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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TSC22D2
Full Name:
TSC22 domain family protein 2
Alias:
KIAA0669; T22D2; TILZ4; TILZ4a; TILZ4b; TILZ4c; TSC22 domain family 2; TSC22 domain family, member 2; TSC22-related-inducible leucine zipper protein 4
Type:
Unknown function
Mass (Da):
79228
Number AA:
780
UniProt ID:
O75157
International Prot ID:
IPI00477806
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
K
M
P
A
K
K
K
S
C
F
Q
I
T
S
V
Site 2
S32
S
I
T
E
D
T
E
S
L
D
D
P
D
E
S
Site 3
S39
S
L
D
D
P
D
E
S
R
T
E
D
V
S
S
Site 4
T41
D
D
P
D
E
S
R
T
E
D
V
S
S
E
I
Site 5
S45
E
S
R
T
E
D
V
S
S
E
I
F
D
V
S
Site 6
S46
S
R
T
E
D
V
S
S
E
I
F
D
V
S
R
Site 7
S52
S
S
E
I
F
D
V
S
R
A
T
D
Y
G
P
Site 8
T55
I
F
D
V
S
R
A
T
D
Y
G
P
E
E
V
Site 9
Y57
D
V
S
R
A
T
D
Y
G
P
E
E
V
C
E
Site 10
S66
P
E
E
V
C
E
R
S
S
S
E
E
T
L
N
Site 11
S67
E
E
V
C
E
R
S
S
S
E
E
T
L
N
N
Site 12
S68
E
V
C
E
R
S
S
S
E
E
T
L
N
N
V
Site 13
T71
E
R
S
S
S
E
E
T
L
N
N
V
G
D
A
Site 14
T80
N
N
V
G
D
A
E
T
P
G
T
V
S
P
N
Site 15
T83
G
D
A
E
T
P
G
T
V
S
P
N
L
L
L
Site 16
S85
A
E
T
P
G
T
V
S
P
N
L
L
L
D
G
Site 17
T148
G
S
S
A
G
P
V
T
A
A
P
S
Q
P
P
Site 18
S152
G
P
V
T
A
A
P
S
Q
P
P
T
T
C
S
Site 19
T156
A
A
P
S
Q
P
P
T
T
C
S
S
R
F
R
Site 20
T157
A
P
S
Q
P
P
T
T
C
S
S
R
F
R
V
Site 21
S159
S
Q
P
P
T
T
C
S
S
R
F
R
V
I
K
Site 22
S171
V
I
K
L
D
H
G
S
G
E
P
Y
R
R
G
Site 23
Y175
D
H
G
S
G
E
P
Y
R
R
G
R
W
T
C
Site 24
Y185
G
R
W
T
C
M
E
Y
Y
E
R
D
S
D
S
Site 25
Y186
R
W
T
C
M
E
Y
Y
E
R
D
S
D
S
S
Site 26
S190
M
E
Y
Y
E
R
D
S
D
S
S
V
L
T
R
Site 27
S192
Y
Y
E
R
D
S
D
S
S
V
L
T
R
S
G
Site 28
S193
Y
E
R
D
S
D
S
S
V
L
T
R
S
G
D
Site 29
T196
D
S
D
S
S
V
L
T
R
S
G
D
C
I
R
Site 30
S198
D
S
S
V
L
T
R
S
G
D
C
I
R
H
S
Site 31
S205
S
G
D
C
I
R
H
S
S
T
F
D
Q
T
A
Site 32
S206
G
D
C
I
R
H
S
S
T
F
D
Q
T
A
E
Site 33
T207
D
C
I
R
H
S
S
T
F
D
Q
T
A
E
R
Site 34
T211
H
S
S
T
F
D
Q
T
A
E
R
D
S
G
L
Site 35
S216
D
Q
T
A
E
R
D
S
G
L
G
A
T
G
G
Site 36
S240
Q
G
A
H
G
P
E
S
G
T
D
S
S
L
T
Site 37
S244
G
P
E
S
G
T
D
S
S
L
T
A
V
S
Q
Site 38
S245
P
E
S
G
T
D
S
S
L
T
A
V
S
Q
L
Site 39
T247
S
G
T
D
S
S
L
T
A
V
S
Q
L
P
P
Site 40
S250
D
S
S
L
T
A
V
S
Q
L
P
P
S
E
K
Site 41
S255
A
V
S
Q
L
P
P
S
E
K
M
S
Q
P
T
Site 42
S259
L
P
P
S
E
K
M
S
Q
P
T
P
A
Q
P
Site 43
T262
S
E
K
M
S
Q
P
T
P
A
Q
P
Q
S
F
Site 44
S268
P
T
P
A
Q
P
Q
S
F
S
V
G
Q
P
Q
Site 45
S270
P
A
Q
P
Q
S
F
S
V
G
Q
P
Q
P
P
Site 46
T323
G
A
G
P
G
G
Q
T
L
P
P
T
N
V
T
Site 47
T327
G
G
Q
T
L
P
P
T
N
V
T
L
A
Q
P
Site 48
S337
T
L
A
Q
P
A
M
S
L
P
P
Q
P
G
P
Site 49
Y359
Q
Q
P
Q
Q
F
A
Y
P
Q
P
Q
I
P
P
Site 50
S375
H
L
L
P
V
Q
P
S
G
Q
S
E
Y
L
Q
Site 51
S392
V
A
G
L
Q
P
P
S
P
A
Q
P
S
S
T
Site 52
S397
P
P
S
P
A
Q
P
S
S
T
G
A
A
A
S
Site 53
S398
P
S
P
A
Q
P
S
S
T
G
A
A
A
S
P
Site 54
S421
G
T
G
Q
N
A
S
S
V
G
A
Q
L
M
G
Site 55
S430
G
A
Q
L
M
G
A
S
S
Q
P
S
E
A
M
Site 56
S431
A
Q
L
M
G
A
S
S
Q
P
S
E
A
M
A
Site 57
S434
M
G
A
S
S
Q
P
S
E
A
M
A
P
R
T
Site 58
T441
S
E
A
M
A
P
R
T
G
P
A
Q
G
G
Q
Site 59
S480
A
G
A
G
Q
P
Q
S
V
P
P
P
Q
M
G
Site 60
S489
P
P
P
Q
M
G
G
S
G
P
L
S
A
V
P
Site 61
S493
M
G
G
S
G
P
L
S
A
V
P
G
G
P
H
Site 62
S538
V
P
A
P
L
A
Q
S
Q
Q
L
S
S
H
T
Site 63
S542
L
A
Q
S
Q
Q
L
S
S
H
T
P
V
S
R
Site 64
S543
A
Q
S
Q
Q
L
S
S
H
T
P
V
S
R
S
Site 65
T545
S
Q
Q
L
S
S
H
T
P
V
S
R
S
S
S
Site 66
S548
L
S
S
H
T
P
V
S
R
S
S
S
I
I
Q
Site 67
S550
S
H
T
P
V
S
R
S
S
S
I
I
Q
H
V
Site 68
S551
H
T
P
V
S
R
S
S
S
I
I
Q
H
V
G
Site 69
S567
P
L
A
P
G
T
H
S
A
P
T
S
L
P
Q
Site 70
T570
P
G
T
H
S
A
P
T
S
L
P
Q
S
D
L
Site 71
S571
G
T
H
S
A
P
T
S
L
P
Q
S
D
L
S
Site 72
S575
A
P
T
S
L
P
Q
S
D
L
S
Q
F
Q
T
Site 73
S578
S
L
P
Q
S
D
L
S
Q
F
Q
T
Q
T
Q
Site 74
T582
S
D
L
S
Q
F
Q
T
Q
T
Q
P
L
V
G
Site 75
T594
L
V
G
Q
V
D
D
T
R
R
K
S
E
P
L
Site 76
S598
V
D
D
T
R
R
K
S
E
P
L
P
Q
P
P
Site 77
S607
P
L
P
Q
P
P
L
S
L
I
A
E
N
K
P
Site 78
S656
G
D
E
D
R
N
P
S
T
A
F
Y
Q
A
F
Site 79
Y660
R
N
P
S
T
A
F
Y
Q
A
F
H
L
N
T
Site 80
T667
Y
Q
A
F
H
L
N
T
L
K
E
S
K
S
L
Site 81
S673
N
T
L
K
E
S
K
S
L
W
D
S
A
S
G
Site 82
S677
E
S
K
S
L
W
D
S
A
S
G
G
G
V
V
Site 83
Y703
L
V
K
S
H
L
M
Y
A
V
R
E
E
V
E
Site 84
S724
K
E
L
V
E
R
N
S
L
L
E
R
E
N
A
Site 85
S735
R
E
N
A
L
L
K
S
L
S
S
N
D
Q
L
Site 86
S737
N
A
L
L
K
S
L
S
S
N
D
Q
L
S
Q
Site 87
S738
A
L
L
K
S
L
S
S
N
D
Q
L
S
Q
L
Site 88
S743
L
S
S
N
D
Q
L
S
Q
L
P
T
Q
Q
A
Site 89
T747
D
Q
L
S
Q
L
P
T
Q
Q
A
N
P
G
S
Site 90
S754
T
Q
Q
A
N
P
G
S
T
S
Q
Q
Q
A
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation