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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLIT3
Full Name:
Slit homolog 3 protein
Alias:
MEGF5; Multiple epidermal growth factor-like domains 5; SLIL2; Slit 3; SLIT1; Slit2; Slit-3
Type:
Mass (Da):
167690
Number AA:
UniProt ID:
O75094
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0007417
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T77
R
N
N
I
T
R
I
T
K
M
D
F
A
G
L
Site 2
T132
P
E
L
L
F
Q
S
T
P
K
L
T
R
L
D
Site 3
S141
K
L
T
R
L
D
L
S
E
N
Q
I
Q
G
I
Site 4
T157
R
K
A
F
R
G
I
T
D
V
K
N
L
Q
L
Site 5
T187
L
R
D
L
E
I
L
T
L
N
N
N
N
I
S
Site 6
T209
N
H
M
P
K
I
R
T
L
R
L
H
S
N
H
Site 7
T235
D
W
L
R
Q
R
R
T
V
G
Q
F
T
L
C
Site 8
Y261
A
D
V
Q
K
K
E
Y
V
C
P
A
P
H
S
Site 9
S268
Y
V
C
P
A
P
H
S
E
P
P
S
C
N
A
Site 10
S272
A
P
H
S
E
P
P
S
C
N
A
N
S
I
S
Site 11
S277
P
P
S
C
N
A
N
S
I
S
C
P
S
P
C
Site 12
S282
A
N
S
I
S
C
P
S
P
C
T
C
S
N
N
Site 13
S318
E
I
R
L
E
Q
N
S
I
K
A
I
P
A
G
Site 14
Y330
P
A
G
A
F
T
Q
Y
K
K
L
K
R
I
D
Site 15
S359
Q
G
L
K
S
L
T
S
L
V
L
Y
G
N
K
Site 16
T398
I
N
C
L
R
V
N
T
F
Q
D
L
Q
N
L
Site 17
S409
L
Q
N
L
N
L
L
S
L
Y
D
N
K
L
Q
Site 18
Y411
N
L
N
L
L
S
L
Y
D
N
K
L
Q
T
I
Site 19
T417
L
Y
D
N
K
L
Q
T
I
S
K
G
L
F
A
Site 20
S419
D
N
K
L
Q
T
I
S
K
G
L
F
A
P
L
Site 21
Y451
H
L
K
W
L
A
D
Y
L
Q
D
N
P
I
E
Site 22
S460
Q
D
N
P
I
E
T
S
G
A
R
C
S
S
P
Site 23
S465
E
T
S
G
A
R
C
S
S
P
R
R
L
A
N
Site 24
S466
T
S
G
A
R
C
S
S
P
R
R
L
A
N
K
Site 25
S476
R
L
A
N
K
R
I
S
Q
I
K
S
K
K
F
Site 26
S480
K
R
I
S
Q
I
K
S
K
K
F
R
C
S
G
Site 27
S486
K
S
K
K
F
R
C
S
G
S
E
D
Y
R
S
Site 28
S488
K
K
F
R
C
S
G
S
E
D
Y
R
S
R
F
Site 29
Y491
R
C
S
G
S
E
D
Y
R
S
R
F
S
S
E
Site 30
S493
S
G
S
E
D
Y
R
S
R
F
S
S
E
C
F
Site 31
S496
E
D
Y
R
S
R
F
S
S
E
C
F
M
D
L
Site 32
S497
D
Y
R
S
R
F
S
S
E
C
F
M
D
L
V
Site 33
S519
E
G
T
I
V
D
C
S
N
Q
K
L
V
R
I
Site 34
S528
Q
K
L
V
R
I
P
S
H
L
P
E
Y
V
T
Site 35
Y533
I
P
S
H
L
P
E
Y
V
T
D
L
R
L
N
Site 36
T535
S
H
L
P
E
Y
V
T
D
L
R
L
N
D
N
Site 37
S565
N
L
R
K
I
N
L
S
N
N
K
I
K
E
V
Site 38
T595
L
T
G
N
Q
L
E
T
V
H
G
R
V
F
R
Site 39
T609
R
G
L
S
G
L
K
T
L
M
L
R
S
N
L
Site 40
T642
S
L
Y
D
N
R
I
T
T
I
T
P
G
A
F
Site 41
T643
L
Y
D
N
R
I
T
T
I
T
P
G
A
F
T
Site 42
T645
D
N
R
I
T
T
I
T
P
G
A
F
T
T
L
Site 43
S685
L
R
K
R
R
I
V
S
G
N
P
R
C
Q
K
Site 44
T710
D
V
A
I
Q
D
F
T
C
D
G
N
E
E
S
Site 45
S717
T
C
D
G
N
E
E
S
S
C
Q
L
S
P
R
Site 46
S718
C
D
G
N
E
E
S
S
C
Q
L
S
P
R
C
Site 47
S722
E
E
S
S
C
Q
L
S
P
R
C
P
E
Q
C
Site 48
S739
M
E
T
V
V
R
C
S
N
K
G
L
R
A
L
Site 49
T755
R
G
M
P
K
D
V
T
E
L
Y
L
E
G
N
Site 50
Y758
P
K
D
V
T
E
L
Y
L
E
G
N
H
L
T
Site 51
T765
Y
L
E
G
N
H
L
T
A
V
P
R
E
L
S
Site 52
Y793
S
I
S
M
L
T
N
Y
T
F
S
N
M
S
H
Site 53
T803
S
N
M
S
H
L
S
T
L
I
L
S
Y
N
R
Site 54
T829
L
R
S
L
R
V
L
T
L
H
G
N
D
I
S
Site 55
S836
T
L
H
G
N
D
I
S
S
V
P
E
G
S
F
Site 56
S837
L
H
G
N
D
I
S
S
V
P
E
G
S
F
N
Site 57
S842
I
S
S
V
P
E
G
S
F
N
D
L
T
S
L
Site 58
T847
E
G
S
F
N
D
L
T
S
L
S
H
L
A
L
Site 59
Y876
S
E
W
V
K
A
G
Y
K
E
P
G
I
A
R
Site 60
S885
E
P
G
I
A
R
C
S
S
P
E
P
M
A
D
Site 61
S886
P
G
I
A
R
C
S
S
P
E
P
M
A
D
R
Site 62
T898
A
D
R
L
L
L
T
T
P
T
H
R
F
Q
C
Site 63
T900
R
L
L
L
T
T
P
T
H
R
F
Q
C
K
G
Site 64
S923
K
C
N
A
C
L
S
S
P
C
K
N
N
G
T
Site 65
Y939
T
Q
D
P
V
E
L
Y
R
C
A
C
P
Y
S
Site 66
Y945
L
Y
R
C
A
C
P
Y
S
Y
K
G
K
D
C
Site 67
S973
H
G
G
T
C
H
L
S
D
S
H
K
D
G
F
Site 68
S975
G
T
C
H
L
S
D
S
H
K
D
G
F
S
C
Site 69
S981
D
S
H
K
D
G
F
S
C
S
C
P
L
G
F
Site 70
S983
H
K
D
G
F
S
C
S
C
P
L
G
F
E
G
Site 71
Y1026
V
C
I
C
P
P
N
Y
T
G
E
L
C
D
E
Site 72
Y1066
S
C
E
C
V
P
G
Y
S
G
K
L
C
E
T
Site 73
S1121
P
M
V
L
L
Q
T
S
P
C
D
Q
Y
E
C
Site 74
Y1126
Q
T
S
P
C
D
Q
Y
E
C
Q
N
G
A
Q
Site 75
T1142
I
V
V
Q
Q
E
P
T
C
R
C
P
P
G
F
Site 76
T1159
P
R
C
E
K
L
I
T
V
N
F
V
G
K
D
Site 77
Y1168
N
F
V
G
K
D
S
Y
V
E
L
A
S
A
K
Site 78
Y1217
Q
G
H
V
R
L
V
Y
D
S
L
S
S
P
P
Site 79
S1219
H
V
R
L
V
Y
D
S
L
S
S
P
P
T
T
Site 80
S1221
R
L
V
Y
D
S
L
S
S
P
P
T
T
V
Y
Site 81
S1222
L
V
Y
D
S
L
S
S
P
P
T
T
V
Y
S
Site 82
T1225
D
S
L
S
S
P
P
T
T
V
Y
S
V
E
T
Site 83
T1226
S
L
S
S
P
P
T
T
V
Y
S
V
E
T
V
Site 84
Y1228
S
S
P
P
T
T
V
Y
S
V
E
T
V
N
D
Site 85
S1229
S
P
P
T
T
V
Y
S
V
E
T
V
N
D
G
Site 86
T1232
T
T
V
Y
S
V
E
T
V
N
D
G
Q
F
H
Site 87
S1240
V
N
D
G
Q
F
H
S
V
E
L
V
T
L
N
Site 88
T1258
N
L
V
V
D
K
G
T
P
K
S
L
G
K
L
Site 89
S1261
V
D
K
G
T
P
K
S
L
G
K
L
Q
K
Q
Site 90
S1289
I
P
T
S
T
G
L
S
A
L
R
Q
G
T
D
Site 91
T1295
L
S
A
L
R
Q
G
T
D
R
P
L
G
G
F
Site 92
S1329
P
P
Q
S
L
G
V
S
P
G
C
K
S
C
T
Site 93
S1345
C
K
H
G
L
C
R
S
V
E
K
D
S
V
V
Site 94
S1350
C
R
S
V
E
K
D
S
V
V
C
E
C
R
P
Site 95
T1385
H
H
G
K
C
V
A
T
G
T
S
Y
M
C
K
Site 96
T1387
G
K
C
V
A
T
G
T
S
Y
M
C
K
C
A
Site 97
S1388
K
C
V
A
T
G
T
S
Y
M
C
K
C
A
E
Site 98
Y1389
C
V
A
T
G
T
S
Y
M
C
K
C
A
E
G
Site 99
Y1431
I
S
D
Q
G
E
P
Y
C
L
C
Q
P
G
F
Site 100
Y1464
V
I
R
R
Q
K
G
Y
A
S
C
A
T
A
S
Site 101
Y1497
T
R
S
K
R
R
K
Y
V
F
Q
C
T
D
G
Site 102
T1502
R
K
Y
V
F
Q
C
T
D
G
S
S
F
V
E
Site 103
S1505
V
F
Q
C
T
D
G
S
S
F
V
E
E
V
E
Site 104
S1506
F
Q
C
T
D
G
S
S
F
V
E
E
V
E
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation