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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE9A
Full Name:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Alias:
CGMP-specific 3',5'-cyclic phosphodiesterase type 9; EC 3.1.4.35; High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; HSPDE9A2; Phosphodiesterase PDE9A21
Type:
EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase
Mass (Da):
68493
Number AA:
593
UniProt ID:
O76083
International Prot ID:
IPI00008806
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0047555
GO:0030145
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
G
S
G
S
S
S
Y
R
P
K
A
Site 2
S7
_
M
G
S
G
S
S
S
Y
R
P
K
A
I
Y
Site 3
Y14
S
Y
R
P
K
A
I
Y
L
D
I
D
G
R
I
Site 4
Y29
Q
K
V
I
F
S
K
Y
C
N
S
S
D
I
M
Site 5
T50
T
G
L
P
R
N
T
T
I
S
L
L
T
T
D
Site 6
S52
L
P
R
N
T
T
I
S
L
L
T
T
D
D
A
Site 7
T66
A
M
V
S
I
D
P
T
M
P
A
N
S
E
R
Site 8
S71
D
P
T
M
P
A
N
S
E
R
T
P
Y
K
V
Site 9
T74
M
P
A
N
S
E
R
T
P
Y
K
V
R
P
V
Site 10
Y76
A
N
S
E
R
T
P
Y
K
V
R
P
V
A
I
Site 11
S87
P
V
A
I
K
Q
L
S
A
G
V
E
D
K
R
Site 12
T95
A
G
V
E
D
K
R
T
T
S
R
G
Q
S
A
Site 13
T96
G
V
E
D
K
R
T
T
S
R
G
Q
S
A
E
Site 14
S97
V
E
D
K
R
T
T
S
R
G
Q
S
A
E
R
Site 15
S101
R
T
T
S
R
G
Q
S
A
E
R
P
L
R
D
Site 16
S125
R
R
E
G
A
F
E
S
G
Q
V
E
P
R
P
Site 17
Y139
P
R
E
P
Q
G
C
Y
Q
E
G
Q
R
I
P
Site 18
S155
E
R
E
E
L
I
Q
S
V
L
A
Q
V
A
E
Site 19
S203
V
E
I
E
K
C
K
S
D
I
K
K
M
R
E
Site 20
S216
R
E
E
L
A
A
R
S
S
R
T
N
C
P
C
Site 21
S217
E
E
L
A
A
R
S
S
R
T
N
C
P
C
K
Site 22
Y225
R
T
N
C
P
C
K
Y
S
F
L
D
N
H
K
Site 23
T235
L
D
N
H
K
K
L
T
P
R
R
D
V
P
T
Site 24
T242
T
P
R
R
D
V
P
T
Y
P
K
Y
L
L
S
Site 25
Y243
P
R
R
D
V
P
T
Y
P
K
Y
L
L
S
P
Site 26
Y246
D
V
P
T
Y
P
K
Y
L
L
S
P
E
T
I
Site 27
S249
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
Site 28
T260
I
E
A
L
R
K
P
T
F
D
V
W
L
W
E
Site 29
Y359
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
Site 30
Y375
R
T
E
L
A
V
R
Y
N
D
I
S
P
L
E
Site 31
S379
A
V
R
Y
N
D
I
S
P
L
E
N
H
H
C
Site 32
S434
R
H
A
E
I
M
D
S
F
K
E
K
M
E
N
Site 33
Y444
E
K
M
E
N
F
D
Y
S
N
E
E
H
M
T
Site 34
Y484
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
Site 35
S488
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
Site 36
S493
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
Site 37
Y550
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
Site 38
T567
M
K
E
L
Q
K
K
T
D
S
L
T
S
G
A
Site 39
S569
E
L
Q
K
K
T
D
S
L
T
S
G
A
T
E
Site 40
T571
Q
K
K
T
D
S
L
T
S
G
A
T
E
K
S
Site 41
S578
T
S
G
A
T
E
K
S
R
E
R
S
R
D
V
Site 42
S582
T
E
K
S
R
E
R
S
R
D
V
K
N
S
E
Site 43
S588
R
S
R
D
V
K
N
S
E
G
D
C
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation