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Updated November 2019
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Protein Info
Short Name:
MYCBP2
Full Name:
Probable E3 ubiquitin-protein ligase MYCBP2
Alias:
EC 6.3.2.-; MYCB2; Myc-binding protein 2; Pam,highwire,rpm-1
Type:
Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ligase
Mass (Da):
510084
Number AA:
4640
UniProt ID:
O75592
International Prot ID:
IPI00289776
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005680
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0030071
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
L
G
L
P
A
A
D
S
R
G
H
Y
Q
L
L
Site 2
Y26
A
A
D
S
R
G
H
Y
Q
L
L
L
S
G
R
Site 3
S31
G
H
Y
Q
L
L
L
S
G
R
A
L
A
D
R
Site 4
Y39
G
R
A
L
A
D
R
Y
R
R
I
Y
T
A
A
Site 5
Y43
A
D
R
Y
R
R
I
Y
T
A
A
L
N
D
R
Site 6
T44
D
R
Y
R
R
I
Y
T
A
A
L
N
D
R
D
Site 7
S56
D
R
D
Q
G
G
G
S
A
G
H
P
A
S
R
Site 8
S62
G
S
A
G
H
P
A
S
R
N
K
K
I
L
N
Site 9
S79
K
L
K
R
K
Q
K
S
K
S
K
V
K
T
R
Site 10
S81
K
R
K
Q
K
S
K
S
K
V
K
T
R
S
K
Site 11
T85
K
S
K
S
K
V
K
T
R
S
K
S
E
N
L
Site 12
S87
K
S
K
V
K
T
R
S
K
S
E
N
L
E
N
Site 13
S89
K
V
K
T
R
S
K
S
E
N
L
E
N
T
V
Site 14
T95
K
S
E
N
L
E
N
T
V
I
I
P
D
I
K
Site 15
S105
I
P
D
I
K
L
H
S
N
P
S
A
F
N
I
Site 16
Y113
N
P
S
A
F
N
I
Y
C
N
V
R
H
C
V
Site 17
S129
E
W
Q
K
K
E
I
S
L
A
A
A
S
K
N
Site 18
S134
E
I
S
L
A
A
A
S
K
N
S
V
Q
S
G
Site 19
S137
L
A
A
A
S
K
N
S
V
Q
S
G
E
S
D
Site 20
S140
A
S
K
N
S
V
Q
S
G
E
S
D
S
D
E
Site 21
S143
N
S
V
Q
S
G
E
S
D
S
D
E
E
E
E
Site 22
S145
V
Q
S
G
E
S
D
S
D
E
E
E
E
S
K
Site 23
S151
D
S
D
E
E
E
E
S
K
E
P
P
I
K
L
Site 24
S179
L
I
K
E
T
R
F
S
H
P
S
L
C
L
R
Site 25
S182
E
T
R
F
S
H
P
S
L
C
L
R
S
L
Q
Site 26
S205
Q
Q
P
E
G
L
Q
S
E
P
P
E
V
L
E
Site 27
T226
L
E
I
T
V
R
S
T
G
M
N
D
S
T
G
Site 28
S231
R
S
T
G
M
N
D
S
T
G
Q
S
L
T
A
Site 29
T232
S
T
G
M
N
D
S
T
G
Q
S
L
T
A
L
Site 30
S235
M
N
D
S
T
G
Q
S
L
T
A
L
S
C
A
Site 31
T257
S
W
G
E
T
G
R
T
L
Q
A
I
S
A
I
Site 32
S284
Q
V
P
T
I
L
N
S
L
Q
R
S
V
Q
A
Site 33
S322
K
W
P
L
K
E
I
S
V
D
E
D
D
Q
C
Site 34
Y347
L
L
C
K
D
G
L
Y
K
I
G
S
G
Y
S
Site 35
S351
D
G
L
Y
K
I
G
S
G
Y
S
G
T
V
R
Site 36
S354
Y
K
I
G
S
G
Y
S
G
T
V
R
G
H
I
Site 37
T356
I
G
S
G
Y
S
G
T
V
R
G
H
I
Y
N
Site 38
Y362
G
T
V
R
G
H
I
Y
N
S
T
S
R
I
R
Site 39
S364
V
R
G
H
I
Y
N
S
T
S
R
I
R
N
R
Site 40
T365
R
G
H
I
Y
N
S
T
S
R
I
R
N
R
K
Site 41
S376
R
N
R
K
E
K
K
S
W
L
G
Y
A
Q
G
Site 42
Y380
E
K
K
S
W
L
G
Y
A
Q
G
Y
L
L
Y
Site 43
Y384
W
L
G
Y
A
Q
G
Y
L
L
Y
R
D
V
N
Site 44
Y387
Y
A
Q
G
Y
L
L
Y
R
D
V
N
N
H
S
Site 45
S401
S
M
T
A
I
R
I
S
P
E
T
L
E
Q
D
Site 46
T404
A
I
R
I
S
P
E
T
L
E
Q
D
G
T
V
Site 47
T410
E
T
L
E
Q
D
G
T
V
M
L
P
D
C
H
Site 48
S486
E
K
D
L
H
I
I
S
T
G
F
D
E
E
S
Site 49
S493
S
T
G
F
D
E
E
S
A
I
L
G
A
G
R
Site 50
T507
R
E
F
A
L
M
K
T
A
N
G
K
I
Y
Y
Site 51
Y513
K
T
A
N
G
K
I
Y
Y
T
G
K
Y
Q
S
Site 52
Y518
K
I
Y
Y
T
G
K
Y
Q
S
L
G
I
K
Q
Site 53
S520
Y
Y
T
G
K
Y
Q
S
L
G
I
K
Q
G
G
Site 54
T539
K
W
V
E
L
P
I
T
K
S
P
K
I
V
H
Site 55
S548
S
P
K
I
V
H
F
S
V
G
H
D
G
S
H
Site 56
T568
E
D
G
S
I
F
F
T
G
S
A
S
K
G
E
Site 57
S570
G
S
I
F
F
T
G
S
A
S
K
G
E
D
G
Site 58
S572
I
F
F
T
G
S
A
S
K
G
E
D
G
E
S
Site 59
S579
S
K
G
E
D
G
E
S
T
K
S
R
R
Q
S
Site 60
T580
K
G
E
D
G
E
S
T
K
S
R
R
Q
S
K
Site 61
S582
E
D
G
E
S
T
K
S
R
R
Q
S
K
P
Y
Site 62
S586
S
T
K
S
R
R
Q
S
K
P
Y
K
P
K
K
Site 63
Y589
S
R
R
Q
S
K
P
Y
K
P
K
K
I
I
K
Site 64
Y604
M
E
G
K
I
V
V
Y
T
A
C
N
N
G
S
Site 65
T605
E
G
K
I
V
V
Y
T
A
C
N
N
G
S
S
Site 66
S611
Y
T
A
C
N
N
G
S
S
S
V
I
S
K
D
Site 67
S613
A
C
N
N
G
S
S
S
V
I
S
K
D
G
E
Site 68
S616
N
G
S
S
S
V
I
S
K
D
G
E
L
Y
M
Site 69
Y622
I
S
K
D
G
E
L
Y
M
F
G
K
D
A
I
Site 70
Y630
M
F
G
K
D
A
I
Y
S
D
S
S
S
L
V
Site 71
S631
F
G
K
D
A
I
Y
S
D
S
S
S
L
V
T
Site 72
S633
K
D
A
I
Y
S
D
S
S
S
L
V
T
D
L
Site 73
S635
A
I
Y
S
D
S
S
S
L
V
T
D
L
K
G
Site 74
T638
S
D
S
S
S
L
V
T
D
L
K
G
H
F
V
Site 75
T679
K
G
Q
C
G
R
D
T
G
A
M
N
Q
G
G
Site 76
T696
F
G
V
E
N
M
A
T
A
M
D
E
D
L
E
Site 77
S743
D
C
T
G
Y
G
A
S
C
V
S
S
G
R
P
Site 78
S747
Y
G
A
S
C
V
S
S
G
R
P
D
R
V
P
Site 79
S861
Q
A
L
A
R
L
R
S
H
P
A
Q
L
K
H
Site 80
S877
R
D
K
H
K
D
G
S
G
E
R
G
E
K
D
Site 81
S886
E
R
G
E
K
D
A
S
K
I
T
T
Y
P
P
Site 82
T889
E
K
D
A
S
K
I
T
T
Y
P
P
G
S
V
Site 83
T890
K
D
A
S
K
I
T
T
Y
P
P
G
S
V
R
Site 84
Y891
D
A
S
K
I
T
T
Y
P
P
G
S
V
R
F
Site 85
S895
I
T
T
Y
P
P
G
S
V
R
F
D
C
E
L
Site 86
Y924
L
M
E
N
G
D
V
Y
T
F
G
Y
G
Q
H
Site 87
Y928
G
D
V
Y
T
F
G
Y
G
Q
H
G
Q
L
G
Site 88
S941
L
G
H
G
D
V
N
S
R
G
C
P
T
L
V
Site 89
T956
Q
A
L
P
G
P
S
T
Q
V
T
A
G
S
N
Site 90
T959
P
G
P
S
T
Q
V
T
A
G
S
N
H
T
A
Site 91
S979
G
Q
V
F
T
F
G
S
F
S
K
G
Q
L
G
Site 92
S981
V
F
T
F
G
S
F
S
K
G
Q
L
G
R
P
Site 93
Y994
R
P
I
L
D
V
P
Y
W
N
A
K
P
A
P
Site 94
Y1009
M
P
N
I
G
S
K
Y
G
R
K
A
T
W
I
Site 95
T1014
S
K
Y
G
R
K
A
T
W
I
G
A
S
G
D
Site 96
T1023
I
G
A
S
G
D
Q
T
F
L
R
I
D
E
A
Site 97
S1040
N
S
H
V
L
A
T
S
E
I
F
A
S
K
H
Site 98
S1073
L
I
N
K
V
D
G
S
C
K
T
F
N
D
S
Site 99
T1076
K
V
D
G
S
C
K
T
F
N
D
S
E
Q
E
Site 100
S1080
S
C
K
T
F
N
D
S
E
Q
E
D
L
Q
G
Site 101
Y1112
N
T
R
E
L
W
C
Y
N
A
V
V
A
D
A
Site 102
S1123
V
A
D
A
R
L
P
S
A
A
D
M
Q
S
R
Site 103
S1129
P
S
A
A
D
M
Q
S
R
C
S
I
L
S
P
Site 104
S1132
A
D
M
Q
S
R
C
S
I
L
S
P
E
L
A
Site 105
S1135
Q
S
R
C
S
I
L
S
P
E
L
A
L
P
T
Site 106
T1142
S
P
E
L
A
L
P
T
G
S
R
A
L
T
T
Site 107
T1148
P
T
G
S
R
A
L
T
T
R
S
H
A
A
L
Site 108
Y1193
K
V
Y
S
K
E
D
Y
S
V
V
N
R
F
E
Site 109
S1194
V
Y
S
K
E
D
Y
S
V
V
N
R
F
E
S
Site 110
S1201
S
V
V
N
R
F
E
S
H
G
G
G
W
G
Y
Site 111
Y1208
S
H
G
G
G
W
G
Y
S
A
H
S
V
E
A
Site 112
S1212
G
W
G
Y
S
A
H
S
V
E
A
I
R
F
S
Site 113
Y1238
L
F
G
G
R
G
E
Y
T
A
K
I
K
L
F
Site 114
T1239
F
G
G
R
G
E
Y
T
A
K
I
K
L
F
E
Site 115
T1256
P
D
G
G
D
H
E
T
D
G
D
L
L
A
E
Site 116
Y1277
D
C
A
A
R
E
K
Y
A
M
M
F
D
E
P
Site 117
Y1293
L
L
Q
A
G
W
W
Y
V
A
W
A
R
V
S
Site 118
S1300
Y
V
A
W
A
R
V
S
G
P
S
S
D
C
G
Site 119
S1303
W
A
R
V
S
G
P
S
S
D
C
G
S
H
G
Site 120
S1304
A
R
V
S
G
P
S
S
D
C
G
S
H
G
Q
Site 121
S1308
G
P
S
S
D
C
G
S
H
G
Q
A
S
I
T
Site 122
S1313
C
G
S
H
G
Q
A
S
I
T
T
D
D
G
V
Site 123
S1326
G
V
V
F
Q
F
K
S
S
K
K
S
N
N
G
Site 124
S1330
Q
F
K
S
S
K
K
S
N
N
G
T
D
V
N
Site 125
T1334
S
K
K
S
N
N
G
T
D
V
N
A
G
Q
I
Site 126
Y1346
G
Q
I
P
Q
L
L
Y
R
L
P
T
S
D
G
Site 127
T1350
Q
L
L
Y
R
L
P
T
S
D
G
S
A
S
K
Site 128
S1351
L
L
Y
R
L
P
T
S
D
G
S
A
S
K
G
Site 129
S1354
R
L
P
T
S
D
G
S
A
S
K
G
K
Q
Q
Site 130
S1363
S
K
G
K
Q
Q
T
S
E
P
V
H
I
L
K
Site 131
T1376
L
K
R
S
F
A
R
T
V
S
V
E
C
F
E
Site 132
Y1440
R
V
Y
T
C
E
I
Y
P
V
S
A
T
G
K
Site 133
T1465
E
C
I
G
K
T
R
T
L
L
R
K
I
L
S
Site 134
S1472
T
L
L
R
K
I
L
S
E
G
V
D
H
C
M
Site 135
Y1489
L
D
N
D
P
Q
G
Y
L
S
Q
P
L
S
L
Site 136
S1491
N
D
P
Q
G
Y
L
S
Q
P
L
S
L
L
E
Site 137
T1544
I
Q
E
A
N
F
K
T
S
S
S
R
L
L
A
Site 138
S1545
Q
E
A
N
F
K
T
S
S
S
R
L
L
A
A
Site 139
S1546
E
A
N
F
K
T
S
S
S
R
L
L
A
A
V
Site 140
S1586
R
S
I
V
K
Q
V
S
T
E
N
D
S
T
L
Site 141
T1587
S
I
V
K
Q
V
S
T
E
N
D
S
T
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Site 445
T4296
M
A
L
A
D
S
K
T
M
K
A
M
V
E
F
Site 446
T4307
M
V
E
F
R
E
H
T
G
K
P
T
T
S
S
Site 447
T4311
R
E
H
T
G
K
P
T
T
S
S
S
E
A
C
Site 448
T4312
E
H
T
G
K
P
T
T
S
S
S
E
A
C
R
Site 449
S4315
G
K
P
T
T
S
S
S
E
A
C
R
F
C
G
Site 450
S4323
E
A
C
R
F
C
G
S
R
S
G
T
E
L
S
Site 451
S4325
C
R
F
C
G
S
R
S
G
T
E
L
S
A
V
Site 452
T4327
F
C
G
S
R
S
G
T
E
L
S
A
V
G
S
Site 453
S4330
S
R
S
G
T
E
L
S
A
V
G
S
V
C
S
Site 454
S4334
T
E
L
S
A
V
G
S
V
C
S
D
A
D
C
Site 455
S4337
S
A
V
G
S
V
C
S
D
A
D
C
Q
E
Y
Site 456
Y4344
S
D
A
D
C
Q
E
Y
A
K
I
A
C
S
K
Site 457
T4352
A
K
I
A
C
S
K
T
H
P
C
G
H
P
C
Site 458
S4378
C
L
H
G
C
D
K
S
A
T
S
L
K
Q
D
Site 459
Y4460
L
D
P
I
K
E
L
Y
E
D
V
R
R
K
A
Site 460
Y4473
K
A
L
M
R
L
E
Y
E
G
L
H
K
S
E
Site 461
S4479
E
Y
E
G
L
H
K
S
E
A
I
T
T
P
G
Site 462
T4483
L
H
K
S
E
A
I
T
T
P
G
V
R
F
Y
Site 463
T4484
H
K
S
E
A
I
T
T
P
G
V
R
F
Y
N
Site 464
Y4490
T
T
P
G
V
R
F
Y
N
D
P
A
G
Y
A
Site 465
Y4501
A
G
Y
A
M
N
R
Y
A
Y
Y
V
C
Y
K
Site 466
Y4504
A
M
N
R
Y
A
Y
Y
V
C
Y
K
C
R
K
Site 467
Y4507
R
Y
A
Y
Y
V
C
Y
K
C
R
K
A
Y
F
Site 468
Y4513
C
Y
K
C
R
K
A
Y
F
G
G
E
A
R
C
Site 469
Y4530
E
A
G
R
G
D
D
Y
D
P
R
E
L
I
C
Site 470
Y4559
H
G
T
D
F
L
E
Y
K
C
R
Y
C
C
S
Site 471
T4590
H
D
D
F
Q
R
M
T
S
I
P
K
E
E
L
Site 472
S4591
D
D
F
Q
R
M
T
S
I
P
K
E
E
L
P
Site 473
T4612
K
G
K
Q
L
E
G
T
E
C
P
L
H
V
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation