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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OFD1
Full Name:
Oral-facial-digital syndrome 1 protein
Alias:
71-7A; CXorf5; CX-ORF5; Oral-facial-digital syndrome 1; Oral-facial-digital syndrome 1 gene; Protein 71-7A
Type:
Cell cycle regulation
Mass (Da):
116671
Number AA:
1012
UniProt ID:
O75665
International Prot ID:
IPI00026580
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005829
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
F
T
V
A
D
V
L
S
Q
D
E
L
R
K
K
Site 2
Y24
D
E
L
R
K
K
L
Y
Q
T
F
K
D
R
G
Site 3
T26
L
R
K
K
L
Y
Q
T
F
K
D
R
G
I
L
Site 4
T35
K
D
R
G
I
L
D
T
L
K
T
Q
L
R
N
Site 5
T38
G
I
L
D
T
L
K
T
Q
L
R
N
Q
L
I
Site 6
S54
E
L
M
H
P
V
L
S
G
E
L
Q
P
R
S
Site 7
S61
S
G
E
L
Q
P
R
S
I
S
V
E
G
S
S
Site 8
S63
E
L
Q
P
R
S
I
S
V
E
G
S
S
L
L
Site 9
Y87
D
H
L
Q
R
C
G
Y
E
Y
S
L
S
V
F
Site 10
S90
Q
R
C
G
Y
E
Y
S
L
S
V
F
F
P
E
Site 11
S92
C
G
Y
E
Y
S
L
S
V
F
F
P
E
S
G
Site 12
S122
I
K
I
N
P
T
S
S
L
Y
K
S
L
V
S
Site 13
Y124
I
N
P
T
S
S
L
Y
K
S
L
V
S
G
S
Site 14
S126
P
T
S
S
L
Y
K
S
L
V
S
G
S
D
K
Site 15
S129
S
L
Y
K
S
L
V
S
G
S
D
K
E
N
Q
Site 16
Y150
F
L
K
E
L
A
E
Y
H
Q
A
K
E
S
C
Site 17
T161
K
E
S
C
N
M
E
T
Q
T
S
S
T
F
N
Site 18
T166
M
E
T
Q
T
S
S
T
F
N
R
D
S
L
A
Site 19
S171
S
S
T
F
N
R
D
S
L
A
E
K
L
Q
L
Site 20
Y187
D
D
Q
F
A
D
A
Y
P
Q
R
I
K
F
E
Site 21
S195
P
Q
R
I
K
F
E
S
L
E
I
K
L
N
E
Site 22
Y203
L
E
I
K
L
N
E
Y
K
R
E
I
E
E
Q
Site 23
Y238
K
M
E
A
K
K
K
Y
E
K
E
L
T
M
F
Site 24
T243
K
K
Y
E
K
E
L
T
M
F
Q
N
D
F
E
Site 25
S257
E
K
A
C
Q
A
K
S
E
A
L
V
L
R
E
Site 26
S266
A
L
V
L
R
E
K
S
T
L
E
R
I
H
K
Site 27
T267
L
V
L
R
E
K
S
T
L
E
R
I
H
K
H
Site 28
Y283
E
I
E
T
K
E
I
Y
A
Q
R
Q
L
L
L
Site 29
S323
L
Q
E
E
K
H
K
S
I
T
E
A
L
R
R
Site 30
S337
R
Q
E
Q
N
I
K
S
F
E
E
T
Y
D
R
Site 31
T341
N
I
K
S
F
E
E
T
Y
D
R
K
L
K
N
Site 32
Y342
I
K
S
F
E
E
T
Y
D
R
K
L
K
N
E
Site 33
Y353
L
K
N
E
L
L
K
Y
Q
L
E
L
K
D
D
Site 34
Y361
Q
L
E
L
K
D
D
Y
I
I
R
T
N
R
L
Site 35
S391
E
E
L
I
A
I
N
S
K
K
E
E
L
N
Q
Site 36
S399
K
K
E
E
L
N
Q
S
V
N
R
V
K
E
L
Site 37
S412
E
L
E
L
E
L
E
S
V
K
A
Q
S
L
A
Site 38
S417
L
E
S
V
K
A
Q
S
L
A
I
T
K
Q
N
Site 39
T421
K
A
Q
S
L
A
I
T
K
Q
N
H
M
L
N
Site 40
S435
N
E
K
V
K
E
M
S
D
Y
S
L
L
K
E
Site 41
Y437
K
V
K
E
M
S
D
Y
S
L
L
K
E
E
K
Site 42
S438
V
K
E
M
S
D
Y
S
L
L
K
E
E
K
L
Site 43
S502
V
E
H
E
E
F
E
S
C
R
Q
A
L
H
K
Site 44
S531
Q
I
L
G
Y
K
A
S
V
K
S
L
T
T
Q
Site 45
S534
G
Y
K
A
S
V
K
S
L
T
T
Q
V
A
D
Site 46
Y558
T
A
L
E
N
E
V
Y
C
N
P
K
Q
S
V
Site 47
S569
K
Q
S
V
I
D
R
S
V
N
G
L
I
N
G
Site 48
Y611
V
A
S
R
I
T
N
Y
P
T
A
W
V
E
G
Site 49
S619
P
T
A
W
V
E
G
S
S
P
D
S
D
L
E
Site 50
S620
T
A
W
V
E
G
S
S
P
D
S
D
L
E
F
Site 51
S623
V
E
G
S
S
P
D
S
D
L
E
F
V
A
N
Site 52
S651
R
L
E
K
A
F
R
S
Y
H
R
R
V
I
K
Site 53
Y652
L
E
K
A
F
R
S
Y
H
R
R
V
I
K
N
Site 54
S660
H
R
R
V
I
K
N
S
A
K
S
P
L
A
A
Site 55
S663
V
I
K
N
S
A
K
S
P
L
A
A
K
S
P
Site 56
S669
K
S
P
L
A
A
K
S
P
P
S
L
H
L
L
Site 57
S684
E
A
F
K
N
I
T
S
S
S
P
E
R
H
I
Site 58
S685
A
F
K
N
I
T
S
S
S
P
E
R
H
I
F
Site 59
S686
F
K
N
I
T
S
S
S
P
E
R
H
I
F
G
Site 60
S699
F
G
E
D
R
V
V
S
E
Q
P
Q
V
G
T
Site 61
S720
V
V
E
A
L
T
G
S
A
A
S
R
L
R
G
Site 62
T729
A
S
R
L
R
G
G
T
S
S
R
R
L
S
S
Site 63
S730
S
R
L
R
G
G
T
S
S
R
R
L
S
S
T
Site 64
S731
R
L
R
G
G
T
S
S
R
R
L
S
S
T
P
Site 65
S735
G
T
S
S
R
R
L
S
S
T
P
L
P
K
A
Site 66
S736
T
S
S
R
R
L
S
S
T
P
L
P
K
A
K
Site 67
T737
S
S
R
R
L
S
S
T
P
L
P
K
A
K
R
Site 68
S745
P
L
P
K
A
K
R
S
L
E
S
E
M
Y
L
Site 69
Y751
R
S
L
E
S
E
M
Y
L
E
G
L
G
R
S
Site 70
S758
Y
L
E
G
L
G
R
S
H
I
A
S
P
S
P
Site 71
S762
L
G
R
S
H
I
A
S
P
S
P
C
P
D
R
Site 72
S764
R
S
H
I
A
S
P
S
P
C
P
D
R
M
P
Site 73
S774
P
D
R
M
P
L
P
S
P
T
E
S
R
H
S
Site 74
T776
R
M
P
L
P
S
P
T
E
S
R
H
S
L
S
Site 75
S778
P
L
P
S
P
T
E
S
R
H
S
L
S
I
P
Site 76
S781
S
P
T
E
S
R
H
S
L
S
I
P
P
V
S
Site 77
S783
T
E
S
R
H
S
L
S
I
P
P
V
S
S
P
Site 78
S788
S
L
S
I
P
P
V
S
S
P
P
E
Q
K
V
Site 79
S789
L
S
I
P
P
V
S
S
P
P
E
Q
K
V
G
Site 80
Y798
P
E
Q
K
V
G
L
Y
R
R
Q
T
E
L
Q
Site 81
T802
V
G
L
Y
R
R
Q
T
E
L
Q
D
K
S
E
Site 82
S808
Q
T
E
L
Q
D
K
S
E
F
S
D
V
D
K
Site 83
S811
L
Q
D
K
S
E
F
S
D
V
D
K
L
A
F
Site 84
S826
K
D
N
E
E
F
E
S
S
F
E
S
A
G
N
Site 85
S827
D
N
E
E
F
E
S
S
F
E
S
A
G
N
M
Site 86
S830
E
F
E
S
S
F
E
S
A
G
N
M
P
R
Q
Site 87
S844
Q
L
E
M
G
G
L
S
P
A
G
D
M
S
H
Site 88
Y863
A
A
A
V
P
L
S
Y
Q
H
P
S
V
D
Q
Site 89
S899
Q
R
E
E
R
R
Q
S
N
L
Q
E
V
L
E
Site 90
Y916
R
R
E
L
E
K
L
Y
Q
E
R
K
M
I
E
Site 91
S943
M
E
N
E
L
E
M
S
N
Q
E
I
K
D
K
Site 92
S951
N
Q
E
I
K
D
K
S
A
H
S
E
N
P
L
Site 93
Y961
S
E
N
P
L
E
K
Y
M
K
I
I
Q
Q
E
Site 94
S973
Q
Q
E
Q
D
Q
E
S
A
D
K
S
S
K
K
Site 95
S977
D
Q
E
S
A
D
K
S
S
K
K
M
V
Q
E
Site 96
S986
K
K
M
V
Q
E
G
S
L
V
D
T
L
Q
S
Site 97
T990
Q
E
G
S
L
V
D
T
L
Q
S
S
D
K
V
Site 98
S994
L
V
D
T
L
Q
S
S
D
K
V
E
S
L
T
Site 99
S999
Q
S
S
D
K
V
E
S
L
T
G
F
S
H
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation