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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCA8
Full Name:
ATP-binding cassette sub-family A member 8
Alias:
Type:
Mass (Da):
179245
Number AA:
1581
UniProt ID:
O94911
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S57
S
H
Q
V
N
D
F
S
S
L
L
T
M
D
L
Site 2
S58
H
Q
V
N
D
F
S
S
L
L
T
M
D
L
G
Site 3
T61
N
D
F
S
S
L
L
T
M
D
L
G
R
V
D
Site 4
T69
M
D
L
G
R
V
D
T
F
N
E
S
R
F
S
Site 5
S76
T
F
N
E
S
R
F
S
V
V
Y
T
P
V
T
Site 6
Y79
E
S
R
F
S
V
V
Y
T
P
V
T
N
T
T
Site 7
T80
S
R
F
S
V
V
Y
T
P
V
T
N
T
T
Q
Site 8
S112
L
G
L
P
D
E
E
S
I
K
E
F
T
A
N
Site 9
Y120
I
K
E
F
T
A
N
Y
P
E
E
I
V
R
V
Site 10
T128
P
E
E
I
V
R
V
T
F
T
N
T
Y
S
Y
Site 11
T130
E
I
V
R
V
T
F
T
N
T
Y
S
Y
H
L
Site 12
Y135
T
F
T
N
T
Y
S
Y
H
L
K
F
L
L
G
Site 13
Y159
K
D
H
T
A
H
C
Y
E
T
N
E
D
V
Y
Site 14
Y166
Y
E
T
N
E
D
V
Y
C
E
V
S
V
F
W
Site 15
S196
I
E
I
T
T
N
H
S
V
M
E
E
L
M
S
Site 16
S203
S
V
M
E
E
L
M
S
V
T
G
K
N
M
K
Site 17
S213
G
K
N
M
K
M
H
S
F
I
G
Q
S
G
V
Site 18
S241
S
S
F
I
Y
Y
A
S
V
N
V
T
R
E
R
Site 19
T256
K
R
M
K
A
L
M
T
M
M
G
L
R
D
S
Site 20
Y381
A
Q
L
L
H
L
D
Y
D
L
N
S
N
A
F
Site 21
S385
H
L
D
Y
D
L
N
S
N
A
F
P
H
P
S
Site 22
S392
S
N
A
F
P
H
P
S
D
G
S
N
L
I
V
Site 23
Y427
E
K
I
L
P
N
E
Y
G
H
R
R
P
P
L
Site 24
S439
P
P
L
F
F
L
K
S
S
F
W
S
Q
T
Q
Site 25
S440
P
L
F
F
L
K
S
S
F
W
S
Q
T
Q
K
Site 26
S443
F
L
K
S
S
F
W
S
Q
T
Q
K
T
D
H
Site 27
T448
F
W
S
Q
T
Q
K
T
D
H
V
A
L
E
D
Site 28
S462
D
E
M
D
A
D
P
S
F
H
D
S
F
E
Q
Site 29
S466
A
D
P
S
F
H
D
S
F
E
Q
A
P
P
E
Site 30
T486
A
I
R
I
R
N
V
T
K
E
Y
K
G
K
P
Site 31
S523
G
H
S
G
A
G
K
S
T
L
L
N
I
L
S
Site 32
T524
H
S
G
A
G
K
S
T
L
L
N
I
L
S
G
Site 33
Y543
T
K
G
S
V
T
I
Y
N
N
K
L
S
E
M
Site 34
T574
N
V
Q
F
D
F
L
T
V
R
E
N
L
R
L
Site 35
S611
T
A
G
L
D
P
F
S
R
H
Q
V
W
N
L
Site 36
T624
N
L
L
K
E
R
K
T
D
R
V
I
L
F
S
Site 37
S631
T
D
R
V
I
L
F
S
T
Q
F
M
D
E
A
Site 38
S649
A
D
R
K
V
F
L
S
Q
G
K
L
K
C
A
Site 39
S658
G
K
L
K
C
A
G
S
S
L
F
L
K
K
K
Site 40
S687
C
V
E
E
N
I
T
S
L
V
K
Q
H
I
P
Site 41
S699
H
I
P
D
A
K
L
S
A
K
S
E
G
K
L
Site 42
Y708
K
S
E
G
K
L
I
Y
T
L
P
L
E
R
T
Site 43
T709
S
E
G
K
L
I
Y
T
L
P
L
E
R
T
N
Site 44
Y722
T
N
K
F
P
E
L
Y
K
D
L
D
S
Y
P
Site 45
S727
E
L
Y
K
D
L
D
S
Y
P
D
L
G
I
E
Site 46
Y728
L
Y
K
D
L
D
S
Y
P
D
L
G
I
E
N
Site 47
S754
F
L
K
L
E
G
K
S
T
I
N
E
S
D
I
Site 48
T755
L
K
L
E
G
K
S
T
I
N
E
S
D
I
A
Site 49
S759
G
K
S
T
I
N
E
S
D
I
A
I
L
G
E
Site 50
T775
Q
A
E
K
A
D
D
T
E
R
L
V
E
M
E
Site 51
S786
V
E
M
E
Q
V
L
S
S
L
N
K
M
R
K
Site 52
S787
E
M
E
Q
V
L
S
S
L
N
K
M
R
K
T
Site 53
T794
S
L
N
K
M
R
K
T
I
G
G
V
A
L
W
Site 54
Y847
E
Y
T
M
V
K
I
Y
Q
N
S
Y
T
W
E
Site 55
T852
K
I
Y
Q
N
S
Y
T
W
E
L
S
P
H
L
Site 56
S856
N
S
Y
T
W
E
L
S
P
H
L
Y
F
L
A
Site 57
Y860
W
E
L
S
P
H
L
Y
F
L
A
P
G
Q
Q
Site 58
T873
Q
Q
P
H
D
P
L
T
Q
L
L
I
I
N
K
Site 59
S884
I
I
N
K
T
G
A
S
I
D
D
F
I
Q
S
Site 60
T910
A
F
G
T
R
N
G
T
D
D
P
S
Y
N
G
Site 61
S914
R
N
G
T
D
D
P
S
Y
N
G
A
I
T
V
Site 62
Y915
N
G
T
D
D
P
S
Y
N
G
A
I
T
V
C
Site 63
S960
L
L
G
M
V
K
P
S
V
H
I
R
T
E
R
Site 64
T969
H
I
R
T
E
R
S
T
F
L
E
N
G
Q
D
Site 65
Y1007
A
M
S
S
I
D
D
Y
K
N
R
A
R
S
Q
Site 66
S1013
D
Y
K
N
R
A
R
S
Q
L
R
I
S
G
L
Site 67
S1018
A
R
S
Q
L
R
I
S
G
L
S
P
S
A
Y
Site 68
S1021
Q
L
R
I
S
G
L
S
P
S
A
Y
W
F
G
Site 69
S1023
R
I
S
G
L
S
P
S
A
Y
W
F
G
Q
A
Site 70
S1147
L
S
S
H
L
L
F
S
S
L
F
S
E
E
R
Site 71
S1148
S
S
H
L
L
F
S
S
L
F
S
E
E
R
M
Site 72
S1151
L
L
F
S
S
L
F
S
E
E
R
M
D
V
Q
Site 73
S1198
K
D
P
F
F
R
I
S
P
R
S
S
D
V
C
Site 74
S1201
F
F
R
I
S
P
R
S
S
D
V
C
Q
N
P
Site 75
S1202
F
R
I
S
P
R
S
S
D
V
C
Q
N
P
E
Site 76
T1225
V
Q
M
E
R
V
R
T
A
N
A
L
N
S
T
Site 77
S1243
E
K
P
V
I
I
A
S
C
L
R
K
E
Y
A
Site 78
Y1249
A
S
C
L
R
K
E
Y
A
G
K
R
K
G
C
Site 79
S1258
G
K
R
K
G
C
F
S
K
R
K
N
K
I
A
Site 80
T1266
K
R
K
N
K
I
A
T
R
N
V
S
F
C
V
Site 81
S1270
K
I
A
T
R
N
V
S
F
C
V
R
K
G
E
Site 82
S1290
G
H
N
G
A
G
K
S
T
S
I
K
V
I
T
Site 83
S1292
N
G
A
G
K
S
T
S
I
K
V
I
T
G
D
Site 84
Y1323
D
A
L
E
F
L
G
Y
C
P
Q
E
N
A
L
Site 85
T1335
N
A
L
W
P
N
L
T
V
R
Q
H
L
E
V
Site 86
Y1343
V
R
Q
H
L
E
V
Y
A
A
V
K
G
L
R
Site 87
T1359
G
D
A
E
V
A
I
T
R
L
V
D
A
L
K
Site 88
S1373
K
L
Q
D
Q
L
K
S
P
V
K
T
L
S
E
Site 89
T1377
Q
L
K
S
P
V
K
T
L
S
E
G
I
K
R
Site 90
S1379
K
S
P
V
K
T
L
S
E
G
I
K
R
K
L
Site 91
S1405
V
V
L
L
D
E
P
S
T
G
M
D
P
E
G
Site 92
T1427
I
R
A
T
F
R
N
T
E
R
G
A
L
L
T
Site 93
T1434
T
E
R
G
A
L
L
T
T
H
Y
M
A
E
A
Site 94
S1461
G
R
L
R
C
I
G
S
I
Q
H
L
K
S
K
Site 95
S1467
G
S
I
Q
H
L
K
S
K
F
G
K
D
Y
L
Site 96
Y1473
K
S
K
F
G
K
D
Y
L
L
E
M
K
V
K
Site 97
S1506
A
A
R
Q
E
R
Y
S
S
L
M
V
Y
K
L
Site 98
S1507
A
R
Q
E
R
Y
S
S
L
M
V
Y
K
L
P
Site 99
Y1511
R
Y
S
S
L
M
V
Y
K
L
P
V
E
D
V
Site 100
S1534
K
L
E
K
V
K
Q
S
F
D
L
E
E
Y
S
Site 101
S1541
S
F
D
L
E
E
Y
S
L
S
Q
S
T
L
E
Site 102
S1543
D
L
E
E
Y
S
L
S
Q
S
T
L
E
Q
V
Site 103
S1545
E
E
Y
S
L
S
Q
S
T
L
E
Q
V
F
L
Site 104
S1555
E
Q
V
F
L
E
L
S
K
E
Q
E
L
G
D
Site 105
S1570
F
E
E
D
F
D
P
S
V
K
W
K
L
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation