KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
BC024868
Full Name:
Leucine-rich repeat-containing protein 68
Alias:
K1986; KIAA1986; Leucine rich repeat containing 68; LOC284352
Type:
Mass (Da):
74320
Number AA:
687
UniProt ID:
O75864
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
E
A
P
A
E
A
G
S
P
S
P
A
S
P
P
Site 2
S29
P
A
E
A
G
S
P
S
P
A
S
P
P
A
D
Site 3
S32
A
G
S
P
S
P
A
S
P
P
A
D
G
R
L
Site 4
T47
K
A
A
A
K
R
V
T
F
P
S
D
E
D
I
Site 5
S50
A
K
R
V
T
F
P
S
D
E
D
I
V
S
G
Site 6
S56
P
S
D
E
D
I
V
S
G
A
V
E
P
K
D
Site 7
Y121
L
K
G
E
K
L
D
Y
K
T
C
E
A
L
E
Site 8
T123
G
E
K
L
D
Y
K
T
C
E
A
L
E
E
V
Site 9
S152
N
L
D
E
D
G
A
S
A
L
F
D
M
I
E
Site 10
Y161
L
F
D
M
I
E
Y
Y
E
S
A
T
H
L
N
Site 11
S170
S
A
T
H
L
N
I
S
F
N
K
H
I
G
T
Site 12
T190
A
A
H
M
M
R
K
T
S
C
L
Q
Y
L
D
Site 13
Y195
R
K
T
S
C
L
Q
Y
L
D
A
R
N
T
P
Site 14
T201
Q
Y
L
D
A
R
N
T
P
L
L
D
H
S
A
Site 15
Y253
N
M
N
L
R
E
L
Y
L
A
D
N
K
L
N
Site 16
T309
E
Q
R
K
G
L
V
T
L
V
L
W
N
N
Q
Site 17
S355
H
L
K
N
G
L
I
S
N
R
S
V
L
R
L
Site 18
S431
P
K
K
E
A
V
K
S
F
I
E
T
Q
K
A
Site 19
S467
K
E
Q
P
P
Q
L
S
A
S
M
P
E
T
T
Site 20
S469
Q
P
P
Q
L
S
A
S
M
P
E
T
T
A
T
Site 21
T473
L
S
A
S
M
P
E
T
T
A
T
E
P
Q
P
Site 22
T476
S
M
P
E
T
T
A
T
E
P
Q
P
D
D
E
Site 23
S494
G
V
Q
N
G
A
P
S
P
A
P
S
P
D
S
Site 24
S498
G
A
P
S
P
A
P
S
P
D
S
D
S
D
S
Site 25
S501
S
P
A
P
S
P
D
S
D
S
D
S
D
S
D
Site 26
S503
A
P
S
P
D
S
D
S
D
S
D
S
D
G
E
Site 27
S505
S
P
D
S
D
S
D
S
D
S
D
G
E
E
E
Site 28
S507
D
S
D
S
D
S
D
S
D
G
E
E
E
E
E
Site 29
T522
E
E
G
E
R
D
E
T
P
C
P
A
L
V
P
Site 30
T531
C
P
A
L
V
P
P
T
D
S
L
G
P
G
D
Site 31
S533
A
L
V
P
P
T
D
S
L
G
P
G
D
R
S
Site 32
S540
S
L
G
P
G
D
R
S
P
P
G
S
P
S
T
Site 33
S544
G
D
R
S
P
P
G
S
P
S
T
P
T
E
Q
Site 34
S546
R
S
P
P
G
S
P
S
T
P
T
E
Q
R
I
Site 35
T547
S
P
P
G
S
P
S
T
P
T
E
Q
R
I
S
Site 36
T549
P
G
S
P
S
T
P
T
E
Q
R
I
S
V
S
Site 37
S554
T
P
T
E
Q
R
I
S
V
S
S
P
G
R
G
Site 38
S556
T
E
Q
R
I
S
V
S
S
P
G
R
G
H
K
Site 39
S557
E
Q
R
I
S
V
S
S
P
G
R
G
H
K
V
Site 40
T568
G
H
K
V
F
V
V
T
R
V
E
S
P
P
E
Site 41
S572
F
V
V
T
R
V
E
S
P
P
E
R
A
E
P
Site 42
S582
E
R
A
E
P
P
A
S
P
T
P
P
S
P
P
Site 43
T584
A
E
P
P
A
S
P
T
P
P
S
P
P
P
P
Site 44
S587
P
A
S
P
T
P
P
S
P
P
P
P
P
S
P
Site 45
S593
P
S
P
P
P
P
P
S
P
P
A
S
P
S
L
Site 46
S597
P
P
P
S
P
P
A
S
P
S
L
P
P
S
G
Site 47
S599
P
S
P
P
A
S
P
S
L
P
P
S
G
A
I
Site 48
S603
A
S
P
S
L
P
P
S
G
A
I
D
T
R
D
Site 49
T608
P
P
S
G
A
I
D
T
R
D
T
G
S
S
E
Site 50
T611
G
A
I
D
T
R
D
T
G
S
S
E
P
Q
P
Site 51
S613
I
D
T
R
D
T
G
S
S
E
P
Q
P
P
P
Site 52
S614
D
T
R
D
T
G
S
S
E
P
Q
P
P
P
E
Site 53
S625
P
P
P
E
P
P
R
S
G
P
P
L
P
N
G
Site 54
S663
C
G
L
E
H
E
L
S
C
S
K
N
E
K
E
Site 55
S665
L
E
H
E
L
S
C
S
K
N
E
K
E
L
E
Site 56
S679
E
E
L
L
L
E
A
S
Q
E
S
G
Q
E
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation