KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CILP
Full Name:
Cartilage intermediate layer protein 1
Alias:
Cartilage intermediate-layer protein
Type:
Mass (Da):
132624
Number AA:
1184
UniProt ID:
O75339
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
T
S
V
L
G
R
Q
T
M
L
T
Q
S
V
R
Site 2
T27
L
G
R
Q
T
M
L
T
Q
S
V
R
R
V
Q
Site 3
S29
R
Q
T
M
L
T
Q
S
V
R
R
V
Q
P
G
Site 4
S41
Q
P
G
K
K
N
P
S
I
F
A
K
P
A
D
Site 5
T49
I
F
A
K
P
A
D
T
L
E
S
P
G
E
W
Site 6
S52
K
P
A
D
T
L
E
S
P
G
E
W
T
T
W
Site 7
Y64
T
T
W
F
N
I
D
Y
P
G
G
K
G
D
Y
Site 8
Y71
Y
P
G
G
K
G
D
Y
E
R
L
D
A
I
R
Site 9
Y80
R
L
D
A
I
R
F
Y
Y
G
D
R
V
C
A
Site 10
Y81
L
D
A
I
R
F
Y
Y
G
D
R
V
C
A
R
Site 11
T96
P
L
R
L
E
A
R
T
T
D
W
T
P
A
G
Site 12
T97
L
R
L
E
A
R
T
T
D
W
T
P
A
G
S
Site 13
T100
E
A
R
T
T
D
W
T
P
A
G
S
T
G
Q
Site 14
S104
T
D
W
T
P
A
G
S
T
G
Q
V
V
H
G
Site 15
S112
T
G
Q
V
V
H
G
S
P
R
E
G
F
W
C
Site 16
Y133
P
G
Q
N
C
S
N
Y
T
V
R
F
L
C
P
Site 17
S143
R
F
L
C
P
P
G
S
L
R
R
D
T
E
R
Site 18
T148
P
G
S
L
R
R
D
T
E
R
I
W
S
P
W
Site 19
S153
R
D
T
E
R
I
W
S
P
W
S
P
W
S
K
Site 20
S186
A
E
M
V
S
L
C
S
E
A
S
E
E
G
Q
Site 21
S189
V
S
L
C
S
E
A
S
E
E
G
Q
H
C
M
Site 22
T254
T
K
T
P
K
L
L
T
Q
T
D
S
D
G
R
Site 23
S258
K
L
L
T
Q
T
D
S
D
G
R
F
R
I
P
Site 24
T288
K
F
A
P
I
V
L
T
M
P
K
T
S
L
K
Site 25
T292
I
V
L
T
M
P
K
T
S
L
K
A
A
T
I
Site 26
S293
V
L
T
M
P
K
T
S
L
K
A
A
T
I
K
Site 27
T298
K
T
S
L
K
A
A
T
I
K
A
E
F
V
R
Site 28
T308
A
E
F
V
R
A
E
T
P
Y
M
V
M
N
P
Site 29
Y310
F
V
R
A
E
T
P
Y
M
V
M
N
P
E
T
Site 30
S325
K
A
R
R
A
G
Q
S
V
S
L
C
C
K
A
Site 31
S327
R
R
A
G
Q
S
V
S
L
C
C
K
A
T
G
Site 32
T333
V
S
L
C
C
K
A
T
G
K
P
R
P
D
K
Site 33
Y341
G
K
P
R
P
D
K
Y
F
W
Y
H
N
D
T
Site 34
Y344
R
P
D
K
Y
F
W
Y
H
N
D
T
L
L
D
Site 35
S353
N
D
T
L
L
D
P
S
L
Y
K
H
E
S
K
Site 36
Y355
T
L
L
D
P
S
L
Y
K
H
E
S
K
L
V
Site 37
S359
P
S
L
Y
K
H
E
S
K
L
V
L
R
K
L
Site 38
Y374
Q
Q
H
Q
A
G
E
Y
F
C
K
A
Q
S
D
Site 39
T400
I
V
I
A
S
D
E
T
P
C
N
P
V
P
E
Site 40
S408
P
C
N
P
V
P
E
S
Y
L
I
R
L
P
H
Site 41
Y409
C
N
P
V
P
E
S
Y
L
I
R
L
P
H
D
Site 42
Y426
Q
N
A
T
N
S
F
Y
Y
D
V
G
R
C
P
Site 43
Y427
N
A
T
N
S
F
Y
Y
D
V
G
R
C
P
V
Site 44
T436
V
G
R
C
P
V
K
T
C
A
G
Q
Q
D
N
Site 45
T460
N
C
C
G
I
S
K
T
E
E
R
E
I
Q
C
Site 46
S468
E
E
R
E
I
Q
C
S
G
Y
T
L
P
T
K
Site 47
Y470
R
E
I
Q
C
S
G
Y
T
L
P
T
K
V
A
Site 48
T486
E
C
S
C
Q
R
C
T
E
T
R
S
I
V
R
Site 49
S497
S
I
V
R
G
R
V
S
A
A
D
N
G
E
P
Site 50
Y511
P
M
R
F
G
H
V
Y
M
G
N
S
R
V
S
Site 51
S518
Y
M
G
N
S
R
V
S
M
T
G
Y
K
G
T
Site 52
Y522
S
R
V
S
M
T
G
Y
K
G
T
F
T
L
H
Site 53
T525
S
M
T
G
Y
K
G
T
F
T
L
H
V
P
Q
Site 54
T527
T
G
Y
K
G
T
F
T
L
H
V
P
Q
D
T
Site 55
T540
D
T
E
R
L
V
L
T
F
V
D
R
L
Q
K
Site 56
T551
R
L
Q
K
F
V
N
T
T
K
V
L
P
F
N
Site 57
T552
L
Q
K
F
V
N
T
T
K
V
L
P
F
N
K
Site 58
T578
L
R
R
K
E
P
I
T
L
E
A
M
E
T
N
Site 59
S607
E
L
E
I
P
S
R
S
F
Y
R
Q
N
G
E
Site 60
Y609
E
I
P
S
R
S
F
Y
R
Q
N
G
E
P
Y
Site 61
T625
G
K
V
K
A
S
V
T
F
L
D
P
R
N
I
Site 62
S633
F
L
D
P
R
N
I
S
T
A
T
A
A
Q
T
Site 63
T651
F
I
N
D
E
G
D
T
F
P
L
R
T
Y
G
Site 64
T656
G
D
T
F
P
L
R
T
Y
G
M
F
S
V
D
Site 65
Y657
D
T
F
P
L
R
T
Y
G
M
F
S
V
D
F
Site 66
T669
V
D
F
R
D
E
V
T
S
E
P
L
N
A
G
Site 67
S670
D
F
R
D
E
V
T
S
E
P
L
N
A
G
K
Site 68
T685
V
K
V
H
L
D
S
T
Q
V
K
M
P
E
H
Site 69
T695
K
M
P
E
H
I
S
T
V
K
L
W
S
L
N
Site 70
T705
L
W
S
L
N
P
D
T
G
L
W
E
E
E
G
Site 71
T728
R
N
K
R
E
D
R
T
F
L
V
G
N
L
E
Site 72
S749
F
N
L
D
V
P
E
S
R
R
C
F
V
K
V
Site 73
Y759
C
F
V
K
V
R
A
Y
R
S
E
R
F
L
P
Site 74
S761
V
K
V
R
A
Y
R
S
E
R
F
L
P
S
E
Site 75
T784
V
I
N
L
E
P
R
T
G
F
L
S
N
P
R
Site 76
S788
E
P
R
T
G
F
L
S
N
P
R
A
W
G
R
Site 77
S798
R
A
W
G
R
F
D
S
V
I
T
G
P
N
G
Site 78
S816
P
A
F
C
D
D
Q
S
P
D
A
Y
S
A
Y
Site 79
Y820
D
D
Q
S
P
D
A
Y
S
A
Y
V
L
A
S
Site 80
S821
D
Q
S
P
D
A
Y
S
A
Y
V
L
A
S
L
Site 81
S838
E
E
L
Q
A
V
E
S
S
P
K
F
N
P
N
Site 82
S839
E
L
Q
A
V
E
S
S
P
K
F
N
P
N
A
Site 83
Y853
A
I
G
V
P
Q
P
Y
L
N
K
L
N
Y
R
Site 84
Y859
P
Y
L
N
K
L
N
Y
R
R
T
D
H
E
D
Site 85
T862
N
K
L
N
Y
R
R
T
D
H
E
D
P
R
V
Site 86
T872
E
D
P
R
V
K
K
T
A
F
Q
I
S
M
A
Site 87
S885
M
A
K
P
R
P
N
S
A
E
E
S
N
G
P
Site 88
S889
R
P
N
S
A
E
E
S
N
G
P
I
Y
A
F
Site 89
Y894
E
E
S
N
G
P
I
Y
A
F
E
N
L
R
A
Site 90
S908
A
C
E
E
A
P
P
S
A
A
H
F
R
F
Y
Site 91
Y915
S
A
A
H
F
R
F
Y
Q
I
E
G
D
R
Y
Site 92
Y922
Y
Q
I
E
G
D
R
Y
D
Y
N
T
V
P
F
Site 93
Y924
I
E
G
D
R
Y
D
Y
N
T
V
P
F
N
E
Site 94
T926
G
D
R
Y
D
Y
N
T
V
P
F
N
E
D
D
Site 95
S970
P
L
E
V
N
V
R
S
R
N
M
G
G
T
H
Site 96
T976
R
S
R
N
M
G
G
T
H
R
R
T
V
G
K
Site 97
T980
M
G
G
T
H
R
R
T
V
G
K
L
Y
G
I
Site 98
Y985
R
R
T
V
G
K
L
Y
G
I
R
D
V
R
S
Site 99
S992
Y
G
I
R
D
V
R
S
T
R
D
R
D
Q
P
Site 100
T993
G
I
R
D
V
R
S
T
R
D
R
D
Q
P
N
Site 101
Y1015
F
K
C
S
G
M
L
Y
D
Q
D
R
V
D
R
Site 102
T1023
D
Q
D
R
V
D
R
T
L
V
K
V
I
P
Q
Site 103
S1032
V
K
V
I
P
Q
G
S
C
R
R
A
S
V
N
Site 104
S1037
Q
G
S
C
R
R
A
S
V
N
P
M
L
H
E
Site 105
Y1077
L
G
H
N
Y
G
I
Y
T
V
T
D
Q
D
P
Site 106
T1078
G
H
N
Y
G
I
Y
T
V
T
D
Q
D
P
R
Site 107
T1086
V
T
D
Q
D
P
R
T
A
K
E
I
A
L
G
Site 108
T1099
L
G
R
C
F
D
G
T
S
D
G
S
S
R
I
Site 109
S1100
G
R
C
F
D
G
T
S
D
G
S
S
R
I
M
Site 110
S1104
D
G
T
S
D
G
S
S
R
I
M
K
S
N
V
Site 111
S1128
E
R
Q
V
G
R
Q
S
A
F
Q
Y
L
Q
S
Site 112
Y1132
G
R
Q
S
A
F
Q
Y
L
Q
S
T
P
A
Q
Site 113
T1136
A
F
Q
Y
L
Q
S
T
P
A
Q
S
P
A
A
Site 114
S1140
L
Q
S
T
P
A
Q
S
P
A
A
G
T
V
Q
Site 115
S1152
T
V
Q
G
R
V
P
S
R
R
Q
Q
R
A
S
Site 116
S1159
S
R
R
Q
Q
R
A
S
R
G
G
Q
R
Q
S
Site 117
S1166
S
R
G
G
Q
R
Q
S
G
V
V
A
S
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation