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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP12
Full Name:
Ubiquitin carboxyl-terminal hydrolase 12
Alias:
Deubiquitinating enzyme 12;Ubiquitin thiolesterase 12;Ubiquitin-hydrolyzing enzyme 1;Ubiquitin-specific-processing protease 12
Type:
Mass (Da):
42858
Number AA:
370
UniProt ID:
O75317
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y38
Q
F
P
V
N
E
H
Y
F
G
L
V
N
F
G
Site 2
Y58
N
S
V
L
Q
A
L
Y
F
C
R
P
F
R
E
Site 3
S72
E
K
V
L
A
Y
K
S
Q
P
R
K
K
E
S
Site 4
S79
S
Q
P
R
K
K
E
S
L
L
T
C
L
A
D
Site 5
T82
R
K
K
E
S
L
L
T
C
L
A
D
L
F
H
Site 6
Y120
E
N
E
L
F
D
N
Y
M
Q
Q
D
A
H
E
Site 7
Y131
D
A
H
E
F
L
N
Y
L
L
N
T
I
A
D
Site 8
T166
D
N
E
N
N
N
S
T
P
D
P
T
W
V
H
Site 9
T181
E
I
F
Q
G
T
L
T
N
E
T
R
C
L
T
Site 10
T188
T
N
E
T
R
C
L
T
C
E
T
I
S
S
K
Site 11
S194
L
T
C
E
T
I
S
S
K
D
E
D
F
L
D
Site 12
S203
D
E
D
F
L
D
L
S
V
D
V
E
Q
N
T
Site 13
S211
V
D
V
E
Q
N
T
S
I
T
H
C
L
R
G
Site 14
S220
T
H
C
L
R
G
F
S
N
T
E
T
L
C
S
Site 15
T222
C
L
R
G
F
S
N
T
E
T
L
C
S
E
Y
Site 16
T224
R
G
F
S
N
T
E
T
L
C
S
E
Y
K
Y
Site 17
Y231
T
L
C
S
E
Y
K
Y
Y
C
E
E
C
R
S
Site 18
Y232
L
C
S
E
Y
K
Y
Y
C
E
E
C
R
S
K
Site 19
Y264
L
H
L
K
R
F
K
Y
M
D
Q
L
H
R
Y
Site 20
Y271
Y
M
D
Q
L
H
R
Y
T
K
L
S
Y
R
V
Site 21
T272
M
D
Q
L
H
R
Y
T
K
L
S
Y
R
V
V
Site 22
S275
L
H
R
Y
T
K
L
S
Y
R
V
V
F
P
L
Site 23
Y276
H
R
Y
T
K
L
S
Y
R
V
V
F
P
L
E
Site 24
S290
E
L
R
L
F
N
T
S
G
D
A
T
N
P
D
Site 25
T294
F
N
T
S
G
D
A
T
N
P
D
R
M
Y
D
Site 26
Y318
S
G
P
N
R
G
H
Y
I
A
I
V
K
S
H
Site 27
S352
E
E
F
Y
G
L
T
S
D
I
S
K
N
S
E
Site 28
S355
Y
G
L
T
S
D
I
S
K
N
S
E
S
G
Y
Site 29
S358
T
S
D
I
S
K
N
S
E
S
G
Y
I
L
F
Site 30
Y362
S
K
N
S
E
S
G
Y
I
L
F
Y
Q
S
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation