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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMCC1
Full Name:
Transmembrane and coiled-coil domains protein 1
Alias:
CDNA FLJ42680 fis, clone BRAMY2040592, highly similar to Transmembrane and coiled-coil domains protein 1; KIAA0779; Putative uncharacterized protein DKFZp686H13261; Transmembrane and coiled-coil domain family 1
Type:
Mass (Da):
72053
Number AA:
653
UniProt ID:
O94876
International Prot ID:
IPI00333063
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
P
S
G
S
E
Q
L
F
E
D
P
Site 2
S19
D
P
D
P
G
G
K
S
Q
D
A
E
A
R
K
Site 3
T28
D
A
E
A
R
K
Q
T
E
S
E
Q
K
L
S
Site 4
S30
E
A
R
K
Q
T
E
S
E
Q
K
L
S
K
M
Site 5
S63
F
Q
H
Q
R
R
R
S
S
V
S
P
H
D
V
Site 6
S64
Q
H
Q
R
R
R
S
S
V
S
P
H
D
V
Q
Site 7
S66
Q
R
R
R
S
S
V
S
P
H
D
V
Q
Q
I
Site 8
S85
E
P
E
M
D
L
E
S
Q
N
A
C
A
E
I
Site 9
T119
P
P
K
M
K
R
G
T
S
L
H
S
R
R
G
Site 10
S120
P
K
M
K
R
G
T
S
L
H
S
R
R
G
K
Site 11
S123
K
R
G
T
S
L
H
S
R
R
G
K
P
E
A
Site 12
S134
K
P
E
A
P
K
G
S
P
Q
I
N
R
K
S
Site 13
S141
S
P
Q
I
N
R
K
S
G
Q
E
M
T
A
V
Site 14
S151
E
M
T
A
V
M
Q
S
G
R
P
R
S
S
S
Site 15
S156
M
Q
S
G
R
P
R
S
S
S
T
T
D
A
P
Site 16
S157
Q
S
G
R
P
R
S
S
S
T
T
D
A
P
T
Site 17
S158
S
G
R
P
R
S
S
S
T
T
D
A
P
T
G
Site 18
T159
G
R
P
R
S
S
S
T
T
D
A
P
T
G
S
Site 19
T160
R
P
R
S
S
S
T
T
D
A
P
T
G
S
A
Site 20
T164
S
S
T
T
D
A
P
T
G
S
A
M
M
E
I
Site 21
S200
I
E
R
L
E
V
S
S
L
A
Q
T
S
S
A
Site 22
T204
E
V
S
S
L
A
Q
T
S
S
A
V
A
S
S
Site 23
S206
S
S
L
A
Q
T
S
S
A
V
A
S
S
T
D
Site 24
S210
Q
T
S
S
A
V
A
S
S
T
D
G
S
I
H
Site 25
S211
T
S
S
A
V
A
S
S
T
D
G
S
I
H
T
Site 26
T212
S
S
A
V
A
S
S
T
D
G
S
I
H
T
D
Site 27
S215
V
A
S
S
T
D
G
S
I
H
T
D
S
V
D
Site 28
T218
S
T
D
G
S
I
H
T
D
S
V
D
G
T
P
Site 29
S220
D
G
S
I
H
T
D
S
V
D
G
T
P
D
P
Site 30
T224
H
T
D
S
V
D
G
T
P
D
P
Q
R
T
K
Site 31
T253
E
Q
I
K
I
A
Q
T
A
R
D
D
N
V
A
Site 32
Y262
R
D
D
N
V
A
E
Y
L
K
L
A
N
S
A
Site 33
S268
E
Y
L
K
L
A
N
S
A
D
K
Q
Q
A
A
Site 34
S288
F
E
K
K
N
Q
K
S
A
Q
T
I
L
Q
L
Site 35
Y302
L
Q
K
K
L
E
H
Y
H
R
K
L
R
E
V
Site 36
T337
K
D
V
G
A
K
V
T
G
F
S
E
G
V
V
Site 37
S346
F
S
E
G
V
V
D
S
V
K
G
G
F
S
S
Site 38
S353
S
V
K
G
G
F
S
S
F
S
Q
A
T
H
S
Site 39
S355
K
G
G
F
S
S
F
S
Q
A
T
H
S
A
A
Site 40
S374
S
K
P
R
E
I
A
S
L
I
R
N
K
F
G
Site 41
S382
L
I
R
N
K
F
G
S
A
D
N
I
P
N
L
Site 42
S392
N
I
P
N
L
K
D
S
L
E
E
G
Q
V
D
Site 43
S409
G
K
A
L
G
V
I
S
N
F
Q
S
S
P
K
Site 44
S413
G
V
I
S
N
F
Q
S
S
P
K
Y
G
S
E
Site 45
S414
V
I
S
N
F
Q
S
S
P
K
Y
G
S
E
E
Site 46
Y417
N
F
Q
S
S
P
K
Y
G
S
E
E
D
C
S
Site 47
S419
Q
S
S
P
K
Y
G
S
E
E
D
C
S
S
A
Site 48
S424
Y
G
S
E
E
D
C
S
S
A
T
S
G
S
V
Site 49
S425
G
S
E
E
D
C
S
S
A
T
S
G
S
V
G
Site 50
S428
E
D
C
S
S
A
T
S
G
S
V
G
A
N
S
Site 51
S430
C
S
S
A
T
S
G
S
V
G
A
N
S
T
T
Site 52
S447
I
A
V
G
A
S
S
S
K
T
N
T
L
D
M
Site 53
T449
V
G
A
S
S
S
K
T
N
T
L
D
M
Q
S
Site 54
T451
A
S
S
S
K
T
N
T
L
D
M
Q
S
S
G
Site 55
S457
N
T
L
D
M
Q
S
S
G
F
D
A
L
L
H
Site 56
T472
E
I
Q
E
I
R
E
T
Q
A
R
L
E
E
S
Site 57
S479
T
Q
A
R
L
E
E
S
F
E
T
L
K
E
H
Site 58
T482
R
L
E
E
S
F
E
T
L
K
E
H
Y
Q
R
Site 59
Y487
F
E
T
L
K
E
H
Y
Q
R
D
Y
S
L
I
Site 60
Y491
K
E
H
Y
Q
R
D
Y
S
L
I
M
Q
T
L
Site 61
Y503
Q
T
L
Q
E
E
R
Y
R
C
E
R
L
E
E
Site 62
T516
E
E
Q
L
N
D
L
T
E
L
H
Q
N
E
I
Site 63
S532
N
L
K
Q
E
L
A
S
M
E
E
K
I
A
Y
Site 64
Y539
S
M
E
E
K
I
A
Y
Q
S
Y
E
R
A
R
Site 65
Y542
E
K
I
A
Y
Q
S
Y
E
R
A
R
D
I
Q
Site 66
T557
E
A
L
E
A
C
Q
T
R
I
S
K
M
E
L
Site 67
S560
E
A
C
Q
T
R
I
S
K
M
E
L
Q
Q
Q
Site 68
T617
C
V
V
P
L
M
K
T
R
N
R
T
F
S
T
Site 69
Y644
H
W
D
A
L
F
S
Y
V
E
R
F
F
S
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation