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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP19
Full Name:
Ubiquitin carboxyl-terminal hydrolase 19
Alias:
Deubiquitinating enzyme 19; KIAA0891; UB19; Ubiquitin specific peptidase 19; Ubiquitin thioesterase 19; Ubiquitin thiolesterase 19; Ubiquitin-specific processing protease 19; UBP19; Zinc finger MYND domain containing 9; ZMYND9
Type:
Ubiquitin conjugating system; Protease; EC 3.1.2.15
Mass (Da):
145651
Number AA:
1318
UniProt ID:
O94966
International Prot ID:
IPI00016589
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0043161
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
G
G
A
S
A
T
G
P
R
R
G
Site 2
T20
G
P
P
G
L
E
D
T
T
S
K
K
K
Q
K
Site 3
T21
P
P
G
L
E
D
T
T
S
K
K
K
Q
K
D
Site 4
S22
P
G
L
E
D
T
T
S
K
K
K
Q
K
D
R
Site 5
S34
K
D
R
A
N
Q
E
S
K
D
G
D
P
R
K
Site 6
T43
D
G
D
P
R
K
E
T
G
S
R
Y
V
A
Q
Site 7
S45
D
P
R
K
E
T
G
S
R
Y
V
A
Q
A
G
Site 8
Y47
R
K
E
T
G
S
R
Y
V
A
Q
A
G
L
E
Site 9
S58
A
G
L
E
P
L
A
S
G
D
P
S
A
S
A
Site 10
S62
P
L
A
S
G
D
P
S
A
S
A
S
H
A
A
Site 11
S64
A
S
G
D
P
S
A
S
A
S
H
A
A
G
I
Site 12
S66
G
D
P
S
A
S
A
S
H
A
A
G
I
T
G
Site 13
S74
H
A
A
G
I
T
G
S
R
H
R
T
R
L
F
Site 14
T78
I
T
G
S
R
H
R
T
R
L
F
F
P
S
S
Site 15
S84
R
T
R
L
F
F
P
S
S
S
G
S
A
S
T
Site 16
S85
T
R
L
F
F
P
S
S
S
G
S
A
S
T
P
Site 17
S86
R
L
F
F
P
S
S
S
G
S
A
S
T
P
Q
Site 18
S88
F
F
P
S
S
S
G
S
A
S
T
P
Q
E
E
Site 19
S90
P
S
S
S
G
S
A
S
T
P
Q
E
E
Q
T
Site 20
T91
S
S
S
G
S
A
S
T
P
Q
E
E
Q
T
K
Site 21
T111
D
P
H
D
L
L
A
T
P
T
P
E
L
L
L
Site 22
Y167
Q
Q
W
G
G
V
F
Y
A
E
I
K
S
S
C
Site 23
S173
F
Y
A
E
I
K
S
S
C
A
K
V
Q
T
R
Site 24
T179
S
S
C
A
K
V
Q
T
R
K
G
S
L
L
H
Site 25
S183
K
V
Q
T
R
K
G
S
L
L
H
L
T
L
P
Site 26
T188
K
G
S
L
L
H
L
T
L
P
K
K
V
P
M
Site 27
S244
P
P
G
N
D
P
V
S
P
A
M
V
R
S
R
Site 28
S250
V
S
P
A
M
V
R
S
R
N
P
G
K
D
D
Site 29
S289
L
A
F
V
K
N
D
S
Y
E
K
G
P
D
S
Site 30
Y290
A
F
V
K
N
D
S
Y
E
K
G
P
D
S
V
Site 31
S296
S
Y
E
K
G
P
D
S
V
V
V
H
V
Y
V
Site 32
T310
V
K
E
I
C
R
D
T
S
R
V
L
F
R
E
Site 33
S311
K
E
I
C
R
D
T
S
R
V
L
F
R
E
Q
Site 34
T321
L
F
R
E
Q
D
F
T
L
I
F
Q
T
R
D
Site 35
S377
I
C
L
R
K
R
Q
S
Q
R
W
G
G
L
E
Site 36
T402
V
A
V
P
T
G
P
T
P
L
D
S
T
P
P
Site 37
S406
T
G
P
T
P
L
D
S
T
P
P
G
G
A
P
Site 38
T407
G
P
T
P
L
D
S
T
P
P
G
G
A
P
H
Site 39
T417
G
G
A
P
H
P
L
T
G
Q
E
E
A
R
A
Site 40
S430
R
A
V
E
K
D
K
S
K
A
R
S
E
D
T
Site 41
S434
K
D
K
S
K
A
R
S
E
D
T
G
L
D
S
Site 42
T437
S
K
A
R
S
E
D
T
G
L
D
S
V
A
T
Site 43
S441
S
E
D
T
G
L
D
S
V
A
T
R
T
P
M
Site 44
T444
T
G
L
D
S
V
A
T
R
T
P
M
E
H
V
Site 45
T446
L
D
S
V
A
T
R
T
P
M
E
H
V
T
P
Site 46
T452
R
T
P
M
E
H
V
T
P
K
P
E
T
H
L
Site 47
T457
H
V
T
P
K
P
E
T
H
L
A
S
P
K
P
Site 48
S461
K
P
E
T
H
L
A
S
P
K
P
T
C
M
V
Site 49
T465
H
L
A
S
P
K
P
T
C
M
V
P
P
M
P
Site 50
S474
M
V
P
P
M
P
H
S
P
V
S
G
D
S
V
Site 51
S477
P
M
P
H
S
P
V
S
G
D
S
V
E
E
E
Site 52
S480
H
S
P
V
S
G
D
S
V
E
E
E
E
E
E
Site 53
S514
F
M
N
S
V
I
Q
S
L
S
N
T
R
E
L
Site 54
S516
N
S
V
I
Q
S
L
S
N
T
R
E
L
R
D
Site 55
T518
V
I
Q
S
L
S
N
T
R
E
L
R
D
F
F
Site 56
Y536
S
F
E
A
E
I
N
Y
N
N
P
L
G
T
G
Site 57
T613
R
I
Q
N
K
P
Y
T
E
T
V
D
S
D
G
Site 58
T615
Q
N
K
P
Y
T
E
T
V
D
S
D
G
R
P
Site 59
S618
P
Y
T
E
T
V
D
S
D
G
R
P
D
E
V
Site 60
S640
R
H
K
M
R
N
D
S
F
I
V
D
L
F
Q
Site 61
Y650
V
D
L
F
Q
G
Q
Y
K
S
K
L
V
C
P
Site 62
Y687
Q
K
V
L
P
V
F
Y
F
A
R
E
P
H
S
Site 63
S694
Y
F
A
R
E
P
H
S
K
P
I
K
F
L
V
Site 64
S702
K
P
I
K
F
L
V
S
V
S
K
E
N
S
T
Site 65
S704
I
K
F
L
V
S
V
S
K
E
N
S
T
A
S
Site 66
S708
V
S
V
S
K
E
N
S
T
A
S
E
V
L
D
Site 67
S711
S
K
E
N
S
T
A
S
E
V
L
D
S
L
S
Site 68
S718
S
E
V
L
D
S
L
S
Q
S
V
H
V
K
P
Site 69
S720
V
L
D
S
L
S
Q
S
V
H
V
K
P
E
N
Site 70
S745
F
H
R
V
F
L
P
S
H
S
L
D
T
V
S
Site 71
S747
R
V
F
L
P
S
H
S
L
D
T
V
S
P
S
Site 72
T750
L
P
S
H
S
L
D
T
V
S
P
S
D
T
L
Site 73
S752
S
H
S
L
D
T
V
S
P
S
D
T
L
L
C
Site 74
S785
Q
Q
R
P
Q
V
P
S
V
P
I
S
K
C
A
Site 75
S789
Q
V
P
S
V
P
I
S
K
C
A
A
C
Q
R
Site 76
S800
A
C
Q
R
K
Q
Q
S
E
D
E
K
L
K
R
Site 77
Y812
L
K
R
C
T
R
C
Y
R
V
G
Y
C
N
Q
Site 78
Y816
T
R
C
Y
R
V
G
Y
C
N
Q
L
C
Q
K
Site 79
Y853
V
P
A
S
R
L
T
Y
A
R
L
A
Q
L
L
Site 80
S867
L
E
G
Y
A
R
Y
S
V
S
V
F
Q
P
P
Site 81
S869
G
Y
A
R
Y
S
V
S
V
F
Q
P
P
F
Q
Site 82
S884
P
G
R
M
A
L
E
S
Q
S
P
G
C
T
T
Site 83
S886
R
M
A
L
E
S
Q
S
P
G
C
T
T
L
L
Site 84
T890
E
S
Q
S
P
G
C
T
T
L
L
S
T
G
S
Site 85
T891
S
Q
S
P
G
C
T
T
L
L
S
T
G
S
L
Site 86
S897
T
T
L
L
S
T
G
S
L
E
A
G
D
S
E
Site 87
S903
G
S
L
E
A
G
D
S
E
R
D
P
I
Q
P
Site 88
T917
P
P
E
L
Q
L
V
T
P
M
A
E
G
D
T
Site 89
T924
T
P
M
A
E
G
D
T
G
L
P
R
V
W
A
Site 90
S940
P
D
R
G
P
V
P
S
T
S
G
I
S
S
E
Site 91
T941
D
R
G
P
V
P
S
T
S
G
I
S
S
E
M
Site 92
S942
R
G
P
V
P
S
T
S
G
I
S
S
E
M
L
Site 93
S946
P
S
T
S
G
I
S
S
E
M
L
A
S
G
P
Site 94
S958
S
G
P
I
E
V
G
S
L
P
A
G
E
R
V
Site 95
S966
L
P
A
G
E
R
V
S
R
P
E
A
A
V
P
Site 96
Y975
P
E
A
A
V
P
G
Y
Q
H
P
S
E
A
M
Site 97
T986
S
E
A
M
N
A
H
T
P
Q
F
F
I
Y
K
Site 98
Y992
H
T
P
Q
F
F
I
Y
K
I
D
S
S
N
R
Site 99
S996
F
F
I
Y
K
I
D
S
S
N
R
E
Q
R
L
Site 100
S997
F
I
Y
K
I
D
S
S
N
R
E
Q
R
L
E
Site 101
T1009
R
L
E
D
K
G
D
T
P
L
E
L
G
D
D
Site 102
S1048
E
C
A
E
D
P
G
S
A
G
E
A
A
R
A
Site 103
Y1080
L
A
P
E
E
A
W
Y
C
P
Q
C
K
Q
H
Site 104
S1091
C
K
Q
H
R
E
A
S
K
Q
L
L
L
W
R
Site 105
S1111
I
V
Q
L
K
R
F
S
F
R
S
F
I
W
R
Site 106
S1114
L
K
R
F
S
F
R
S
F
I
W
R
D
K
I
Site 107
S1135
P
V
R
N
L
D
L
S
K
F
C
I
G
Q
K
Site 108
Y1149
K
E
E
Q
L
P
S
Y
D
L
Y
A
V
I
N
Site 109
Y1152
Q
L
P
S
Y
D
L
Y
A
V
I
N
H
Y
G
Site 110
S1177
A
R
L
P
N
D
R
S
S
Q
R
S
D
V
G
Site 111
S1178
R
L
P
N
D
R
S
S
Q
R
S
D
V
G
W
Site 112
S1181
N
D
R
S
S
Q
R
S
D
V
G
W
R
L
F
Site 113
S1191
G
W
R
L
F
D
D
S
T
V
T
T
V
D
E
Site 114
T1192
W
R
L
F
D
D
S
T
V
T
T
V
D
E
S
Site 115
T1195
F
D
D
S
T
V
T
T
V
D
E
S
Q
V
V
Site 116
S1199
T
V
T
T
V
D
E
S
Q
V
V
T
R
Y
A
Site 117
Y1205
E
S
Q
V
V
T
R
Y
A
Y
V
L
F
Y
R
Site 118
Y1207
Q
V
V
T
R
Y
A
Y
V
L
F
Y
R
R
R
Site 119
Y1211
R
Y
A
Y
V
L
F
Y
R
R
R
N
S
P
V
Site 120
S1216
L
F
Y
R
R
R
N
S
P
V
E
R
P
P
R
Site 121
S1227
R
P
P
R
A
G
H
S
E
H
H
P
D
L
G
Site 122
S1242
P
A
A
E
A
A
A
S
Q
A
S
R
I
W
Q
Site 123
S1262
E
E
P
V
P
E
G
S
G
P
L
G
P
W
G
Site 124
T1282
G
P
L
P
R
G
P
T
T
P
D
E
G
C
L
Site 125
T1283
P
L
P
R
G
P
T
T
P
D
E
G
C
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation