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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DGK-I
Full Name:
Diacylglycerol kinase iota
Alias:
DAG kinase iota; DGKI; DGK-iota; DGK-IOTA; Diacylglycerol kinase, iota; Diglyceride kinase
Type:
Lipid Metabolism - glycerolipid; Kinase, lipid; Lipid Metabolism - glycerophospholipid; EC 2.7.1.107
Mass (Da):
116997
Number AA:
1065
UniProt ID:
O75912
International Prot ID:
IPI00027380
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004143
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007205
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S38
A
S
P
P
G
P
C
S
G
A
A
C
A
P
S
Site 2
S57
A
G
A
M
N
P
S
S
S
A
G
E
E
K
G
Site 3
S58
G
A
M
N
P
S
S
S
A
G
E
E
K
G
A
Site 4
T66
A
G
E
E
K
G
A
T
G
G
S
S
S
S
G
Site 5
S69
E
K
G
A
T
G
G
S
S
S
S
G
S
G
A
Site 6
S70
K
G
A
T
G
G
S
S
S
S
G
S
G
A
G
Site 7
S71
G
A
T
G
G
S
S
S
S
G
S
G
A
G
S
Site 8
S72
A
T
G
G
S
S
S
S
G
S
G
A
G
S
C
Site 9
S74
G
G
S
S
S
S
G
S
G
A
G
S
C
C
L
Site 10
S78
S
S
G
S
G
A
G
S
C
C
L
G
A
E
G
Site 11
T126
E
E
K
L
R
N
L
T
F
R
K
Q
V
S
Y
Site 12
S132
L
T
F
R
K
Q
V
S
Y
R
K
A
I
S
R
Site 13
Y133
T
F
R
K
Q
V
S
Y
R
K
A
I
S
R
A
Site 14
S138
V
S
Y
R
K
A
I
S
R
A
G
L
Q
H
L
Site 15
T166
P
A
K
E
P
R
A
T
L
D
W
S
E
N
A
Site 16
S170
P
R
A
T
L
D
W
S
E
N
A
V
N
G
E
Site 17
Y191
N
V
S
G
D
L
C
Y
L
G
E
E
N
C
Q
Site 18
S204
C
Q
V
R
F
A
K
S
A
L
R
R
K
C
A
Site 19
T235
I
N
F
R
C
K
P
T
F
R
E
G
G
S
R
Site 20
S243
F
R
E
G
G
S
R
S
P
R
E
N
F
V
R
Site 21
S275
K
G
F
Q
Q
K
F
S
F
H
S
K
E
I
V
Site 22
S310
H
H
I
E
E
P
C
S
L
G
A
H
A
A
V
Site 23
S333
K
V
K
K
P
Q
N
S
L
K
A
S
N
R
K
Site 24
S337
P
Q
N
S
L
K
A
S
N
R
K
K
K
R
T
Site 25
T344
S
N
R
K
K
K
R
T
S
F
K
R
K
A
S
Site 26
S345
N
R
K
K
K
R
T
S
F
K
R
K
A
S
K
Site 27
S351
T
S
F
K
R
K
A
S
K
R
G
M
E
Q
E
Site 28
S385
L
V
F
V
N
P
K
S
G
G
N
Q
G
T
K
Site 29
Y400
V
L
Q
M
F
M
W
Y
L
N
P
R
Q
V
F
Site 30
S410
P
R
Q
V
F
D
L
S
Q
E
G
P
K
D
A
Site 31
Y421
P
K
D
A
L
E
L
Y
R
K
V
P
N
L
R
Site 32
T470
T
G
N
D
L
A
R
T
L
N
W
G
G
G
Y
Site 33
T478
L
N
W
G
G
G
Y
T
D
E
P
V
S
K
I
Site 34
T493
L
C
Q
V
E
D
G
T
V
V
Q
L
D
R
W
Site 35
T540
L
G
F
D
A
H
V
T
L
E
F
H
E
S
R
Site 36
S546
V
T
L
E
F
H
E
S
R
E
A
N
P
E
K
Site 37
Y564
R
F
R
N
K
M
F
Y
A
G
A
A
F
S
D
Site 38
S570
F
Y
A
G
A
A
F
S
D
F
L
Q
R
S
S
Site 39
S576
F
S
D
F
L
Q
R
S
S
R
D
L
S
K
H
Site 40
S577
S
D
F
L
Q
R
S
S
R
D
L
S
K
H
V
Site 41
S581
Q
R
S
S
R
D
L
S
K
H
V
K
V
V
C
Site 42
T594
V
C
D
G
T
D
L
T
P
K
I
Q
E
L
K
Site 43
Y638
P
Q
R
H
D
D
G
Y
I
E
V
I
G
F
T
Site 44
S694
A
P
A
M
I
R
I
S
L
R
N
Q
A
N
M
Site 45
S705
Q
A
N
M
V
Q
K
S
K
R
R
T
S
M
P
Site 46
T709
V
Q
K
S
K
R
R
T
S
M
P
L
L
N
D
Site 47
S710
Q
K
S
K
R
R
T
S
M
P
L
L
N
D
P
Site 48
S719
P
L
L
N
D
P
Q
S
V
P
D
R
L
R
I
Site 49
S732
R
I
R
V
N
K
I
S
L
Q
D
Y
E
G
F
Site 50
Y736
N
K
I
S
L
Q
D
Y
E
G
F
H
Y
D
K
Site 51
Y741
Q
D
Y
E
G
F
H
Y
D
K
E
K
L
R
E
Site 52
S750
K
E
K
L
R
E
A
S
I
S
D
W
L
R
T
Site 53
S752
K
L
R
E
A
S
I
S
D
W
L
R
T
I
A
Site 54
Y788
D
L
E
T
C
R
M
Y
I
D
R
L
Q
E
D
Site 55
S798
R
L
Q
E
D
L
Q
S
V
S
S
G
S
Q
R
Site 56
S801
E
D
L
Q
S
V
S
S
G
S
Q
R
V
H
Y
Site 57
S803
L
Q
S
V
S
S
G
S
Q
R
V
H
Y
Q
D
Site 58
Y808
S
G
S
Q
R
V
H
Y
Q
D
H
E
T
S
F
Site 59
T813
V
H
Y
Q
D
H
E
T
S
F
P
R
A
L
S
Site 60
S814
H
Y
Q
D
H
E
T
S
F
P
R
A
L
S
A
Site 61
S820
T
S
F
P
R
A
L
S
A
Q
R
L
S
P
R
Site 62
S825
A
L
S
A
Q
R
L
S
P
R
W
C
F
L
D
Site 63
S860
L
D
P
D
M
V
V
S
Q
P
A
G
T
P
P
Site 64
T865
V
V
S
Q
P
A
G
T
P
P
G
M
P
D
L
Site 65
S896
R
K
R
M
L
S
D
S
G
L
G
M
I
A
P
Site 66
Y904
G
L
G
M
I
A
P
Y
Y
E
D
S
D
L
K
Site 67
Y905
L
G
M
I
A
P
Y
Y
E
D
S
D
L
K
D
Site 68
S908
I
A
P
Y
Y
E
D
S
D
L
K
D
L
S
H
Site 69
S914
D
S
D
L
K
D
L
S
H
S
R
V
L
Q
S
Site 70
S921
S
H
S
R
V
L
Q
S
P
V
S
S
E
D
H
Site 71
S924
R
V
L
Q
S
P
V
S
S
E
D
H
A
I
L
Site 72
S925
V
L
Q
S
P
V
S
S
E
D
H
A
I
L
Q
Site 73
S945
D
L
M
K
L
I
E
S
Y
K
N
G
G
S
L
Site 74
S951
E
S
Y
K
N
G
G
S
L
L
I
Q
G
P
D
Site 75
Y965
D
H
C
S
L
L
H
Y
A
A
K
T
G
N
G
Site 76
Y977
G
N
G
E
I
V
K
Y
I
L
D
H
G
P
S
Site 77
S984
Y
I
L
D
H
G
P
S
E
L
L
D
M
A
D
Site 78
S992
E
L
L
D
M
A
D
S
E
T
G
E
T
A
L
Site 79
T994
L
D
M
A
D
S
E
T
G
E
T
A
L
H
K
Site 80
S1020
L
L
V
D
A
G
A
S
L
R
K
T
D
S
K
Site 81
T1024
A
G
A
S
L
R
K
T
D
S
K
G
K
T
P
Site 82
S1026
A
S
L
R
K
T
D
S
K
G
K
T
P
Q
E
Site 83
T1030
K
T
D
S
K
G
K
T
P
Q
E
R
A
Q
Q
Site 84
Y1046
G
D
P
D
L
A
A
Y
L
E
S
R
Q
N
Y
Site 85
S1049
D
L
A
A
Y
L
E
S
R
Q
N
Y
K
V
I
Site 86
Y1053
Y
L
E
S
R
Q
N
Y
K
V
I
G
H
E
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation