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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WDHD1
Full Name:
WD repeat and HMG-box DNA-binding protein 1
Alias:
Acidic nucleoplasmic DNA- binding protein 1; AND1; And-1; WD repeat and HMG-box DNA binding protein 1; WDH1
Type:
DNA binding protein
Mass (Da):
125967
Number AA:
1129
UniProt ID:
O75717
International Prot ID:
IPI00411614
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
P
A
T
R
K
P
M
R
Y
G
Site 2
Y10
A
T
R
K
P
M
R
Y
G
H
T
E
G
H
T
Site 3
T30
D
S
G
S
F
I
V
T
C
G
S
D
G
D
V
Site 4
S33
S
F
I
V
T
C
G
S
D
G
D
V
R
I
W
Site 5
S59
N
V
G
E
K
A
Y
S
C
A
L
K
S
G
K
Site 6
T80
N
N
T
I
Q
V
H
T
F
P
E
G
V
P
D
Site 7
S126
K
I
V
D
V
M
D
S
S
Q
Q
K
T
F
R
Site 8
S127
I
V
D
V
M
D
S
S
Q
Q
K
T
F
R
G
Site 9
T131
M
D
S
S
Q
Q
K
T
F
R
G
H
D
A
P
Site 10
S141
G
H
D
A
P
V
L
S
L
S
F
D
P
K
D
Site 11
S159
A
S
A
S
C
D
G
S
V
R
V
W
Q
I
S
Site 12
S198
R
L
A
W
Q
P
K
S
G
K
L
L
A
I
P
Site 13
S209
L
A
I
P
V
E
K
S
V
K
L
Y
R
R
E
Site 14
Y213
V
E
K
S
V
K
L
Y
R
R
E
S
W
S
H
Site 15
S217
V
K
L
Y
R
R
E
S
W
S
H
Q
F
D
L
Site 16
S219
L
Y
R
R
E
S
W
S
H
Q
F
D
L
S
D
Site 17
T232
S
D
N
F
I
S
Q
T
L
N
I
V
T
W
S
Site 18
T237
S
Q
T
L
N
I
V
T
W
S
P
C
G
Q
Y
Site 19
Y244
T
W
S
P
C
G
Q
Y
L
A
A
G
S
I
N
Site 20
Y274
R
V
K
H
E
K
G
Y
A
I
C
G
L
A
W
Site 21
S289
H
P
T
C
G
R
I
S
Y
T
D
A
E
G
N
Site 22
Y290
P
T
C
G
R
I
S
Y
T
D
A
E
G
N
L
Site 23
S307
L
E
N
V
C
D
P
S
G
K
T
S
S
S
K
Site 24
T310
V
C
D
P
S
G
K
T
S
S
S
K
V
S
S
Site 25
S311
C
D
P
S
G
K
T
S
S
S
K
V
S
S
R
Site 26
S312
D
P
S
G
K
T
S
S
S
K
V
S
S
R
V
Site 27
S313
P
S
G
K
T
S
S
S
K
V
S
S
R
V
E
Site 28
S316
K
T
S
S
S
K
V
S
S
R
V
E
K
D
Y
Site 29
S317
T
S
S
S
K
V
S
S
R
V
E
K
D
Y
N
Site 30
Y323
S
S
R
V
E
K
D
Y
N
D
L
F
D
G
D
Site 31
S333
L
F
D
G
D
D
M
S
N
A
G
D
F
L
N
Site 32
S348
D
N
A
V
E
I
P
S
F
S
K
G
I
I
N
Site 33
S350
A
V
E
I
P
S
F
S
K
G
I
I
N
D
D
Site 34
S367
D
E
D
L
M
M
A
S
G
R
P
R
Q
R
S
Site 35
S374
S
G
R
P
R
Q
R
S
H
I
L
E
D
D
E
Site 36
S383
I
L
E
D
D
E
N
S
V
D
I
S
M
L
K
Site 37
S387
D
E
N
S
V
D
I
S
M
L
K
T
G
S
S
Site 38
S393
I
S
M
L
K
T
G
S
S
L
L
K
E
E
E
Site 39
S394
S
M
L
K
T
G
S
S
L
L
K
E
E
E
E
Site 40
S407
E
E
D
G
Q
E
G
S
I
H
N
L
P
L
V
Site 41
S416
H
N
L
P
L
V
T
S
Q
R
P
F
Y
D
G
Site 42
Y421
V
T
S
Q
R
P
F
Y
D
G
P
M
P
T
P
Site 43
T427
F
Y
D
G
P
M
P
T
P
R
Q
K
P
F
Q
Site 44
S435
P
R
Q
K
P
F
Q
S
G
S
T
P
L
H
L
Site 45
S437
Q
K
P
F
Q
S
G
S
T
P
L
H
L
T
H
Site 46
T438
K
P
F
Q
S
G
S
T
P
L
H
L
T
H
R
Site 47
Y458
S
I
G
I
I
R
C
Y
N
D
E
Q
D
N
A
Site 48
T488
L
S
N
T
L
N
Y
T
I
A
D
L
S
H
E
Site 49
S509
E
S
T
D
E
L
A
S
K
L
H
C
L
H
F
Site 50
S517
K
L
H
C
L
H
F
S
S
W
D
S
S
K
E
Site 51
Y587
G
E
Q
L
F
I
V
Y
H
R
G
T
G
F
D
Site 52
T591
F
I
V
Y
H
R
G
T
G
F
D
G
D
Q
C
Site 53
T622
H
G
D
P
L
P
L
T
R
K
S
Y
L
A
W
Site 54
T637
I
G
F
S
A
E
G
T
P
C
Y
V
D
S
E
Site 55
Y640
S
A
E
G
T
P
C
Y
V
D
S
E
G
I
V
Site 56
T659
R
G
L
G
N
T
W
T
P
I
C
N
T
R
E
Site 57
Y675
C
K
G
K
S
D
H
Y
W
V
V
G
I
H
E
Site 58
S695
R
C
I
P
C
K
G
S
R
F
P
P
T
L
P
Site 59
T700
K
G
S
R
F
P
P
T
L
P
R
P
A
V
A
Site 60
Y741
I
F
H
N
H
L
D
Y
L
A
K
N
G
Y
E
Site 61
Y747
D
Y
L
A
K
N
G
Y
E
Y
E
E
S
T
K
Site 62
Y749
L
A
K
N
G
Y
E
Y
E
E
S
T
K
N
Q
Site 63
S752
N
G
Y
E
Y
E
E
S
T
K
N
Q
A
T
K
Site 64
Y799
A
V
N
L
A
I
K
Y
A
S
R
S
R
K
L
Site 65
S801
N
L
A
I
K
Y
A
S
R
S
R
K
L
I
L
Site 66
S803
A
I
K
Y
A
S
R
S
R
K
L
I
L
A
Q
Site 67
S813
L
I
L
A
Q
K
L
S
E
L
A
V
E
K
A
Site 68
T826
K
A
A
E
L
T
A
T
Q
V
E
E
E
E
E
Site 69
S846
K
K
L
N
A
G
Y
S
N
T
A
T
E
W
S
Site 70
T850
A
G
Y
S
N
T
A
T
E
W
S
Q
P
R
F
Site 71
S853
S
N
T
A
T
E
W
S
Q
P
R
F
R
N
Q
Site 72
S868
V
E
E
D
A
E
D
S
G
E
A
D
D
E
E
Site 73
S886
I
H
K
P
G
Q
N
S
F
S
K
S
T
N
S
Site 74
S888
K
P
G
Q
N
S
F
S
K
S
T
N
S
S
D
Site 75
S890
G
Q
N
S
F
S
K
S
T
N
S
S
D
V
S
Site 76
S893
S
F
S
K
S
T
N
S
S
D
V
S
A
K
S
Site 77
S894
F
S
K
S
T
N
S
S
D
V
S
A
K
S
G
Site 78
S897
S
T
N
S
S
D
V
S
A
K
S
G
A
V
T
Site 79
S900
S
S
D
V
S
A
K
S
G
A
V
T
F
S
S
Site 80
T904
S
A
K
S
G
A
V
T
F
S
S
Q
G
R
V
Site 81
S906
K
S
G
A
V
T
F
S
S
Q
G
R
V
N
P
Site 82
S907
S
G
A
V
T
F
S
S
Q
G
R
V
N
P
F
Site 83
S917
R
V
N
P
F
K
V
S
A
S
S
K
E
P
A
Site 84
S920
P
F
K
V
S
A
S
S
K
E
P
A
M
S
M
Site 85
S926
S
S
K
E
P
A
M
S
M
N
S
A
R
S
T
Site 86
S929
E
P
A
M
S
M
N
S
A
R
S
T
N
I
L
Site 87
T933
S
M
N
S
A
R
S
T
N
I
L
D
N
M
G
Site 88
S942
I
L
D
N
M
G
K
S
S
K
K
S
T
A
L
Site 89
S946
M
G
K
S
S
K
K
S
T
A
L
S
R
T
T
Site 90
T947
G
K
S
S
K
K
S
T
A
L
S
R
T
T
N
Site 91
S950
S
K
K
S
T
A
L
S
R
T
T
N
N
E
K
Site 92
T953
S
T
A
L
S
R
T
T
N
N
E
K
S
P
I
Site 93
S958
R
T
T
N
N
E
K
S
P
I
I
K
P
L
I
Site 94
S977
P
K
Q
A
S
A
A
S
Y
F
Q
K
R
N
S
Site 95
Y978
K
Q
A
S
A
A
S
Y
F
Q
K
R
N
S
Q
Site 96
S984
S
Y
F
Q
K
R
N
S
Q
T
N
K
T
E
E
Site 97
T986
F
Q
K
R
N
S
Q
T
N
K
T
E
E
V
K
Site 98
T989
R
N
S
Q
T
N
K
T
E
E
V
K
E
E
N
Site 99
S1002
E
N
L
K
N
V
L
S
E
T
P
A
I
C
P
Site 100
T1004
L
K
N
V
L
S
E
T
P
A
I
C
P
P
Q
Site 101
T1020
T
E
N
Q
R
P
K
T
G
F
Q
M
W
L
E
Site 102
S1031
M
W
L
E
E
N
R
S
N
I
L
S
D
N
P
Site 103
S1035
E
N
R
S
N
I
L
S
D
N
P
D
F
S
D
Site 104
S1041
L
S
D
N
P
D
F
S
D
E
A
D
I
I
K
Site 105
S1058
M
I
R
F
R
V
L
S
T
E
E
R
K
V
W
Site 106
T1073
A
N
K
A
K
G
E
T
A
S
E
G
T
E
A
Site 107
S1090
R
K
R
V
V
D
E
S
D
E
T
E
N
Q
E
Site 108
T1093
V
V
D
E
S
D
E
T
E
N
Q
E
E
K
A
Site 109
S1107
A
K
E
N
L
N
L
S
K
K
Q
K
P
L
D
Site 110
T1117
Q
K
P
L
D
F
S
T
N
Q
K
L
S
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation