S
S
T
S
D
V
V
R
Site 62
S612
N
Q
L
W
P
E
S
S
T
S
D
V
V
R
D
Site 63
S614
L
W
P
E
S
S
T
S
D
V
V
R
D
D
I
Site 64
T641
Q
N
Q
E
L
K
E
T
E
G
K
L
R
N
T
Site 65
T648
T
E
G
K
L
R
N
T
N
Q
D
L
C
N
Q
Site 66
Y678
V
D
R
C
E
R
T
Y
Q
Q
H
H
E
A
M
Site 67
T687
Q
H
H
E
A
M
K
T
Q
I
R
E
S
L
L
Site 68
S692
M
K
T
Q
I
R
E
S
L
L
A
K
H
A
L
Site 69
Y708
K
Q
Q
L
F
E
A
Y
E
R
T
H
L
Q
L
Site 70
Y733
V
T
A
V
Q
E
C
Y
L
E
V
C
R
E
K
Site 71
T746
E
K
D
N
L
E
L
T
L
R
K
T
T
E
K
Site 72
T750
L
E
L
T
L
R
K
T
T
E
K
E
Q
Q
T
Site 73
T751
E
L
T
L
R
K
T
T
E
K
E
Q
Q
T
Q
Site 74
T788
I
K
A
M
K
K
K
T
L
D
C
G
S
Q
T
Site 75
S793
K
K
T
L
D
C
G
S
Q
T
D
Q
V
T
T
Site 76
T795
T
L
D
C
G
S
Q
T
D
Q
V
T
T
S
D
Site 77
T799
G
S
Q
T
D
Q
V
T
T
S
D
V
I
S
K
Site 78
S801
Q
T
D
Q
V
T
T
S
D
V
I
S
K
K
E
Site 79
Y876
E
L
P
E
L
A
E
Y
Q
A
L
V
K
A
E
Site 80
S900
V
S
V
N
K
R
I
S
F
A
V
S
E
A
K
Site 81
S904
K
R
I
S
F
A
V
S
E
A
K
E
K
W
K
Site 82
S912
E
A
K
E
K
W
K
S
E
L
E
N
M
R
K
Site 83
S933
E
L
E
E
K
I
H
S
L
Q
K
E
L
E
L
Site 84
S958
A
E
L
A
K
A
R
S
E
W
N
K
E
K
Q
Site 85
Y979
Q
E
Q
N
E
Q
D
Y
R
Q
F
L
D
D
H
Site 86
T1028
D
Q
S
R
R
E
W
T
M
Q
E
A
K
R
I
Site 87
Y1040
K
R
I
Q
L
E
I
Y
Q
Y
E
E
D
I
L
Site 88
T1057
L
G
V
L
L
S
D
T
Q
K
E
H
I
S
D
Site 89
S1063
D
T
Q
K
E
H
I
S
D
S
E
D
K
Q
L
Site 90
S1065
Q
K
E
H
I
S
D
S
E
D
K
Q
L
L
E
Site 91
T1076
Q
L
L
E
I
M
S
T
C
S
S
K
W
M
S
Site 92
Y1086
S
K
W
M
S
V
Q
Y
F
E
K
L
K
G
C
Site 93
T1101
I
Q
K
A
F
Q
D
T
L
P
L
L
V
E
N
Site 94
S1122
K
R
N
M
A
E
L
S
K
D
S
A
S
Q
G
Site 95
S1127
E
L
S
K
D
S
A
S
Q
G
T
G
Q
G
D
Site 96
T1181
N
K
L
E
E
L
Q
T
L
C
K
T
P
P
R
Site 97
T1185
E
L
Q
T
L
C
K
T
P
P
R
S
L
S
A
Site 98
S1189
L
C
K
T
P
P
R
S
L
S
A
G
A
I
E
Site 99
S1191
K
T
P
P
R
S
L
S
A
G
A
I
E
N
A
Site 100
Y1214
L
E
E
L
R
G
Q
Y
I
K
A
V
K
K
I
Site 101
S1232
M
L
R
Y
I
Q
E
S
K
E
R
A
A
E
M
Site 102
T1251
V
L
R
E
R
Q
E
T
A
R
K
M
R
K
Y
Site 103
Y1258
T
A
R
K
M
R
K
Y
Y
L
I
C
L
Q
Q
Site 104
Y1259
A
R
K
M
R
K
Y
Y
L
I
C
L
Q
Q
I
Site 105
S1284
K
K
I
M
N
A
A
S
K
L
A
T
M
A
K
Site 106
T1295
T
M
A
K
L
L
E
T
P
I
S
S
K
S
Q
Site 107
S1298
K
L
L
E
T
P
I
S
S
K
S
Q
S
K
T
Site 108
S1299
L
L
E
T
P
I
S
S
K
S
Q
S
K
T
T
Site 109
S1301
E
T
P
I
S
S
K
S
Q
S
K
T
T
Q
S
Site 110
S1303
P
I
S
S
K
S
Q
S
K
T
T
Q
S
A
L
Site 111
T1305
S
S
K
S
Q
S
K
T
T
Q
S
A
L
P
L
Site 112
S1308
S
Q
S
K
T
T
Q
S
A
L
P
L
T
S
E
Site 113
S1323
M
L
I
A
V
K
K
S
K
R
N
D
V
N
Q
Site 114
S1338
K
I
P
C
C
I
E
S
K
S
N
S
V
N
T
Site 115
S1340
P
C
C
I
E
S
K
S
N
S
V
N
T
I
T
Site 116
S1342
C
I
E
S
K
S
N
S
V
N
T
I
T
R
T
Site 117
T1345
S
K
S
N
S
V
N
T
I
T
R
T
L
C
E
Site 118
T1349
S
V
N
T
I
T
R
T
L
C
E
Q
A
P
K
Site 119
S1370
L
Q
R
L
L
E
N
S
E
H
Q
S
I
K
H
Site 120
S1374
L
E
N
S
E
H
Q
S
I
K
H
V
G
S
K
Site 121
S1393
E
F
Q
F
G
D
G
S
C
K
H
L
N
S
L
Site 122
S1399
G
S
C
K
H
L
N
S
L
P
R
N
V
S
P
Site 123
S1405
N
S
L
P
R
N
V
S
P
E
F
V
P
C
E
Site 124
S1427
H
K
K
K
D
L
L
S
D
N
G
S
E
S
L
Site 125
S1431
D
L
L
S
D
N
G
S
E
S
L
P
H
S
A
Site 126
S1433
L
S
D
N
G
S
E
S
L
P
H
S
A
A
Y
Site 127
S1437
G
S
E
S
L
P
H
S
A
A
Y
P
F
L
G
Site 128
T1445
A
A
Y
P
F
L
G
T
L
G
N
K
P
S
P
Site 129
S1451
G
T
L
G
N
K
P
S
P
R
C
T
P
G
P
Site 130
T1455
N
K
P
S
P
R
C
T
P
G
P
S
E
S
G
Site 131
S1459
P
R
C
T
P
G
P
S
E
S
G
C
M
H
I
Site 132
T1467
E
S
G
C
M
H
I
T
F
R
D
S
N
E
R
Site 133
S1471
M
H
I
T
F
R
D
S
N
E
R
L
G
L
K
Site 134
Y1480
E
R
L
G
L
K
V
Y
K
C
N
P
L
M
E
Site 135
S1488
K
C
N
P
L
M
E
S
E
N
A
A
S
E
K
Site 136
S1493
M
E
S
E
N
A
A
S
E
K
S
Q
G
L
D
Site 137
S1513
V
K
D
G
G
D
L
S
D
C
L
G
W
P
S
Site 138
S1520
S
D
C
L
G
W
P
S
S
S
A
T
L
S
F
Site 139
S1521
D
C
L
G
W
P
S
S
S
A
T
L
S
F
D
Site 140
S1522
C
L
G
W
P
S
S
S
A
T
L
S
F
D
S
Site 141
T1524
G
W
P
S
S
S
A
T
L
S
F
D
S
R
E
Site 142
S1526
P
S
S
S
A
T
L
S
F
D
S
R
E
A
S
Site 143
S1529
S
A
T
L
S
F
D
S
R
E
A
S
F
V
H
Site 144
S1533
S
F
D
S
R
E
A
S
F
V
H
G
R
P
Q
Site 145
S1547
Q
G
T
L
E
I
P
S
E
S
V
K
S
K
Q
Site 146
S1549
T
L
E
I
P
S
E
S
V
K
S
K
Q
F
S
Site 147
S1552
I
P
S
E
S
V
K
S
K
Q
F
S
P
S
G
Site 148
S1556
S
V
K
S
K
Q
F
S
P
S
G
Y
L
S
D
Site 149
S1558
K
S
K
Q
F
S
P
S
G
Y
L
S
D
T
E
Site 150
Y1560
K
Q
F
S
P
S
G
Y
L
S
D
T
E
E
S
Site 151
S1562
F
S
P
S
G
Y
L
S
D
T
E
E
S
N
M
Site 152
T1564
P
S
G
Y
L
S
D
T
E
E
S
N
M
I
C
Site 153
Y1579
Q
T
M
K
C
Q
R
Y
Q
T
P
Y
L
S
E
Site 154
T1581
M
K
C
Q
R
Y
Q
T
P
Y
L
S
E
E
T
Site 155
Y1583
C
Q
R
Y
Q
T
P
Y
L
S
E
E
T
T
Y
Site 156
T1589
P
Y
L
S
E
E
T
T
Y
L
E
P
G
K
I
Site 157
Y1590
Y
L
S
E
E
T
T
Y
L
E
P
G
K
I
S
Site 158
S1597
Y
L
E
P
G
K
I
S
V
N
C
G
H
P
S
Site 159
S1613
H
K
A
D
R
L
K
S
D
F
K
K
L
S
S
Site 160
S1619
K
S
D
F
K
K
L
S
S
T
L
P
S
S
V
Site 161
S1620
S
D
F
K
K
L
S
S
T
L
P
S
S
V
C
Site 162
T1621
D
F
K
K
L
S
S
T
L
P
S
S
V
C
Q
Site 163
S1624
K
L
S
S
T
L
P
S
S
V
C
Q
Q
P
S
Site 164
S1625
L
S
S
T
L
P
S
S
V
C
Q
Q
P
S
R
Site 165
S1639
R
K
L
I
V
P
L
S
S
Q
Q
D
S
G
F
Site 166
S1640
K
L
I
V
P
L
S
S
Q
Q
D
S
G
F
D
Site 167
S1644
P
L
S
S
Q
Q
D
S
G
F
D
S
P
F
V
Site 168
S1648
Q
Q
D
S
G
F
D
S
P
F
V
N
L
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation