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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GUCY1B2
Full Name:
Guanylate cyclase soluble subunit beta-2
Alias:
Type:
Mass (Da):
70368
Number AA:
617
UniProt ID:
O75343
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
G
Y
D
R
M
L
R
T
L
G
G
N
L
M
E
Site 2
S27
E
N
L
D
A
L
H
S
Y
L
A
L
S
Y
Q
Site 3
Y28
N
L
D
A
L
H
S
Y
L
A
L
S
Y
Q
E
Site 4
S32
L
H
S
Y
L
A
L
S
Y
Q
E
M
N
A
P
Site 5
S40
Y
Q
E
M
N
A
P
S
F
R
V
E
R
G
A
Site 6
Y55
D
G
K
M
F
L
H
Y
Y
S
D
R
S
G
L
Site 7
Y56
G
K
M
F
L
H
Y
Y
S
D
R
S
G
L
C
Site 8
T117
A
H
R
K
M
R
K
T
K
P
K
R
L
Q
D
Site 9
S125
K
P
K
R
L
Q
D
S
Q
G
M
E
R
D
Q
Site 10
Y146
F
L
K
M
K
E
K
Y
L
N
V
S
A
C
P
Site 11
S157
S
A
C
P
V
K
K
S
H
W
D
V
V
R
S
Site 12
T176
G
K
G
H
L
M
N
T
F
E
P
I
Y
P
E
Site 13
Y181
M
N
T
F
E
P
I
Y
P
E
R
L
W
I
E
Site 14
S205
F
H
I
V
F
D
E
S
L
Q
V
K
Q
A
R
Site 15
Y218
A
R
V
N
I
Q
K
Y
V
P
G
L
Q
T
Q
Site 16
Y232
Q
N
I
Q
L
D
E
Y
F
S
I
I
H
P
Q
Site 17
S253
S
I
R
R
F
I
N
S
Q
F
V
L
K
T
R
Site 18
T259
N
S
Q
F
V
L
K
T
R
R
E
M
M
P
V
Site 19
T273
V
A
W
Q
S
R
T
T
L
K
L
Q
G
Q
M
Site 20
Y291
E
S
M
W
C
M
V
Y
L
C
S
P
K
L
R
Site 21
S299
L
C
S
P
K
L
R
S
L
Q
E
L
E
E
L
Site 22
S311
E
E
L
N
M
H
L
S
D
I
A
P
N
D
T
Site 23
T318
S
D
I
A
P
N
D
T
T
R
D
L
I
L
L
Site 24
S336
R
L
A
E
I
E
L
S
N
Q
L
E
R
K
K
Site 25
T360
L
A
I
E
K
K
K
T
E
T
L
L
Y
A
M
Site 26
Y365
K
K
T
E
T
L
L
Y
A
M
L
P
K
H
V
Site 27
S421
N
V
L
N
S
M
Y
S
K
F
D
R
L
T
S
Site 28
T427
Y
S
K
F
D
R
L
T
S
V
H
A
V
Y
K
Site 29
S428
S
K
F
D
R
L
T
S
V
H
A
V
Y
K
V
Site 30
T478
K
E
V
T
N
P
V
T
G
E
P
I
Q
L
R
Site 31
Y505
V
G
D
K
M
P
R
Y
C
L
F
G
D
T
V
Site 32
S516
G
D
T
V
N
T
A
S
R
M
E
S
H
G
L
Site 33
S520
N
T
A
S
R
M
E
S
H
G
L
P
N
K
V
Site 34
S530
L
P
N
K
V
H
L
S
P
T
A
Y
R
A
L
Site 35
Y534
V
H
L
S
P
T
A
Y
R
A
L
K
N
Q
G
Site 36
T559
V
K
G
K
G
R
M
T
T
Y
F
L
I
Q
N
Site 37
T560
K
G
K
G
R
M
T
T
Y
F
L
I
Q
N
L
Site 38
Y561
G
K
G
R
M
T
T
Y
F
L
I
Q
N
L
N
Site 39
S578
E
D
E
I
M
G
R
S
K
T
P
V
D
H
K
Site 40
T580
E
I
M
G
R
S
K
T
P
V
D
H
K
G
S
Site 41
T588
P
V
D
H
K
G
S
T
Q
K
A
S
L
P
T
Site 42
S592
K
G
S
T
Q
K
A
S
L
P
T
T
K
L
Q
Site 43
T596
Q
K
A
S
L
P
T
T
K
L
Q
G
S
V
Q
Site 44
S601
P
T
T
K
L
Q
G
S
V
Q
P
S
C
P
E
Site 45
S605
L
Q
G
S
V
Q
P
S
C
P
E
H
S
S
L
Site 46
S610
Q
P
S
C
P
E
H
S
S
L
A
S
W
L
L
Site 47
S611
P
S
C
P
E
H
S
S
L
A
S
W
L
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation