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Updated November 2019
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Protein Info
Short Name:
SASH1
Full Name:
SAM and SH3 domain-containing protein 1
Alias:
DJ323M4.1; KIAA0790; PEPE1; Proline-glutamate repeat-containing protein; SAM and SH3 domain containing 1; SAM and SH3 domain containing protein 1; SH3D6A
Type:
Tumor suppressor
Mass (Da):
136653
Number AA:
1247
UniProt ID:
O94885
International Prot ID:
IPI00304817
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S38
P
K
P
G
A
G
T
S
E
A
F
S
R
L
W
Site 2
S42
A
G
T
S
E
A
F
S
R
L
W
T
D
V
M
Site 3
Y69
L
A
Q
Q
Y
A
D
Y
Y
N
T
C
F
S
D
Site 4
Y70
A
Q
Q
Y
A
D
Y
Y
N
T
C
F
S
D
V
Site 5
S90
E
L
R
K
R
R
V
S
Q
D
L
E
V
E
K
Site 6
S101
E
V
E
K
P
D
A
S
P
T
S
L
Q
L
R
Site 7
S104
K
P
D
A
S
P
T
S
L
Q
L
R
S
Q
I
Site 8
S109
P
T
S
L
Q
L
R
S
Q
I
E
E
S
L
G
Site 9
T123
G
F
C
S
A
V
S
T
P
E
V
E
R
K
N
Site 10
S135
R
K
N
P
L
H
K
S
N
S
E
D
S
S
V
Site 11
S137
N
P
L
H
K
S
N
S
E
D
S
S
V
G
K
Site 12
S141
K
S
N
S
E
D
S
S
V
G
K
G
D
W
K
Site 13
T169
Q
K
G
I
M
R
Q
T
S
K
G
E
D
V
G
Site 14
S170
K
G
I
M
R
Q
T
S
K
G
E
D
V
G
Y
Site 15
Y177
S
K
G
E
D
V
G
Y
V
A
S
E
I
T
M
Site 16
S180
E
D
V
G
Y
V
A
S
E
I
T
M
S
D
E
Site 17
S185
V
A
S
E
I
T
M
S
D
E
E
R
I
Q
L
Site 18
S220
Y
E
A
Q
H
R
Q
S
A
A
L
D
P
A
D
Site 19
S232
P
A
D
W
P
D
G
S
Y
P
T
F
D
G
S
Site 20
Y233
A
D
W
P
D
G
S
Y
P
T
F
D
G
S
S
Site 21
T235
W
P
D
G
S
Y
P
T
F
D
G
S
S
N
C
Site 22
S239
S
Y
P
T
F
D
G
S
S
N
C
N
S
R
E
Site 23
S240
Y
P
T
F
D
G
S
S
N
C
N
S
R
E
Q
Site 24
S244
D
G
S
S
N
C
N
S
R
E
Q
S
D
D
E
Site 25
S248
N
C
N
S
R
E
Q
S
D
D
E
T
E
E
S
Site 26
T252
R
E
Q
S
D
D
E
T
E
E
S
V
K
F
K
Site 27
S255
S
D
D
E
T
E
E
S
V
K
F
K
R
L
H
Site 28
S267
R
L
H
K
L
V
N
S
T
R
R
V
R
K
K
Site 29
T286
E
E
M
K
K
P
S
T
E
G
G
E
E
H
V
Site 30
S297
E
E
H
V
F
E
N
S
P
V
L
D
E
R
S
Site 31
S304
S
P
V
L
D
E
R
S
A
L
Y
S
G
V
H
Site 32
Y307
L
D
E
R
S
A
L
Y
S
G
V
H
K
K
P
Site 33
S308
D
E
R
S
A
L
Y
S
G
V
H
K
K
P
L
Site 34
S320
K
P
L
F
F
D
G
S
P
E
K
P
P
E
D
Site 35
S329
E
K
P
P
E
D
D
S
D
S
L
T
T
S
P
Site 36
S331
P
P
E
D
D
S
D
S
L
T
T
S
P
S
S
Site 37
T333
E
D
D
S
D
S
L
T
T
S
P
S
S
S
S
Site 38
T334
D
D
S
D
S
L
T
T
S
P
S
S
S
S
L
Site 39
S335
D
S
D
S
L
T
T
S
P
S
S
S
S
L
D
Site 40
S337
D
S
L
T
T
S
P
S
S
S
S
L
D
T
W
Site 41
S338
S
L
T
T
S
P
S
S
S
S
L
D
T
W
G
Site 42
S339
L
T
T
S
P
S
S
S
S
L
D
T
W
G
A
Site 43
S340
T
T
S
P
S
S
S
S
L
D
T
W
G
A
G
Site 44
T343
P
S
S
S
S
L
D
T
W
G
A
G
R
K
L
Site 45
T353
A
G
R
K
L
V
K
T
F
S
K
G
E
S
R
Site 46
S355
R
K
L
V
K
T
F
S
K
G
E
S
R
G
L
Site 47
S359
K
T
F
S
K
G
E
S
R
G
L
I
K
P
P
Site 48
T371
K
P
P
K
K
M
G
T
F
F
S
Y
P
E
E
Site 49
S374
K
K
M
G
T
F
F
S
Y
P
E
E
E
K
A
Site 50
Y375
K
M
G
T
F
F
S
Y
P
E
E
E
K
A
Q
Site 51
S387
K
A
Q
K
V
S
R
S
L
T
E
G
E
M
K
Site 52
T389
Q
K
V
S
R
S
L
T
E
G
E
M
K
K
G
Site 53
S399
E
M
K
K
G
L
G
S
L
S
H
G
R
T
C
Site 54
S401
K
K
G
L
G
S
L
S
H
G
R
T
C
S
F
Site 55
T405
G
S
L
S
H
G
R
T
C
S
F
G
G
F
D
Site 56
S407
L
S
H
G
R
T
C
S
F
G
G
F
D
L
T
Site 57
T414
S
F
G
G
F
D
L
T
N
R
S
L
H
V
G
Site 58
S417
G
F
D
L
T
N
R
S
L
H
V
G
S
N
N
Site 59
S422
N
R
S
L
H
V
G
S
N
N
S
D
P
M
G
Site 60
Y436
G
K
E
G
D
F
V
Y
K
E
V
I
K
S
P
Site 61
S442
V
Y
K
E
V
I
K
S
P
T
A
S
R
I
S
Site 62
S446
V
I
K
S
P
T
A
S
R
I
S
L
G
K
K
Site 63
S449
S
P
T
A
S
R
I
S
L
G
K
K
V
K
S
Site 64
S456
S
L
G
K
K
V
K
S
V
K
E
T
M
R
K
Site 65
T460
K
V
K
S
V
K
E
T
M
R
K
R
M
S
K
Site 66
S466
E
T
M
R
K
R
M
S
K
K
Y
S
S
S
V
Site 67
Y469
R
K
R
M
S
K
K
Y
S
S
S
V
S
E
Q
Site 68
S470
K
R
M
S
K
K
Y
S
S
S
V
S
E
Q
D
Site 69
S472
M
S
K
K
Y
S
S
S
V
S
E
Q
D
S
G
Site 70
S474
K
K
Y
S
S
S
V
S
E
Q
D
S
G
L
D
Site 71
S478
S
S
V
S
E
Q
D
S
G
L
D
G
M
P
G
Site 72
S486
G
L
D
G
M
P
G
S
P
P
P
S
Q
P
D
Site 73
S490
M
P
G
S
P
P
P
S
Q
P
D
P
E
H
L
Site 74
S507
P
K
L
K
A
G
G
S
V
E
S
L
R
S
S
Site 75
S510
K
A
G
G
S
V
E
S
L
R
S
S
L
S
G
Site 76
S513
G
S
V
E
S
L
R
S
S
L
S
G
Q
S
S
Site 77
S514
S
V
E
S
L
R
S
S
L
S
G
Q
S
S
M
Site 78
S516
E
S
L
R
S
S
L
S
G
Q
S
S
M
S
G
Site 79
S520
S
S
L
S
G
Q
S
S
M
S
G
Q
T
V
S
Site 80
S522
L
S
G
Q
S
S
M
S
G
Q
T
V
S
T
T
Site 81
T525
Q
S
S
M
S
G
Q
T
V
S
T
T
D
S
S
Site 82
S527
S
M
S
G
Q
T
V
S
T
T
D
S
S
T
S
Site 83
T528
M
S
G
Q
T
V
S
T
T
D
S
S
T
S
N
Site 84
T529
S
G
Q
T
V
S
T
T
D
S
S
T
S
N
R
Site 85
S531
Q
T
V
S
T
T
D
S
S
T
S
N
R
E
S
Site 86
T533
V
S
T
T
D
S
S
T
S
N
R
E
S
V
K
Site 87
S534
S
T
T
D
S
S
T
S
N
R
E
S
V
K
S
Site 88
S538
S
S
T
S
N
R
E
S
V
K
S
E
D
G
D
Site 89
S541
S
N
R
E
S
V
K
S
E
D
G
D
D
E
E
Site 90
Y551
G
D
D
E
E
P
P
Y
R
G
P
F
C
G
R
Site 91
T563
C
G
R
A
R
V
H
T
D
F
T
P
S
P
Y
Site 92
T566
A
R
V
H
T
D
F
T
P
S
P
Y
D
T
D
Site 93
S568
V
H
T
D
F
T
P
S
P
Y
D
T
D
S
L
Site 94
Y570
T
D
F
T
P
S
P
Y
D
T
D
S
L
K
L
Site 95
T572
F
T
P
S
P
Y
D
T
D
S
L
K
L
K
K
Site 96
S574
P
S
P
Y
D
T
D
S
L
K
L
K
K
G
D
Site 97
S614
F
I
Y
V
D
V
L
S
E
D
E
E
K
P
K
Site 98
T624
E
E
K
P
K
R
P
T
R
R
R
R
K
G
R
Site 99
S637
G
R
P
P
Q
P
K
S
V
E
D
L
L
D
R
Site 100
T653
N
L
K
E
H
M
P
T
F
L
F
N
G
Y
E
Site 101
T664
N
G
Y
E
D
L
D
T
F
K
L
L
E
E
E
Site 102
Y697
A
V
E
L
L
Q
E
Y
D
S
N
S
D
Q
S
Site 103
S699
E
L
L
Q
E
Y
D
S
N
S
D
Q
S
G
S
Site 104
S701
L
Q
E
Y
D
S
N
S
D
Q
S
G
S
Q
E
Site 105
S706
S
N
S
D
Q
S
G
S
Q
E
K
L
L
V
D
Site 106
S714
Q
E
K
L
L
V
D
S
Q
G
L
S
G
C
S
Site 107
S718
L
V
D
S
Q
G
L
S
G
C
S
P
R
D
S
Site 108
S721
S
Q
G
L
S
G
C
S
P
R
D
S
G
C
Y
Site 109
S725
S
G
C
S
P
R
D
S
G
C
Y
E
S
S
E
Site 110
Y728
S
P
R
D
S
G
C
Y
E
S
S
E
N
L
E
Site 111
S730
R
D
S
G
C
Y
E
S
S
E
N
L
E
N
G
Site 112
S731
D
S
G
C
Y
E
S
S
E
N
L
E
N
G
K
Site 113
T739
E
N
L
E
N
G
K
T
R
K
A
S
L
L
S
Site 114
S743
N
G
K
T
R
K
A
S
L
L
S
A
K
S
S
Site 115
S746
T
R
K
A
S
L
L
S
A
K
S
S
T
E
P
Site 116
S749
A
S
L
L
S
A
K
S
S
T
E
P
S
L
K
Site 117
S750
S
L
L
S
A
K
S
S
T
E
P
S
L
K
S
Site 118
S754
A
K
S
S
T
E
P
S
L
K
S
F
S
R
N
Site 119
S757
S
T
E
P
S
L
K
S
F
S
R
N
Q
L
G
Site 120
S759
E
P
S
L
K
S
F
S
R
N
Q
L
G
N
Y
Site 121
Y766
S
R
N
Q
L
G
N
Y
P
T
L
P
L
M
K
Site 122
T768
N
Q
L
G
N
Y
P
T
L
P
L
M
K
S
G
Site 123
S774
P
T
L
P
L
M
K
S
G
D
A
L
K
Q
G
Site 124
T795
G
G
G
L
A
P
D
T
S
K
S
C
D
P
P
Site 125
S796
G
G
L
A
P
D
T
S
K
S
C
D
P
P
G
Site 126
S798
L
A
P
D
T
S
K
S
C
D
P
P
G
V
T
Site 127
S813
G
L
N
K
N
R
R
S
L
P
V
S
I
C
R
Site 128
S817
N
R
R
S
L
P
V
S
I
C
R
S
C
E
T
Site 129
S821
L
P
V
S
I
C
R
S
C
E
T
L
E
G
P
Site 130
T830
E
T
L
E
G
P
Q
T
V
D
T
W
P
R
S
Site 131
T833
E
G
P
Q
T
V
D
T
W
P
R
S
H
S
L
Site 132
S837
T
V
D
T
W
P
R
S
H
S
L
D
D
L
Q
Site 133
S839
D
T
W
P
R
S
H
S
L
D
D
L
Q
V
E
Site 134
T855
G
A
E
Q
D
V
P
T
E
V
T
E
P
P
P
Site 135
T872
V
P
E
V
P
Q
K
T
T
A
S
S
T
K
A
Site 136
T895
V
D
N
A
L
L
L
T
Q
S
K
R
F
S
E
Site 137
S897
N
A
L
L
L
T
Q
S
K
R
F
S
E
P
Q
Site 138
S901
L
T
Q
S
K
R
F
S
E
P
Q
K
L
T
T
Site 139
S914
T
T
K
K
L
E
G
S
I
A
A
S
G
R
G
Site 140
S918
L
E
G
S
I
A
A
S
G
R
G
L
S
P
P
Site 141
S923
A
A
S
G
R
G
L
S
P
P
Q
C
L
P
R
Site 142
Y932
P
Q
C
L
P
R
N
Y
D
A
Q
P
P
G
A
Site 143
T946
A
K
H
G
L
A
R
T
P
L
E
G
H
R
K
Site 144
T960
K
G
H
E
F
E
G
T
H
H
P
L
G
T
K
Site 145
S982
R
M
Q
P
K
I
P
S
Q
P
P
P
V
P
A
Site 146
S992
P
P
V
P
A
K
K
S
R
E
R
L
A
N
G
Site 147
S1013
G
P
S
G
A
L
P
S
P
D
A
P
C
L
P
Site 148
S1025
C
L
P
V
K
R
G
S
P
A
S
P
T
S
P
Site 149
S1028
V
K
R
G
S
P
A
S
P
T
S
P
S
D
C
Site 150
T1030
R
G
S
P
A
S
P
T
S
P
S
D
C
P
P
Site 151
S1031
G
S
P
A
S
P
T
S
P
S
D
C
P
P
A
Site 152
S1033
P
A
S
P
T
S
P
S
D
C
P
P
A
L
A
Site 153
S1045
A
L
A
P
R
P
L
S
G
Q
A
P
G
S
P
Site 154
S1051
L
S
G
Q
A
P
G
S
P
P
S
T
R
P
P
Site 155
S1054
Q
A
P
G
S
P
P
S
T
R
P
P
P
W
L
Site 156
T1055
A
P
G
S
P
P
S
T
R
P
P
P
W
L
S
Site 157
S1062
T
R
P
P
P
W
L
S
E
L
P
E
N
T
S
Site 158
S1069
S
E
L
P
E
N
T
S
L
Q
E
H
G
V
K
Site 159
S1086
P
A
L
T
R
K
V
S
C
A
R
G
V
D
L
Site 160
T1095
A
R
G
V
D
L
E
T
L
T
E
N
K
L
H
Site 161
T1109
H
A
E
G
I
D
L
T
E
E
P
Y
S
D
K
Site 162
Y1113
I
D
L
T
E
E
P
Y
S
D
K
H
G
R
C
Site 163
S1114
D
L
T
E
E
P
Y
S
D
K
H
G
R
C
G
Site 164
S1163
Q
H
R
M
A
I
P
S
G
G
L
T
E
I
C
Site 165
S1207
T
A
G
F
S
T
L
S
Q
V
P
S
L
S
H
Site 166
S1211
S
T
L
S
Q
V
P
S
L
S
H
T
C
L
Q
Site 167
S1213
L
S
Q
V
P
S
L
S
H
T
C
L
Q
E
A
Site 168
T1223
C
L
Q
E
A
G
I
T
E
E
R
H
I
R
K
Site 169
S1233
R
H
I
R
K
L
L
S
A
A
R
L
F
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation