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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MPDZ
Full Name:
Multiple PDZ domain protein
Alias:
Multi PDZ domain protein 1; Multi-PDZ domain protein 1; Multi-PDZ-domain protein 1; MUPP1; Multi PDZ domain protein 1; multi-PDZ-domain protein 1; MUPP1
Type:
Adaptor/scaffold
Mass (Da):
218597
Number AA:
2042
UniProt ID:
O75970
International Prot ID:
IPI00552988
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030425
GO:0014069
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
H
A
A
E
R
L
Q
T
K
L
R
E
R
G
D
Site 2
S34
V
A
N
E
D
K
L
S
L
L
K
S
V
L
Q
Site 3
S54
Q
I
L
S
L
Q
T
S
V
Q
Q
L
K
D
Q
Site 4
Y74
S
A
T
S
N
I
E
Y
A
H
V
P
H
L
S
Site 5
S92
I
P
T
L
Q
N
E
S
F
L
L
S
P
N
N
Site 6
S96
Q
N
E
S
F
L
L
S
P
N
N
G
N
L
E
Site 7
T106
N
G
N
L
E
A
L
T
G
P
G
I
P
H
I
Site 8
S157
F
S
V
V
G
L
R
S
E
N
R
G
E
L
G
Site 9
S174
V
Q
E
I
Q
E
G
S
V
A
H
R
D
G
R
Site 10
T199
N
G
Q
A
L
D
Q
T
I
T
H
Q
Q
A
I
Site 11
S224
Q
L
V
I
A
R
G
S
L
P
Q
L
V
S
P
Site 12
S230
G
S
L
P
Q
L
V
S
P
I
V
S
R
S
P
Site 13
S234
Q
L
V
S
P
I
V
S
R
S
P
S
A
A
S
Site 14
S241
S
R
S
P
S
A
A
S
T
I
S
A
H
S
N
Site 15
T242
R
S
P
S
A
A
S
T
I
S
A
H
S
N
P
Site 16
S244
P
S
A
A
S
T
I
S
A
H
S
N
P
V
H
Site 17
S298
D
Q
H
G
R
L
C
S
G
D
H
I
L
K
I
Site 18
T350
A
P
T
A
L
G
I
T
L
S
S
S
P
T
S
Site 19
S353
A
L
G
I
T
L
S
S
S
P
T
S
T
P
E
Site 20
S354
L
G
I
T
L
S
S
S
P
T
S
T
P
E
L
Site 21
T356
I
T
L
S
S
S
P
T
S
T
P
E
L
R
V
Site 22
S357
T
L
S
S
S
P
T
S
T
P
E
L
R
V
D
Site 23
T358
L
S
S
S
P
T
S
T
P
E
L
R
V
D
A
Site 24
S366
P
E
L
R
V
D
A
S
T
Q
K
G
E
E
S
Site 25
T367
E
L
R
V
D
A
S
T
Q
K
G
E
E
S
E
Site 26
S373
S
T
Q
K
G
E
E
S
E
T
F
D
V
E
L
Site 27
T375
Q
K
G
E
E
S
E
T
F
D
V
E
L
T
K
Site 28
S413
F
V
K
S
I
T
K
S
S
A
V
E
H
D
G
Site 29
T458
T
G
Q
T
V
L
L
T
L
M
R
R
G
M
K
Site 30
T477
L
M
S
R
E
D
V
T
K
D
A
D
L
S
P
Site 31
S483
V
T
K
D
A
D
L
S
P
V
N
A
S
I
I
Site 32
S502
E
K
D
E
D
F
L
S
S
T
R
N
T
N
I
Site 33
S503
K
D
E
D
F
L
S
S
T
R
N
T
N
I
L
Site 34
T507
F
L
S
S
T
R
N
T
N
I
L
P
T
E
E
Site 35
Y517
L
P
T
E
E
E
G
Y
P
L
L
S
A
E
I
Site 36
S521
E
E
G
Y
P
L
L
S
A
E
I
E
E
I
E
Site 37
S557
E
I
V
V
A
H
V
S
K
F
S
E
N
S
G
Site 38
S568
E
N
S
G
L
G
I
S
L
E
A
T
V
G
H
Site 39
S595
G
H
S
G
K
L
F
S
G
D
E
L
L
E
V
Site 40
T627
K
E
L
P
I
E
V
T
M
V
C
C
R
R
T
Site 41
T634
T
M
V
C
C
R
R
T
V
P
P
T
T
Q
S
Site 42
T638
C
R
R
T
V
P
P
T
T
Q
S
E
L
D
S
Site 43
T639
R
R
T
V
P
P
T
T
Q
S
E
L
D
S
L
Site 44
S641
T
V
P
P
T
T
Q
S
E
L
D
S
L
D
L
Site 45
S645
T
T
Q
S
E
L
D
S
L
D
L
C
D
I
E
Site 46
T654
D
L
C
D
I
E
L
T
E
K
P
H
V
D
L
Site 47
S667
D
L
G
E
F
I
G
S
S
E
T
E
D
P
V
Site 48
S713
G
S
K
G
L
G
F
S
I
L
D
Y
Q
D
P
Site 49
Y717
L
G
F
S
I
L
D
Y
Q
D
P
I
D
P
A
Site 50
T726
D
P
I
D
P
A
S
T
V
I
I
I
R
S
L
Site 51
S790
V
A
K
P
L
P
L
S
P
E
E
G
Y
V
S
Site 52
Y795
P
L
S
P
E
E
G
Y
V
S
A
K
E
D
S
Site 53
S797
S
P
E
E
G
Y
V
S
A
K
E
D
S
F
L
Site 54
S802
Y
V
S
A
K
E
D
S
F
L
Y
P
P
H
S
Site 55
Y805
A
K
E
D
S
F
L
Y
P
P
H
S
C
E
E
Site 56
S809
S
F
L
Y
P
P
H
S
C
E
E
A
G
L
A
Site 57
S839
D
A
D
L
V
D
E
S
T
F
E
S
P
Y
S
Site 58
T840
A
D
L
V
D
E
S
T
F
E
S
P
Y
S
P
Site 59
S843
V
D
E
S
T
F
E
S
P
Y
S
P
E
N
D
Site 60
S846
S
T
F
E
S
P
Y
S
P
E
N
D
S
I
Y
Site 61
S851
P
Y
S
P
E
N
D
S
I
Y
S
T
Q
A
S
Site 62
Y853
S
P
E
N
D
S
I
Y
S
T
Q
A
S
I
L
Site 63
S854
P
E
N
D
S
I
Y
S
T
Q
A
S
I
L
S
Site 64
T855
E
N
D
S
I
Y
S
T
Q
A
S
I
L
S
L
Site 65
S861
S
T
Q
A
S
I
L
S
L
H
G
S
S
C
G
Site 66
Y873
S
C
G
D
G
L
N
Y
G
S
S
L
P
S
S
Site 67
S875
G
D
G
L
N
Y
G
S
S
L
P
S
S
P
P
Site 68
S876
D
G
L
N
Y
G
S
S
L
P
S
S
P
P
K
Site 69
S879
N
Y
G
S
S
L
P
S
S
P
P
K
D
V
I
Site 70
S880
Y
G
S
S
L
P
S
S
P
P
K
D
V
I
E
Site 71
S889
P
K
D
V
I
E
N
S
C
D
P
V
L
D
L
Site 72
S899
P
V
L
D
L
H
M
S
L
E
E
L
Y
T
Q
Site 73
Y904
H
M
S
L
E
E
L
Y
T
Q
N
L
L
Q
R
Site 74
T905
M
S
L
E
E
L
Y
T
Q
N
L
L
Q
R
Q
Site 75
T916
L
Q
R
Q
D
E
N
T
P
S
V
D
I
S
M
Site 76
S918
R
Q
D
E
N
T
P
S
V
D
I
S
M
G
P
Site 77
S922
N
T
P
S
V
D
I
S
M
G
P
A
S
G
F
Site 78
S927
D
I
S
M
G
P
A
S
G
F
T
I
N
D
Y
Site 79
Y934
S
G
F
T
I
N
D
Y
T
P
A
N
A
I
E
Site 80
T935
G
F
T
I
N
D
Y
T
P
A
N
A
I
E
Q
Site 81
Y944
A
N
A
I
E
Q
Q
Y
E
C
E
N
T
I
V
Site 82
S955
N
T
I
V
W
T
E
S
H
L
P
S
E
V
I
Site 83
S959
W
T
E
S
H
L
P
S
E
V
I
S
S
A
E
Site 84
S974
L
P
S
V
L
P
D
S
A
G
K
G
S
E
Y
Site 85
Y981
S
A
G
K
G
S
E
Y
L
L
E
Q
S
S
L
Site 86
S987
E
Y
L
L
E
Q
S
S
L
A
C
N
A
E
C
Site 87
S1004
L
Q
N
V
S
K
E
S
F
E
R
T
I
N
I
Site 88
T1008
S
K
E
S
F
E
R
T
I
N
I
A
K
G
N
Site 89
T1021
G
N
S
S
L
G
M
T
V
S
A
N
K
D
G
Site 90
S1023
S
S
L
G
M
T
V
S
A
N
K
D
G
L
G
Site 91
S1064
I
N
E
E
S
T
I
S
V
T
N
A
Q
A
R
Site 92
S1078
R
A
M
L
R
R
H
S
L
I
G
P
D
I
K
Site 93
Y1088
G
P
D
I
K
I
T
Y
V
P
A
E
H
L
E
Site 94
S1100
H
L
E
E
F
K
I
S
L
G
Q
Q
S
G
R
Site 95
S1105
K
I
S
L
G
Q
Q
S
G
R
V
M
A
L
D
Site 96
T1118
L
D
I
F
S
S
Y
T
G
R
D
I
P
E
L
Site 97
S1136
E
E
G
E
G
E
E
S
E
L
Q
N
T
A
Y
Site 98
T1141
E
E
S
E
L
Q
N
T
A
Y
S
N
W
N
Q
Site 99
Y1143
S
E
L
Q
N
T
A
Y
S
N
W
N
Q
P
R
Site 100
S1159
V
E
L
W
R
E
P
S
K
S
L
G
I
S
I
Site 101
S1165
P
S
K
S
L
G
I
S
I
V
G
G
R
G
M
Site 102
S1174
V
G
G
R
G
M
G
S
R
L
S
N
G
E
V
Site 103
S1177
R
G
M
G
S
R
L
S
N
G
E
V
M
R
G
Site 104
S1194
I
K
H
V
L
E
D
S
P
A
G
K
N
G
T
Site 105
T1201
S
P
A
G
K
N
G
T
L
K
P
G
D
R
I
Site 106
S1220
G
M
D
L
R
D
A
S
H
E
Q
A
V
E
A
Site 107
S1249
I
I
N
R
P
R
K
S
P
L
P
S
L
L
H
Site 108
S1253
P
R
K
S
P
L
P
S
L
L
H
N
L
Y
P
Site 109
Y1259
P
S
L
L
H
N
L
Y
P
K
Y
N
F
S
S
Site 110
Y1262
L
H
N
L
Y
P
K
Y
N
F
S
S
T
N
P
Site 111
S1265
L
Y
P
K
Y
N
F
S
S
T
N
P
F
A
D
Site 112
S1266
Y
P
K
Y
N
F
S
S
T
N
P
F
A
D
S
Site 113
T1267
P
K
Y
N
F
S
S
T
N
P
F
A
D
S
L
Site 114
S1273
S
T
N
P
F
A
D
S
L
Q
I
N
A
D
K
Site 115
S1283
I
N
A
D
K
A
P
S
Q
S
E
S
E
P
E
Site 116
S1287
K
A
P
S
Q
S
E
S
E
P
E
K
A
P
L
Site 117
S1296
P
E
K
A
P
L
C
S
V
P
P
P
P
P
S
Site 118
S1303
S
V
P
P
P
P
P
S
A
F
A
E
M
G
S
Site 119
S1310
S
A
F
A
E
M
G
S
D
H
T
Q
S
S
A
Site 120
T1313
A
E
M
G
S
D
H
T
Q
S
S
A
S
K
I
Site 121
S1315
M
G
S
D
H
T
Q
S
S
A
S
K
I
S
Q
Site 122
S1316
G
S
D
H
T
Q
S
S
A
S
K
I
S
Q
D
Site 123
S1333
K
E
D
E
F
G
Y
S
W
K
N
I
R
E
R
Site 124
Y1341
W
K
N
I
R
E
R
Y
G
T
L
T
G
E
L
Site 125
T1343
N
I
R
E
R
Y
G
T
L
T
G
E
L
H
M
Site 126
T1345
R
E
R
Y
G
T
L
T
G
E
L
H
M
I
E
Site 127
S1363
G
H
S
G
L
G
L
S
L
A
G
N
K
D
R
Site 128
S1374
N
K
D
R
S
R
M
S
V
F
I
V
G
I
D
Site 129
Y1407
E
I
N
G
Q
I
L
Y
G
R
S
H
Q
N
A
Site 130
S1410
G
Q
I
L
Y
G
R
S
H
Q
N
A
S
S
I
Site 131
S1416
R
S
H
Q
N
A
S
S
I
I
K
C
A
P
S
Site 132
S1452
N
A
V
E
P
L
P
S
N
S
E
N
L
Q
N
Site 133
T1465
Q
N
K
E
T
E
P
T
V
T
T
S
D
A
A
Site 134
T1467
K
E
T
E
P
T
V
T
T
S
D
A
A
V
D
Site 135
S1476
S
D
A
A
V
D
L
S
S
F
K
N
V
Q
H
Site 136
S1477
D
A
A
V
D
L
S
S
F
K
N
V
Q
H
L
Site 137
S1567
I
H
A
E
N
P
D
S
Q
A
V
P
S
A
A
Site 138
S1572
P
D
S
Q
A
V
P
S
A
A
G
A
A
S
G
Site 139
S1578
P
S
A
A
G
A
A
S
G
E
K
K
N
S
S
Site 140
S1584
A
S
G
E
K
K
N
S
S
Q
S
L
M
V
P
Site 141
S1585
S
G
E
K
K
N
S
S
Q
S
L
M
V
P
Q
Site 142
S1587
E
K
K
N
S
S
Q
S
L
M
V
P
Q
S
G
Site 143
S1593
Q
S
L
M
V
P
Q
S
G
S
P
E
P
E
S
Site 144
S1595
L
M
V
P
Q
S
G
S
P
E
P
E
S
I
R
Site 145
S1600
S
G
S
P
E
P
E
S
I
R
N
T
S
R
S
Site 146
T1604
E
P
E
S
I
R
N
T
S
R
S
S
T
P
A
Site 147
S1605
P
E
S
I
R
N
T
S
R
S
S
T
P
A
I
Site 148
S1607
S
I
R
N
T
S
R
S
S
T
P
A
I
F
A
Site 149
S1608
I
R
N
T
S
R
S
S
T
P
A
I
F
A
S
Site 150
T1609
R
N
T
S
R
S
S
T
P
A
I
F
A
S
D
Site 151
S1633
C
E
T
T
I
E
I
S
K
G
R
T
G
L
G
Site 152
T1689
G
I
D
L
R
K
A
T
H
D
E
A
I
N
V
Site 153
T1700
A
I
N
V
L
R
Q
T
P
Q
R
V
R
L
T
Site 154
T1707
T
P
Q
R
V
R
L
T
L
Y
R
D
E
A
P
Site 155
Y1709
Q
R
V
R
L
T
L
Y
R
D
E
A
P
Y
K
Site 156
Y1715
L
Y
R
D
E
A
P
Y
K
E
E
E
V
C
D
Site 157
T1723
K
E
E
E
V
C
D
T
L
T
I
E
L
Q
K
Site 158
T1725
E
E
V
C
D
T
L
T
I
E
L
Q
K
K
P
Site 159
S1739
P
G
K
G
L
G
L
S
I
V
G
K
R
N
D
Site 160
T1784
G
E
D
V
R
N
A
T
Q
E
A
V
A
A
L
Site 161
S1810
V
G
R
I
K
A
G
S
S
T
S
E
S
L
E
Site 162
S1811
G
R
I
K
A
G
S
S
T
S
E
S
L
E
S
Site 163
T1812
R
I
K
A
G
S
S
T
S
E
S
L
E
S
S
Site 164
S1813
I
K
A
G
S
S
T
S
E
S
L
E
S
S
S
Site 165
S1815
A
G
S
S
T
S
E
S
L
E
S
S
S
K
K
Site 166
S1818
S
T
S
E
S
L
E
S
S
S
K
K
N
A
L
Site 167
S1819
T
S
E
S
L
E
S
S
S
K
K
N
A
L
A
Site 168
S1820
S
E
S
L
E
S
S
S
K
K
N
A
L
A
S
Site 169
S1827
S
K
K
N
A
L
A
S
E
I
Q
G
L
R
T
Site 170
T1834
S
E
I
Q
G
L
R
T
V
E
M
K
K
G
P
Site 171
S1844
M
K
K
G
P
T
D
S
L
G
I
S
I
A
G
Site 172
T1887
R
V
G
D
R
I
V
T
I
C
G
T
S
T
E
Site 173
T1899
S
T
E
G
M
T
H
T
Q
A
V
N
L
L
K
Site 174
S1934
G
H
Q
Q
E
P
A
S
S
S
L
S
F
T
G
Site 175
S1935
H
Q
Q
E
P
A
S
S
S
L
S
F
T
G
L
Site 176
S1936
Q
Q
E
P
A
S
S
S
L
S
F
T
G
L
T
Site 177
S1938
E
P
A
S
S
S
L
S
F
T
G
L
T
S
S
Site 178
S1944
L
S
F
T
G
L
T
S
S
S
I
F
Q
D
D
Site 179
S1945
S
F
T
G
L
T
S
S
S
I
F
Q
D
D
L
Site 180
S1959
L
G
P
P
Q
C
K
S
I
T
L
E
R
G
P
Site 181
T1961
P
P
Q
C
K
S
I
T
L
E
R
G
P
D
G
Site 182
Y1977
G
F
S
I
V
G
G
Y
G
S
P
H
G
D
L
Site 183
S1998
V
F
A
K
G
A
A
S
E
D
G
R
L
K
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation