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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRP6
Full Name:
Pre-mRNA-processing factor 6
Alias:
Androgen receptor N-terminal domain transactivating protein-1; ANT-1; BB152O15.1; C20orf14; Mitochondrial outer membrane protein import receptor; P102 U5 small nuclear ribonucleoprotein particle-binding; PRP6 homolog; PRPF6; TOM; U5 snRNP-associated 102 kDa; U5 snRNP-associated 102 kDa protein; U5-102 kDa; U5-102K
Type:
Nuclear receptor co-regulator; RNA binding protein
Mass (Da):
106925
Number AA:
941
UniProt ID:
O94906
International Prot ID:
IPI00305068
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005681
Uniprot
OncoNet
Molecular Function:
GO:0050681
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0000244
GO:0045944
GO:0000245
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
G
M
P
A
P
L
G
Y
V
P
G
L
G
R
G
Site 2
T26
P
G
L
G
R
G
A
T
G
F
T
T
R
S
D
Site 3
T30
R
G
A
T
G
F
T
T
R
S
D
I
G
P
A
Site 4
S32
A
T
G
F
T
T
R
S
D
I
G
P
A
R
D
Site 5
T55
H
A
P
P
G
K
R
T
V
G
D
Q
M
K
K
Site 6
T76
D
D
E
D
L
N
D
T
N
Y
D
E
F
N
G
Site 7
Y78
E
D
L
N
D
T
N
Y
D
E
F
N
G
Y
A
Site 8
Y84
N
Y
D
E
F
N
G
Y
A
G
S
L
F
S
S
Site 9
S87
E
F
N
G
Y
A
G
S
L
F
S
S
G
P
Y
Site 10
S91
Y
A
G
S
L
F
S
S
G
P
Y
E
K
D
D
Site 11
Y94
S
L
F
S
S
G
P
Y
E
K
D
D
E
E
A
Site 12
Y105
D
E
E
A
D
A
I
Y
A
A
L
D
K
R
M
Site 13
Y131
E
K
E
E
I
E
K
Y
R
M
E
R
P
K
I
Site 14
S143
P
K
I
Q
Q
Q
F
S
D
L
K
R
K
L
A
Site 15
S159
V
T
E
E
E
W
L
S
I
P
E
V
G
D
A
Site 16
Y176
K
R
Q
R
N
P
R
Y
E
K
L
T
P
V
P
Site 17
T180
N
P
R
Y
E
K
L
T
P
V
P
D
S
F
F
Site 18
S185
K
L
T
P
V
P
D
S
F
F
A
K
H
L
Q
Site 19
S199
Q
T
G
E
N
H
T
S
V
D
P
R
Q
T
Q
Site 20
T205
T
S
V
D
P
R
Q
T
Q
F
G
G
L
N
T
Site 21
T212
T
Q
F
G
G
L
N
T
P
Y
P
G
G
L
N
Site 22
Y214
F
G
G
L
N
T
P
Y
P
G
G
L
N
T
P
Site 23
T220
P
Y
P
G
G
L
N
T
P
Y
P
G
G
M
T
Site 24
Y222
P
G
G
L
N
T
P
Y
P
G
G
M
T
P
G
Site 25
T227
T
P
Y
P
G
G
M
T
P
G
L
M
T
P
G
Site 26
T232
G
M
T
P
G
L
M
T
P
G
T
G
E
L
D
Site 27
T235
P
G
L
M
T
P
G
T
G
E
L
D
M
R
K
Site 28
T249
K
I
G
Q
A
R
N
T
L
M
D
M
R
L
S
Site 29
S256
T
L
M
D
M
R
L
S
Q
V
S
D
S
V
S
Site 30
S259
D
M
R
L
S
Q
V
S
D
S
V
S
G
Q
T
Site 31
S261
R
L
S
Q
V
S
D
S
V
S
G
Q
T
V
V
Site 32
S263
S
Q
V
S
D
S
V
S
G
Q
T
V
V
D
P
Site 33
T266
S
D
S
V
S
G
Q
T
V
V
D
P
K
G
Y
Site 34
Y273
T
V
V
D
P
K
G
Y
L
T
D
L
N
S
M
Site 35
T275
V
D
P
K
G
Y
L
T
D
L
N
S
M
I
P
Site 36
S279
G
Y
L
T
D
L
N
S
M
I
P
T
H
G
G
Site 37
T283
D
L
N
S
M
I
P
T
H
G
G
D
I
N
D
Site 38
S300
K
A
R
L
L
L
K
S
V
R
E
T
N
P
H
Site 39
T304
L
L
K
S
V
R
E
T
N
P
H
H
P
P
A
Site 40
S315
H
P
P
A
W
I
A
S
A
R
L
E
E
V
T
Site 41
S342
G
T
E
M
C
P
K
S
E
D
V
W
L
E
A
Site 42
S372
A
V
R
H
L
P
Q
S
V
R
I
Y
I
R
A
Site 43
Y376
L
P
Q
S
V
R
I
Y
I
R
A
A
E
L
E
Site 44
S403
A
L
E
H
V
P
N
S
V
R
L
W
K
A
A
Site 45
S424
E
D
A
R
I
M
L
S
R
A
V
E
C
C
P
Site 46
T445
L
A
L
A
R
L
E
T
Y
E
N
A
R
K
V
Site 47
T462
K
A
R
E
N
I
P
T
D
R
H
I
W
I
T
Site 48
T469
T
D
R
H
I
W
I
T
A
A
K
L
E
E
A
Site 49
S518
E
E
C
D
R
A
G
S
V
A
T
C
Q
A
V
Site 50
T542
E
E
E
D
R
K
H
T
W
M
E
D
A
D
S
Site 51
Y563
L
E
C
A
R
A
I
Y
A
Y
A
L
Q
V
F
Site 52
Y565
C
A
R
A
I
Y
A
Y
A
L
Q
V
F
P
S
Site 53
S572
Y
A
L
Q
V
F
P
S
K
K
S
V
W
L
R
Site 54
S575
Q
V
F
P
S
K
K
S
V
W
L
R
A
A
Y
Site 55
Y582
S
V
W
L
R
A
A
Y
F
E
K
N
H
G
T
Site 56
S592
K
N
H
G
T
R
E
S
L
E
A
L
L
Q
R
Site 57
S641
A
F
Q
A
N
P
N
S
E
E
I
W
L
A
A
Site 58
Y658
L
E
S
E
N
D
E
Y
E
R
A
R
R
L
L
Site 59
S670
R
L
L
A
K
A
R
S
S
A
P
T
A
R
V
Site 60
T674
K
A
R
S
S
A
P
T
A
R
V
F
M
K
S
Site 61
S681
T
A
R
V
F
M
K
S
V
K
L
E
W
V
Q
Site 62
Y705
C
E
E
A
L
R
H
Y
E
D
F
P
K
L
W
Site 63
Y732
M
E
K
A
R
E
A
Y
N
Q
G
L
K
K
C
Site 64
S769
A
R
A
I
L
E
K
S
R
L
K
N
P
K
N
Site 65
S783
N
P
G
L
W
L
E
S
V
R
L
E
Y
R
A
Site 66
Y788
L
E
S
V
R
L
E
Y
R
A
G
L
K
N
I
Site 67
T798
G
L
K
N
I
A
N
T
L
M
A
K
A
L
Q
Site 68
S810
A
L
Q
E
C
P
N
S
G
I
L
W
S
E
A
Site 69
T828
E
A
R
P
Q
R
R
T
K
S
V
D
A
L
K
Site 70
S830
R
P
Q
R
R
T
K
S
V
D
A
L
K
K
C
Site 71
S853
A
V
A
K
L
F
W
S
Q
R
K
I
T
K
A
Site 72
T867
A
R
E
W
F
H
R
T
V
K
I
D
S
D
L
Site 73
Y882
G
D
A
W
A
F
F
Y
K
F
E
L
Q
H
G
Site 74
S903
E
V
R
K
R
C
E
S
A
E
P
R
H
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation