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Updated November 2019
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Protein Info
Short Name:
POLQ
Full Name:
DNA polymerase theta
Alias:
DNA polymerase eta
Type:
Mass (Da):
197597
Number AA:
1762
UniProt ID:
O75417
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
S
F
P
I
S
L
C
S
A
R
K
A
V
D
E
Site 2
T33
E
E
R
R
N
M
R
T
I
W
V
T
G
R
K
Site 3
T37
N
M
R
T
I
W
V
T
G
R
K
G
L
T
E
Site 4
T43
V
T
G
R
K
G
L
T
E
R
E
A
A
A
L
Site 5
S78
N
P
C
A
L
L
H
S
S
T
C
S
L
T
H
Site 6
T80
C
A
L
L
H
S
S
T
C
S
L
T
H
S
E
Site 7
S82
L
L
H
S
S
T
C
S
L
T
H
S
E
S
E
Site 8
T84
H
S
S
T
C
S
L
T
H
S
E
S
E
V
K
Site 9
S86
S
T
C
S
L
T
H
S
E
S
E
V
K
E
H
Site 10
S88
C
S
L
T
H
S
E
S
E
V
K
E
H
T
F
Site 11
T94
E
S
E
V
K
E
H
T
F
I
S
Q
T
K
S
Site 12
S97
V
K
E
H
T
F
I
S
Q
T
K
S
S
Y
K
Site 13
S101
T
F
I
S
Q
T
K
S
S
Y
K
K
L
T
S
Site 14
S102
F
I
S
Q
T
K
S
S
Y
K
K
L
T
S
K
Site 15
S108
S
S
Y
K
K
L
T
S
K
N
K
S
N
T
I
Site 16
S112
K
L
T
S
K
N
K
S
N
T
I
F
S
D
S
Site 17
S117
N
K
S
N
T
I
F
S
D
S
Y
I
K
H
S
Site 18
S119
S
N
T
I
F
S
D
S
Y
I
K
H
S
P
N
Site 19
Y120
N
T
I
F
S
D
S
Y
I
K
H
S
P
N
I
Site 20
S124
S
D
S
Y
I
K
H
S
P
N
I
V
Q
D
L
Site 21
S134
I
V
Q
D
L
N
K
S
R
E
H
T
S
S
F
Site 22
T138
L
N
K
S
R
E
H
T
S
S
F
N
C
N
F
Site 23
S140
K
S
R
E
H
T
S
S
F
N
C
N
F
Q
N
Site 24
S165
F
R
A
R
K
R
A
S
L
D
I
N
K
E
K
Site 25
S183
S
Q
N
E
G
K
T
S
D
K
K
V
V
Q
T
Site 26
T190
S
D
K
K
V
V
Q
T
F
S
Q
K
T
K
K
Site 27
S192
K
K
V
V
Q
T
F
S
Q
K
T
K
K
A
P
Site 28
S204
K
A
P
L
N
F
N
S
E
K
M
S
R
S
F
Site 29
S208
N
F
N
S
E
K
M
S
R
S
F
R
S
W
K
Site 30
S210
N
S
E
K
M
S
R
S
F
R
S
W
K
R
R
Site 31
S213
K
M
S
R
S
F
R
S
W
K
R
R
K
H
L
Site 32
S223
R
R
K
H
L
K
R
S
R
D
S
S
P
L
K
Site 33
S226
H
L
K
R
S
R
D
S
S
P
L
K
D
S
G
Site 34
S227
L
K
R
S
R
D
S
S
P
L
K
D
S
G
A
Site 35
S232
D
S
S
P
L
K
D
S
G
A
C
R
I
H
L
Site 36
T243
R
I
H
L
Q
G
Q
T
L
S
N
P
S
L
C
Site 37
S245
H
L
Q
G
Q
T
L
S
N
P
S
L
C
E
D
Site 38
S248
G
Q
T
L
S
N
P
S
L
C
E
D
P
F
T
Site 39
T255
S
L
C
E
D
P
F
T
L
D
E
K
K
T
E
Site 40
T261
F
T
L
D
E
K
K
T
E
F
R
N
S
G
P
Site 41
S266
K
K
T
E
F
R
N
S
G
P
F
A
K
N
V
Site 42
S274
G
P
F
A
K
N
V
S
L
S
G
K
E
K
D
Site 43
T284
G
K
E
K
D
N
K
T
S
F
P
L
Q
I
K
Site 44
S285
K
E
K
D
N
K
T
S
F
P
L
Q
I
K
Q
Site 45
T311
N
F
V
E
H
I
V
T
G
S
Q
S
K
N
V
Site 46
S313
V
E
H
I
V
T
G
S
Q
S
K
N
V
T
C
Site 47
T319
G
S
Q
S
K
N
V
T
C
Q
A
T
S
V
V
Site 48
Y367
D
I
H
P
I
N
Q
Y
L
R
K
Q
S
H
E
Site 49
S372
N
Q
Y
L
R
K
Q
S
H
E
Q
T
S
T
I
Site 50
T376
R
K
Q
S
H
E
Q
T
S
T
I
T
K
Q
K
Site 51
T378
Q
S
H
E
Q
T
S
T
I
T
K
Q
K
N
I
Site 52
S397
M
P
C
E
A
V
S
S
Y
I
N
R
D
S
N
Site 53
Y398
P
C
E
A
V
S
S
Y
I
N
R
D
S
N
V
Site 54
S403
S
S
Y
I
N
R
D
S
N
V
T
I
N
C
E
Site 55
T406
I
N
R
D
S
N
V
T
I
N
C
E
R
I
K
Site 56
T416
C
E
R
I
K
L
N
T
E
E
N
K
P
S
H
Site 57
S422
N
T
E
E
N
K
P
S
H
F
Q
A
L
G
D
Site 58
S432
Q
A
L
G
D
D
I
S
R
T
V
I
P
S
E
Site 59
S448
L
P
S
A
G
A
F
S
K
S
E
G
Q
H
E
Site 60
S450
S
A
G
A
F
S
K
S
E
G
Q
H
E
N
F
Site 61
T467
I
S
R
L
Q
E
K
T
G
T
Y
T
T
N
K
Site 62
T469
R
L
Q
E
K
T
G
T
Y
T
T
N
K
T
K
Site 63
S493
V
L
C
D
F
E
D
S
F
Y
L
D
T
Q
S
Site 64
Y495
C
D
F
E
D
S
F
Y
L
D
T
Q
S
E
K
Site 65
T498
E
D
S
F
Y
L
D
T
Q
S
E
K
I
I
Q
Site 66
S529
A
A
G
I
M
Q
K
S
L
V
Q
Q
N
S
M
Site 67
S535
K
S
L
V
Q
Q
N
S
M
N
S
F
Q
K
E
Site 68
T566
I
D
H
L
D
L
K
T
V
G
T
M
K
Q
S
Site 69
T569
L
D
L
K
T
V
G
T
M
K
Q
S
S
D
S
Site 70
S574
V
G
T
M
K
Q
S
S
D
S
H
G
V
D
I
Site 71
T583
S
H
G
V
D
I
L
T
P
E
S
P
I
F
H
Site 72
S591
P
E
S
P
I
F
H
S
P
I
L
L
E
E
N
Site 73
S608
F
L
K
K
N
E
V
S
V
T
D
S
Q
L
N
Site 74
T610
K
K
N
E
V
S
V
T
D
S
Q
L
N
S
F
Site 75
S612
N
E
V
S
V
T
D
S
Q
L
N
S
F
L
Q
Site 76
S616
V
T
D
S
Q
L
N
S
F
L
Q
G
Y
Q
T
Site 77
Y621
L
N
S
F
L
Q
G
Y
Q
T
Q
E
T
V
K
Site 78
T623
S
F
L
Q
G
Y
Q
T
Q
E
T
V
K
P
V
Site 79
T626
Q
G
Y
Q
T
Q
E
T
V
K
P
V
I
L
L
Site 80
T639
L
L
I
P
Q
K
R
T
P
T
G
V
E
G
E
Site 81
T641
I
P
Q
K
R
T
P
T
G
V
E
G
E
C
L
Site 82
T653
E
C
L
P
V
P
E
T
S
L
N
M
S
D
S
Site 83
S658
P
E
T
S
L
N
M
S
D
S
L
L
F
D
S
Site 84
S660
T
S
L
N
M
S
D
S
L
L
F
D
S
F
S
Site 85
S665
S
D
S
L
L
F
D
S
F
S
D
D
Y
L
V
Site 86
S667
S
L
L
F
D
S
F
S
D
D
Y
L
V
K
E
Site 87
Y670
F
D
S
F
S
D
D
Y
L
V
K
E
Q
L
P
Site 88
S687
Q
M
K
E
P
L
P
S
E
V
T
S
N
H
F
Site 89
S691
P
L
P
S
E
V
T
S
N
H
F
S
D
S
L
Site 90
S695
E
V
T
S
N
H
F
S
D
S
L
C
L
Q
E
Site 91
S697
T
S
N
H
F
S
D
S
L
C
L
Q
E
D
L
Site 92
S708
Q
E
D
L
I
K
K
S
N
V
N
E
N
Q
D
Site 93
T716
N
V
N
E
N
Q
D
T
H
Q
Q
L
T
C
S
Site 94
S727
L
T
C
S
N
D
E
S
I
I
F
S
E
M
D
Site 95
S731
N
D
E
S
I
I
F
S
E
M
D
S
V
Q
M
Site 96
T756
P
V
Q
E
K
N
H
T
V
V
S
P
R
A
L
Site 97
S759
E
K
N
H
T
V
V
S
P
R
A
L
E
L
S
Site 98
S766
S
P
R
A
L
E
L
S
D
P
V
L
D
E
H
Site 99
S790
Q
D
E
R
A
E
K
S
K
L
T
G
T
R
Q
Site 100
T793
R
A
E
K
S
K
L
T
G
T
R
Q
N
H
S
Site 101
S800
T
G
T
R
Q
N
H
S
F
I
W
S
G
A
S
Site 102
S804
Q
N
H
S
F
I
W
S
G
A
S
F
D
L
S
Site 103
S822
Q
R
I
L
D
K
V
S
S
P
L
E
N
E
K
Site 104
S823
R
I
L
D
K
V
S
S
P
L
E
N
E
K
L
Site 105
S832
L
E
N
E
K
L
K
S
M
T
I
N
F
S
S
Site 106
T834
N
E
K
L
K
S
M
T
I
N
F
S
S
L
N
Site 107
S839
S
M
T
I
N
F
S
S
L
N
R
K
N
T
E
Site 108
T845
S
S
L
N
R
K
N
T
E
L
N
E
E
Q
E
Site 109
T859
E
V
I
S
N
L
E
T
K
Q
V
Q
G
I
S
Site 110
S866
T
K
Q
V
Q
G
I
S
F
S
S
N
N
E
V
Site 111
S868
Q
V
Q
G
I
S
F
S
S
N
N
E
V
K
S
Site 112
S875
S
S
N
N
E
V
K
S
K
I
E
M
L
E
N
Site 113
T889
N
N
A
N
H
D
E
T
S
S
L
L
P
R
K
Site 114
S891
A
N
H
D
E
T
S
S
L
L
P
R
K
E
S
Site 115
S898
S
L
L
P
R
K
E
S
N
I
V
D
D
N
G
Site 116
T910
D
N
G
L
I
P
P
T
P
I
P
T
S
A
S
Site 117
S915
P
P
T
P
I
P
T
S
A
S
K
L
T
F
P
Site 118
T920
P
T
S
A
S
K
L
T
F
P
G
I
L
E
T
Site 119
T927
T
F
P
G
I
L
E
T
P
V
N
P
W
K
T
Site 120
S943
N
V
L
Q
P
G
E
S
Y
L
F
G
S
P
S
Site 121
Y944
V
L
Q
P
G
E
S
Y
L
F
G
S
P
S
D
Site 122
S948
G
E
S
Y
L
F
G
S
P
S
D
I
K
N
H
Site 123
S950
S
Y
L
F
G
S
P
S
D
I
K
N
H
D
L
Site 124
S958
D
I
K
N
H
D
L
S
P
G
S
R
N
G
F
Site 125
S961
N
H
D
L
S
P
G
S
R
N
G
F
K
D
N
Site 126
S969
R
N
G
F
K
D
N
S
P
I
S
D
T
S
F
Site 127
S972
F
K
D
N
S
P
I
S
D
T
S
F
S
L
Q
Site 128
S975
N
S
P
I
S
D
T
S
F
S
L
Q
L
S
Q
Site 129
S977
P
I
S
D
T
S
F
S
L
Q
L
S
Q
D
G
Site 130
S981
T
S
F
S
L
Q
L
S
Q
D
G
L
Q
L
T
Site 131
T988
S
Q
D
G
L
Q
L
T
P
A
S
S
S
S
E
Site 132
S991
G
L
Q
L
T
P
A
S
S
S
S
E
S
L
S
Site 133
S992
L
Q
L
T
P
A
S
S
S
S
E
S
L
S
I
Site 134
S993
Q
L
T
P
A
S
S
S
S
E
S
L
S
I
I
Site 135
S994
L
T
P
A
S
S
S
S
E
S
L
S
I
I
D
Site 136
S998
S
S
S
S
E
S
L
S
I
I
D
V
A
S
D
Site 137
T1011
S
D
Q
N
L
F
Q
T
F
I
K
E
W
R
C
Site 138
S1023
W
R
C
K
K
R
F
S
I
S
L
A
C
E
K
Site 139
S1025
C
K
K
R
F
S
I
S
L
A
C
E
K
I
R
Site 140
S1033
L
A
C
E
K
I
R
S
L
T
S
S
K
T
A
Site 141
T1035
C
E
K
I
R
S
L
T
S
S
K
T
A
T
I
Site 142
S1037
K
I
R
S
L
T
S
S
K
T
A
T
I
G
S
Site 143
T1039
R
S
L
T
S
S
K
T
A
T
I
G
S
R
F
Site 144
T1041
L
T
S
S
K
T
A
T
I
G
S
R
F
K
Q
Site 145
S1044
S
K
T
A
T
I
G
S
R
F
K
Q
A
S
S
Site 146
S1050
G
S
R
F
K
Q
A
S
S
P
Q
E
I
P
I
Site 147
S1051
S
R
F
K
Q
A
S
S
P
Q
E
I
P
I
R
Site 148
Y1085
C
W
G
G
R
D
A
Y
Y
F
S
L
Q
K
E
Site 149
Y1086
W
G
G
R
D
A
Y
Y
F
S
L
Q
K
E
Q
Site 150
S1088
G
R
D
A
Y
Y
F
S
L
Q
K
E
Q
K
H
Site 151
S1096
L
Q
K
E
Q
K
H
S
E
I
S
A
S
L
V
Site 152
S1099
E
Q
K
H
S
E
I
S
A
S
L
V
P
P
S
Site 153
S1101
K
H
S
E
I
S
A
S
L
V
P
P
S
L
D
Site 154
S1110
V
P
P
S
L
D
P
S
L
T
L
K
D
R
M
Site 155
T1112
P
S
L
D
P
S
L
T
L
K
D
R
M
W
Y
Site 156
Y1119
T
L
K
D
R
M
W
Y
L
Q
S
C
L
R
K
Site 157
S1128
Q
S
C
L
R
K
E
S
D
K
E
C
S
V
V
Site 158
S1133
K
E
S
D
K
E
C
S
V
V
I
Y
D
F
I
Site 159
Y1137
K
E
C
S
V
V
I
Y
D
F
I
Q
S
Y
K
Site 160
S1157
C
G
I
S
L
E
Q
S
Y
E
D
P
K
V
A
Site 161
Y1158
G
I
S
L
E
Q
S
Y
E
D
P
K
V
A
C
Site 162
S1172
C
W
L
L
D
P
D
S
Q
E
P
T
L
H
S
Site 163
T1176
D
P
D
S
Q
E
P
T
L
H
S
I
V
T
S
Site 164
S1179
S
Q
E
P
T
L
H
S
I
V
T
S
F
L
P
Site 165
T1197
P
L
L
E
G
M
E
T
S
Q
G
I
Q
S
L
Site 166
S1198
L
L
E
G
M
E
T
S
Q
G
I
Q
S
L
G
Site 167
S1203
E
T
S
Q
G
I
Q
S
L
G
L
N
A
G
S
Site 168
S1210
S
L
G
L
N
A
G
S
E
H
S
G
R
Y
R
Site 169
S1213
L
N
A
G
S
E
H
S
G
R
Y
R
A
S
V
Site 170
S1219
H
S
G
R
Y
R
A
S
V
E
S
I
L
I
F
Site 171
S1234
N
S
M
N
Q
L
N
S
L
L
Q
K
E
N
L
Site 172
T1287
A
K
L
D
A
I
E
T
Q
A
Y
Q
L
A
G
Site 173
Y1290
D
A
I
E
T
Q
A
Y
Q
L
A
G
H
S
F
Site 174
S1296
A
Y
Q
L
A
G
H
S
F
S
F
T
S
S
D
Site 175
S1298
Q
L
A
G
H
S
F
S
F
T
S
S
D
D
I
Site 176
T1300
A
G
H
S
F
S
F
T
S
S
D
D
I
A
E
Site 177
S1302
H
S
F
S
F
T
S
S
D
D
I
A
E
V
L
Site 178
S1332
G
S
K
K
T
L
G
S
T
R
R
G
I
D
N
Site 179
T1333
S
K
K
T
L
G
S
T
R
R
G
I
D
N
G
Site 180
S1350
L
R
L
G
R
Q
F
S
T
S
K
D
V
L
N
Site 181
S1352
L
G
R
Q
F
S
T
S
K
D
V
L
N
K
L
Site 182
Y1402
F
L
G
M
E
R
I
Y
P
V
S
Q
S
H
T
Site 183
S1405
M
E
R
I
Y
P
V
S
Q
S
H
T
A
T
G
Site 184
T1409
Y
P
V
S
Q
S
H
T
A
T
G
R
I
T
F
Site 185
T1411
V
S
Q
S
H
T
A
T
G
R
I
T
F
T
E
Site 186
T1415
H
T
A
T
G
R
I
T
F
T
E
P
N
I
Q
Site 187
T1434
D
F
E
I
K
M
P
T
L
V
G
E
S
P
P
Site 188
S1439
M
P
T
L
V
G
E
S
P
P
S
Q
A
V
G
Site 189
S1442
L
V
G
E
S
P
P
S
Q
A
V
G
K
G
L
Site 190
Y1457
L
P
M
G
R
G
K
Y
K
K
G
F
S
V
N
Site 191
S1462
G
K
Y
K
K
G
F
S
V
N
P
R
C
Q
A
Site 192
S1483
A
D
R
G
M
P
F
S
I
S
M
R
H
A
F
Site 193
S1515
L
R
I
L
A
H
L
S
H
D
R
R
L
I
Q
Site 194
S1545
W
K
M
I
E
P
E
S
V
G
D
D
L
R
Q
Site 195
Y1584
K
E
N
D
A
A
C
Y
I
D
S
F
K
S
R
Site 196
S1587
D
A
A
C
Y
I
D
S
F
K
S
R
Y
T
G
Site 197
T1593
D
S
F
K
S
R
Y
T
G
I
N
Q
F
M
T
Site 198
Y1621
T
I
L
G
R
R
R
Y
L
P
G
I
K
D
N
Site 199
T1643
A
E
R
Q
A
I
N
T
I
V
Q
G
S
A
A
Site 200
T1666
N
I
Q
K
Q
L
E
T
F
H
S
T
F
K
S
Site 201
S1669
K
Q
L
E
T
F
H
S
T
F
K
S
H
G
H
Site 202
T1670
Q
L
E
T
F
H
S
T
F
K
S
H
G
H
R
Site 203
S1683
H
R
E
G
M
L
Q
S
D
R
T
G
L
S
R
Site 204
S1689
Q
S
D
R
T
G
L
S
R
K
R
K
L
Q
G
Site 205
Y1716
Q
L
H
D
E
L
L
Y
E
V
V
E
E
D
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation