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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SIN3B
Full Name:
Paired amphipathic helix protein Sin3b
Alias:
Histone deacetylase complex Sin3b; KIAA0700; Paired amphipathic helix Sin3b; SIN3 B, transcription regulator; SIN3 homolog B, transcription regulator; Transcriptional corepressor Sin3b
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
133066
Number AA:
1162
UniProt ID:
O75182
International Prot ID:
IPI00464980
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
A
G
G
G
S
G
G
S
G
A
G
G
P
A
G
Site 2
S22
G
P
A
G
R
G
L
S
G
A
R
W
G
R
S
Site 3
S29
S
G
A
R
W
G
R
S
G
S
A
G
H
E
K
Site 4
S31
A
R
W
G
R
S
G
S
A
G
H
E
K
L
P
Site 5
S57
Q
V
K
I
R
F
G
S
D
P
A
T
Y
N
G
Site 6
T61
R
F
G
S
D
P
A
T
Y
N
G
F
L
E
I
Site 7
S74
E
I
M
K
E
F
K
S
Q
S
I
D
T
P
G
Site 8
T79
F
K
S
Q
S
I
D
T
P
G
V
I
R
R
V
Site 9
S87
P
G
V
I
R
R
V
S
Q
L
F
H
E
H
P
Site 10
S122
N
G
K
L
N
I
Q
S
P
L
T
S
Q
E
N
Site 11
T125
L
N
I
Q
S
P
L
T
S
Q
E
N
S
H
N
Site 12
S126
N
I
Q
S
P
L
T
S
Q
E
N
S
H
N
H
Site 13
S130
P
L
T
S
Q
E
N
S
H
N
H
G
D
G
A
Site 14
Y146
D
F
K
Q
Q
V
P
Y
K
E
D
K
P
Q
V
Site 15
S157
K
P
Q
V
P
L
E
S
D
S
V
E
F
N
N
Site 16
S159
Q
V
P
L
E
S
D
S
V
E
F
N
N
A
I
Site 17
Y168
E
F
N
N
A
I
S
Y
V
N
K
I
K
T
R
Site 18
S185
D
H
P
E
I
Y
R
S
F
L
E
I
L
H
T
Site 19
T192
S
F
L
E
I
L
H
T
Y
Q
K
E
Q
L
N
Site 20
S209
G
R
P
F
R
G
M
S
E
E
E
V
F
T
E
Site 21
T215
M
S
E
E
E
V
F
T
E
V
A
N
L
F
R
Site 22
S229
R
G
Q
E
D
L
L
S
E
F
G
Q
F
L
P
Site 23
S241
F
L
P
E
A
K
R
S
L
F
T
G
N
G
P
Site 24
T262
Q
K
N
E
H
D
K
T
P
E
H
S
R
K
R
Site 25
S266
H
D
K
T
P
E
H
S
R
K
R
S
R
P
S
Site 26
S270
P
E
H
S
R
K
R
S
R
P
S
L
L
R
P
Site 27
S273
S
R
K
R
S
R
P
S
L
L
R
P
V
S
A
Site 28
S279
P
S
L
L
R
P
V
S
A
P
A
K
K
K
M
Site 29
T291
K
K
M
K
L
R
G
T
K
D
L
S
I
A
A
Site 30
S295
L
R
G
T
K
D
L
S
I
A
A
V
G
K
Y
Site 31
S309
Y
G
T
L
Q
E
F
S
F
F
D
K
V
R
R
Site 32
S320
K
V
R
R
V
L
K
S
Q
E
V
Y
E
N
F
Site 33
Y324
V
L
K
S
Q
E
V
Y
E
N
F
L
R
C
I
Site 34
S378
L
S
F
A
P
P
M
S
D
R
S
G
D
G
I
Site 35
S381
A
P
P
M
S
D
R
S
G
D
G
I
S
R
E
Site 36
S386
D
R
S
G
D
G
I
S
R
E
I
D
Y
A
S
Site 37
Y391
G
I
S
R
E
I
D
Y
A
S
C
K
R
I
G
Site 38
S393
S
R
E
I
D
Y
A
S
C
K
R
I
G
S
S
Site 39
S399
A
S
C
K
R
I
G
S
S
Y
R
A
L
P
K
Site 40
S400
S
C
K
R
I
G
S
S
Y
R
A
L
P
K
T
Site 41
Y401
C
K
R
I
G
S
S
Y
R
A
L
P
K
T
Y
Site 42
T407
S
Y
R
A
L
P
K
T
Y
Q
Q
P
K
C
S
Site 43
Y408
Y
R
A
L
P
K
T
Y
Q
Q
P
K
C
S
G
Site 44
T434
T
L
L
Q
G
S
W
T
D
D
Y
C
M
S
K
Site 45
Y437
Q
G
S
W
T
D
D
Y
C
M
S
K
F
K
N
Site 46
Y451
N
T
C
W
I
P
G
Y
S
A
G
V
L
N
D
Site 47
T459
S
A
G
V
L
N
D
T
W
V
S
F
P
S
W
Site 48
S462
V
L
N
D
T
W
V
S
F
P
S
W
S
E
D
Site 49
S465
D
T
W
V
S
F
P
S
W
S
E
D
S
T
F
Site 50
S467
W
V
S
F
P
S
W
S
E
D
S
T
F
V
S
Site 51
S470
F
P
S
W
S
E
D
S
T
F
V
S
S
K
K
Site 52
T471
P
S
W
S
E
D
S
T
F
V
S
S
K
K
T
Site 53
S474
S
E
D
S
T
F
V
S
S
K
K
T
P
Y
E
Site 54
T478
T
F
V
S
S
K
K
T
P
Y
E
E
Q
L
H
Site 55
Y480
V
S
S
K
K
T
P
Y
E
E
Q
L
H
R
C
Site 56
S510
A
T
I
R
V
L
E
S
V
Q
K
K
L
S
R
Site 57
S516
E
S
V
Q
K
K
L
S
R
M
A
P
E
D
Q
Site 58
S531
E
K
F
R
L
D
D
S
L
G
G
T
S
E
V
Site 59
T535
L
D
D
S
L
G
G
T
S
E
V
I
Q
R
R
Site 60
Y545
V
I
Q
R
R
A
I
Y
R
I
Y
G
D
K
A
Site 61
Y548
R
R
A
I
Y
R
I
Y
G
D
K
A
P
E
I
Site 62
S558
K
A
P
E
I
I
E
S
L
K
K
N
P
V
T
Site 63
Y596
N
K
I
W
R
E
Q
Y
E
K
A
Y
L
K
S
Site 64
Y600
R
E
Q
Y
E
K
A
Y
L
K
S
L
D
H
Q
Site 65
S603
Y
E
K
A
Y
L
K
S
L
D
H
Q
A
V
N
Site 66
S623
T
K
A
L
R
S
K
S
L
L
N
E
I
E
S
Site 67
S630
S
L
L
N
E
I
E
S
V
Y
D
E
H
Q
E
Site 68
Y632
L
N
E
I
E
S
V
Y
D
E
H
Q
E
Q
H
Site 69
S640
D
E
H
Q
E
Q
H
S
E
G
R
S
A
P
S
Site 70
S644
E
Q
H
S
E
G
R
S
A
P
S
S
E
P
H
Site 71
S647
S
E
G
R
S
A
P
S
S
E
P
H
L
I
F
Site 72
S648
E
G
R
S
A
P
S
S
E
P
H
L
I
F
V
Site 73
Y656
E
P
H
L
I
F
V
Y
E
D
R
Q
I
L
E
Site 74
T686
I
Q
K
E
D
Q
G
T
I
H
Q
L
L
H
Q
Site 75
S709
Q
Q
L
D
L
G
A
S
E
E
S
A
D
E
D
Site 76
S719
S
A
D
E
D
R
D
S
P
Q
G
Q
T
T
D
Site 77
T724
R
D
S
P
Q
G
Q
T
T
D
P
S
E
R
K
Site 78
S728
Q
G
Q
T
T
D
P
S
E
R
K
K
P
A
P
Site 79
S739
K
P
A
P
G
P
H
S
S
P
P
E
E
K
G
Site 80
S740
P
A
P
G
P
H
S
S
P
P
E
E
K
G
A
Site 81
T754
A
F
G
D
A
P
A
T
E
Q
P
P
L
P
P
Site 82
Y772
H
K
P
L
D
D
V
Y
S
L
F
F
A
N
N
Site 83
S773
K
P
L
D
D
V
Y
S
L
F
F
A
N
N
N
Site 84
Y799
C
S
R
L
L
K
I
Y
R
Q
A
Q
K
Q
L
Site 85
S828
E
G
R
R
E
K
G
S
D
P
A
M
E
L
R
Site 86
S840
E
L
R
L
K
Q
P
S
E
V
E
L
E
E
Y
Site 87
Y847
S
E
V
E
L
E
E
Y
Y
P
A
F
L
D
M
Site 88
S862
V
R
S
L
L
E
G
S
I
D
P
T
Q
Y
E
Site 89
T866
L
E
G
S
I
D
P
T
Q
Y
E
D
T
L
R
Site 90
T871
D
P
T
Q
Y
E
D
T
L
R
E
M
F
T
I
Site 91
S902
R
Q
L
H
H
L
V
S
D
D
V
C
L
K
V
Site 92
Y913
C
L
K
V
V
E
L
Y
L
N
E
K
K
R
G
Site 93
S928
A
A
G
G
N
L
S
S
R
C
V
R
A
A
R
Site 94
T937
C
V
R
A
A
R
E
T
S
Y
Q
W
K
A
E
Site 95
S938
V
R
A
A
R
E
T
S
Y
Q
W
K
A
E
R
Site 96
T973
M
T
I
E
L
L
D
T
E
E
A
Q
T
E
D
Site 97
T978
L
D
T
E
E
A
Q
T
E
D
P
V
E
V
Q
Site 98
Y990
E
V
Q
H
L
A
R
Y
V
E
Q
Y
V
G
T
Site 99
Y994
L
A
R
Y
V
E
Q
Y
V
G
T
E
G
A
S
Site 100
T997
Y
V
E
Q
Y
V
G
T
E
G
A
S
S
S
P
Site 101
S1001
Y
V
G
T
E
G
A
S
S
S
P
T
E
G
F
Site 102
S1002
V
G
T
E
G
A
S
S
S
P
T
E
G
F
L
Site 103
S1003
G
T
E
G
A
S
S
S
P
T
E
G
F
L
L
Site 104
T1005
E
G
A
S
S
S
P
T
E
G
F
L
L
K
P
Site 105
S1028
K
F
R
R
R
W
Q
S
E
Q
A
R
A
L
R
Site 106
S1040
A
L
R
G
E
A
R
S
S
W
K
R
L
V
G
Site 107
S1041
L
R
G
E
A
R
S
S
W
K
R
L
V
G
V
Site 108
S1050
K
R
L
V
G
V
E
S
A
C
D
V
D
C
R
Site 109
S1071
K
M
V
F
I
V
N
S
E
D
Y
M
Y
R
R
Site 110
Y1074
F
I
V
N
S
E
D
Y
M
Y
R
R
G
T
L
Site 111
Y1076
V
N
S
E
D
Y
M
Y
R
R
G
T
L
C
R
Site 112
T1080
D
Y
M
Y
R
R
G
T
L
C
R
A
K
Q
V
Site 113
T1149
H
V
H
G
L
P
V
T
R
Y
R
V
Q
Y
S
Site 114
Y1151
H
G
L
P
V
T
R
Y
R
V
Q
Y
S
R
R
Site 115
Y1155
V
T
R
Y
R
V
Q
Y
S
R
R
P
A
S
P
Site 116
S1156
T
R
Y
R
V
Q
Y
S
R
R
P
A
S
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation