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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALOX12B
Full Name:
Arachidonate 12-lipoxygenase, 12R-type
Alias:
Epidermis-type lipoxygenase 12
Type:
Mass (Da):
80338
Number AA:
701
UniProt ID:
O75342
International Prot ID:
IPI00025278
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004052
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006082
GO:0006629
GO:0006631
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
T
Y
K
V
R
V
A
T
G
T
D
L
L
S
G
Site 2
T12
K
V
R
V
A
T
G
T
D
L
L
S
G
T
R
Site 3
S16
A
T
G
T
D
L
L
S
G
T
R
D
S
I
S
Site 4
T18
G
T
D
L
L
S
G
T
R
D
S
I
S
L
T
Site 5
S23
S
G
T
R
D
S
I
S
L
T
I
V
G
T
Q
Site 6
T25
T
R
D
S
I
S
L
T
I
V
G
T
Q
G
E
Site 7
T29
I
S
L
T
I
V
G
T
Q
G
E
S
H
K
Q
Site 8
T47
H
F
G
R
D
F
A
T
G
A
V
G
Q
Y
T
Site 9
Y53
A
T
G
A
V
G
Q
Y
T
V
Q
C
P
Q
D
Site 10
T54
T
G
A
V
G
Q
Y
T
V
Q
C
P
Q
D
L
Site 11
Y108
A
Y
Q
W
M
D
G
Y
E
T
L
A
L
R
E
Site 12
T117
T
L
A
L
R
E
A
T
G
K
T
T
A
D
D
Site 13
S125
G
K
T
T
A
D
D
S
L
P
V
L
L
E
H
Site 14
Y144
I
R
A
K
Q
D
F
Y
H
W
R
V
F
L
P
Site 15
Y156
F
L
P
G
L
P
S
Y
V
H
I
P
S
Y
R
Site 16
S161
P
S
Y
V
H
I
P
S
Y
R
P
P
V
R
R
Site 17
Y162
S
Y
V
H
I
P
S
Y
R
P
P
V
R
R
H
Site 18
Y180
N
R
P
E
W
N
G
Y
I
P
G
F
P
I
L
Site 19
S232
G
L
L
D
C
K
H
S
W
K
R
L
K
D
I
Site 20
S248
K
I
F
P
G
K
K
S
V
V
S
E
Y
V
A
Site 21
S251
P
G
K
K
S
V
V
S
E
Y
V
A
E
H
W
Site 22
Y253
K
K
S
V
V
S
E
Y
V
A
E
H
W
A
E
Site 23
Y266
A
E
D
T
F
F
G
Y
Q
Y
L
N
G
V
N
Site 24
Y268
D
T
F
F
G
Y
Q
Y
L
N
G
V
N
P
G
Site 25
T281
P
G
L
I
R
R
C
T
R
I
P
D
K
F
P
Site 26
Y314
E
L
E
K
G
N
I
Y
L
A
D
Y
R
I
M
Site 27
T326
R
I
M
E
G
I
P
T
V
E
L
S
G
R
K
Site 28
S330
G
I
P
T
V
E
L
S
G
R
K
Q
H
H
C
Site 29
Y387
L
A
K
T
W
V
R
Y
A
E
F
Y
S
H
E
Site 30
Y391
W
V
R
Y
A
E
F
Y
S
H
E
A
I
A
H
Site 31
T431
Y
K
L
L
I
P
H
T
R
Y
T
V
Q
I
N
Site 32
T434
L
I
P
H
T
R
Y
T
V
Q
I
N
S
I
G
Site 33
Y476
R
A
L
S
E
L
T
Y
D
S
L
Y
L
P
N
Site 34
S478
L
S
E
L
T
Y
D
S
L
Y
L
P
N
D
F
Site 35
Y480
E
L
T
Y
D
S
L
Y
L
P
N
D
F
V
E
Site 36
Y496
G
V
Q
D
L
P
G
Y
Y
Y
R
D
D
S
L
Site 37
Y497
V
Q
D
L
P
G
Y
Y
Y
R
D
D
S
L
A
Site 38
Y498
Q
D
L
P
G
Y
Y
Y
R
D
D
S
L
A
V
Site 39
T514
N
A
L
E
K
Y
V
T
E
I
I
T
Y
Y
Y
Site 40
Y519
Y
V
T
E
I
I
T
Y
Y
Y
P
S
D
A
A
Site 41
Y521
T
E
I
I
T
Y
Y
Y
P
S
D
A
A
V
E
Site 42
S523
I
I
T
Y
Y
Y
P
S
D
A
A
V
E
G
D
Site 43
S550
E
C
L
L
G
R
E
S
S
G
F
P
R
C
L
Site 44
S551
C
L
L
G
R
E
S
S
G
F
P
R
C
L
R
Site 45
T559
G
F
P
R
C
L
R
T
V
P
E
L
I
R
Y
Site 46
T614
K
G
L
T
T
L
E
T
F
M
D
T
L
P
D
Site 47
T618
T
L
E
T
F
M
D
T
L
P
D
V
K
T
T
Site 48
S636
L
L
V
L
W
T
L
S
R
E
P
D
D
R
R
Site 49
S661
V
E
E
A
P
R
R
S
I
E
A
F
R
Q
R
Site 50
S673
R
Q
R
L
N
Q
I
S
H
D
I
R
Q
R
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation