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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
JMJD2A
Full Name:
Lysine-specific demethylase 4A
Alias:
JHD3A; JHDM3A; JMJ2A; JMJD2; jumonji C domain-containing histone demethylase 3A; KIAA0677; lysine (K)-specific demethylase 4A
Type:
Transcription, coactivator/corepressor; EC 1.14.11.-; Oxidoreductase; Demethylase
Mass (Da):
120720
Number AA:
1064
UniProt ID:
O75164
International Prot ID:
IPI00005666
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0051864
GO:0005506
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
GO:0016577
GO:0044419
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
S
E
S
E
T
L
N
P
S
A
Site 2
T7
_
M
A
S
E
S
E
T
L
N
P
S
A
R
I
Site 3
S11
E
S
E
T
L
N
P
S
A
R
I
M
T
F
Y
Site 4
T16
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
Site 5
Y18
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
Site 6
S28
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
Site 7
Y30
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
Site 8
Y33
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
Site 9
S36
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
Site 10
S58
K
E
W
K
P
R
A
S
Y
D
D
I
D
D
L
Site 11
Y59
E
W
K
P
R
A
S
Y
D
D
I
D
D
L
V
Site 12
T83
T
G
Q
S
G
L
F
T
Q
Y
N
I
Q
K
K
Site 13
T93
N
I
Q
K
K
A
M
T
V
R
E
F
R
K
I
Site 14
S103
E
F
R
K
I
A
N
S
D
K
Y
C
T
P
R
Site 15
Y106
K
I
A
N
S
D
K
Y
C
T
P
R
Y
S
E
Site 16
T108
A
N
S
D
K
Y
C
T
P
R
Y
S
E
F
E
Site 17
Y111
D
K
Y
C
T
P
R
Y
S
E
F
E
E
L
E
Site 18
S112
K
Y
C
T
P
R
Y
S
E
F
E
E
L
E
R
Site 19
Y121
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
N
Site 20
Y132
L
T
F
N
P
P
I
Y
G
A
D
V
N
G
T
Site 21
Y141
A
D
V
N
G
T
L
Y
E
K
H
V
D
E
W
Site 22
T155
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
Site 23
T167
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Site 24
Y175
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
Site 25
Y177
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
Site 26
Y195
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
Site 27
Y199
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
Site 28
S207
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
Site 29
Y209
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
Site 30
S210
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
Site 31
S230
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
Site 32
S233
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
Site 33
S246
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
Site 34
Y253
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
Site 35
T261
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
Site 36
T270
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
Site 37
Y299
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
Site 38
S316
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
Site 39
T339
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
Site 40
T344
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
Site 41
T387
G
E
E
G
D
L
K
T
S
L
A
K
H
R
I
Site 42
S388
E
E
G
D
L
K
T
S
L
A
K
H
R
I
G
Site 43
T396
L
A
K
H
R
I
G
T
K
R
H
R
V
C
L
Site 44
S410
L
E
I
P
Q
E
V
S
Q
S
E
L
F
P
K
Site 45
S412
I
P
Q
E
V
S
Q
S
E
L
F
P
K
E
D
Site 46
S421
L
F
P
K
E
D
L
S
S
E
Q
Y
E
M
T
Site 47
S422
F
P
K
E
D
L
S
S
E
Q
Y
E
M
T
E
Site 48
Y425
E
D
L
S
S
E
Q
Y
E
M
T
E
C
P
A
Site 49
T428
S
S
E
Q
Y
E
M
T
E
C
P
A
A
L
A
Site 50
T440
A
L
A
P
V
R
P
T
H
S
S
V
R
Q
V
Site 51
S443
P
V
R
P
T
H
S
S
V
R
Q
V
E
D
G
Site 52
T452
R
Q
V
E
D
G
L
T
F
P
D
Y
S
D
S
Site 53
Y456
D
G
L
T
F
P
D
Y
S
D
S
T
E
V
K
Site 54
S457
G
L
T
F
P
D
Y
S
D
S
T
E
V
K
F
Site 55
S459
T
F
P
D
Y
S
D
S
T
E
V
K
F
E
E
Site 56
T460
F
P
D
Y
S
D
S
T
E
V
K
F
E
E
L
Site 57
S502
V
G
G
R
L
V
F
S
G
S
K
K
K
S
S
Site 58
S504
G
R
L
V
F
S
G
S
K
K
K
S
S
S
S
Site 59
S508
F
S
G
S
K
K
K
S
S
S
S
L
G
S
G
Site 60
S509
S
G
S
K
K
K
S
S
S
S
L
G
S
G
S
Site 61
S510
G
S
K
K
K
S
S
S
S
L
G
S
G
S
S
Site 62
S511
S
K
K
K
S
S
S
S
L
G
S
G
S
S
R
Site 63
S514
K
S
S
S
S
L
G
S
G
S
S
R
D
S
I
Site 64
S516
S
S
S
L
G
S
G
S
S
R
D
S
I
S
S
Site 65
S517
S
S
L
G
S
G
S
S
R
D
S
I
S
S
D
Site 66
S520
G
S
G
S
S
R
D
S
I
S
S
D
S
E
T
Site 67
S522
G
S
S
R
D
S
I
S
S
D
S
E
T
S
E
Site 68
S523
S
S
R
D
S
I
S
S
D
S
E
T
S
E
P
Site 69
S525
R
D
S
I
S
S
D
S
E
T
S
E
P
L
S
Site 70
T527
S
I
S
S
D
S
E
T
S
E
P
L
S
C
R
Site 71
S528
I
S
S
D
S
E
T
S
E
P
L
S
C
R
A
Site 72
S532
S
E
T
S
E
P
L
S
C
R
A
Q
G
Q
T
Site 73
T539
S
C
R
A
Q
G
Q
T
G
V
L
T
V
H
S
Site 74
T543
Q
G
Q
T
G
V
L
T
V
H
S
Y
A
K
G
Site 75
S546
T
G
V
L
T
V
H
S
Y
A
K
G
D
G
R
Site 76
Y547
G
V
L
T
V
H
S
Y
A
K
G
D
G
R
V
Site 77
T555
A
K
G
D
G
R
V
T
V
G
E
P
C
T
R
Site 78
S566
P
C
T
R
K
K
G
S
A
A
R
S
F
S
E
Site 79
S570
K
K
G
S
A
A
R
S
F
S
E
R
E
L
A
Site 80
S572
G
S
A
A
R
S
F
S
E
R
E
L
A
E
V
Site 81
Y583
L
A
E
V
A
D
E
Y
M
F
S
L
E
E
N
Site 82
S586
V
A
D
E
Y
M
F
S
L
E
E
N
K
K
S
Site 83
S593
S
L
E
E
N
K
K
S
K
G
R
R
Q
P
L
Site 84
S601
K
G
R
R
Q
P
L
S
K
L
P
R
H
H
P
Site 85
S616
L
V
L
Q
E
C
V
S
D
D
E
T
S
E
Q
Site 86
T620
E
C
V
S
D
D
E
T
S
E
Q
L
T
P
E
Site 87
T625
D
E
T
S
E
Q
L
T
P
E
E
E
A
E
E
Site 88
T633
P
E
E
E
A
E
E
T
E
A
W
A
K
P
L
Site 89
S641
E
A
W
A
K
P
L
S
Q
L
W
Q
N
R
P
Site 90
T660
A
E
K
E
F
N
E
T
M
A
Q
Q
A
P
H
Site 91
T714
P
E
M
C
F
T
S
T
G
C
S
T
D
I
N
Site 92
S723
C
S
T
D
I
N
L
S
T
P
Y
L
E
E
D
Site 93
T724
S
T
D
I
N
L
S
T
P
Y
L
E
E
D
G
Site 94
Y726
D
I
N
L
S
T
P
Y
L
E
E
D
G
T
S
Site 95
T732
P
Y
L
E
E
D
G
T
S
I
L
V
S
C
K
Site 96
S733
Y
L
E
E
D
G
T
S
I
L
V
S
C
K
K
Site 97
S737
D
G
T
S
I
L
V
S
C
K
K
C
S
V
R
Site 98
S758
G
V
P
P
A
K
A
S
E
D
W
M
C
S
R
Site 99
S779
E
E
D
C
C
L
C
S
L
R
G
G
A
L
Q
Site 100
S819
E
R
S
P
V
D
V
S
K
I
P
L
P
R
F
Site 101
T840
C
K
K
R
R
K
R
T
A
G
C
C
V
Q
C
Site 102
S898
R
A
K
G
A
L
Q
S
I
T
A
G
Q
K
V
Site 103
Y915
K
H
K
N
G
R
F
Y
Q
C
E
V
V
R
L
Site 104
T923
Q
C
E
V
V
R
L
T
T
E
T
F
Y
E
V
Site 105
T924
C
E
V
V
R
L
T
T
E
T
F
Y
E
V
N
Site 106
T926
V
V
R
L
T
T
E
T
F
Y
E
V
N
F
D
Site 107
Y928
R
L
T
T
E
T
F
Y
E
V
N
F
D
D
G
Site 108
S936
E
V
N
F
D
D
G
S
F
S
D
N
L
Y
P
Site 109
S938
N
F
D
D
G
S
F
S
D
N
L
Y
P
E
D
Site 110
Y942
G
S
F
S
D
N
L
Y
P
E
D
I
V
S
Q
Site 111
S948
L
Y
P
E
D
I
V
S
Q
D
C
L
Q
F
G
Site 112
T968
E
V
V
Q
V
R
W
T
D
G
Q
V
Y
G
A
Site 113
Y973
R
W
T
D
G
Q
V
Y
G
A
K
F
V
A
S
Site 114
Y986
A
S
H
P
I
Q
M
Y
Q
V
E
F
E
D
G
Site 115
S994
Q
V
E
F
E
D
G
S
Q
L
V
V
K
R
D
Site 116
Y1004
V
V
K
R
D
D
V
Y
T
L
D
E
E
L
P
Site 117
T1005
V
K
R
D
D
V
Y
T
L
D
E
E
L
P
K
Site 118
S1016
E
L
P
K
R
V
K
S
R
L
S
V
A
S
D
Site 119
S1019
K
R
V
K
S
R
L
S
V
A
S
D
M
R
F
Site 120
S1022
K
S
R
L
S
V
A
S
D
M
R
F
N
E
I
Site 121
S1047
K
R
Q
R
V
I
N
S
R
Y
R
E
D
Y
I
Site 122
Y1053
N
S
R
Y
R
E
D
Y
I
E
P
A
L
Y
R
Site 123
Y1059
D
Y
I
E
P
A
L
Y
R
A
I
M
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation