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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BEST1
Full Name:
Bestrophin-1
Alias:
BEST; Best disease; Bestrophin 1; BMD; TU15B; Vitelliform macular dystrophy 2; VMD2
Type:
Membrane fraction, Plasma membrane, Cytosol, Basolateral plasma membrane, Integral membrane protein
Mass (Da):
67684
Number AA:
585
UniProt ID:
O76090
International Prot ID:
IPI00181929
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016323
GO:0034707
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005254
GO:0031404
PhosphoSite+
KinaseNET
Biological Process:
GO:0050896
GO:0030321
GO:0007601
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T2
_
_
_
_
_
_
M
T
I
T
Y
T
S
Q
V
Site 2
S16
V
A
N
A
R
L
G
S
F
S
R
L
L
L
C
Site 3
S111
D
R
L
M
S
L
V
S
G
F
V
E
G
K
D
Site 4
T127
Q
G
R
L
L
R
R
T
L
I
R
Y
A
N
L
Site 5
Y131
L
R
R
T
L
I
R
Y
A
N
L
G
N
V
L
Site 6
Y148
R
S
V
S
T
A
V
Y
K
R
F
P
S
A
Q
Site 7
S153
A
V
Y
K
R
F
P
S
A
Q
H
L
V
Q
A
Site 8
T164
L
V
Q
A
G
F
M
T
P
A
E
H
K
Q
L
Site 9
S209
R
D
P
I
L
L
Q
S
L
L
N
E
M
N
T
Site 10
T216
S
L
L
N
E
M
N
T
L
R
T
Q
C
G
H
Site 11
Y264
F
L
N
P
A
K
A
Y
P
G
H
E
L
D
L
Site 12
Y337
P
R
M
E
P
D
M
Y
W
N
K
P
E
P
Q
Site 13
Y347
K
P
E
P
Q
P
P
Y
T
A
A
S
A
Q
F
Site 14
T348
P
E
P
Q
P
P
Y
T
A
A
S
A
Q
F
R
Site 15
S358
S
A
Q
F
R
R
A
S
F
M
G
S
T
F
N
Site 16
S362
R
R
A
S
F
M
G
S
T
F
N
I
S
L
N
Site 17
T363
R
A
S
F
M
G
S
T
F
N
I
S
L
N
K
Site 18
S367
M
G
S
T
F
N
I
S
L
N
K
E
E
M
E
Site 19
S398
G
R
F
L
G
L
Q
S
H
D
H
H
P
P
R
Site 20
S408
H
H
P
P
R
A
N
S
R
T
K
L
L
W
P
Site 21
T410
P
P
R
A
N
S
R
T
K
L
L
W
P
K
R
Site 22
S419
L
L
W
P
K
R
E
S
L
L
H
E
G
L
P
Site 23
S455
K
A
V
D
A
F
K
S
A
P
L
Y
Q
R
P
Site 24
Y459
A
F
K
S
A
P
L
Y
Q
R
P
G
Y
Y
S
Site 25
Y464
P
L
Y
Q
R
P
G
Y
Y
S
A
P
Q
T
P
Site 26
Y465
L
Y
Q
R
P
G
Y
Y
S
A
P
Q
T
P
L
Site 27
S466
Y
Q
R
P
G
Y
Y
S
A
P
Q
T
P
L
S
Site 28
T470
G
Y
Y
S
A
P
Q
T
P
L
S
P
T
P
M
Site 29
S473
S
A
P
Q
T
P
L
S
P
T
P
M
F
F
P
Site 30
T475
P
Q
T
P
L
S
P
T
P
M
F
F
P
L
E
Site 31
S484
M
F
F
P
L
E
P
S
A
P
S
K
L
H
S
Site 32
S487
P
L
E
P
S
A
P
S
K
L
H
S
V
T
G
Site 33
S491
S
A
P
S
K
L
H
S
V
T
G
I
D
T
K
Site 34
T497
H
S
V
T
G
I
D
T
K
D
K
S
L
K
T
Site 35
S501
G
I
D
T
K
D
K
S
L
K
T
V
S
S
G
Site 36
T504
T
K
D
K
S
L
K
T
V
S
S
G
A
K
K
Site 37
S506
D
K
S
L
K
T
V
S
S
G
A
K
K
S
F
Site 38
S507
K
S
L
K
T
V
S
S
G
A
K
K
S
F
E
Site 39
S512
V
S
S
G
A
K
K
S
F
E
L
L
S
E
S
Site 40
S517
K
K
S
F
E
L
L
S
E
S
D
G
A
L
M
Site 41
S519
S
F
E
L
L
S
E
S
D
G
A
L
M
E
H
Site 42
S530
L
M
E
H
P
E
V
S
Q
V
R
R
K
T
V
Site 43
T536
V
S
Q
V
R
R
K
T
V
E
F
N
L
T
D
Site 44
T542
K
T
V
E
F
N
L
T
D
M
P
E
I
P
E
Site 45
S559
L
K
E
P
L
E
Q
S
P
T
N
I
H
T
T
Site 46
T561
E
P
L
E
Q
S
P
T
N
I
H
T
T
L
K
Site 47
Y574
L
K
D
H
M
D
P
Y
W
A
L
E
N
R
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation