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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DYSF
Full Name:
Dysferlin
Alias:
Dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive); Dystrophy associated fer-1-like protein; FER1L1; Fer-1-like protein 1; LGMD2B
Type:
Membrane protein, integral
Mass (Da):
237295
Number AA:
2080
UniProt ID:
O75923
International Prot ID:
IPI00020210
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031410
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006936
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
L
Y
A
E
N
V
H
T
P
D
T
D
I
S
D
Site 2
T17
E
N
V
H
T
P
D
T
D
I
S
D
A
Y
C
Site 3
S20
H
T
P
D
T
D
I
S
D
A
Y
C
S
A
V
Site 4
Y23
D
T
D
I
S
D
A
Y
C
S
A
V
F
A
G
Site 5
S25
D
I
S
D
A
Y
C
S
A
V
F
A
G
V
K
Site 6
T74
V
V
V
K
D
H
E
T
M
G
R
N
R
F
L
Site 7
T94
P
L
R
E
V
L
A
T
P
S
L
S
A
S
F
Site 8
S96
R
E
V
L
A
T
P
S
L
S
A
S
F
N
A
Site 9
S100
A
T
P
S
L
S
A
S
F
N
A
P
L
L
D
Site 10
S116
K
K
Q
P
T
G
A
S
L
V
L
Q
V
S
Y
Site 11
T137
V
P
L
F
P
P
P
T
P
L
E
P
S
P
T
Site 12
S142
P
P
T
P
L
E
P
S
P
T
L
P
D
L
D
Site 13
T144
T
P
L
E
P
S
P
T
L
P
D
L
D
V
V
Site 14
T160
D
T
G
G
E
E
D
T
E
D
Q
G
L
T
G
Site 15
S177
A
E
P
F
L
D
Q
S
G
G
P
G
A
P
T
Site 16
T184
S
G
G
P
G
A
P
T
T
P
R
K
L
P
S
Site 17
T185
G
G
P
G
A
P
T
T
P
R
K
L
P
S
R
Site 18
S191
T
T
P
R
K
L
P
S
R
P
P
P
H
Y
P
Site 19
Y197
P
S
R
P
P
P
H
Y
P
G
I
K
R
K
R
Site 20
S205
P
G
I
K
R
K
R
S
A
P
T
S
R
K
L
Site 21
T208
K
R
K
R
S
A
P
T
S
R
K
L
L
S
D
Site 22
S209
R
K
R
S
A
P
T
S
R
K
L
L
S
D
K
Site 23
S214
P
T
S
R
K
L
L
S
D
K
P
Q
D
F
Q
Site 24
S259
T
R
I
H
K
G
N
S
P
L
F
N
E
T
L
Site 25
T307
E
F
R
M
D
V
G
T
I
Y
R
E
P
R
H
Site 26
Y309
R
M
D
V
G
T
I
Y
R
E
P
R
H
A
Y
Site 27
Y316
Y
R
E
P
R
H
A
Y
L
R
K
W
L
L
L
Site 28
S324
L
R
K
W
L
L
L
S
D
P
D
D
F
S
A
Site 29
S330
L
S
D
P
D
D
F
S
A
G
A
R
G
Y
L
Site 30
S358
P
L
E
R
K
D
P
S
E
D
K
E
D
I
E
Site 31
S366
E
D
K
E
D
I
E
S
N
L
L
R
P
T
G
Site 32
T372
E
S
N
L
L
R
P
T
G
V
A
L
R
G
A
Site 33
T437
C
S
K
I
L
E
K
T
A
N
P
Q
W
N
Q
Site 34
Y479
N
D
I
V
A
T
T
Y
L
S
M
S
K
I
S
Site 35
S483
A
T
T
Y
L
S
M
S
K
I
S
A
P
G
G
Site 36
S503
P
A
G
A
V
K
P
S
K
A
S
D
L
D
D
Site 37
Y511
K
A
S
D
L
D
D
Y
L
G
F
L
P
T
F
Site 38
Y526
G
P
C
Y
I
N
L
Y
G
S
P
R
E
F
T
Site 39
S528
C
Y
I
N
L
Y
G
S
P
R
E
F
T
G
F
Site 40
T533
Y
G
S
P
R
E
F
T
G
F
P
D
P
Y
T
Site 41
Y539
F
T
G
F
P
D
P
Y
T
E
L
N
T
G
K
Site 42
T540
T
G
F
P
D
P
Y
T
E
L
N
T
G
K
G
Site 43
Y552
G
K
G
E
G
V
A
Y
R
G
R
L
L
L
S
Site 44
S559
Y
R
G
R
L
L
L
S
L
E
T
K
L
V
E
Site 45
Y586
D
I
L
R
V
E
K
Y
L
R
R
R
K
Y
S
Site 46
Y592
K
Y
L
R
R
R
K
Y
S
L
F
A
A
F
Y
Site 47
S593
Y
L
R
R
R
K
Y
S
L
F
A
A
F
Y
S
Site 48
Y620
F
E
V
S
I
G
N
Y
G
N
K
F
D
M
T
Site 49
T627
Y
G
N
K
F
D
M
T
C
L
P
L
A
S
T
Site 50
S633
M
T
C
L
P
L
A
S
T
T
Q
Y
S
R
A
Site 51
Y637
P
L
A
S
T
T
Q
Y
S
R
A
V
F
D
G
Site 52
Y664
P
V
V
V
L
S
S
Y
W
E
D
I
S
H
R
Site 53
T674
D
I
S
H
R
I
E
T
Q
N
Q
L
L
G
I
Site 54
S701
L
A
L
K
A
Q
C
S
T
E
D
V
D
S
L
Site 55
S707
C
S
T
E
D
V
D
S
L
V
A
Q
L
T
D
Site 56
S721
D
E
L
I
A
G
C
S
Q
P
L
G
D
I
H
Site 57
T730
P
L
G
D
I
H
E
T
P
S
A
T
H
L
D
Site 58
S732
G
D
I
H
E
T
P
S
A
T
H
L
D
Q
Y
Site 59
Y739
S
A
T
H
L
D
Q
Y
L
Y
Q
L
R
T
H
Site 60
Y741
T
H
L
D
Q
Y
L
Y
Q
L
R
T
H
H
L
Site 61
T745
Q
Y
L
Y
Q
L
R
T
H
H
L
S
Q
I
T
Site 62
S749
Q
L
R
T
H
H
L
S
Q
I
T
E
A
A
L
Site 63
S789
L
A
E
E
P
Q
N
S
L
P
D
I
V
I
W
Site 64
Y806
Q
G
D
K
R
V
A
Y
Q
R
V
P
A
H
Q
Site 65
Y823
F
S
R
R
G
A
N
Y
C
G
K
N
C
G
K
Site 66
S861
V
K
L
W
F
G
L
S
V
D
E
K
E
F
N
Site 67
S876
Q
F
A
E
G
K
L
S
V
F
A
E
T
Y
E
Site 68
T900
N
W
G
T
T
G
L
T
Y
P
K
F
S
D
V
Site 69
Y901
W
G
T
T
G
L
T
Y
P
K
F
S
D
V
T
Site 70
S905
G
L
T
Y
P
K
F
S
D
V
T
G
K
I
K
Site 71
T908
Y
P
K
F
S
D
V
T
G
K
I
K
L
P
K
Site 72
S917
K
I
K
L
P
K
D
S
F
R
P
S
A
G
W
Site 73
S921
P
K
D
S
F
R
P
S
A
G
W
T
W
A
G
Site 74
S948
D
M
D
A
G
H
L
S
F
V
E
E
V
F
E
Site 75
T958
E
E
V
F
E
N
Q
T
R
L
P
G
G
Q
W
Site 76
Y967
L
P
G
G
Q
W
I
Y
M
S
D
N
Y
T
D
Site 77
Y972
W
I
Y
M
S
D
N
Y
T
D
V
N
G
E
K
Site 78
T973
I
Y
M
S
D
N
Y
T
D
V
N
G
E
K
V
Site 79
S1015
D
E
Q
G
W
E
Y
S
I
T
I
P
P
E
R
Site 80
T1017
Q
G
W
E
Y
S
I
T
I
P
P
E
R
K
P
Site 81
Y1034
W
V
P
A
E
K
M
Y
Y
T
H
R
R
R
R
Site 82
Y1035
V
P
A
E
K
M
Y
Y
T
H
R
R
R
R
W
Site 83
S1051
R
L
R
R
R
D
L
S
Q
M
E
A
L
K
R
Site 84
Y1071
A
E
G
E
G
W
E
Y
A
S
L
F
G
W
K
Site 85
T1086
F
H
L
E
Y
R
K
T
D
A
F
R
R
R
R
Site 86
S1124
G
G
V
M
D
D
K
S
E
D
S
M
S
V
S
Site 87
S1127
M
D
D
K
S
E
D
S
M
S
V
S
T
L
S
Site 88
S1129
D
K
S
E
D
S
M
S
V
S
T
L
S
F
G
Site 89
S1131
S
E
D
S
M
S
V
S
T
L
S
F
G
V
N
Site 90
S1134
S
M
S
V
S
T
L
S
F
G
V
N
R
P
T
Site 91
Y1148
T
I
S
C
I
F
D
Y
G
N
R
Y
H
L
R
Site 92
Y1157
N
R
Y
H
L
R
C
Y
M
Y
Q
A
R
D
L
Site 93
Y1159
Y
H
L
R
C
Y
M
Y
Q
A
R
D
L
A
A
Site 94
S1171
L
A
A
M
D
K
D
S
F
S
D
P
Y
A
I
Site 95
S1173
A
M
D
K
D
S
F
S
D
P
Y
A
I
V
S
Site 96
Y1176
K
D
S
F
S
D
P
Y
A
I
V
S
F
L
H
Site 97
S1180
S
D
P
Y
A
I
V
S
F
L
H
Q
S
Q
K
Site 98
T1188
F
L
H
Q
S
Q
K
T
V
V
V
K
N
T
L
Site 99
T1216
E
I
F
G
E
P
A
T
V
A
E
Q
P
P
S
Site 100
Y1229
P
S
I
V
V
E
L
Y
D
H
D
T
Y
G
A
Site 101
Y1234
E
L
Y
D
H
D
T
Y
G
A
D
E
F
M
G
Site 102
S1248
G
R
C
I
C
Q
P
S
L
E
R
M
P
R
L
Site 103
T1261
R
L
A
W
F
P
L
T
R
G
S
Q
P
S
G
Site 104
S1264
W
F
P
L
T
R
G
S
Q
P
S
G
E
L
L
Site 105
S1267
L
T
R
G
S
Q
P
S
G
E
L
L
A
S
F
Site 106
S1273
P
S
G
E
L
L
A
S
F
E
L
I
Q
R
E
Site 107
T1295
P
G
F
E
V
Q
E
T
S
R
I
L
D
E
S
Site 108
S1302
T
S
R
I
L
D
E
S
E
D
T
D
L
P
Y
Site 109
T1305
I
L
D
E
S
E
D
T
D
L
P
Y
P
P
P
Site 110
Y1309
S
E
D
T
D
L
P
Y
P
P
P
Q
R
E
A
Site 111
Y1319
P
Q
R
E
A
N
I
Y
M
V
P
Q
N
I
K
Site 112
Y1347
G
L
R
N
M
K
S
Y
Q
L
A
N
I
S
S
Site 113
T1384
N
P
N
F
D
I
C
T
L
F
M
E
V
M
L
Site 114
Y1397
M
L
P
R
E
E
L
Y
C
P
P
I
T
V
K
Site 115
T1402
E
L
Y
C
P
P
I
T
V
K
V
I
D
N
R
Site 116
T1421
R
P
V
V
G
Q
C
T
I
R
S
L
E
S
F
Site 117
S1427
C
T
I
R
S
L
E
S
F
L
C
D
P
Y
S
Site 118
Y1433
E
S
F
L
C
D
P
Y
S
A
E
S
P
S
P
Site 119
S1434
S
F
L
C
D
P
Y
S
A
E
S
P
S
P
Q
Site 120
S1437
C
D
P
Y
S
A
E
S
P
S
P
Q
G
G
P
Site 121
S1439
P
Y
S
A
E
S
P
S
P
Q
G
G
P
D
D
Site 122
S1448
Q
G
G
P
D
D
V
S
L
L
S
P
G
E
D
Site 123
S1493
G
E
R
E
K
C
G
S
Y
L
E
K
D
F
D
Site 124
T1501
Y
L
E
K
D
F
D
T
L
K
V
Y
D
T
Q
Site 125
Y1505
D
F
D
T
L
K
V
Y
D
T
Q
L
E
N
V
Site 126
T1507
D
T
L
K
V
Y
D
T
Q
L
E
N
V
E
A
Site 127
S1519
V
E
A
F
E
G
L
S
D
F
C
N
T
F
K
Site 128
T1524
G
L
S
D
F
C
N
T
F
K
L
Y
R
G
K
Site 129
T1532
F
K
L
Y
R
G
K
T
Q
E
E
T
E
D
P
Site 130
T1536
R
G
K
T
Q
E
E
T
E
D
P
S
V
I
G
Site 131
S1540
Q
E
E
T
E
D
P
S
V
I
G
E
F
K
G
Site 132
Y1552
F
K
G
L
F
K
I
Y
P
L
P
E
D
P
A
Site 133
Y1602
P
N
G
K
C
D
P
Y
I
K
I
S
I
G
K
Site 134
S1606
C
D
P
Y
I
K
I
S
I
G
K
K
S
V
S
Site 135
S1611
K
I
S
I
G
K
K
S
V
S
D
Q
D
N
Y
Site 136
S1613
S
I
G
K
K
S
V
S
D
Q
D
N
Y
I
P
Site 137
Y1618
S
V
S
D
Q
D
N
Y
I
P
C
T
L
E
P
Site 138
T1622
Q
D
N
Y
I
P
C
T
L
E
P
V
F
G
K
Site 139
Y1648
K
D
L
K
I
T
L
Y
D
Y
D
L
L
S
K
Site 140
Y1650
L
K
I
T
L
Y
D
Y
D
L
L
S
K
D
E
Site 141
S1654
L
Y
D
Y
D
L
L
S
K
D
E
K
I
G
E
Site 142
T1662
K
D
E
K
I
G
E
T
V
V
D
L
E
N
R
Site 143
S1672
D
L
E
N
R
L
L
S
K
F
G
A
R
C
G
Site 144
T1683
A
R
C
G
L
P
Q
T
Y
C
V
S
G
P
N
Site 145
Y1684
R
C
G
L
P
Q
T
Y
C
V
S
G
P
N
Q
Site 146
S1687
L
P
Q
T
Y
C
V
S
G
P
N
Q
W
R
D
Site 147
S1699
W
R
D
Q
L
R
P
S
Q
L
L
H
L
F
C
Site 148
Y1716
H
R
V
K
A
P
V
Y
R
T
D
R
V
M
F
Site 149
T1718
V
K
A
P
V
Y
R
T
D
R
V
M
F
Q
D
Site 150
Y1728
V
M
F
Q
D
K
E
Y
S
I
E
E
I
E
A
Site 151
S1729
M
F
Q
D
K
E
Y
S
I
E
E
I
E
A
G
Site 152
S1767
L
V
P
E
H
V
E
S
R
P
L
Y
S
P
L
Site 153
Y1771
H
V
E
S
R
P
L
Y
S
P
L
Q
P
D
I
Site 154
S1772
V
E
S
R
P
L
Y
S
P
L
Q
P
D
I
E
Site 155
T1804
P
G
P
P
F
N
I
T
P
R
R
A
R
R
F
Site 156
S1829
D
V
I
L
D
D
L
S
L
T
G
E
K
M
S
Site 157
T1831
I
L
D
D
L
S
L
T
G
E
K
M
S
D
I
Site 158
S1836
S
L
T
G
E
K
M
S
D
I
Y
V
K
G
W
Site 159
Y1839
G
E
K
M
S
D
I
Y
V
K
G
W
M
I
G
Site 160
Y1858
K
Q
K
T
D
V
H
Y
R
S
L
G
G
E
G
Site 161
S1860
K
T
D
V
H
Y
R
S
L
G
G
E
G
N
F
Site 162
T1898
A
F
W
R
L
D
K
T
E
S
K
I
P
A
R
Site 163
S1900
W
R
L
D
K
T
E
S
K
I
P
A
R
V
V
Site 164
S1924
S
F
D
D
F
L
G
S
L
Q
L
D
L
N
R
Site 165
T1938
R
M
P
K
P
A
K
T
A
K
K
C
S
L
D
Site 166
T1964
V
S
L
F
E
Q
K
T
V
K
G
W
W
P
C
Site 167
T2023
E
D
P
R
R
P
D
T
S
F
L
W
F
T
S
Site 168
S2024
D
P
R
R
P
D
T
S
F
L
W
F
T
S
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation