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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAMTS4
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 4
Alias:
ADMP-1;Aggrecanase-1
Type:
Mass (Da):
90225
Number AA:
837
UniProt ID:
O75173
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
Q
T
G
S
H
P
G
R
G
L
A
Site 2
S53
L
P
S
A
R
L
A
S
P
L
P
R
E
E
E
Site 3
S70
F
P
E
K
L
N
G
S
V
L
P
G
S
G
A
Site 4
T126
L
G
G
A
E
P
G
T
Y
L
T
G
T
I
N
Site 5
Y127
G
G
A
E
P
G
T
Y
L
T
G
T
I
N
G
Site 6
T131
P
G
T
Y
L
T
G
T
I
N
G
D
P
E
S
Site 7
S138
T
I
N
G
D
P
E
S
V
A
S
L
H
W
D
Site 8
S141
G
D
P
E
S
V
A
S
L
H
W
D
G
G
A
Site 9
T169
L
Q
P
L
E
G
G
T
P
N
S
A
G
G
P
Site 10
S172
L
E
G
G
T
P
N
S
A
G
G
P
G
A
H
Site 11
S185
A
H
I
L
R
R
K
S
P
A
S
G
Q
G
P
Site 12
S188
L
R
R
K
S
P
A
S
G
Q
G
P
M
C
N
Site 13
S202
N
V
K
A
P
L
G
S
P
S
P
R
P
R
R
Site 14
S204
K
A
P
L
G
S
P
S
P
R
P
R
R
A
K
Site 15
S215
R
R
A
K
R
F
A
S
L
S
R
F
V
E
T
Site 16
Y241
H
G
A
G
L
K
R
Y
L
L
T
V
M
A
A
Site 17
T244
G
L
K
R
Y
L
L
T
V
M
A
A
A
A
K
Site 18
S257
A
K
A
F
K
H
P
S
I
R
N
P
V
S
L
Site 19
S274
T
R
L
V
I
L
G
S
G
E
E
G
P
Q
V
Site 20
S284
E
G
P
Q
V
G
P
S
A
A
Q
T
L
R
S
Site 21
S291
S
A
A
Q
T
L
R
S
F
C
A
W
Q
R
G
Site 22
T301
A
W
Q
R
G
L
N
T
P
E
D
S
D
P
D
Site 23
S305
G
L
N
T
P
E
D
S
D
P
D
H
F
D
T
Site 24
T312
S
D
P
D
H
F
D
T
A
I
L
F
T
R
Q
Site 25
T358
D
G
L
Q
S
A
F
T
A
A
H
E
L
G
H
Site 26
S379
D
N
S
K
P
C
I
S
L
N
G
P
L
S
T
Site 27
T386
S
L
N
G
P
L
S
T
S
R
H
V
M
A
P
Site 28
S405
V
D
P
E
E
P
W
S
P
C
S
A
R
F
I
Site 29
T413
P
C
S
A
R
F
I
T
D
F
L
D
N
G
Y
Site 30
Y420
T
D
F
L
D
N
G
Y
G
H
C
L
L
D
K
Site 31
T437
A
P
L
H
L
P
V
T
F
P
G
K
D
Y
D
Site 32
Y443
V
T
F
P
G
K
D
Y
D
A
D
R
Q
C
Q
Site 33
T452
A
D
R
Q
C
Q
L
T
F
G
P
D
S
R
H
Site 34
S457
Q
L
T
F
G
P
D
S
R
H
C
P
Q
L
P
Site 35
T493
H
S
P
W
A
D
G
T
P
C
G
P
A
Q
A
Site 36
S543
C
G
G
G
V
Q
F
S
S
R
D
C
T
R
P
Site 37
S544
G
G
G
V
Q
F
S
S
R
D
C
T
R
P
V
Site 38
T548
Q
F
S
S
R
D
C
T
R
P
V
P
R
N
G
Site 39
Y558
V
P
R
N
G
G
K
Y
C
E
G
R
R
T
R
Site 40
S568
G
R
R
T
R
F
R
S
C
N
T
E
D
C
P
Site 41
T576
C
N
T
E
D
C
P
T
G
S
A
L
T
F
R
Site 42
T581
C
P
T
G
S
A
L
T
F
R
E
E
Q
C
A
Site 43
Y590
R
E
E
Q
C
A
A
Y
N
H
R
T
D
L
F
Site 44
Y610
P
M
D
W
V
P
R
Y
T
G
V
A
P
Q
D
Site 45
T611
M
D
W
V
P
R
Y
T
G
V
A
P
Q
D
Q
Site 46
Y631
Q
A
R
A
L
G
Y
Y
Y
V
L
E
P
R
V
Site 47
T642
E
P
R
V
V
D
G
T
P
C
S
P
D
S
S
Site 48
S645
V
V
D
G
T
P
C
S
P
D
S
S
S
V
C
Site 49
S648
G
T
P
C
S
P
D
S
S
S
V
C
V
Q
G
Site 50
S649
T
P
C
S
P
D
S
S
S
V
C
V
Q
G
R
Site 51
S650
P
C
S
P
D
S
S
S
V
C
V
Q
G
R
C
Site 52
S683
M
V
C
G
G
D
G
S
G
C
S
K
Q
S
G
Site 53
S686
G
G
D
G
S
G
C
S
K
Q
S
G
S
F
R
Site 54
S689
G
S
G
C
S
K
Q
S
G
S
F
R
K
F
R
Site 55
S691
G
C
S
K
Q
S
G
S
F
R
K
F
R
Y
G
Site 56
Y699
F
R
K
F
R
Y
G
Y
N
N
V
V
T
I
P
Site 57
Y726
N
P
G
H
R
S
I
Y
L
A
L
K
L
P
D
Site 58
Y736
L
K
L
P
D
G
S
Y
A
L
N
G
E
Y
T
Site 59
T743
Y
A
L
N
G
E
Y
T
L
M
P
S
P
T
D
Site 60
S762
G
A
V
S
L
R
Y
S
G
A
T
A
A
S
E
Site 61
T765
S
L
R
Y
S
G
A
T
A
A
S
E
T
L
S
Site 62
S768
Y
S
G
A
T
A
A
S
E
T
L
S
G
H
G
Site 63
T770
G
A
T
A
A
S
E
T
L
S
G
H
G
P
L
Site 64
S772
T
A
A
S
E
T
L
S
G
H
G
P
L
A
Q
Site 65
T794
V
A
G
N
P
Q
D
T
R
L
R
Y
S
F
F
Site 66
Y798
P
Q
D
T
R
L
R
Y
S
F
F
V
P
R
P
Site 67
S799
Q
D
T
R
L
R
Y
S
F
F
V
P
R
P
T
Site 68
T806
S
F
F
V
P
R
P
T
P
S
T
P
R
P
T
Site 69
S808
F
V
P
R
P
T
P
S
T
P
R
P
T
P
Q
Site 70
T809
V
P
R
P
T
P
S
T
P
R
P
T
P
Q
D
Site 71
T813
T
P
S
T
P
R
P
T
P
Q
D
W
L
H
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation