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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RECQL5
Full Name:
ATP-dependent DNA helicase Q5
Alias:
FLJ90603; RecQ 5; RecQ protein 5; RecQ protein-like 5; RECQ5
Type:
Helicase; EC 3.6.1.-; DNA repair
Mass (Da):
108858
Number AA:
991
UniProt ID:
O94762
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003678
PhosphoSite+
KinaseNET
Biological Process:
GO:0006310
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
S
S
H
H
T
T
F
P
F
D
P
E
R
Site 2
S18
D
P
E
R
R
V
R
S
T
L
K
K
V
F
G
Site 3
T19
P
E
R
R
V
R
S
T
L
K
K
V
F
G
F
Site 4
S28
K
K
V
F
G
F
D
S
F
K
T
P
L
Q
E
Site 5
T31
F
G
F
D
S
F
K
T
P
L
Q
E
S
A
T
Site 6
T92
D
Q
V
D
H
L
L
T
L
K
V
R
V
S
S
Site 7
S99
T
L
K
V
R
V
S
S
L
N
S
K
L
S
A
Site 8
S102
V
R
V
S
S
L
N
S
K
L
S
A
Q
E
R
Site 9
S105
S
S
L
N
S
K
L
S
A
Q
E
R
K
E
L
Site 10
T123
L
E
R
E
K
P
Q
T
K
I
L
Y
I
T
P
Site 11
Y127
K
P
Q
T
K
I
L
Y
I
T
P
E
M
A
A
Site 12
T129
Q
T
K
I
L
Y
I
T
P
E
M
A
A
S
S
Site 13
S135
I
T
P
E
M
A
A
S
S
S
F
Q
P
T
L
Site 14
S137
P
E
M
A
A
S
S
S
F
Q
P
T
L
N
S
Site 15
T141
A
S
S
S
F
Q
P
T
L
N
S
L
V
S
R
Site 16
S144
S
F
Q
P
T
L
N
S
L
V
S
R
H
L
L
Site 17
Y173
G
H
D
F
R
P
D
Y
L
R
L
G
A
L
R
Site 18
Y239
K
E
L
I
S
D
P
Y
G
N
L
K
D
F
C
Site 19
S280
E
Q
L
A
I
E
L
S
C
R
G
V
N
A
K
Site 20
Y289
R
G
V
N
A
K
A
Y
H
A
G
L
K
A
S
Site 21
S296
Y
H
A
G
L
K
A
S
E
R
T
L
V
Q
N
Site 22
Y343
I
A
K
S
M
A
G
Y
Y
Q
E
S
G
R
A
Site 23
Y344
A
K
S
M
A
G
Y
Y
Q
E
S
G
R
A
G
Site 24
S347
M
A
G
Y
Y
Q
E
S
G
R
A
G
R
D
G
Site 25
S357
A
G
R
D
G
K
P
S
W
C
R
L
Y
Y
S
Site 26
Y362
K
P
S
W
C
R
L
Y
Y
S
R
N
D
R
D
Site 27
Y363
P
S
W
C
R
L
Y
Y
S
R
N
D
R
D
Q
Site 28
S372
R
N
D
R
D
Q
V
S
F
L
I
R
K
E
V
Site 29
S391
E
K
R
G
N
K
A
S
D
K
A
T
I
M
A
Site 30
T395
N
K
A
S
D
K
A
T
I
M
A
F
D
A
L
Site 31
S451
L
E
A
L
E
R
S
S
S
W
S
K
T
C
I
Site 32
S452
E
A
L
E
R
S
S
S
W
S
K
T
C
I
G
Site 33
S454
L
E
R
S
S
S
W
S
K
T
C
I
G
P
S
Site 34
T456
R
S
S
S
W
S
K
T
C
I
G
P
S
Q
G
Site 35
S461
S
K
T
C
I
G
P
S
Q
G
N
G
F
D
P
Site 36
Y471
N
G
F
D
P
E
L
Y
E
G
G
R
K
G
Y
Site 37
Y478
Y
E
G
G
R
K
G
Y
G
D
F
S
R
Y
D
Site 38
S482
R
K
G
Y
G
D
F
S
R
Y
D
E
G
S
G
Site 39
Y484
G
Y
G
D
F
S
R
Y
D
E
G
S
G
G
S
Site 40
S488
F
S
R
Y
D
E
G
S
G
G
S
G
D
E
G
Site 41
S491
Y
D
E
G
S
G
G
S
G
D
E
G
R
D
E
Site 42
Y508
K
R
E
W
N
L
F
Y
Q
K
Q
M
Q
L
R
Site 43
S538
N
C
P
L
K
E
A
S
S
R
R
I
P
R
L
Site 44
S539
C
P
L
K
E
A
S
S
R
R
I
P
R
L
T
Site 45
T546
S
R
R
I
P
R
L
T
V
K
A
R
E
H
C
Site 46
S562
R
L
L
E
E
A
L
S
S
N
R
Q
S
T
R
Site 47
S563
L
L
E
E
A
L
S
S
N
R
Q
S
T
R
T
Site 48
S567
A
L
S
S
N
R
Q
S
T
R
T
A
D
E
A
Site 49
T568
L
S
S
N
R
Q
S
T
R
T
A
D
E
A
D
Site 50
T570
S
N
R
Q
S
T
R
T
A
D
E
A
D
L
R
Site 51
T587
A
V
E
L
E
H
E
T
F
R
N
A
K
V
A
Site 52
Y597
N
A
K
V
A
N
L
Y
K
A
S
V
L
K
K
Site 53
S612
V
A
D
I
H
R
A
S
K
D
G
Q
P
Y
D
Site 54
Y618
A
S
K
D
G
Q
P
Y
D
M
G
G
S
A
K
Site 55
S626
D
M
G
G
S
A
K
S
C
S
A
Q
A
E
P
Site 56
Y639
E
P
P
E
P
N
E
Y
D
I
P
P
A
S
H
Site 57
S645
E
Y
D
I
P
P
A
S
H
V
Y
S
L
K
P
Site 58
S649
P
P
A
S
H
V
Y
S
L
K
P
K
R
V
G
Site 59
S663
G
A
G
F
P
K
G
S
C
P
F
Q
T
A
T
Site 60
T675
T
A
T
E
L
M
E
T
T
R
I
R
E
Q
A
Site 61
S695
G
G
E
H
E
P
P
S
R
P
C
G
L
L
D
Site 62
S706
G
L
L
D
E
D
G
S
E
P
L
P
G
P
R
Site 63
S720
R
G
E
V
P
G
G
S
A
H
Y
G
G
P
S
Site 64
Y723
V
P
G
G
S
A
H
Y
G
G
P
S
P
E
K
Site 65
S727
S
A
H
Y
G
G
P
S
P
E
K
K
A
K
S
Site 66
S734
S
P
E
K
K
A
K
S
S
S
G
G
S
S
L
Site 67
S735
P
E
K
K
A
K
S
S
S
G
G
S
S
L
A
Site 68
S736
E
K
K
A
K
S
S
S
G
G
S
S
L
A
K
Site 69
S739
A
K
S
S
S
G
G
S
S
L
A
K
G
R
A
Site 70
S740
K
S
S
S
G
G
S
S
L
A
K
G
R
A
S
Site 71
S747
S
L
A
K
G
R
A
S
K
K
Q
Q
L
L
A
Site 72
S761
A
T
A
A
H
K
D
S
Q
S
I
A
R
F
F
Site 73
S763
A
A
H
K
D
S
Q
S
I
A
R
F
F
C
R
Site 74
S780
E
S
P
A
L
L
A
S
A
P
E
A
E
G
A
Site 75
S790
E
A
E
G
A
C
P
S
C
E
G
V
Q
G
P
Site 76
S815
E
D
G
A
G
G
H
S
P
A
P
P
Q
T
E
Site 77
T821
H
S
P
A
P
P
Q
T
E
E
C
L
R
E
R
Site 78
S830
E
C
L
R
E
R
P
S
T
C
P
P
R
D
Q
Site 79
T831
C
L
R
E
R
P
S
T
C
P
P
R
D
Q
G
Site 80
T839
C
P
P
R
D
Q
G
T
P
E
V
Q
P
T
P
Site 81
T845
G
T
P
E
V
Q
P
T
P
A
K
D
T
W
K
Site 82
S858
W
K
G
K
R
P
R
S
Q
Q
E
N
P
E
S
Site 83
S865
S
Q
Q
E
N
P
E
S
Q
P
Q
K
R
P
R
Site 84
S874
P
Q
K
R
P
R
P
S
A
K
P
S
V
V
A
Site 85
S878
P
R
P
S
A
K
P
S
V
V
A
E
V
K
G
Site 86
S886
V
V
A
E
V
K
G
S
V
S
A
S
E
Q
G
Site 87
S888
A
E
V
K
G
S
V
S
A
S
E
Q
G
T
L
Site 88
S890
V
K
G
S
V
S
A
S
E
Q
G
T
L
N
P
Site 89
T894
V
S
A
S
E
Q
G
T
L
N
P
T
A
Q
D
Site 90
S906
A
Q
D
P
F
Q
L
S
A
P
G
V
S
L
K
Site 91
T924
N
V
V
V
K
C
L
T
P
F
Y
K
E
G
K
Site 92
Y927
V
K
C
L
T
P
F
Y
K
E
G
K
F
A
S
Site 93
S934
Y
K
E
G
K
F
A
S
K
E
L
F
K
G
F
Site 94
S946
K
G
F
A
R
H
L
S
H
L
L
T
Q
K
T
Site 95
T950
R
H
L
S
H
L
L
T
Q
K
T
S
P
G
R
Site 96
T953
S
H
L
L
T
Q
K
T
S
P
G
R
S
V
K
Site 97
S954
H
L
L
T
Q
K
T
S
P
G
R
S
V
K
E
Site 98
S958
Q
K
T
S
P
G
R
S
V
K
E
E
A
Q
N
Site 99
S979
H
G
R
A
R
C
E
S
E
A
D
W
H
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation