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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RECQL4
Full Name:
ATP-dependent DNA helicase Q4
Alias:
DNA helicase, RecQ-like type 4;RTS;RecQ protein-like 4
Type:
Mass (Da):
133077
Number AA:
1208
UniProt ID:
O94761
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
R
Q
R
G
R
R
P
S
Q
D
D
V
E
A
A
Site 2
Y42
P
E
E
T
R
A
L
Y
R
E
Y
R
T
L
K
Site 3
Y45
T
R
A
L
Y
R
E
Y
R
T
L
K
R
T
T
Site 4
T51
E
Y
R
T
L
K
R
T
T
G
Q
A
G
G
G
Site 5
T52
Y
R
T
L
K
R
T
T
G
Q
A
G
G
G
L
Site 6
S61
Q
A
G
G
G
L
R
S
S
E
S
L
P
A
A
Site 7
S62
A
G
G
G
L
R
S
S
E
S
L
P
A
A
A
Site 8
S64
G
G
L
R
S
S
E
S
L
P
A
A
A
E
E
Site 9
T87
P
H
L
N
R
A
A
T
K
S
P
Q
P
T
P
Site 10
S89
L
N
R
A
A
T
K
S
P
Q
P
T
P
G
R
Site 11
T93
A
T
K
S
P
Q
P
T
P
G
R
S
R
Q
G
Site 12
S97
P
Q
P
T
P
G
R
S
R
Q
G
S
V
P
D
Site 13
S101
P
G
R
S
R
Q
G
S
V
P
D
Y
G
Q
R
Site 14
Y105
R
Q
G
S
V
P
D
Y
G
Q
R
L
K
A
N
Site 15
S134
P
W
P
L
G
R
A
S
S
K
A
S
T
P
K
Site 16
S135
W
P
L
G
R
A
S
S
K
A
S
T
P
K
P
Site 17
S138
G
R
A
S
S
K
A
S
T
P
K
P
P
G
T
Site 18
T139
R
A
S
S
K
A
S
T
P
K
P
P
G
T
G
Site 19
T145
S
T
P
K
P
P
G
T
G
P
V
P
S
F
A
Site 20
S150
P
G
T
G
P
V
P
S
F
A
E
K
V
S
D
Site 21
S156
P
S
F
A
E
K
V
S
D
E
P
P
Q
L
P
Site 22
S178
R
L
Q
H
L
Q
A
S
L
S
Q
R
L
G
S
Site 23
S180
Q
H
L
Q
A
S
L
S
Q
R
L
G
S
L
D
Site 24
S185
S
L
S
Q
R
L
G
S
L
D
P
G
W
L
Q
Site 25
S196
G
W
L
Q
R
C
H
S
E
V
P
D
F
L
G
Site 26
S214
A
C
R
P
D
L
G
S
E
E
S
Q
L
L
I
Site 27
S217
P
D
L
G
S
E
E
S
Q
L
L
I
P
G
E
Site 28
S234
V
L
G
P
G
A
G
S
Q
G
P
E
A
S
A
Site 29
S240
G
S
Q
G
P
E
A
S
A
F
Q
E
V
S
I
Site 30
S246
A
S
A
F
Q
E
V
S
I
R
V
G
S
P
Q
Site 31
S251
E
V
S
I
R
V
G
S
P
Q
P
S
S
S
G
Site 32
S255
R
V
G
S
P
Q
P
S
S
S
G
G
E
K
R
Site 33
S256
V
G
S
P
Q
P
S
S
S
G
G
E
K
R
R
Site 34
S257
G
S
P
Q
P
S
S
S
G
G
E
K
R
R
W
Site 35
S271
W
N
E
E
P
W
E
S
P
A
Q
V
Q
Q
E
Site 36
S280
A
Q
V
Q
Q
E
S
S
Q
A
G
P
P
S
E
Site 37
S286
S
S
Q
A
G
P
P
S
E
G
A
G
A
V
A
Site 38
S312
A
Q
P
P
Q
P
C
S
S
P
S
N
P
R
Y
Site 39
S313
Q
P
P
Q
P
C
S
S
P
S
N
P
R
Y
H
Site 40
S315
P
Q
P
C
S
S
P
S
N
P
R
Y
H
G
L
Site 41
Y319
S
S
P
S
N
P
R
Y
H
G
L
S
P
S
S
Site 42
S323
N
P
R
Y
H
G
L
S
P
S
S
Q
A
R
A
Site 43
S325
R
Y
H
G
L
S
P
S
S
Q
A
R
A
G
K
Site 44
S326
Y
H
G
L
S
P
S
S
Q
A
R
A
G
K
A
Site 45
Y353
A
R
H
D
R
G
N
Y
V
R
L
N
M
K
Q
Site 46
Y363
L
N
M
K
Q
K
H
Y
V
R
G
R
A
L
R
Site 47
S421
A
Q
C
P
R
P
A
S
E
E
D
T
D
A
V
Site 48
T425
R
P
A
S
E
E
D
T
D
A
V
G
P
E
P
Site 49
S436
G
P
E
P
L
V
P
S
P
Q
P
V
P
E
V
Site 50
S445
Q
P
V
P
E
V
P
S
L
D
P
T
V
L
P
Site 51
Y454
D
P
T
V
L
P
L
Y
S
L
G
P
S
G
Q
Site 52
S459
P
L
Y
S
L
G
P
S
G
Q
L
A
E
T
P
Site 53
T465
P
S
G
Q
L
A
E
T
P
A
E
V
F
Q
A
Site 54
Y519
Y
Q
L
P
A
L
L
Y
S
R
R
S
P
C
L
Site 55
S520
Q
L
P
A
L
L
Y
S
R
R
S
P
C
L
T
Site 56
S542
S
L
M
D
D
Q
V
S
G
L
P
P
C
L
K
Site 57
S564
M
T
R
K
Q
R
E
S
V
L
Q
K
I
R
A
Site 58
Y621
S
H
N
F
R
P
C
Y
L
R
V
C
K
V
L
Site 59
T645
L
G
L
T
A
T
A
T
R
R
T
A
S
D
V
Site 60
T648
T
A
T
A
T
R
R
T
A
S
D
V
A
Q
H
Site 61
S650
T
A
T
R
R
T
A
S
D
V
A
Q
H
L
A
Site 62
S677
V
P
T
N
L
H
L
S
V
S
M
D
R
D
T
Site 63
S679
T
N
L
H
L
S
V
S
M
D
R
D
T
D
Q
Site 64
T684
S
V
S
M
D
R
D
T
D
Q
A
L
L
T
L
Site 65
T690
D
T
D
Q
A
L
L
T
L
L
Q
G
K
R
F
Site 66
Y706
N
L
D
S
I
I
I
Y
C
N
R
R
E
D
T
Site 67
T713
Y
C
N
R
R
E
D
T
E
R
I
A
A
L
L
Site 68
S732
H
A
A
W
V
P
G
S
G
G
R
A
P
K
T
Site 69
T739
S
G
G
R
A
P
K
T
T
A
E
A
Y
H
A
Site 70
T740
G
G
R
A
P
K
T
T
A
E
A
Y
H
A
G
Site 71
Y744
P
K
T
T
A
E
A
Y
H
A
G
M
C
S
R
Site 72
S750
A
Y
H
A
G
M
C
S
R
E
R
R
R
V
Q
Site 73
S797
G
L
P
P
S
F
E
S
Y
V
Q
A
V
G
R
Site 74
Y798
L
P
P
S
F
E
S
Y
V
Q
A
V
G
R
A
Site 75
T837
R
H
V
H
A
D
S
T
D
F
L
A
V
K
R
Site 76
T856
V
F
P
A
C
T
C
T
C
T
R
P
P
S
E
Site 77
T858
P
A
C
T
C
T
C
T
R
P
P
S
E
Q
E
Site 78
S862
C
T
C
T
R
P
P
S
E
Q
E
G
A
V
G
Site 79
Y877
G
E
R
P
V
P
K
Y
P
P
Q
E
A
E
Q
Site 80
S886
P
Q
E
A
E
Q
L
S
H
Q
A
A
P
G
P
Site 81
T943
E
L
L
A
T
T
Y
T
H
C
R
L
N
C
P
Site 82
S983
E
D
P
G
Q
G
S
S
S
V
E
F
D
M
V
Site 83
S984
D
P
G
Q
G
S
S
S
V
E
F
D
M
V
K
Site 84
S1002
S
M
G
W
E
L
A
S
V
R
R
A
L
C
Q
Site 85
T1018
Q
W
D
H
E
P
R
T
G
V
R
R
G
T
G
Site 86
T1024
R
T
G
V
R
R
G
T
G
V
L
V
E
F
S
Site 87
S1039
E
L
A
F
H
L
R
S
P
G
D
L
T
A
E
Site 88
T1044
L
R
S
P
G
D
L
T
A
E
E
K
D
Q
I
Site 89
Y1056
D
Q
I
C
D
F
L
Y
G
R
V
Q
A
R
E
Site 90
T1073
A
L
A
R
L
R
R
T
F
Q
A
F
H
S
V
Site 91
S1097
E
Q
Q
D
E
E
R
S
T
R
L
K
D
L
L
Site 92
T1098
Q
Q
D
E
E
R
S
T
R
L
K
D
L
L
G
Site 93
Y1107
L
K
D
L
L
G
R
Y
F
E
E
E
E
G
Q
Site 94
S1148
C
D
I
R
Q
F
L
S
L
R
P
E
E
K
F
Site 95
S1156
L
R
P
E
E
K
F
S
S
R
A
V
A
R
I
Site 96
S1157
R
P
E
E
K
F
S
S
R
A
V
A
R
I
F
Site 97
Y1172
H
G
I
G
S
P
C
Y
P
A
Q
V
Y
G
Q
Site 98
Y1187
D
R
R
F
W
R
K
Y
L
H
L
S
F
H
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation