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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FCHSD2
Full Name:
FCH and double SH3 domains protein 2
Alias:
Carom; FCH and double SH3 domains 2; FCSD2; KIAA0769; SH3 multiple domains protein 3; SH3MD3
Type:
Adaptor/scaffold
Mass (Da):
84276
Number AA:
740
UniProt ID:
O94868
International Prot ID:
IPI00410639
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
P
P
R
K
V
K
V
T
Q
E
L
K
N
I
Q
Site 2
T41
D
L
L
E
D
M
R
T
F
S
Q
K
K
A
A
Site 3
S43
L
E
D
M
R
T
F
S
Q
K
K
A
A
I
E
Site 4
Y53
K
A
A
I
E
R
E
Y
A
Q
G
M
Q
K
L
Site 5
S62
Q
G
M
Q
K
L
A
S
Q
Y
L
K
R
D
W
Site 6
Y80
K
A
D
D
R
N
D
Y
R
S
M
Y
P
V
W
Site 7
Y84
R
N
D
Y
R
S
M
Y
P
V
W
K
S
F
L
Site 8
Y108
R
M
N
I
C
E
N
Y
K
N
F
I
S
E
P
Site 9
S113
E
N
Y
K
N
F
I
S
E
P
A
R
T
V
R
Site 10
T118
F
I
S
E
P
A
R
T
V
R
S
L
K
E
Q
Site 11
T135
K
R
C
V
D
Q
L
T
K
I
Q
T
E
L
Q
Site 12
T144
I
Q
T
E
L
Q
E
T
V
K
D
L
A
K
G
Site 13
Y155
L
A
K
G
K
K
K
Y
F
E
T
E
Q
M
A
Site 14
S175
K
A
D
I
E
A
K
S
K
L
S
L
F
Q
S
Site 15
S178
I
E
A
K
S
K
L
S
L
F
Q
S
R
I
S
Site 16
S182
S
K
L
S
L
F
Q
S
R
I
S
L
Q
K
A
Site 17
S185
S
L
F
Q
S
R
I
S
L
Q
K
A
S
V
K
Site 18
S198
V
K
L
K
A
R
R
S
E
C
N
S
K
A
T
Site 19
S202
A
R
R
S
E
C
N
S
K
A
T
H
A
R
N
Site 20
T214
A
R
N
D
Y
L
L
T
L
A
A
A
N
A
H
Site 21
Y225
A
N
A
H
Q
D
R
Y
Y
Q
T
D
L
V
N
Site 22
Y226
N
A
H
Q
D
R
Y
Y
Q
T
D
L
V
N
I
Site 23
Y242
K
A
L
D
G
N
V
Y
D
H
L
K
D
Y
L
Site 24
Y248
V
Y
D
H
L
K
D
Y
L
I
A
F
S
R
T
Site 25
T266
T
C
Q
A
V
Q
N
T
F
Q
F
L
L
E
N
Site 26
S275
Q
F
L
L
E
N
S
S
K
V
V
R
D
Y
N
Site 27
Y281
S
S
K
V
V
R
D
Y
N
L
Q
L
F
L
Q
Site 28
S306
F
Q
F
Q
P
C
D
S
D
T
S
R
Q
L
E
Site 29
T308
F
Q
P
C
D
S
D
T
S
R
Q
L
E
S
E
Site 30
T318
Q
L
E
S
E
T
G
T
T
E
E
H
S
L
N
Site 31
T319
L
E
S
E
T
G
T
T
E
E
H
S
L
N
K
Site 32
S323
T
G
T
T
E
E
H
S
L
N
K
E
A
R
K
Site 33
T333
K
E
A
R
K
W
A
T
R
V
A
R
E
H
K
Site 34
S360
E
C
H
G
A
A
V
S
E
Q
S
R
A
E
L
Site 35
T429
W
A
R
P
P
A
V
T
S
N
G
T
L
H
S
Site 36
S430
A
R
P
P
A
V
T
S
N
G
T
L
H
S
L
Site 37
S436
T
S
N
G
T
L
H
S
L
N
A
D
T
E
R
Site 38
T441
L
H
S
L
N
A
D
T
E
R
E
E
G
E
E
Site 39
S459
N
M
D
V
F
D
D
S
S
S
S
P
S
G
T
Site 40
S460
M
D
V
F
D
D
S
S
S
S
P
S
G
T
L
Site 41
S461
D
V
F
D
D
S
S
S
S
P
S
G
T
L
R
Site 42
S462
V
F
D
D
S
S
S
S
P
S
G
T
L
R
N
Site 43
S464
D
D
S
S
S
S
P
S
G
T
L
R
N
Y
P
Site 44
T466
S
S
S
S
P
S
G
T
L
R
N
Y
P
L
T
Site 45
Y470
P
S
G
T
L
R
N
Y
P
L
T
C
K
V
V
Site 46
T473
T
L
R
N
Y
P
L
T
C
K
V
V
Y
S
Y
Site 47
S479
L
T
C
K
V
V
Y
S
Y
K
A
S
Q
P
D
Site 48
S483
V
V
Y
S
Y
K
A
S
Q
P
D
E
L
T
I
Site 49
T489
A
S
Q
P
D
E
L
T
I
E
E
H
E
V
L
Site 50
Y519
N
K
V
G
Q
V
G
Y
V
P
E
K
Y
L
Q
Site 51
Y524
V
G
Y
V
P
E
K
Y
L
Q
F
P
T
S
N
Site 52
T529
E
K
Y
L
Q
F
P
T
S
N
S
L
L
S
M
Site 53
S545
Q
S
L
A
A
L
D
S
R
S
H
T
S
S
N
Site 54
S547
L
A
A
L
D
S
R
S
H
T
S
S
N
S
T
Site 55
T549
A
L
D
S
R
S
H
T
S
S
N
S
T
E
A
Site 56
S551
D
S
R
S
H
T
S
S
N
S
T
E
A
E
L
Site 57
S553
R
S
H
T
S
S
N
S
T
E
A
E
L
V
S
Site 58
T554
S
H
T
S
S
N
S
T
E
A
E
L
V
S
G
Site 59
S562
E
A
E
L
V
S
G
S
L
N
G
D
A
S
V
Site 60
Y576
V
C
F
V
K
A
L
Y
D
Y
E
G
Q
T
D
Site 61
Y578
F
V
K
A
L
Y
D
Y
E
G
Q
T
D
D
E
Site 62
S587
G
Q
T
D
D
E
L
S
F
P
E
G
A
I
I
Site 63
S628
S
V
L
V
E
E
L
S
A
S
E
N
G
D
T
Site 64
S630
L
V
E
E
L
S
A
S
E
N
G
D
T
P
W
Site 65
T635
S
A
S
E
N
G
D
T
P
W
M
R
E
I
Q
Site 66
S644
W
M
R
E
I
Q
I
S
P
S
P
K
P
H
A
Site 67
S646
R
E
I
Q
I
S
P
S
P
K
P
H
A
S
L
Site 68
S652
P
S
P
K
P
H
A
S
L
P
P
L
P
L
Y
Site 69
Y659
S
L
P
P
L
P
L
Y
D
Q
P
P
S
S
P
Site 70
S664
P
L
Y
D
Q
P
P
S
S
P
Y
P
S
P
D
Site 71
S665
L
Y
D
Q
P
P
S
S
P
Y
P
S
P
D
K
Site 72
Y667
D
Q
P
P
S
S
P
Y
P
S
P
D
K
R
S
Site 73
S669
P
P
S
S
P
Y
P
S
P
D
K
R
S
S
L
Site 74
S674
Y
P
S
P
D
K
R
S
S
L
Y
F
P
R
S
Site 75
S675
P
S
P
D
K
R
S
S
L
Y
F
P
R
S
P
Site 76
Y677
P
D
K
R
S
S
L
Y
F
P
R
S
P
S
A
Site 77
S681
S
S
L
Y
F
P
R
S
P
S
A
N
E
K
S
Site 78
S683
L
Y
F
P
R
S
P
S
A
N
E
K
S
L
H
Site 79
S688
S
P
S
A
N
E
K
S
L
H
A
E
S
P
G
Site 80
S693
E
K
S
L
H
A
E
S
P
G
F
S
Q
A
S
Site 81
S697
H
A
E
S
P
G
F
S
Q
A
S
R
H
T
P
Site 82
T703
F
S
Q
A
S
R
H
T
P
E
T
S
Y
G
K
Site 83
T706
A
S
R
H
T
P
E
T
S
Y
G
K
L
R
P
Site 84
T722
R
A
A
P
P
P
P
T
Q
N
H
R
R
P
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation