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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NPHP4
Full Name:
Nephrocystin-4
Alias:
KIAA0673; Nephronophthisis 4; Nephroretinin; Senior-Loken syndrome 4; SLSN4
Type:
Cytoskeletal protein
Mass (Da):
157600
Number AA:
UniProt ID:
O75161
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005929
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0016337
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
N
D
W
H
R
I
F
T
Q
N
V
L
V
P
P
Site 2
Y67
V
S
F
F
D
V
T
Y
R
H
F
F
G
R
T
Site 3
T77
F
F
G
R
T
W
K
T
T
V
K
P
T
K
R
Site 4
T78
F
G
R
T
W
K
T
T
V
K
P
T
K
R
P
Site 5
T82
W
K
T
T
V
K
P
T
K
R
P
P
S
R
I
Site 6
S87
K
P
T
K
R
P
P
S
R
I
V
F
N
E
P
Site 7
Y96
I
V
F
N
E
P
L
Y
F
H
T
S
L
N
H
Site 8
S122
E
G
K
K
R
D
G
S
L
Q
T
L
S
C
G
Site 9
T125
K
R
D
G
S
L
Q
T
L
S
C
G
F
G
I
Site 10
S142
I
F
S
N
Q
P
D
S
P
I
S
A
S
Q
D
Site 11
S145
N
Q
P
D
S
P
I
S
A
S
Q
D
K
R
L
Site 12
S147
P
D
S
P
I
S
A
S
Q
D
K
R
L
R
L
Site 13
Y155
Q
D
K
R
L
R
L
Y
H
G
T
P
R
A
L
Site 14
T158
R
L
R
L
Y
H
G
T
P
R
A
L
L
H
P
Site 15
T178
A
E
Q
N
R
H
M
T
L
I
E
N
C
S
L
Site 16
S184
M
T
L
I
E
N
C
S
L
Q
Y
T
L
K
P
Site 17
T188
E
N
C
S
L
Q
Y
T
L
K
P
H
P
A
L
Site 18
T247
H
L
D
D
L
F
F
T
L
Y
P
S
L
E
K
Site 19
Y249
D
D
L
F
F
T
L
Y
P
S
L
E
K
F
E
Site 20
S251
L
F
F
T
L
Y
P
S
L
E
K
F
E
E
E
Site 21
T315
P
E
M
D
V
A
L
T
R
S
A
S
F
S
R
Site 22
S317
M
D
V
A
L
T
R
S
A
S
F
S
R
K
V
Site 23
S319
V
A
L
T
R
S
A
S
F
S
R
K
V
V
S
Site 24
S321
L
T
R
S
A
S
F
S
R
K
V
V
S
S
S
Site 25
S326
S
F
S
R
K
V
V
S
S
S
K
T
S
S
G
Site 26
S327
F
S
R
K
V
V
S
S
S
K
T
S
S
G
S
Site 27
S328
S
R
K
V
V
S
S
S
K
T
S
S
G
S
Q
Site 28
T330
K
V
V
S
S
S
K
T
S
S
G
S
Q
A
L
Site 29
S331
V
V
S
S
S
K
T
S
S
G
S
Q
A
L
V
Site 30
S332
V
S
S
S
K
T
S
S
G
S
Q
A
L
V
L
Site 31
S334
S
S
K
T
S
S
G
S
Q
A
L
V
L
R
S
Site 32
S366
Q
L
E
Y
V
F
S
S
P
A
G
V
D
G
N
Site 33
S402
N
P
L
L
E
A
D
S
G
R
V
T
L
P
L
Site 34
T406
E
A
D
S
G
R
V
T
L
P
L
Q
G
G
I
Site 35
Y423
N
P
S
H
C
L
V
Y
K
V
P
S
A
S
M
Site 36
S427
C
L
V
Y
K
V
P
S
A
S
M
S
S
E
E
Site 37
S429
V
Y
K
V
P
S
A
S
M
S
S
E
E
V
K
Site 38
S431
K
V
P
S
A
S
M
S
S
E
E
V
K
Q
V
Site 39
T442
V
K
Q
V
E
S
G
T
L
R
F
Q
F
S
L
Site 40
S448
G
T
L
R
F
Q
F
S
L
G
S
E
E
H
L
Site 41
S451
R
F
Q
F
S
L
G
S
E
E
H
L
D
A
P
Site 42
T459
E
E
H
L
D
A
P
T
E
P
V
S
G
P
K
Site 43
S463
D
A
P
T
E
P
V
S
G
P
K
V
E
R
R
Site 44
S472
P
K
V
E
R
R
P
S
R
K
P
P
T
S
P
Site 45
T477
R
P
S
R
K
P
P
T
S
P
S
S
P
P
A
Site 46
S478
P
S
R
K
P
P
T
S
P
S
S
P
P
A
P
Site 47
S480
R
K
P
P
T
S
P
S
S
P
P
A
P
V
P
Site 48
S481
K
P
P
T
S
P
S
S
P
P
A
P
V
P
R
Site 49
S510
S
I
S
Q
L
A
A
S
P
R
S
P
T
Q
H
Site 50
S513
Q
L
A
A
S
P
R
S
P
T
Q
H
C
L
A
Site 51
T515
A
A
S
P
R
S
P
T
Q
H
C
L
A
R
P
Site 52
T523
Q
H
C
L
A
R
P
T
S
Q
L
P
H
G
S
Site 53
S524
H
C
L
A
R
P
T
S
Q
L
P
H
G
S
Q
Site 54
S530
T
S
Q
L
P
H
G
S
Q
A
S
P
A
Q
A
Site 55
S533
L
P
H
G
S
Q
A
S
P
A
Q
A
Q
E
F
Site 56
S554
S
H
L
E
A
D
L
S
Q
T
S
L
V
L
E
Site 57
S563
T
S
L
V
L
E
T
S
I
A
E
Q
L
Q
E
Site 58
T584
H
A
P
I
V
V
G
T
Q
T
R
S
S
A
G
Site 59
S588
V
V
G
T
Q
T
R
S
S
A
G
Q
P
S
R
Site 60
S589
V
G
T
Q
T
R
S
S
A
G
Q
P
S
R
A
Site 61
S594
R
S
S
A
G
Q
P
S
R
A
S
M
V
L
L
Site 62
S597
A
G
Q
P
S
R
A
S
M
V
L
L
Q
S
S
Site 63
T627
V
S
A
T
E
P
V
T
F
N
P
Q
K
E
E
Site 64
S635
F
N
P
Q
K
E
E
S
D
C
L
Q
S
N
E
Site 65
T660
V
A
Q
D
C
R
G
T
S
W
P
K
T
V
Y
Site 66
Y667
T
S
W
P
K
T
V
Y
F
T
F
Q
F
Y
R
Site 67
T679
F
Y
R
F
P
P
A
T
T
P
R
L
Q
L
V
Site 68
T680
Y
R
F
P
P
A
T
T
P
R
L
Q
L
V
Q
Site 69
S695
L
D
E
A
G
Q
P
S
S
G
A
L
T
H
I
Site 70
S696
D
E
A
G
Q
P
S
S
G
A
L
T
H
I
L
Site 71
T711
V
P
V
S
R
D
G
T
F
D
A
G
S
P
G
Site 72
S716
D
G
T
F
D
A
G
S
P
G
F
Q
L
R
Y
Site 73
Y741
E
R
R
C
F
A
R
Y
L
A
V
Q
T
L
Q
Site 74
T789
H
E
L
E
V
V
A
T
E
Y
E
Q
D
N
M
Site 75
S799
E
Q
D
N
M
V
V
S
G
D
M
L
G
F
G
Site 76
T824
V
K
G
R
L
H
L
T
L
A
N
V
G
H
P
Site 77
S840
E
Q
K
V
R
G
C
S
T
L
P
P
S
R
S
Site 78
T841
Q
K
V
R
G
C
S
T
L
P
P
S
R
S
R
Site 79
S845
G
C
S
T
L
P
P
S
R
S
R
V
I
S
N
Site 80
S847
S
T
L
P
P
S
R
S
R
V
I
S
N
D
G
Site 81
S851
P
S
R
S
R
V
I
S
N
D
G
A
S
R
F
Site 82
S856
V
I
S
N
D
G
A
S
R
F
S
G
G
S
L
Site 83
S859
N
D
G
A
S
R
F
S
G
G
S
L
L
T
T
Site 84
S862
A
S
R
F
S
G
G
S
L
L
T
T
G
S
S
Site 85
T865
F
S
G
G
S
L
L
T
T
G
S
S
R
R
K
Site 86
T866
S
G
G
S
L
L
T
T
G
S
S
R
R
K
H
Site 87
S868
G
S
L
L
T
T
G
S
S
R
R
K
H
V
V
Site 88
S869
S
L
L
T
T
G
S
S
R
R
K
H
V
V
Q
Site 89
T893
E
L
A
A
M
L
L
T
H
A
R
Q
G
K
G
Site 90
S908
P
Q
D
V
S
R
E
S
D
A
T
R
R
R
K
Site 91
T911
V
S
R
E
S
D
A
T
R
R
R
K
L
E
R
Site 92
S921
R
K
L
E
R
M
R
S
V
R
L
Q
E
A
G
Site 93
T936
G
D
L
G
R
R
G
T
S
V
L
A
Q
Q
S
Site 94
S937
D
L
G
R
R
G
T
S
V
L
A
Q
Q
S
V
Site 95
S943
T
S
V
L
A
Q
Q
S
V
R
T
Q
H
L
R
Site 96
T962
I
A
A
Y
R
E
R
T
K
A
E
S
I
A
S
Site 97
S966
R
E
R
T
K
A
E
S
I
A
S
L
L
S
L
Site 98
T1004
N
P
H
N
T
Q
H
T
V
T
V
E
I
D
N
Site 99
S1015
E
I
D
N
P
E
L
S
V
I
V
D
S
Q
E
Site 100
S1020
E
L
S
V
I
V
D
S
Q
E
W
R
D
F
K
Site 101
T1034
K
G
A
A
G
L
H
T
P
V
E
E
D
M
F
Site 102
Y1052
G
S
L
A
P
Q
L
Y
L
R
P
H
E
T
A
Site 103
S1079
Q
L
A
M
V
Q
A
S
P
G
L
S
N
E
K
Site 104
S1083
V
Q
A
S
P
G
L
S
N
E
K
G
M
D
A
Site 105
S1092
E
K
G
M
D
A
V
S
P
W
K
S
S
A
V
Site 106
S1096
D
A
V
S
P
W
K
S
S
A
V
P
T
K
H
Site 107
S1097
A
V
S
P
W
K
S
S
A
V
P
T
K
H
A
Site 108
T1101
W
K
S
S
A
V
P
T
K
H
A
K
V
L
F
Site 109
S1142
R
F
Y
H
P
E
L
S
F
L
K
K
A
I
R
Site 110
S1175
P
P
V
H
V
R
C
S
D
P
N
V
I
C
E
Site 111
T1183
D
P
N
V
I
C
E
T
Q
N
V
G
P
G
E
Site 112
S1203
L
K
V
A
S
G
P
S
P
E
I
K
D
F
F
Site 113
T1221
Y
S
D
R
W
L
A
T
P
T
Q
T
W
Q
V
Site 114
Y1229
P
T
Q
T
W
Q
V
Y
L
H
S
L
Q
R
V
Site 115
S1232
T
W
Q
V
Y
L
H
S
L
Q
R
V
D
V
S
Site 116
T1255
L
S
L
V
L
R
G
T
Q
T
V
R
K
V
R
Site 117
T1265
V
R
K
V
R
A
F
T
S
H
P
Q
E
L
K
Site 118
S1266
R
K
V
R
A
F
T
S
H
P
Q
E
L
K
T
Site 119
T1273
S
H
P
Q
E
L
K
T
D
P
K
G
V
F
V
Site 120
T1351
K
G
V
N
K
R
I
T
Y
T
N
P
Y
P
S
Site 121
Y1352
G
V
N
K
R
I
T
Y
T
N
P
Y
P
S
R
Site 122
Y1356
R
I
T
Y
T
N
P
Y
P
S
R
R
T
F
H
Site 123
T1361
N
P
Y
P
S
R
R
T
F
H
L
H
S
D
H
Site 124
S1366
R
R
T
F
H
L
H
S
D
H
P
E
L
L
R
Site 125
S1378
L
L
R
F
R
E
D
S
F
Q
V
G
G
G
E
Site 126
S1396
I
G
L
Q
F
A
P
S
Q
R
V
G
E
E
E
Site 127
Y1407
G
E
E
E
I
L
I
Y
I
N
D
H
E
D
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation