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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GIGYF1
Full Name:
PERQ amino acid-rich with GYF domain-containing protein 1
Alias:
CDS2; GRB10 interacting GYF protein 1; Grb10- interacting GYF protein 1; GRB10-interacting GYF protein 1; GYF domain containing 1; GYF1
Type:
Uncharacterized protein
Mass (Da):
114601
Number AA:
1035
UniProt ID:
O75420
International Prot ID:
IPI00021739
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
P
E
W
L
R
A
L
S
G
G
G
S
V
A
S
Site 2
S21
R
A
L
S
G
G
G
S
V
A
S
P
P
P
S
Site 3
S24
S
G
G
G
S
V
A
S
P
P
P
S
P
A
M
Site 4
S28
S
V
A
S
P
P
P
S
P
A
M
P
K
Y
K
Site 5
Y34
P
S
P
A
M
P
K
Y
K
L
A
D
Y
R
Y
Site 6
Y39
P
K
Y
K
L
A
D
Y
R
Y
G
R
E
E
M
Site 7
Y41
Y
K
L
A
D
Y
R
Y
G
R
E
E
M
L
A
Site 8
Y50
R
E
E
M
L
A
L
Y
V
K
E
N
K
V
P
Site 9
T83
P
L
A
L
E
P
L
T
E
E
E
Q
R
N
F
Site 10
S91
E
E
E
Q
R
N
F
S
L
S
V
N
S
V
A
Site 11
T114
A
G
P
P
L
A
G
T
S
R
G
R
G
S
T
Site 12
S115
G
P
P
L
A
G
T
S
R
G
R
G
S
T
R
Site 13
S120
G
T
S
R
G
R
G
S
T
R
S
R
G
R
G
Site 14
T121
T
S
R
G
R
G
S
T
R
S
R
G
R
G
R
Site 15
S123
R
G
R
G
S
T
R
S
R
G
R
G
R
G
D
Site 16
S131
R
G
R
G
R
G
D
S
C
F
Y
Q
R
S
I
Site 17
Y134
G
R
G
D
S
C
F
Y
Q
R
S
I
E
E
G
Site 18
S137
D
S
C
F
Y
Q
R
S
I
E
E
G
D
G
A
Site 19
S148
G
D
G
A
F
G
R
S
P
R
E
I
Q
R
S
Site 20
S155
S
P
R
E
I
Q
R
S
Q
S
W
D
D
R
G
Site 21
S157
R
E
I
Q
R
S
Q
S
W
D
D
R
G
E
R
Site 22
S169
G
E
R
R
F
E
K
S
A
R
R
D
G
A
R
Site 23
S193
P
R
K
E
H
A
R
S
D
S
E
N
W
R
S
Site 24
S195
K
E
H
A
R
S
D
S
E
N
W
R
S
L
R
Site 25
S200
S
D
S
E
N
W
R
S
L
R
E
E
Q
E
E
Site 26
S212
Q
E
E
E
E
E
G
S
W
R
L
G
A
G
P
Site 27
S228
R
D
G
D
R
W
R
S
A
S
P
D
G
G
P
Site 28
S230
G
D
R
W
R
S
A
S
P
D
G
G
P
R
S
Site 29
S237
S
P
D
G
G
P
R
S
A
G
W
R
E
H
G
Site 30
S272
E
G
R
G
G
G
G
S
S
H
L
R
R
C
R
Site 31
S273
G
R
G
G
G
G
S
S
H
L
R
R
C
R
A
Site 32
T305
D
E
D
E
E
M
G
T
F
D
A
S
G
A
F
Site 33
S341
L
E
E
E
E
E
P
S
E
G
L
E
E
E
G
Site 34
T357
E
A
G
G
K
E
L
T
P
L
P
P
Q
E
E
Site 35
S366
L
P
P
Q
E
E
K
S
S
S
P
S
P
L
P
Site 36
S367
P
P
Q
E
E
K
S
S
S
P
S
P
L
P
T
Site 37
S368
P
Q
E
E
K
S
S
S
P
S
P
L
P
T
L
Site 38
S370
E
E
K
S
S
S
P
S
P
L
P
T
L
G
P
Site 39
T374
S
S
P
S
P
L
P
T
L
G
P
L
W
G
T
Site 40
T388
T
N
G
D
G
D
E
T
A
E
K
E
P
P
A
Site 41
S406
D
I
R
G
I
Q
L
S
P
G
V
G
S
S
A
Site 42
S411
Q
L
S
P
G
V
G
S
S
A
G
P
P
G
D
Site 43
S412
L
S
P
G
V
G
S
S
A
G
P
P
G
D
L
Site 44
S438
E
A
E
K
L
V
A
S
L
Q
D
S
S
L
E
Site 45
S442
L
V
A
S
L
Q
D
S
S
L
E
E
E
Q
F
Site 46
S443
V
A
S
L
Q
D
S
S
L
E
E
E
Q
F
T
Site 47
T450
S
L
E
E
E
Q
F
T
A
A
M
Q
T
Q
G
Site 48
S461
Q
T
Q
G
L
R
H
S
A
A
A
T
A
L
P
Site 49
S470
A
A
T
A
L
P
L
S
H
G
A
A
R
K
W
Site 50
Y479
G
A
A
R
K
W
F
Y
K
D
P
Q
G
E
I
Site 51
S538
V
P
F
A
P
G
P
S
P
P
P
L
L
G
N
Site 52
S576
Q
Q
F
L
Q
L
V
S
S
R
Q
L
P
Q
C
Site 53
S577
Q
F
L
Q
L
V
S
S
R
Q
L
P
Q
C
A
Site 54
T595
K
A
A
L
G
D
L
T
P
P
P
P
P
P
P
Site 55
T632
G
D
Q
N
L
L
P
T
M
S
R
S
L
S
V
Site 56
S634
Q
N
L
L
P
T
M
S
R
S
L
S
V
P
D
Site 57
S636
L
L
P
T
M
S
R
S
L
S
V
P
D
S
G
Site 58
S638
P
T
M
S
R
S
L
S
V
P
D
S
G
R
L
Site 59
S642
R
S
L
S
V
P
D
S
G
R
L
W
D
V
H
Site 60
T650
G
R
L
W
D
V
H
T
S
A
S
S
Q
S
G
Site 61
S651
R
L
W
D
V
H
T
S
A
S
S
Q
S
G
G
Site 62
S654
D
V
H
T
S
A
S
S
Q
S
G
G
E
A
S
Site 63
S661
S
Q
S
G
G
E
A
S
L
W
D
I
P
I
N
Site 64
T671
D
I
P
I
N
S
S
T
Q
G
P
I
L
E
Q
Site 65
S755
V
P
V
P
P
A
P
S
S
P
P
P
L
W
A
Site 66
S756
P
V
P
P
A
P
S
S
P
P
P
L
W
A
G
Site 67
S770
G
L
A
K
Q
G
L
S
M
K
T
L
L
E
L
Site 68
S819
A
P
L
N
Q
W
V
S
E
A
G
P
L
W
G
Site 69
S831
L
W
G
G
P
D
K
S
G
G
G
S
S
G
L
Site 70
S835
P
D
K
S
G
G
G
S
S
G
L
G
L
W
E
Site 71
S836
D
K
S
G
G
G
S
S
G
L
G
L
W
E
D
Site 72
T844
G
L
G
L
W
E
D
T
P
K
S
G
G
S
L
Site 73
S847
L
W
E
D
T
P
K
S
G
G
S
L
V
R
G
Site 74
S850
D
T
P
K
S
G
G
S
L
V
R
G
L
G
L
Site 75
S860
R
G
L
G
L
K
N
S
R
S
S
P
S
L
S
Site 76
S862
L
G
L
K
N
S
R
S
S
P
S
L
S
D
S
Site 77
S863
G
L
K
N
S
R
S
S
P
S
L
S
D
S
Y
Site 78
S865
K
N
S
R
S
S
P
S
L
S
D
S
Y
S
H
Site 79
S867
S
R
S
S
P
S
L
S
D
S
Y
S
H
L
S
Site 80
S869
S
S
P
S
L
S
D
S
Y
S
H
L
S
G
R
Site 81
Y870
S
P
S
L
S
D
S
Y
S
H
L
S
G
R
P
Site 82
S871
P
S
L
S
D
S
Y
S
H
L
S
G
R
P
I
Site 83
S874
S
D
S
Y
S
H
L
S
G
R
P
I
R
K
K
Site 84
T882
G
R
P
I
R
K
K
T
E
E
E
E
K
L
L
Site 85
S933
A
I
L
K
E
V
E
S
P
Y
D
V
H
D
Y
Site 86
Y935
L
K
E
V
E
S
P
Y
D
V
H
D
Y
I
R
Site 87
Y940
S
P
Y
D
V
H
D
Y
I
R
S
C
L
G
D
Site 88
S943
D
V
H
D
Y
I
R
S
C
L
G
D
T
L
E
Site 89
T948
I
R
S
C
L
G
D
T
L
E
A
K
E
F
A
Site 90
S968
R
R
A
K
Q
K
A
S
Q
Q
R
Q
Q
Q
Q
Site 91
S980
Q
Q
Q
E
A
W
L
S
S
A
S
L
Q
T
A
Site 92
S981
Q
Q
E
A
W
L
S
S
A
S
L
Q
T
A
F
Site 93
S1002
K
L
G
P
G
E
G
S
K
A
K
R
R
A
L
Site 94
S1013
R
R
A
L
M
L
H
S
D
P
S
I
L
G
Y
Site 95
Y1020
S
D
P
S
I
L
G
Y
S
L
H
G
S
S
G
Site 96
S1021
D
P
S
I
L
G
Y
S
L
H
G
S
S
G
E
Site 97
S1025
L
G
Y
S
L
H
G
S
S
G
E
I
E
S
V
Site 98
S1026
G
Y
S
L
H
G
S
S
G
E
I
E
S
V
D
Site 99
S1031
G
S
S
G
E
I
E
S
V
D
D
Y
_
_
_
Site 100
Y1035
E
I
E
S
V
D
D
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation