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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA0754
Full Name:
Uncharacterized protein KIAA0754
Alias:
K0754
Type:
Mass (Da):
135147
Number AA:
1291
UniProt ID:
O94854
International Prot ID:
IPI00788299
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
F
A
E
R
I
E
A
S
L
S
E
V
S
E
A
Site 2
S17
E
R
I
E
A
S
L
S
E
V
S
E
A
G
A
Site 3
S20
E
A
S
L
S
E
V
S
E
A
G
A
S
N
P
Site 4
S25
E
V
S
E
A
G
A
S
N
P
S
L
Q
E
K
Site 5
S28
E
A
G
A
S
N
P
S
L
Q
E
K
K
E
S
Site 6
S35
S
L
Q
E
K
K
E
S
S
S
A
L
T
E
S
Site 7
S37
Q
E
K
K
E
S
S
S
A
L
T
E
S
S
G
Site 8
T40
K
E
S
S
S
A
L
T
E
S
S
G
H
L
D
Site 9
S42
S
S
S
A
L
T
E
S
S
G
H
L
D
H
R
Site 10
S53
L
D
H
R
E
P
Q
S
E
S
V
T
L
E
H
Site 11
S55
H
R
E
P
Q
S
E
S
V
T
L
E
H
V
S
Site 12
T57
E
P
Q
S
E
S
V
T
L
E
H
V
S
K
S
Site 13
S64
T
L
E
H
V
S
K
S
I
G
I
P
E
V
Q
Site 14
S77
V
Q
D
F
K
N
L
S
G
D
C
Q
D
F
R
Site 15
S101
H
K
F
Q
P
V
E
S
E
A
V
A
T
S
G
Site 16
S116
N
T
D
V
M
Q
E
S
R
F
S
S
A
T
W
Site 17
S119
V
M
Q
E
S
R
F
S
S
A
T
W
P
R
A
Site 18
S120
M
Q
E
S
R
F
S
S
A
T
W
P
R
A
T
Site 19
T122
E
S
R
F
S
S
A
T
W
P
R
A
T
K
S
Site 20
T127
S
A
T
W
P
R
A
T
K
S
L
A
K
G
G
Site 21
S129
T
W
P
R
A
T
K
S
L
A
K
G
G
F
S
Site 22
T145
K
Q
H
P
L
G
D
T
A
C
T
V
E
M
P
Site 23
S159
P
P
L
S
P
C
L
S
E
E
L
L
D
P
E
Site 24
T172
P
E
L
H
V
L
I
T
P
S
L
R
E
K
T
Site 25
S174
L
H
V
L
I
T
P
S
L
R
E
K
T
E
S
Site 26
T179
T
P
S
L
R
E
K
T
E
S
E
L
K
F
E
Site 27
S181
S
L
R
E
K
T
E
S
E
L
K
F
E
E
D
Site 28
S206
E
W
E
E
E
K
L
S
D
R
E
K
T
F
L
Site 29
T211
K
L
S
D
R
E
K
T
F
L
M
A
D
E
K
Site 30
S220
L
M
A
D
E
K
N
S
L
A
D
I
F
E
E
Site 31
T233
E
E
R
E
Q
A
N
T
A
V
V
E
D
G
S
Site 32
S323
T
I
D
A
E
Q
L
S
D
T
D
S
V
Q
M
Site 33
T325
D
A
E
Q
L
S
D
T
D
S
V
Q
M
F
L
Site 34
S327
E
Q
L
S
D
T
D
S
V
Q
M
F
L
E
L
Site 35
S355
V
E
L
Q
N
Q
I
S
S
E
G
L
A
A
S
Site 36
S362
S
S
E
G
L
A
A
S
Q
D
A
E
N
L
L
Site 37
Y395
L
H
V
R
A
K
D
Y
D
T
R
L
D
C
G
Site 38
Y403
D
T
R
L
D
C
G
Y
F
N
T
L
D
S
S
Site 39
T406
L
D
C
G
Y
F
N
T
L
D
S
S
Q
V
P
Site 40
S409
G
Y
F
N
T
L
D
S
S
Q
V
P
N
A
V
Site 41
S410
Y
F
N
T
L
D
S
S
Q
V
P
N
A
V
E
Site 42
T428
H
V
D
I
M
R
D
T
S
T
V
S
K
E
E
Site 43
S429
V
D
I
M
R
D
T
S
T
V
S
K
E
E
C
Site 44
T430
D
I
M
R
D
T
S
T
V
S
K
E
E
C
E
Site 45
S442
E
C
E
K
V
P
F
S
P
R
T
A
E
F
K
Site 46
T445
K
V
P
F
S
P
R
T
A
E
F
K
S
R
Q
Site 47
S458
R
Q
P
A
D
L
D
S
L
E
K
L
D
P
G
Site 48
S470
D
P
G
G
L
L
N
S
D
H
R
V
S
H
E
Site 49
S475
L
N
S
D
H
R
V
S
H
E
E
K
L
S
G
Site 50
S481
V
S
H
E
E
K
L
S
G
F
I
A
S
E
L
Site 51
S494
E
L
A
K
D
N
G
S
L
S
Q
G
D
C
S
Site 52
S496
A
K
D
N
G
S
L
S
Q
G
D
C
S
Q
T
Site 53
S501
S
L
S
Q
G
D
C
S
Q
T
E
G
N
G
E
Site 54
T525
F
A
F
N
H
E
L
T
D
V
T
S
G
P
E
Site 55
T528
N
H
E
L
T
D
V
T
S
G
P
E
V
E
V
Site 56
S529
H
E
L
T
D
V
T
S
G
P
E
V
E
V
L
Site 57
Y537
G
P
E
V
E
V
L
Y
E
S
N
L
L
T
D
Site 58
T543
L
Y
E
S
N
L
L
T
D
E
I
H
L
E
S
Site 59
T554
H
L
E
S
G
N
V
T
V
N
Q
E
N
N
S
Site 60
S561
T
V
N
Q
E
N
N
S
L
T
S
M
G
N
V
Site 61
Y590
G
E
A
K
E
L
D
Y
Q
A
T
L
L
E
D
Site 62
S619
F
Q
D
L
Q
R
K
S
P
E
S
E
I
L
S
Site 63
S622
L
Q
R
K
S
P
E
S
E
I
L
S
L
H
L
Site 64
S626
S
P
E
S
E
I
L
S
L
H
L
L
V
E
E
Site 65
S656
P
E
L
N
V
A
S
S
E
G
G
E
M
E
R
Site 66
S666
G
E
M
E
R
R
D
S
D
S
F
L
N
I
F
Site 67
S668
M
E
R
R
D
S
D
S
F
L
N
I
F
P
E
Site 68
T679
I
F
P
E
K
Q
V
T
K
A
G
N
T
E
P
Site 69
S699
I
P
V
L
Q
R
P
S
R
T
A
A
V
P
T
Site 70
S717
A
L
D
A
A
L
P
S
P
E
E
G
T
S
I
Site 71
S723
P
S
P
E
E
G
T
S
I
A
A
V
P
A
P
Site 72
T761
S
L
E
E
E
D
V
T
A
A
A
V
S
A
P
Site 73
T834
P
I
T
E
E
D
G
T
P
E
G
P
V
T
P
Site 74
T840
G
T
P
E
G
P
V
T
P
A
T
T
V
H
A
Site 75
T843
E
G
P
V
T
P
A
T
T
V
H
A
P
E
E
Site 76
T853
H
A
P
E
E
P
D
T
A
A
V
R
V
S
T
Site 77
S859
D
T
A
A
V
R
V
S
T
P
E
E
P
A
S
Site 78
T860
T
A
A
V
R
V
S
T
P
E
E
P
A
S
P
Site 79
S866
S
T
P
E
E
P
A
S
P
A
A
A
V
P
T
Site 80
T873
S
P
A
A
A
V
P
T
P
E
E
P
T
S
P
Site 81
S879
P
T
P
E
E
P
T
S
P
A
A
A
V
P
T
Site 82
S892
P
T
P
E
E
P
T
S
P
A
A
A
V
P
P
Site 83
S905
P
P
P
E
E
P
T
S
P
A
A
A
V
P
T
Site 84
T977
S
P
A
A
A
V
P
T
P
E
E
P
A
S
P
Site 85
S983
P
T
P
E
E
P
A
S
P
A
A
A
V
P
T
Site 86
T1003
S
P
A
A
A
V
P
T
P
E
E
P
A
F
P
Site 87
T1016
F
P
A
P
A
V
P
T
P
E
E
S
A
S
A
Site 88
S1022
P
T
P
E
E
S
A
S
A
A
V
A
V
P
T
Site 89
T1029
S
A
A
V
A
V
P
T
P
E
E
S
A
S
P
Site 90
S1035
P
T
P
E
E
S
A
S
P
A
A
A
V
P
T
Site 91
S1061
A
T
L
E
E
P
T
S
P
A
A
S
V
P
T
Site 92
S1065
E
P
T
S
P
A
A
S
V
P
T
P
A
A
M
Site 93
S1085
E
F
T
S
P
A
A
S
V
P
T
S
E
E
P
Site 94
S1089
P
A
A
S
V
P
T
S
E
E
P
A
S
L
A
Site 95
S1094
P
T
S
E
E
P
A
S
L
A
A
A
V
S
N
Site 96
S1100
A
S
L
A
A
A
V
S
N
P
E
E
P
T
S
Site 97
S1107
S
N
P
E
E
P
T
S
P
A
A
A
V
P
T
Site 98
T1127
S
S
A
A
A
V
L
T
P
E
E
L
S
S
P
Site 99
S1133
L
T
P
E
E
L
S
S
P
A
A
S
V
P
T
Site 100
S1137
E
L
S
S
P
A
A
S
V
P
T
P
E
E
P
Site 101
T1140
S
P
A
A
S
V
P
T
P
E
E
P
A
S
P
Site 102
S1146
P
T
P
E
E
P
A
S
P
A
A
A
V
S
N
Site 103
S1152
A
S
P
A
A
A
V
S
N
L
E
E
P
A
S
Site 104
S1159
S
N
L
E
E
P
A
S
P
A
A
A
V
P
T
Site 105
S1212
G
V
S
A
H
T
D
S
V
P
I
S
E
E
G
Site 106
S1216
H
T
D
S
V
P
I
S
E
E
G
T
P
V
L
Site 107
T1220
V
P
I
S
E
E
G
T
P
V
L
E
E
A
S
Site 108
S1228
P
V
L
E
E
A
S
S
T
G
M
W
I
K
E
Site 109
T1229
V
L
E
E
A
S
S
T
G
M
W
I
K
E
D
Site 110
S1239
W
I
K
E
D
L
D
S
L
V
F
G
I
K
E
Site 111
S1275
E
V
I
V
H
F
D
S
G
K
G
L
K
S
K
Site 112
S1281
D
S
G
K
G
L
K
S
K
V
R
F
A
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation