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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
JMJD2B
Full Name:
Lysine-specific demethylase 4B
Alias:
JHD3B; JMJ2B; JmjC domain-containing histone demethylation protein 3B; Jumonji domain containing protein 2B; Jumonji domain-containing protein 2B; KIAA0876; Lysine (K)-specific demethylase 4B
Type:
Oxidoreductase; EC 1.14.11.-; Demethylase
Mass (Da):
121897
Number AA:
1096
UniProt ID:
O94953
International Prot ID:
IPI00013205
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005506
GO:0003676
GO:0016702
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0055114
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
N
P
S
C
K
I
M
T
F
R
P
T
M
E
E
Site 2
T21
K
I
M
T
F
R
P
T
M
E
E
F
K
D
F
Site 3
Y31
E
F
K
D
F
N
K
Y
V
A
Y
I
E
S
Q
Site 4
Y34
D
F
N
K
Y
V
A
Y
I
E
S
Q
G
A
H
Site 5
T59
K
E
W
K
P
R
Q
T
Y
D
D
I
D
D
V
Site 6
Y60
E
W
K
P
R
Q
T
Y
D
D
I
D
D
V
V
Site 7
T84
T
G
Q
S
G
L
F
T
Q
Y
N
I
Q
K
K
Site 8
S104
E
Y
R
R
L
A
N
S
E
K
Y
C
T
P
R
Site 9
Y107
R
L
A
N
S
E
K
Y
C
T
P
R
H
Q
D
Site 10
T109
A
N
S
E
K
Y
C
T
P
R
H
Q
D
F
D
Site 11
Y122
F
D
D
L
E
R
K
Y
W
K
N
L
T
F
V
Site 12
T127
R
K
Y
W
K
N
L
T
F
V
S
P
I
Y
G
Site 13
S138
P
I
Y
G
A
D
I
S
G
S
L
Y
D
D
D
Site 14
S140
Y
G
A
D
I
S
G
S
L
Y
D
D
D
V
A
Site 15
Y142
A
D
I
S
G
S
L
Y
D
D
D
V
A
Q
W
Site 16
Y176
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
Site 17
Y178
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
T
Site 18
Y196
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
Site 19
Y200
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
Site 20
S208
L
H
F
G
E
P
K
S
W
Y
A
I
P
P
E
Site 21
Y210
F
G
E
P
K
S
W
Y
A
I
P
P
E
H
G
Site 22
S247
R
H
K
M
T
L
I
S
P
I
I
L
K
K
Y
Site 23
S259
K
K
Y
G
I
P
F
S
R
I
T
Q
E
A
G
Site 24
T262
G
I
P
F
S
R
I
T
Q
E
A
G
E
F
M
Site 25
T271
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
Site 26
T294
A
E
S
T
N
F
A
T
L
R
W
I
D
Y
G
Site 27
Y300
A
T
L
R
W
I
D
Y
G
K
V
A
T
Q
C
Site 28
T305
I
D
Y
G
K
V
A
T
Q
C
T
C
R
K
D
Site 29
T308
G
K
V
A
T
Q
C
T
C
R
K
D
M
V
K
Site 30
Y330
R
I
L
Q
P
E
R
Y
E
L
W
K
Q
G
K
Site 31
T340
W
K
Q
G
K
D
L
T
V
L
D
H
T
R
P
Site 32
T345
D
L
T
V
L
D
H
T
R
P
T
A
L
T
S
Site 33
T348
V
L
D
H
T
R
P
T
A
L
T
S
P
E
L
Site 34
T351
H
T
R
P
T
A
L
T
S
P
E
L
S
S
W
Site 35
S352
T
R
P
T
A
L
T
S
P
E
L
S
S
W
S
Site 36
S356
A
L
T
S
P
E
L
S
S
W
S
A
S
R
A
Site 37
S357
L
T
S
P
E
L
S
S
W
S
A
S
R
A
S
Site 38
S359
S
P
E
L
S
S
W
S
A
S
R
A
S
L
K
Site 39
S361
E
L
S
S
W
S
A
S
R
A
S
L
K
A
K
Site 40
S364
S
W
S
A
S
R
A
S
L
K
A
K
L
L
R
Site 41
S373
K
A
K
L
L
R
R
S
H
R
K
R
S
Q
P
Site 42
S378
R
R
S
H
R
K
R
S
Q
P
K
K
P
K
P
Site 43
S407
L
L
E
E
A
G
G
S
V
K
E
E
A
G
P
Site 44
T448
G
R
G
K
L
R
P
T
K
A
K
S
E
R
K
Site 45
S452
L
R
P
T
K
A
K
S
E
R
K
K
K
S
F
Site 46
S458
K
S
E
R
K
K
K
S
F
G
L
L
P
P
Q
Site 47
S475
P
P
P
A
H
F
P
S
E
E
A
L
W
L
P
Site 48
S500
G
P
A
A
M
E
E
S
P
L
P
A
P
L
N
Site 49
S566
P
T
W
K
E
P
V
S
P
M
E
L
T
G
P
Site 50
S580
P
E
D
G
A
A
S
S
G
A
G
R
M
E
T
Site 51
T587
S
G
A
G
R
M
E
T
K
A
R
A
G
E
G
Site 52
S598
A
G
E
G
Q
A
P
S
T
F
S
K
L
K
M
Site 53
T599
G
E
G
Q
A
P
S
T
F
S
K
L
K
M
E
Site 54
S610
L
K
M
E
I
K
K
S
R
R
H
P
L
G
R
Site 55
T620
H
P
L
G
R
P
P
T
R
S
P
L
S
V
V
Site 56
S622
L
G
R
P
P
T
R
S
P
L
S
V
V
K
Q
Site 57
S625
P
P
T
R
S
P
L
S
V
V
K
Q
E
A
S
Site 58
S632
S
V
V
K
Q
E
A
S
S
D
E
E
A
S
P
Site 59
S633
V
V
K
Q
E
A
S
S
D
E
E
A
S
P
F
Site 60
S638
A
S
S
D
E
E
A
S
P
F
S
G
E
E
D
Site 61
S647
F
S
G
E
E
D
V
S
D
P
D
A
L
R
P
Site 62
S657
D
A
L
R
P
L
L
S
L
Q
W
K
N
R
A
Site 63
S666
Q
W
K
N
R
A
A
S
F
Q
A
E
R
K
F
Site 64
S707
E
K
E
A
P
I
A
S
L
G
K
G
C
P
A
Site 65
T715
L
G
K
G
C
P
A
T
L
P
S
K
S
R
Q
Site 66
S718
G
C
P
A
T
L
P
S
K
S
R
Q
K
T
R
Site 67
S720
P
A
T
L
P
S
K
S
R
Q
K
T
R
P
L
Site 68
T724
P
S
K
S
R
Q
K
T
R
P
L
I
P
E
M
Site 69
T734
L
I
P
E
M
C
F
T
S
G
G
E
N
T
E
Site 70
Y748
E
P
L
P
A
N
S
Y
I
G
D
D
G
T
S
Site 71
S755
Y
I
G
D
D
G
T
S
P
L
I
A
C
G
K
Site 72
S841
E
R
H
P
V
D
I
S
A
I
P
E
Q
R
W
Site 73
Y854
R
W
K
L
K
C
V
Y
C
R
K
R
M
K
K
Site 74
S863
R
K
R
M
K
K
V
S
G
A
C
I
Q
C
S
Site 75
S908
I
T
C
L
K
H
K
S
G
G
H
A
V
Q
L
Site 76
T927
S
L
G
Q
V
V
I
T
K
N
R
N
G
L
Y
Site 77
Y934
T
K
N
R
N
G
L
Y
Y
R
C
R
V
I
G
Site 78
Y935
K
N
R
N
G
L
Y
Y
R
C
R
V
I
G
A
Site 79
Y948
G
A
A
S
Q
T
C
Y
E
V
N
F
D
D
G
Site 80
S956
E
V
N
F
D
D
G
S
Y
S
D
N
L
Y
P
Site 81
Y957
V
N
F
D
D
G
S
Y
S
D
N
L
Y
P
E
Site 82
S958
N
F
D
D
G
S
Y
S
D
N
L
Y
P
E
S
Site 83
Y962
G
S
Y
S
D
N
L
Y
P
E
S
I
T
S
R
Site 84
S965
S
D
N
L
Y
P
E
S
I
T
S
R
D
C
V
Site 85
S968
L
Y
P
E
S
I
T
S
R
D
C
V
Q
L
G
Site 86
T988
E
L
V
E
L
R
W
T
D
G
N
L
Y
K
A
Site 87
Y993
R
W
T
D
G
N
L
Y
K
A
K
F
I
S
S
Site 88
S1000
Y
K
A
K
F
I
S
S
V
T
S
H
I
Y
Q
Site 89
Y1006
S
S
V
T
S
H
I
Y
Q
V
E
F
E
D
G
Site 90
S1014
Q
V
E
F
E
D
G
S
Q
L
T
V
K
R
G
Site 91
T1017
F
E
D
G
S
Q
L
T
V
K
R
G
D
I
F
Site 92
T1025
V
K
R
G
D
I
F
T
L
E
E
E
L
P
K
Site 93
S1036
E
L
P
K
R
V
R
S
R
L
S
L
S
T
G
Site 94
S1039
K
R
V
R
S
R
L
S
L
S
T
G
A
P
Q
Site 95
S1041
V
R
S
R
L
S
L
S
T
G
A
P
Q
E
P
Site 96
T1042
R
S
R
L
S
L
S
T
G
A
P
Q
E
P
A
Site 97
S1051
A
P
Q
E
P
A
F
S
G
E
E
A
K
A
A
Site 98
T1065
A
K
R
P
R
V
G
T
P
L
A
T
E
D
S
Site 99
T1069
R
V
G
T
P
L
A
T
E
D
S
G
R
S
Q
Site 100
S1072
T
P
L
A
T
E
D
S
G
R
S
Q
D
Y
V
Site 101
Y1078
D
S
G
R
S
Q
D
Y
V
A
F
V
E
S
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation