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Updated November 2019
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Protein Info
Short Name:
DEPDC5
Full Name:
DEP domain-containing protein 5
Alias:
DEP domain containing 5; DEP.5; DEPD5; KIAA0645
Type:
Unknown function
Mass (Da):
177910
Number AA:
1572
UniProt ID:
O75140
International Prot ID:
IPI00005665
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
R
T
T
K
V
Y
K
L
V
I
H
K
K
Site 2
Y48
I
A
H
P
N
D
E
Y
S
P
L
L
L
Q
V
Site 3
S49
A
H
P
N
D
E
Y
S
P
L
L
L
Q
V
K
Site 4
S57
P
L
L
L
Q
V
K
S
L
K
E
D
L
Q
K
Site 5
Y82
Q
V
F
R
L
R
P
Y
Q
D
V
Y
V
N
V
Site 6
Y86
L
R
P
Y
Q
D
V
Y
V
N
V
V
D
P
K
Site 7
Y108
E
L
T
F
K
D
Q
Y
I
G
R
G
D
M
W
Site 8
T124
L
K
K
S
L
V
S
T
C
A
Y
I
T
Q
K
Site 9
T160
C
G
Y
I
S
E
D
T
R
V
V
F
R
S
T
Site 10
Y187
E
M
W
D
F
D
I
Y
G
D
L
Y
F
E
K
Site 11
Y191
F
D
I
Y
G
D
L
Y
F
E
K
A
V
N
G
Site 12
T205
G
F
L
A
D
L
F
T
K
W
K
E
K
N
C
Site 13
T217
K
N
C
S
H
E
V
T
V
V
L
F
S
R
T
Site 14
Y226
V
L
F
S
R
T
F
Y
D
A
K
S
V
D
E
Site 15
S230
R
T
F
Y
D
A
K
S
V
D
E
F
P
E
I
Site 16
S241
F
P
E
I
N
R
A
S
I
R
Q
D
H
K
G
Site 17
Y251
Q
D
H
K
G
R
F
Y
E
D
F
Y
K
V
V
Site 18
Y255
G
R
F
Y
E
D
F
Y
K
V
V
V
Q
N
E
Site 19
S269
E
R
R
E
E
W
T
S
L
L
V
T
I
K
K
Site 20
T273
E
W
T
S
L
L
V
T
I
K
K
L
F
I
Q
Site 21
S299
G
F
P
Q
G
D
N
S
T
S
A
Q
G
N
Y
Site 22
Y306
S
T
S
A
Q
G
N
Y
L
E
A
I
N
L
S
Site 23
Y321
F
N
V
F
D
K
H
Y
I
N
R
N
F
D
R
Site 24
T329
I
N
R
N
F
D
R
T
G
Q
M
S
V
V
I
Site 25
T353
D
R
L
L
M
I
L
T
K
Q
R
M
I
D
N
Site 26
S386
L
F
K
L
H
N
R
S
A
P
R
D
S
R
L
Site 27
S391
N
R
S
A
P
R
D
S
R
L
G
D
D
Y
N
Site 28
Y397
D
S
R
L
G
D
D
Y
N
I
P
H
W
I
N
Site 29
S418
K
S
Q
L
F
C
N
S
F
T
P
R
I
K
L
Site 30
S432
L
A
G
K
K
P
A
S
E
K
A
K
N
G
R
Site 31
T441
K
A
K
N
G
R
D
T
S
L
G
S
P
K
E
Site 32
S442
A
K
N
G
R
D
T
S
L
G
S
P
K
E
S
Site 33
S445
G
R
D
T
S
L
G
S
P
K
E
S
E
N
A
Site 34
S449
S
L
G
S
P
K
E
S
E
N
A
L
P
I
Q
Site 35
Y459
A
L
P
I
Q
V
D
Y
D
A
Y
D
A
Q
V
Site 36
Y462
I
Q
V
D
Y
D
A
Y
D
A
Q
V
F
R
L
Site 37
S473
V
F
R
L
P
G
P
S
R
A
Q
C
L
T
T
Site 38
T479
P
S
R
A
Q
C
L
T
T
C
R
S
V
R
E
Site 39
S483
Q
C
L
T
T
C
R
S
V
R
E
R
E
S
H
Site 40
S489
R
S
V
R
E
R
E
S
H
S
R
K
S
A
S
Site 41
S491
V
R
E
R
E
S
H
S
R
K
S
A
S
S
C
Site 42
S494
R
E
S
H
S
R
K
S
A
S
S
C
D
V
S
Site 43
S496
S
H
S
R
K
S
A
S
S
C
D
V
S
S
S
Site 44
S497
H
S
R
K
S
A
S
S
C
D
V
S
S
S
P
Site 45
S501
S
A
S
S
C
D
V
S
S
S
P
S
L
P
S
Site 46
S502
A
S
S
C
D
V
S
S
S
P
S
L
P
S
R
Site 47
S503
S
S
C
D
V
S
S
S
P
S
L
P
S
R
T
Site 48
S505
C
D
V
S
S
S
P
S
L
P
S
R
T
L
P
Site 49
S508
S
S
S
P
S
L
P
S
R
T
L
P
T
E
E
Site 50
T510
S
P
S
L
P
S
R
T
L
P
T
E
E
V
R
Site 51
S518
L
P
T
E
E
V
R
S
Q
A
S
D
D
S
S
Site 52
S521
E
E
V
R
S
Q
A
S
D
D
S
S
L
G
K
Site 53
S524
R
S
Q
A
S
D
D
S
S
L
G
K
S
A
N
Site 54
S525
S
Q
A
S
D
D
S
S
L
G
K
S
A
N
I
Site 55
S529
D
D
S
S
L
G
K
S
A
N
I
L
M
I
P
Site 56
Y543
P
H
P
H
L
H
Q
Y
E
V
S
S
S
L
G
Site 57
S547
L
H
Q
Y
E
V
S
S
S
L
G
Y
T
S
T
Site 58
S548
H
Q
Y
E
V
S
S
S
L
G
Y
T
S
T
R
Site 59
T552
V
S
S
S
L
G
Y
T
S
T
R
D
V
L
E
Site 60
S553
S
S
S
L
G
Y
T
S
T
R
D
V
L
E
N
Site 61
T554
S
S
L
G
Y
T
S
T
R
D
V
L
E
N
M
Site 62
S569
M
E
P
P
Q
R
D
S
S
A
P
G
R
F
H
Site 63
S570
E
P
P
Q
R
D
S
S
A
P
G
R
F
H
V
Site 64
S579
P
G
R
F
H
V
G
S
A
E
S
M
L
H
V
Site 65
S582
F
H
V
G
S
A
E
S
M
L
H
V
R
P
G
Site 66
Y591
L
H
V
R
P
G
G
Y
T
P
Q
R
A
L
I
Site 67
T592
H
V
R
P
G
G
Y
T
P
Q
R
A
L
I
N
Site 68
T611
S
R
M
P
M
K
L
T
S
N
R
R
R
W
M
Site 69
T620
N
R
R
R
W
M
H
T
F
P
V
G
P
S
G
Site 70
S646
N
M
A
E
L
Q
G
S
G
Q
R
D
P
T
H
Site 71
T652
G
S
G
Q
R
D
P
T
H
S
S
A
E
L
L
Site 72
S654
G
Q
R
D
P
T
H
S
S
A
E
L
L
E
L
Site 73
Y663
A
E
L
L
E
L
A
Y
H
E
A
A
G
R
H
Site 74
S671
H
E
A
A
G
R
H
S
N
S
R
Q
P
G
D
Site 75
S673
A
A
G
R
H
S
N
S
R
Q
P
G
D
G
M
Site 76
S681
R
Q
P
G
D
G
M
S
F
L
N
F
S
G
T
Site 77
S692
F
S
G
T
E
E
L
S
V
G
L
L
S
N
S
Site 78
S699
S
V
G
L
L
S
N
S
G
A
G
M
N
P
R
Site 79
T707
G
A
G
M
N
P
R
T
Q
N
K
D
S
L
E
Site 80
S712
P
R
T
Q
N
K
D
S
L
E
D
S
V
S
T
Site 81
S716
N
K
D
S
L
E
D
S
V
S
T
S
P
D
P
Site 82
S718
D
S
L
E
D
S
V
S
T
S
P
D
P
M
P
Site 83
S720
L
E
D
S
V
S
T
S
P
D
P
M
P
G
F
Site 84
T740
V
D
W
K
S
L
T
T
P
A
C
L
P
L
T
Site 85
T747
T
P
A
C
L
P
L
T
T
D
Y
F
P
D
R
Site 86
Y750
C
L
P
L
T
T
D
Y
F
P
D
R
Q
G
L
Site 87
Y761
R
Q
G
L
Q
N
D
Y
T
E
G
C
Y
D
L
Site 88
T762
Q
G
L
Q
N
D
Y
T
E
G
C
Y
D
L
L
Site 89
Y802
C
Q
R
L
M
Q
G
Y
Q
I
I
V
Q
P
K
Site 90
T810
Q
I
I
V
Q
P
K
T
Q
K
P
N
P
A
V
Site 91
S822
P
A
V
P
P
P
L
S
S
S
P
L
Y
S
R
Site 92
S823
A
V
P
P
P
L
S
S
S
P
L
Y
S
R
G
Site 93
S824
V
P
P
P
L
S
S
S
P
L
Y
S
R
G
L
Site 94
Y827
P
L
S
S
S
P
L
Y
S
R
G
L
V
S
R
Site 95
S828
L
S
S
S
P
L
Y
S
R
G
L
V
S
R
N
Site 96
Y843
R
P
E
E
E
D
Q
Y
W
L
S
M
G
R
T
Site 97
T850
Y
W
L
S
M
G
R
T
F
H
K
V
T
L
K
Site 98
T862
T
L
K
D
K
M
I
T
V
T
R
Y
L
P
K
Site 99
Y866
K
M
I
T
V
T
R
Y
L
P
K
Y
P
Y
E
Site 100
Y870
V
T
R
Y
L
P
K
Y
P
Y
E
S
A
Q
I
Site 101
Y872
R
Y
L
P
K
Y
P
Y
E
S
A
Q
I
H
Y
Site 102
T880
E
S
A
Q
I
H
Y
T
Y
S
L
C
P
S
H
Site 103
Y881
S
A
Q
I
H
Y
T
Y
S
L
C
P
S
H
S
Site 104
S882
A
Q
I
H
Y
T
Y
S
L
C
P
S
H
S
D
Site 105
S886
Y
T
Y
S
L
C
P
S
H
S
D
S
E
F
V
Site 106
S888
Y
S
L
C
P
S
H
S
D
S
E
F
V
S
C
Site 107
Y907
S
H
E
R
L
E
E
Y
K
W
N
Y
L
D
Q
Site 108
Y911
L
E
E
Y
K
W
N
Y
L
D
Q
Y
I
C
S
Site 109
Y915
K
W
N
Y
L
D
Q
Y
I
C
S
A
G
S
E
Site 110
S921
Q
Y
I
C
S
A
G
S
E
D
F
S
L
I
E
Site 111
S925
S
A
G
S
E
D
F
S
L
I
E
S
L
K
F
Site 112
S929
E
D
F
S
L
I
E
S
L
K
F
W
R
T
R
Site 113
T951
V
T
A
T
K
R
I
T
E
G
E
A
H
C
D
Site 114
Y960
G
E
A
H
C
D
I
Y
G
D
R
P
R
A
D
Site 115
S993
R
I
R
R
R
H
R
S
D
R
M
M
R
K
G
Site 116
T1001
D
R
M
M
R
K
G
T
A
M
K
G
L
Q
M
Site 117
T1009
A
M
K
G
L
Q
M
T
G
P
I
S
T
H
S
Site 118
S1013
L
Q
M
T
G
P
I
S
T
H
S
L
E
S
T
Site 119
S1016
T
G
P
I
S
T
H
S
L
E
S
T
A
P
P
Site 120
S1019
I
S
T
H
S
L
E
S
T
A
P
P
V
G
K
Site 121
T1020
S
T
H
S
L
E
S
T
A
P
P
V
G
K
K
Site 122
S1033
K
K
G
T
S
A
L
S
A
L
L
E
M
E
A
Site 123
S1041
A
L
L
E
M
E
A
S
Q
K
C
L
G
E
Q
Site 124
S1057
A
A
V
H
G
G
K
S
S
A
Q
S
A
E
S
Site 125
S1058
A
V
H
G
G
K
S
S
A
Q
S
A
E
S
S
Site 126
S1061
G
G
K
S
S
A
Q
S
A
E
S
S
S
V
A
Site 127
S1064
S
S
A
Q
S
A
E
S
S
S
V
A
M
T
P
Site 128
S1065
S
A
Q
S
A
E
S
S
S
V
A
M
T
P
T
Site 129
S1066
A
Q
S
A
E
S
S
S
V
A
M
T
P
T
Y
Site 130
T1070
E
S
S
S
V
A
M
T
P
T
Y
M
D
S
P
Site 131
T1072
S
S
V
A
M
T
P
T
Y
M
D
S
P
R
K
Site 132
Y1073
S
V
A
M
T
P
T
Y
M
D
S
P
R
K
V
Site 133
S1076
M
T
P
T
Y
M
D
S
P
R
K
V
S
V
D
Site 134
S1081
M
D
S
P
R
K
V
S
V
D
Q
T
A
T
P
Site 135
T1085
R
K
V
S
V
D
Q
T
A
T
P
M
L
D
G
Site 136
T1087
V
S
V
D
Q
T
A
T
P
M
L
D
G
T
S
Site 137
S1102
L
G
I
C
T
G
Q
S
M
D
R
G
N
S
Q
Site 138
S1108
Q
S
M
D
R
G
N
S
Q
T
F
G
N
S
Q
Site 139
T1110
M
D
R
G
N
S
Q
T
F
G
N
S
Q
N
I
Site 140
S1114
N
S
Q
T
F
G
N
S
Q
N
I
G
E
Q
G
Site 141
S1123
N
I
G
E
Q
G
Y
S
S
T
N
S
S
D
S
Site 142
S1124
I
G
E
Q
G
Y
S
S
T
N
S
S
D
S
S
Site 143
T1125
G
E
Q
G
Y
S
S
T
N
S
S
D
S
S
S
Site 144
S1127
Q
G
Y
S
S
T
N
S
S
D
S
S
S
Q
Q
Site 145
S1128
G
Y
S
S
T
N
S
S
D
S
S
S
Q
Q
L
Site 146
S1130
S
S
T
N
S
S
D
S
S
S
Q
Q
L
V
A
Site 147
S1131
S
T
N
S
S
D
S
S
S
Q
Q
L
V
A
S
Site 148
S1132
T
N
S
S
D
S
S
S
Q
Q
L
V
A
S
S
Site 149
S1138
S
S
Q
Q
L
V
A
S
S
L
T
S
S
S
T
Site 150
S1139
S
Q
Q
L
V
A
S
S
L
T
S
S
S
T
L
Site 151
T1158
E
A
M
K
H
P
S
T
G
V
Q
L
L
S
E
Site 152
S1164
S
T
G
V
Q
L
L
S
E
Q
K
G
L
S
P
Site 153
S1170
L
S
E
Q
K
G
L
S
P
Y
C
F
I
S
A
Site 154
Y1172
E
Q
K
G
L
S
P
Y
C
F
I
S
A
E
V
Site 155
T1210
M
L
E
E
Q
L
I
T
H
A
S
G
E
A
W
Site 156
S1213
E
Q
L
I
T
H
A
S
G
E
A
W
R
T
F
Site 157
S1291
W
L
P
S
R
P
A
S
Y
A
S
R
H
S
S
Site 158
Y1292
L
P
S
R
P
A
S
Y
A
S
R
H
S
S
F
Site 159
S1294
S
R
P
A
S
Y
A
S
R
H
S
S
F
S
R
Site 160
S1297
A
S
Y
A
S
R
H
S
S
F
S
R
S
F
G
Site 161
S1298
S
Y
A
S
R
H
S
S
F
S
R
S
F
G
G
Site 162
S1300
A
S
R
H
S
S
F
S
R
S
F
G
G
R
S
Site 163
S1302
R
H
S
S
F
S
R
S
F
G
G
R
S
Q
A
Site 164
S1307
S
R
S
F
G
G
R
S
Q
A
A
A
L
L
A
Site 165
T1324
V
P
E
Q
R
T
V
T
L
D
V
D
V
N
N
Site 166
T1333
D
V
D
V
N
N
R
T
D
R
L
E
W
C
S
Site 167
T1379
Q
G
W
H
R
K
A
T
S
C
G
F
L
L
V
Site 168
S1397
E
G
P
F
A
L
P
S
Y
L
Y
G
D
P
L
Site 169
Y1398
G
P
F
A
L
P
S
Y
L
Y
G
D
P
L
R
Site 170
Y1400
F
A
L
P
S
Y
L
Y
G
D
P
L
R
A
Q
Site 171
S1422
S
C
L
L
K
E
G
S
E
H
L
F
D
S
F
Site 172
S1428
G
S
E
H
L
F
D
S
F
E
P
E
T
Y
W
Site 173
Y1434
D
S
F
E
P
E
T
Y
W
D
R
M
H
L
F
Site 174
Y1456
F
G
F
V
Q
D
K
Y
S
A
S
A
F
N
F
Site 175
S1457
G
F
V
Q
D
K
Y
S
A
S
A
F
N
F
P
Site 176
Y1471
P
A
E
N
K
P
Q
Y
I
H
V
T
G
T
V
Site 177
S1485
V
F
L
Q
L
P
Y
S
K
R
K
F
S
G
Q
Site 178
S1490
P
Y
S
K
R
K
F
S
G
Q
Q
R
R
R
R
Site 179
S1499
Q
Q
R
R
R
R
N
S
T
S
S
T
N
Q
N
Site 180
T1500
Q
R
R
R
R
N
S
T
S
S
T
N
Q
N
M
Site 181
S1501
R
R
R
R
N
S
T
S
S
T
N
Q
N
M
F
Site 182
S1502
R
R
R
N
S
T
S
S
T
N
Q
N
M
F
C
Site 183
T1503
R
R
N
S
T
S
S
T
N
Q
N
M
F
C
E
Site 184
Y1515
F
C
E
E
R
V
G
Y
N
W
A
Y
N
T
M
Site 185
Y1519
R
V
G
Y
N
W
A
Y
N
T
M
L
T
K
T
Site 186
T1526
Y
N
T
M
L
T
K
T
W
R
S
S
A
T
G
Site 187
S1530
L
T
K
T
W
R
S
S
A
T
G
D
E
K
F
Site 188
T1558
N
R
D
N
R
L
V
T
F
W
T
S
C
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation