PhosphoNET

           
Protein Info 
   
Short Name:  ZMPSTE24
Full Name:  CAAX prenyl protease 1 homolog
Alias:  CAAX prenyl protease 1; EC 3.4.24.84; FACE1; FACE-1; Farnesylated proteins-converting enzyme 1; Prenyl protein-specific endoprotease 1; STE24; Ste24p; Zinc metallopeptidase; Zinc metalloproteinase Ste24
Type:  Protease
Mass (Da):  54813
Number AA:  475
UniProt ID:  O75844
International Prot ID:  IPI00027180
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005794  GO:0005783  GO:0016021 Uniprot OncoNet
Molecular Function:  GO:0008235  GO:0008270   PhosphoSite+ KinaseNET
Biological Process:  GO:0006508     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y45AQRQRRIYKTTTHVP
Site 2T47RQRRIYKTTTHVPPE
Site 3T48QRRIYKTTTHVPPEL
Site 4T49RRIYKTTTHVPPELG
Site 5T63GQIMDSETFEKSRLY
Site 6Y70TFEKSRLYQLDKSTF
Site 7S75RLYQLDKSTFSFWSG
Site 8T76LYQLDKSTFSFWSGL
Site 9S78QLDKSTFSFWSGLYS
Site 10S81KSTFSFWSGLYSETE
Site 11Y84FSFWSGLYSETEGTL
Site 12S85SFWSGLYSETEGTLI
Site 13Y111LSGRFCGYAGFGPEY
Site 14Y118YAGFGPEYEITQSLV
Site 15T146LPWSLYNTFVIEEKH
Site 16T227APLFDKFTPLPEGKL
Site 17Y253DFPLTKVYVVEGSKR
Site 18S258KVYVVEGSKRSSHSN
Site 19S262VEGSKRSSHSNAYFY
Site 20S264GSKRSSHSNAYFYGF
Site 21Y267RSSHSNAYFYGFFKN
Site 22Y269SHSNAYFYGFFKNKR
Site 23S288DTLLEEYSVLNKDIQ
Site 24S298NKDIQEDSGMEPRNE
Site 25S310RNEEEGNSEEIKAKV
Site 26T345GHWKLGHTVKNIIIS
Site 27S433GKAKDLYSALIKLNK
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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