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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRKRA
Full Name:
Interferon-inducible double stranded RNA-dependent protein kinase activator A
Alias:
DKFZp564I0123; DYT16; HSD14; Hypothetical protein DKFZp564I0123; PKR-associating protein RAX; PRKRA protein; Protein activator of the interferon-induced protein kinase; Protein kinase, interferon- inducible double stranded RNA dependent activator; Protein kinase, interferon-inducible double stranded RNA dependent activator; Protein kinase, interferon-inducible double stranded RNA-dependent activator; RAX
Type:
Activator protein; RNA processing; RNA binding protein
Mass (Da):
34404
Number AA:
313
UniProt ID:
O75569
International Prot ID:
IPI00021167
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0003725
GO:0008047
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0008285
GO:0030422
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
P
P
L
E
R
E
D
S
G
T
F
S
L
G
K
Site 2
T20
L
E
R
E
D
S
G
T
F
S
L
G
K
M
I
Site 3
S22
R
E
D
S
G
T
F
S
L
G
K
M
I
T
A
Site 4
T28
F
S
L
G
K
M
I
T
A
K
P
G
K
T
P
Site 5
T34
I
T
A
K
P
G
K
T
P
I
Q
V
L
H
E
Site 6
Y42
P
I
Q
V
L
H
E
Y
G
M
K
T
K
N
I
Site 7
Y52
K
T
K
N
I
P
V
Y
E
C
E
R
S
D
V
Site 8
S57
P
V
Y
E
C
E
R
S
D
V
Q
I
H
V
P
Site 9
T67
Q
I
H
V
P
T
F
T
F
R
V
T
V
G
D
Site 10
T71
P
T
F
T
F
R
V
T
V
G
D
I
T
C
T
Site 11
T76
R
V
T
V
G
D
I
T
C
T
G
E
G
T
S
Site 12
T78
T
V
G
D
I
T
C
T
G
E
G
T
S
K
K
Site 13
S118
D
P
L
M
P
D
P
S
K
Q
P
K
N
Q
L
Site 14
S130
N
Q
L
N
P
I
G
S
L
Q
E
L
A
I
H
Site 15
Y145
H
G
W
R
L
P
E
Y
T
L
S
Q
E
G
G
Site 16
T146
G
W
R
L
P
E
Y
T
L
S
Q
E
G
G
P
Site 17
S148
R
L
P
E
Y
T
L
S
Q
E
G
G
P
A
H
Site 18
Y159
G
P
A
H
K
R
E
Y
T
T
I
C
R
L
E
Site 19
T160
P
A
H
K
R
E
Y
T
T
I
C
R
L
E
S
Site 20
T161
A
H
K
R
E
Y
T
T
I
C
R
L
E
S
F
Site 21
S167
T
T
I
C
R
L
E
S
F
M
E
T
G
K
G
Site 22
T171
R
L
E
S
F
M
E
T
G
K
G
A
S
K
K
Site 23
S176
M
E
T
G
K
G
A
S
K
K
Q
A
K
R
N
Site 24
S193
E
K
F
L
A
K
F
S
N
I
S
P
E
N
H
Site 25
S196
L
A
K
F
S
N
I
S
P
E
N
H
I
S
L
Site 26
S202
I
S
P
E
N
H
I
S
L
T
N
V
V
G
H
Site 27
T204
P
E
N
H
I
S
L
T
N
V
V
G
H
S
L
Site 28
T214
V
G
H
S
L
G
C
T
W
H
S
L
R
N
S
Site 29
S217
S
L
G
C
T
W
H
S
L
R
N
S
P
G
E
Site 30
S221
T
W
H
S
L
R
N
S
P
G
E
K
I
N
L
Site 31
S232
K
I
N
L
L
K
R
S
L
L
S
I
P
N
T
Site 32
S235
L
L
K
R
S
L
L
S
I
P
N
T
D
Y
I
Site 33
S246
T
D
Y
I
Q
L
L
S
E
I
A
K
E
Q
G
Site 34
Y258
E
Q
G
F
N
I
T
Y
L
D
I
D
E
L
S
Site 35
Y270
E
L
S
A
N
G
Q
Y
Q
C
L
A
E
L
S
Site 36
S287
P
I
T
V
C
H
G
S
G
I
S
C
G
N
A
Site 37
S296
I
S
C
G
N
A
Q
S
D
A
A
H
N
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation