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Updated November 2019
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Protein Info
Short Name:
MICAL2
Full Name:
Protein MICAL-2
Alias:
Flavoprotein oxidoreductase MICAL2; KIAA0750; MICA2; MICAL2PV1; MICAL2PV2; Microtubule associated monoxygenase, calponin and LIM domain containing 2
Type:
Adaptor/scaffold
Mass (Da):
126689
Number AA:
1124
UniProt ID:
O94851
International Prot ID:
IPI00183018
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0004497
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y50
P
L
D
H
R
N
F
Y
S
K
L
K
S
K
V
Site 2
S51
L
D
H
R
N
F
Y
S
K
L
K
S
K
V
T
Site 3
S55
N
F
Y
S
K
L
K
S
K
V
T
T
W
K
A
Site 4
T59
K
L
K
S
K
V
T
T
W
K
A
K
A
L
W
Site 5
S74
Y
K
L
D
K
R
G
S
H
K
E
Y
K
R
G
Site 6
Y78
K
R
G
S
H
K
E
Y
K
R
G
K
S
C
T
Site 7
S83
K
E
Y
K
R
G
K
S
C
T
N
T
K
C
L
Site 8
T85
Y
K
R
G
K
S
C
T
N
T
K
C
L
I
V
Site 9
T87
R
G
K
S
C
T
N
T
K
C
L
I
V
G
G
Site 10
S120
V
V
V
E
K
R
D
S
F
S
R
N
N
V
L
Site 11
S122
V
E
K
R
D
S
F
S
R
N
N
V
L
H
L
Site 12
T207
W
R
A
E
F
L
P
T
D
H
S
L
S
E
F
Site 13
S210
E
F
L
P
T
D
H
S
L
S
E
F
E
F
D
Site 14
S212
L
P
T
D
H
S
L
S
E
F
E
F
D
V
I
Site 15
T228
G
A
D
G
R
R
N
T
L
E
G
F
R
R
K
Site 16
S254
A
N
F
I
N
R
N
S
T
A
E
A
K
V
E
Site 17
T255
N
F
I
N
R
N
S
T
A
E
A
K
V
E
E
Site 18
Y291
I
D
L
E
N
I
V
Y
Y
K
D
C
T
H
Y
Site 19
Y292
D
L
E
N
I
V
Y
Y
K
D
C
T
H
Y
F
Site 20
Y298
Y
Y
K
D
C
T
H
Y
F
V
M
T
A
K
K
Site 21
S337
V
N
Q
D
N
L
L
S
Y
A
R
E
A
A
D
Site 22
T347
R
E
A
A
D
F
A
T
N
Y
Q
L
P
S
L
Site 23
Y349
A
A
D
F
A
T
N
Y
Q
L
P
S
L
D
F
Site 24
Y361
L
D
F
A
M
N
H
Y
G
Q
P
D
V
A
M
Site 25
T432
V
K
S
W
N
Q
G
T
P
P
L
E
L
L
A
Site 26
S443
E
L
L
A
E
R
E
S
L
Y
R
L
L
P
Q
Site 27
T451
L
Y
R
L
L
P
Q
T
T
P
E
N
I
N
K
Site 28
T452
Y
R
L
L
P
Q
T
T
P
E
N
I
N
K
N
Site 29
T464
N
K
N
F
E
Q
Y
T
L
D
P
G
T
R
Y
Site 30
T469
Q
Y
T
L
D
P
G
T
R
Y
P
N
L
N
S
Site 31
Y471
T
L
D
P
G
T
R
Y
P
N
L
N
S
H
C
Site 32
Y488
P
H
Q
V
K
H
L
Y
I
T
K
E
L
E
H
Site 33
Y496
I
T
K
E
L
E
H
Y
P
L
E
R
L
G
S
Site 34
S503
Y
P
L
E
R
L
G
S
V
R
R
S
V
N
L
Site 35
S507
R
L
G
S
V
R
R
S
V
N
L
S
R
K
E
Site 36
S511
V
R
R
S
V
N
L
S
R
K
E
S
D
I
R
Site 37
S515
V
N
L
S
R
K
E
S
D
I
R
P
S
K
L
Site 38
S520
K
E
S
D
I
R
P
S
K
L
L
T
W
C
Q
Site 39
T524
I
R
P
S
K
L
L
T
W
C
Q
Q
Q
T
E
Site 40
T542
H
V
N
V
T
D
L
T
T
S
W
R
S
G
L
Site 41
T543
V
N
V
T
D
L
T
T
S
W
R
S
G
L
A
Site 42
S544
N
V
T
D
L
T
T
S
W
R
S
G
L
A
L
Site 43
S567
P
E
L
I
N
F
D
S
L
N
E
D
D
A
V
Site 44
T594
E
F
G
I
P
P
V
T
T
G
K
E
M
A
S
Site 45
S609
A
Q
E
P
D
K
L
S
M
V
M
Y
L
S
K
Site 46
T624
F
Y
E
L
F
R
G
T
P
L
R
P
V
D
S
Site 47
S631
T
P
L
R
P
V
D
S
W
R
K
N
Y
G
E
Site 48
Y636
V
D
S
W
R
K
N
Y
G
E
N
A
D
L
S
Site 49
S643
Y
G
E
N
A
D
L
S
L
A
K
S
S
I
S
Site 50
S647
A
D
L
S
L
A
K
S
S
I
S
N
N
Y
L
Site 51
S648
D
L
S
L
A
K
S
S
I
S
N
N
Y
L
N
Site 52
Y653
K
S
S
I
S
N
N
Y
L
N
L
T
F
P
R
Site 53
T657
S
N
N
Y
L
N
L
T
F
P
R
K
R
T
P
Site 54
T663
L
T
F
P
R
K
R
T
P
R
V
D
G
Q
T
Site 55
T670
T
P
R
V
D
G
Q
T
G
E
N
D
M
N
K
Site 56
T684
K
R
R
R
K
G
F
T
N
L
D
E
P
S
N
Site 57
S690
F
T
N
L
D
E
P
S
N
F
S
S
R
S
L
Site 58
S693
L
D
E
P
S
N
F
S
S
R
S
L
G
S
N
Site 59
S694
D
E
P
S
N
F
S
S
R
S
L
G
S
N
Q
Site 60
S696
P
S
N
F
S
S
R
S
L
G
S
N
Q
E
C
Site 61
S699
F
S
S
R
S
L
G
S
N
Q
E
C
G
S
S
Site 62
S705
G
S
N
Q
E
C
G
S
S
K
E
G
G
N
Q
Site 63
S706
S
N
Q
E
C
G
S
S
K
E
G
G
N
Q
N
Site 64
S717
G
N
Q
N
K
V
K
S
M
A
N
Q
L
L
A
Site 65
S729
L
L
A
K
F
E
E
S
T
R
N
P
S
L
M
Site 66
T730
L
A
K
F
E
E
S
T
R
N
P
S
L
M
K
Site 67
S734
E
E
S
T
R
N
P
S
L
M
K
Q
E
R
R
Site 68
S743
M
K
Q
E
R
R
V
S
G
I
G
K
P
V
L
Site 69
S753
G
K
P
V
L
C
S
S
S
G
P
P
V
H
S
Site 70
S754
K
P
V
L
C
S
S
S
G
P
P
V
H
S
C
Site 71
S760
S
S
G
P
P
V
H
S
C
C
P
K
P
E
E
Site 72
T769
C
P
K
P
E
E
A
T
P
S
P
S
P
P
L
Site 73
S771
K
P
E
E
A
T
P
S
P
S
P
P
L
K
R
Site 74
S773
E
E
A
T
P
S
P
S
P
P
L
K
R
Q
F
Site 75
S800
L
K
Q
V
S
A
G
S
E
C
L
S
R
P
W
Site 76
S804
S
A
G
S
E
C
L
S
R
P
W
R
A
R
A
Site 77
S813
P
W
R
A
R
A
K
S
D
L
Q
L
G
G
T
Site 78
T825
G
G
T
E
N
F
A
T
L
P
S
T
R
P
R
Site 79
S828
E
N
F
A
T
L
P
S
T
R
P
R
A
Q
A
Site 80
S837
R
P
R
A
Q
A
L
S
G
V
L
W
R
L
Q
Site 81
S877
E
K
A
A
H
L
A
S
M
F
G
H
G
D
F
Site 82
S891
F
P
Q
N
K
L
L
S
K
G
L
S
H
T
H
Site 83
S895
K
L
L
S
K
G
L
S
H
T
H
P
P
S
P
Site 84
T897
L
S
K
G
L
S
H
T
H
P
P
S
P
P
S
Site 85
S901
L
S
H
T
H
P
P
S
P
P
S
R
L
P
S
Site 86
S904
T
H
P
P
S
P
P
S
R
L
P
S
P
D
P
Site 87
S908
S
P
P
S
R
L
P
S
P
D
P
A
A
S
S
Site 88
S914
P
S
P
D
P
A
A
S
S
S
P
S
T
V
D
Site 89
S915
S
P
D
P
A
A
S
S
S
P
S
T
V
D
S
Site 90
S916
P
D
P
A
A
S
S
S
P
S
T
V
D
S
A
Site 91
S918
P
A
A
S
S
S
P
S
T
V
D
S
A
S
P
Site 92
T919
A
A
S
S
S
P
S
T
V
D
S
A
S
P
A
Site 93
S922
S
S
P
S
T
V
D
S
A
S
P
A
R
K
E
Site 94
S924
P
S
T
V
D
S
A
S
P
A
R
K
E
K
K
Site 95
S932
P
A
R
K
E
K
K
S
P
S
G
F
H
F
H
Site 96
S934
R
K
E
K
K
S
P
S
G
F
H
F
H
P
S
Site 97
S941
S
G
F
H
F
H
P
S
H
L
R
T
V
H
P
Site 98
T945
F
H
P
S
H
L
R
T
V
H
P
Q
L
T
V
Site 99
T951
R
T
V
H
P
Q
L
T
V
G
K
V
S
S
G
Site 100
Y970
A
E
V
L
V
N
L
Y
M
N
D
H
R
P
K
Site 101
S982
R
P
K
A
Q
A
T
S
P
D
L
E
S
M
R
Site 102
S987
A
T
S
P
D
L
E
S
M
R
K
S
F
P
L
Site 103
S991
D
L
E
S
M
R
K
S
F
P
L
N
L
G
G
Site 104
T1001
L
N
L
G
G
S
D
T
C
Y
F
C
K
K
R
Site 105
Y1003
L
G
G
S
D
T
C
Y
F
C
K
K
R
V
Y
Site 106
Y1010
Y
F
C
K
K
R
V
Y
V
M
E
R
L
S
A
Site 107
T1042
T
L
R
L
A
A
Y
T
F
D
C
D
E
G
K
Site 108
T1081
Q
Q
R
E
E
E
A
T
W
Q
E
Q
E
A
P
Site 109
T1092
Q
E
A
P
R
R
D
T
P
T
E
S
S
C
A
Site 110
T1094
A
P
R
R
D
T
P
T
E
S
S
C
A
V
A
Site 111
S1096
R
R
D
T
P
T
E
S
S
C
A
V
A
A
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation