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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHG5
Full Name:
Pleckstrin homology domain-containing family G member 5
Alias:
Dsma4; Gef720; Guanine nucleotide exchange factor 720; Kiaa0720; Pleckstrin homology domain containing family g member 5; Pleckstrin homology domain containing, family g (with rhogef domain) member 5; Pleckstriny domain containing, family G (with RhoGef domain) member 5; Plekhg5; Rp4-650h14.3
Type:
Mass (Da):
117432
Number AA:
1062
UniProt ID:
O94827
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0043123
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y59
K
F
H
S
T
M
H
Y
D
G
H
V
R
F
D
Site 2
S72
F
D
L
P
P
Q
G
S
V
L
A
R
N
V
S
Site 3
S79
S
V
L
A
R
N
V
S
T
R
S
C
P
P
R
Site 4
S82
A
R
N
V
S
T
R
S
C
P
P
R
T
S
P
Site 5
S88
R
S
C
P
P
R
T
S
P
A
V
D
L
E
E
Site 6
S100
L
E
E
E
E
E
E
S
S
V
D
G
K
G
D
Site 7
S101
E
E
E
E
E
E
S
S
V
D
G
K
G
D
R
Site 8
S110
D
G
K
G
D
R
K
S
T
G
L
K
L
S
K
Site 9
T111
G
K
G
D
R
K
S
T
G
L
K
L
S
K
K
Site 10
S116
K
S
T
G
L
K
L
S
K
K
K
A
R
R
R
Site 11
T125
K
K
A
R
R
R
H
T
D
D
P
S
K
E
C
Site 12
S129
R
R
H
T
D
D
P
S
K
E
C
F
T
L
K
Site 13
S155
V
P
A
M
K
K
K
S
L
G
E
V
L
L
P
Site 14
Y177
A
L
G
K
V
D
I
Y
L
D
Q
S
N
T
P
Site 15
S181
V
D
I
Y
L
D
Q
S
N
T
P
L
S
L
T
Site 16
T183
I
Y
L
D
Q
S
N
T
P
L
S
L
T
F
E
Site 17
S186
D
Q
S
N
T
P
L
S
L
T
F
E
A
Y
R
Site 18
T188
S
N
T
P
L
S
L
T
F
E
A
Y
R
F
G
Site 19
Y192
L
S
L
T
F
E
A
Y
R
F
G
G
H
Y
L
Site 20
Y198
A
Y
R
F
G
G
H
Y
L
R
V
K
A
P
A
Site 21
S220
V
E
Q
G
M
K
D
S
K
S
L
S
L
P
I
Site 22
S222
Q
G
M
K
D
S
K
S
L
S
L
P
I
L
R
Site 23
S224
M
K
D
S
K
S
L
S
L
P
I
L
R
P
A
Site 24
T233
P
I
L
R
P
A
G
T
G
P
P
A
L
E
R
Site 25
S245
L
E
R
V
D
A
Q
S
R
R
E
S
L
D
I
Site 26
S249
D
A
Q
S
R
R
E
S
L
D
I
L
A
P
G
Site 27
S263
G
R
R
R
K
N
M
S
E
F
L
G
E
A
S
Site 28
S270
S
E
F
L
G
E
A
S
I
P
G
Q
E
P
P
Site 29
T278
I
P
G
Q
E
P
P
T
P
S
S
C
S
L
P
Site 30
S280
G
Q
E
P
P
T
P
S
S
C
S
L
P
S
G
Site 31
S281
Q
E
P
P
T
P
S
S
C
S
L
P
S
G
S
Site 32
S283
P
P
T
P
S
S
C
S
L
P
S
G
S
S
G
Site 33
S286
P
S
S
C
S
L
P
S
G
S
S
G
S
T
N
Site 34
S288
S
C
S
L
P
S
G
S
S
G
S
T
N
T
G
Site 35
S289
C
S
L
P
S
G
S
S
G
S
T
N
T
G
D
Site 36
S291
L
P
S
G
S
S
G
S
T
N
T
G
D
S
W
Site 37
T292
P
S
G
S
S
G
S
T
N
T
G
D
S
W
K
Site 38
S304
S
W
K
N
R
A
A
S
R
F
S
G
F
F
S
Site 39
S307
N
R
A
A
S
R
F
S
G
F
F
S
S
G
P
Site 40
S311
S
R
F
S
G
F
F
S
S
G
P
S
T
S
A
Site 41
S312
R
F
S
G
F
F
S
S
G
P
S
T
S
A
F
Site 42
S315
G
F
F
S
S
G
P
S
T
S
A
F
G
R
E
Site 43
T316
F
F
S
S
G
P
S
T
S
A
F
G
R
E
V
Site 44
S317
F
S
S
G
P
S
T
S
A
F
G
R
E
V
D
Site 45
Y336
L
E
G
K
L
H
T
Y
S
L
F
G
L
P
R
Site 46
S337
E
G
K
L
H
T
Y
S
L
F
G
L
P
R
L
Site 47
S354
G
L
R
F
D
H
D
S
W
E
E
E
Y
D
E
Site 48
S375
A
C
L
R
L
E
D
S
W
R
E
L
I
D
G
Site 49
T403
A
V
W
E
L
L
H
T
E
A
S
Y
I
R
K
Site 50
S406
E
L
L
H
T
E
A
S
Y
I
R
K
L
R
V
Site 51
S441
V
E
A
E
R
L
F
S
N
I
P
E
I
A
Q
Site 52
T468
V
L
E
K
A
R
R
T
R
A
L
L
Q
P
G
Site 53
S486
K
G
F
K
M
F
G
S
L
F
K
P
Y
I
R
Site 54
Y491
F
G
S
L
F
K
P
Y
I
R
Y
C
M
E
E
Site 55
Y494
L
F
K
P
Y
I
R
Y
C
M
E
E
E
G
C
Site 56
Y504
E
E
E
G
C
M
E
Y
M
R
G
L
L
R
D
Site 57
Y518
D
N
D
L
F
R
A
Y
I
T
W
A
E
K
H
Site 58
S534
Q
C
Q
R
L
K
L
S
D
M
L
A
K
P
H
Site 59
T545
A
K
P
H
Q
R
L
T
K
Y
P
L
L
L
K
Site 60
Y547
P
H
Q
R
L
T
K
Y
P
L
L
L
K
S
V
Site 61
S553
K
Y
P
L
L
L
K
S
V
L
R
K
T
E
E
Site 62
T558
L
K
S
V
L
R
K
T
E
E
P
R
A
K
E
Site 63
Y604
V
V
S
R
I
D
A
Y
E
V
V
E
S
S
S
Site 64
S609
D
A
Y
E
V
V
E
S
S
S
D
E
V
D
K
Site 65
S610
A
Y
E
V
V
E
S
S
S
D
E
V
D
K
L
Site 66
S611
Y
E
V
V
E
S
S
S
D
E
V
D
K
L
L
Site 67
S634
T
A
P
I
P
G
A
S
P
E
E
T
R
Q
L
Site 68
T638
P
G
A
S
P
E
E
T
R
Q
L
L
L
E
G
Site 69
S646
R
Q
L
L
L
E
G
S
L
R
M
K
E
G
K
Site 70
Y660
K
D
S
K
M
D
V
Y
C
F
L
F
T
D
L
Site 71
S702
R
E
L
R
D
P
G
S
F
L
L
I
Y
L
N
Site 72
T719
H
S
A
V
G
A
Y
T
F
Q
A
S
G
Q
A
Site 73
Y736
R
G
W
V
D
T
I
Y
N
A
Q
N
Q
L
Q
Site 74
S753
R
A
Q
E
P
P
G
S
Q
Q
P
L
Q
S
L
Site 75
S759
G
S
Q
Q
P
L
Q
S
L
E
E
E
E
D
E
Site 76
S783
E
E
E
E
G
E
D
S
G
T
S
A
A
S
S
Site 77
T785
E
E
G
E
D
S
G
T
S
A
A
S
S
P
T
Site 78
S786
E
G
E
D
S
G
T
S
A
A
S
S
P
T
I
Site 79
S790
S
G
T
S
A
A
S
S
P
T
I
M
R
K
S
Site 80
T792
T
S
A
A
S
S
P
T
I
M
R
K
S
S
G
Site 81
S797
S
P
T
I
M
R
K
S
S
G
S
P
D
S
Q
Site 82
S798
P
T
I
M
R
K
S
S
G
S
P
D
S
Q
H
Site 83
S800
I
M
R
K
S
S
G
S
P
D
S
Q
H
C
A
Site 84
S803
K
S
S
G
S
P
D
S
Q
H
C
A
S
D
G
Site 85
S808
P
D
S
Q
H
C
A
S
D
G
S
T
E
T
L
Site 86
T825
V
V
V
E
P
G
D
T
L
S
S
P
E
F
D
Site 87
S827
V
E
P
G
D
T
L
S
S
P
E
F
D
S
G
Site 88
S828
E
P
G
D
T
L
S
S
P
E
F
D
S
G
P
Site 89
S833
L
S
S
P
E
F
D
S
G
P
F
S
S
Q
S
Site 90
S837
E
F
D
S
G
P
F
S
S
Q
S
D
E
T
S
Site 91
S838
F
D
S
G
P
F
S
S
Q
S
D
E
T
S
L
Site 92
S840
S
G
P
F
S
S
Q
S
D
E
T
S
L
S
T
Site 93
S844
S
S
Q
S
D
E
T
S
L
S
T
T
A
S
S
Site 94
S846
Q
S
D
E
T
S
L
S
T
T
A
S
S
A
T
Site 95
T848
D
E
T
S
L
S
T
T
A
S
S
A
T
P
T
Site 96
S850
T
S
L
S
T
T
A
S
S
A
T
P
T
S
E
Site 97
S851
S
L
S
T
T
A
S
S
A
T
P
T
S
E
L
Site 98
T853
S
T
T
A
S
S
A
T
P
T
S
E
L
L
P
Site 99
S856
A
S
S
A
T
P
T
S
E
L
L
P
L
G
P
Site 100
S868
L
G
P
V
D
G
R
S
C
S
M
D
S
A
Y
Site 101
S870
P
V
D
G
R
S
C
S
M
D
S
A
Y
G
T
Site 102
S873
G
R
S
C
S
M
D
S
A
Y
G
T
L
S
P
Site 103
Y875
S
C
S
M
D
S
A
Y
G
T
L
S
P
T
S
Site 104
T877
S
M
D
S
A
Y
G
T
L
S
P
T
S
L
Q
Site 105
S879
D
S
A
Y
G
T
L
S
P
T
S
L
Q
D
F
Site 106
S882
Y
G
T
L
S
P
T
S
L
Q
D
F
V
A
P
Site 107
S902
L
V
P
R
A
P
E
S
P
R
V
P
S
P
P
Site 108
S907
P
E
S
P
R
V
P
S
P
P
P
S
P
R
L
Site 109
S911
R
V
P
S
P
P
P
S
P
R
L
R
R
R
T
Site 110
T918
S
P
R
L
R
R
R
T
P
V
Q
L
L
S
C
Site 111
S924
R
T
P
V
Q
L
L
S
C
P
P
H
L
L
K
Site 112
S932
C
P
P
H
L
L
K
S
K
S
E
A
S
L
L
Site 113
S934
P
H
L
L
K
S
K
S
E
A
S
L
L
Q
L
Site 114
T950
A
G
A
G
T
H
G
T
P
S
A
P
S
R
S
Site 115
S952
A
G
T
H
G
T
P
S
A
P
S
R
S
L
S
Site 116
S955
H
G
T
P
S
A
P
S
R
S
L
S
E
L
C
Site 117
S957
T
P
S
A
P
S
R
S
L
S
E
L
C
L
A
Site 118
S975
P
G
I
R
T
Q
G
S
P
Q
E
A
G
P
S
Site 119
S982
S
P
Q
E
A
G
P
S
W
D
C
R
G
A
P
Site 120
S990
W
D
C
R
G
A
P
S
P
G
S
G
P
G
L
Site 121
S993
R
G
A
P
S
P
G
S
G
P
G
L
V
G
C
Site 122
S1008
L
A
G
E
P
A
G
S
H
R
K
R
C
G
D
Site 123
S1018
K
R
C
G
D
L
P
S
G
A
S
P
R
V
Q
Site 124
S1021
G
D
L
P
S
G
A
S
P
R
V
Q
P
E
P
Site 125
T1040
S
A
Q
H
R
K
L
T
L
A
Q
L
Y
R
I
Site 126
T1049
A
Q
L
Y
R
I
R
T
T
L
L
L
N
S
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation