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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRE1
Full Name:
Serine/threonine-protein kinase/endoribonuclease IRE1
Alias:
endoplasmic reticulum to nucleus signaling 1; ERN1; IRE1P; kinase IRE1; Protein kinase/endoribonulcease
Type:
Apoptosis; Endoplasmic reticulum; EC 2.7.11.1; Ribonuclease; Chaperone; EC 3.1.26.-; Protein kinase, Ser/Thr (non-receptor); Other group; IRE family
Mass (Da):
109690
Number AA:
UniProt ID:
O75460
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030176
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016891
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006987
GO:0006915
GO:0007050
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S41
F
V
S
T
L
D
G
S
L
H
A
V
S
K
R
Site 2
S46
D
G
S
L
H
A
V
S
K
R
T
G
S
I
K
Site 3
S51
A
V
S
K
R
T
G
S
I
K
W
T
L
K
E
Site 4
T55
R
T
G
S
I
K
W
T
L
K
E
D
P
V
L
Site 5
S81
L
P
D
P
N
D
G
S
L
Y
T
L
G
S
K
Site 6
Y83
D
P
N
D
G
S
L
Y
T
L
G
S
K
N
N
Site 7
S87
G
S
L
Y
T
L
G
S
K
N
N
E
G
L
T
Site 8
T94
S
K
N
N
E
G
L
T
K
L
P
F
T
I
P
Site 9
S107
I
P
E
L
V
Q
A
S
P
C
R
S
S
D
G
Site 10
S111
V
Q
A
S
P
C
R
S
S
D
G
I
L
Y
M
Site 11
S112
Q
A
S
P
C
R
S
S
D
G
I
L
Y
M
G
Site 12
Y117
R
S
S
D
G
I
L
Y
M
G
K
K
Q
D
I
Site 13
Y126
G
K
K
Q
D
I
W
Y
V
I
D
L
L
T
G
Site 14
T132
W
Y
V
I
D
L
L
T
G
E
K
Q
Q
T
L
Site 15
T138
L
T
G
E
K
Q
Q
T
L
S
S
A
F
A
D
Site 16
S140
G
E
K
Q
Q
T
L
S
S
A
F
A
D
S
L
Site 17
S141
E
K
Q
Q
T
L
S
S
A
F
A
D
S
L
C
Site 18
S152
D
S
L
C
P
S
T
S
L
L
Y
L
G
R
T
Site 19
Y155
C
P
S
T
S
L
L
Y
L
G
R
T
E
Y
T
Site 20
Y161
L
Y
L
G
R
T
E
Y
T
I
T
M
Y
D
T
Site 21
T164
G
R
T
E
Y
T
I
T
M
Y
D
T
K
T
R
Site 22
Y166
T
E
Y
T
I
T
M
Y
D
T
K
T
R
E
L
Site 23
T170
I
T
M
Y
D
T
K
T
R
E
L
R
W
N
A
Site 24
Y179
E
L
R
W
N
A
T
Y
F
D
Y
A
A
S
L
Site 25
Y182
W
N
A
T
Y
F
D
Y
A
A
S
L
P
E
D
Site 26
Y193
L
P
E
D
D
V
D
Y
K
M
S
H
F
V
S
Site 27
T208
N
G
D
G
L
V
V
T
V
D
S
E
S
G
D
Site 28
T264
S
G
E
V
G
R
I
T
K
W
K
Y
P
F
P
Site 29
Y268
G
R
I
T
K
W
K
Y
P
F
P
K
E
T
E
Site 30
T274
K
Y
P
F
P
K
E
T
E
A
K
S
K
L
T
Site 31
S278
P
K
E
T
E
A
K
S
K
L
T
P
T
L
Y
Site 32
T281
T
E
A
K
S
K
L
T
P
T
L
Y
V
G
K
Site 33
T283
A
K
S
K
L
T
P
T
L
Y
V
G
K
Y
S
Site 34
Y285
S
K
L
T
P
T
L
Y
V
G
K
Y
S
T
S
Site 35
Y289
P
T
L
Y
V
G
K
Y
S
T
S
L
Y
A
S
Site 36
S290
T
L
Y
V
G
K
Y
S
T
S
L
Y
A
S
P
Site 37
S292
Y
V
G
K
Y
S
T
S
L
Y
A
S
P
S
M
Site 38
Y294
G
K
Y
S
T
S
L
Y
A
S
P
S
M
V
H
Site 39
S296
Y
S
T
S
L
Y
A
S
P
S
M
V
H
E
G
Site 40
T321
P
L
L
E
G
P
Q
T
D
G
V
T
I
G
D
Site 41
T325
G
P
Q
T
D
G
V
T
I
G
D
K
G
E
C
Site 42
T335
D
K
G
E
C
V
I
T
P
S
T
D
V
K
F
Site 43
T338
E
C
V
I
T
P
S
T
D
V
K
F
D
P
G
Site 44
S348
K
F
D
P
G
L
K
S
K
N
K
L
N
Y
L
Site 45
Y354
K
S
K
N
K
L
N
Y
L
R
N
Y
W
L
L
Site 46
Y358
K
L
N
Y
L
R
N
Y
W
L
L
I
G
H
H
Site 47
T367
L
L
I
G
H
H
E
T
P
L
S
A
S
T
K
Site 48
S370
G
H
H
E
T
P
L
S
A
S
T
K
M
L
E
Site 49
S395
E
N
V
I
P
A
D
S
E
K
K
S
F
E
E
Site 50
S399
P
A
D
S
E
K
K
S
F
E
E
V
I
N
L
Site 51
S411
I
N
L
V
D
Q
T
S
E
N
A
P
T
T
V
Site 52
T416
Q
T
S
E
N
A
P
T
T
V
S
R
D
V
E
Site 53
T417
T
S
E
N
A
P
T
T
V
S
R
D
V
E
E
Site 54
T513
Q
D
G
E
L
L
D
T
S
G
P
Y
S
E
S
Site 55
S514
D
G
E
L
L
D
T
S
G
P
Y
S
E
S
S
Site 56
Y517
L
L
D
T
S
G
P
Y
S
E
S
S
G
T
S
Site 57
S518
L
D
T
S
G
P
Y
S
E
S
S
G
T
S
S
Site 58
S520
T
S
G
P
Y
S
E
S
S
G
T
S
S
P
S
Site 59
S521
S
G
P
Y
S
E
S
S
G
T
S
S
P
S
T
Site 60
T523
P
Y
S
E
S
S
G
T
S
S
P
S
T
S
P
Site 61
S524
Y
S
E
S
S
G
T
S
S
P
S
T
S
P
R
Site 62
S525
S
E
S
S
G
T
S
S
P
S
T
S
P
R
A
Site 63
S527
S
S
G
T
S
S
P
S
T
S
P
R
A
S
N
Site 64
T528
S
G
T
S
S
P
S
T
S
P
R
A
S
N
H
Site 65
S529
G
T
S
S
P
S
T
S
P
R
A
S
N
H
S
Site 66
S533
P
S
T
S
P
R
A
S
N
H
S
L
C
S
G
Site 67
S536
S
P
R
A
S
N
H
S
L
C
S
G
S
S
A
Site 68
S539
A
S
N
H
S
L
C
S
G
S
S
A
S
K
A
Site 69
S542
H
S
L
C
S
G
S
S
A
S
K
A
G
S
S
Site 70
S544
L
C
S
G
S
S
A
S
K
A
G
S
S
P
S
Site 71
S548
S
S
A
S
K
A
G
S
S
P
S
L
E
Q
D
Site 72
S549
S
A
S
K
A
G
S
S
P
S
L
E
Q
D
D
Site 73
S551
S
K
A
G
S
S
P
S
L
E
Q
D
D
G
D
Site 74
T561
Q
D
D
G
D
E
E
T
S
V
V
I
V
G
K
Site 75
S562
D
D
G
D
E
E
T
S
V
V
I
V
G
K
I
Site 76
S607
R
I
L
P
E
C
F
S
F
A
D
R
E
V
Q
Site 77
S619
E
V
Q
L
L
R
E
S
D
E
H
P
N
V
I
Site 78
Y628
E
H
P
N
V
I
R
Y
F
C
T
E
K
D
R
Site 79
Y639
E
K
D
R
Q
F
Q
Y
I
A
I
E
L
C
A
Site 80
Y652
C
A
A
T
L
Q
E
Y
V
E
Q
K
D
F
A
Site 81
S674
T
L
L
Q
Q
T
T
S
G
L
A
H
L
H
S
Site 82
S681
S
G
L
A
H
L
H
S
L
N
I
V
H
R
D
Site 83
S697
K
P
H
N
I
L
I
S
M
P
N
A
H
G
K
Site 84
S710
G
K
I
K
A
M
I
S
D
F
G
L
C
K
K
Site 85
S724
K
L
A
V
G
R
H
S
F
S
R
R
S
G
V
Site 86
S726
A
V
G
R
H
S
F
S
R
R
S
G
V
P
G
Site 87
S729
R
H
S
F
S
R
R
S
G
V
P
G
T
E
G
Site 88
Y753
D
C
K
E
N
P
T
Y
T
V
D
I
F
S
A
Site 89
T754
C
K
E
N
P
T
Y
T
V
D
I
F
S
A
G
Site 90
S778
G
S
H
P
F
G
K
S
L
Q
R
Q
A
N
I
Site 91
S822
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
Site 92
S846
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
Site 93
S853
S
D
R
I
E
K
E
S
L
D
G
P
I
V
K
Site 94
T891
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
Site 95
Y892
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
Site 96
S896
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
Site 97
T921
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
Site 98
S924
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Site 99
Y932
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
Site 100
Y945
P
H
L
L
A
H
T
Y
R
A
M
E
L
C
S
Site 101
Y960
H
E
R
L
F
Q
P
Y
Y
F
H
E
P
P
E
Site 102
Y961
E
R
L
F
Q
P
Y
Y
F
H
E
P
P
E
P
Site 103
T973
P
E
P
Q
P
P
V
T
P
D
A
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation