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Updated November 2019
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Protein Info
Short Name:
SLIT1
Full Name:
Slit homolog 1 protein
Alias:
Multiple epidermal growth factor-like domains protein 4
Type:
Mass (Da):
167926
Number AA:
1534
UniProt ID:
O75093
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
L
T
P
G
W
G
S
S
A
G
P
V
R
P
E
Site 2
T63
P
K
N
I
P
R
N
T
E
R
L
E
L
N
G
Site 3
T74
E
L
N
G
N
N
I
T
R
I
H
K
N
D
F
Site 4
T157
R
K
A
F
R
G
A
T
D
L
K
N
L
Q
L
Site 5
S170
Q
L
D
K
N
Q
I
S
C
I
E
E
G
A
F
Site 6
T187
L
R
G
L
E
V
L
T
L
N
N
N
N
I
T
Site 7
T194
T
L
N
N
N
N
I
T
T
I
P
V
S
S
F
Site 8
T195
L
N
N
N
N
I
T
T
I
P
V
S
S
F
N
Site 9
T235
Q
W
L
R
Q
R
P
T
I
G
L
F
T
Q
C
Site 10
T240
R
P
T
I
G
L
F
T
Q
C
S
G
P
A
S
Site 11
S247
T
Q
C
S
G
P
A
S
L
R
G
L
N
V
A
Site 12
S259
N
V
A
E
V
Q
K
S
E
F
S
C
S
G
Q
Site 13
S262
E
V
Q
K
S
E
F
S
C
S
G
Q
G
E
A
Site 14
S264
Q
K
S
E
F
S
C
S
G
Q
G
E
A
G
R
Site 15
T274
G
E
A
G
R
V
P
T
C
T
L
S
S
G
S
Site 16
T276
A
G
R
V
P
T
C
T
L
S
S
G
S
C
P
Site 17
T301
D
C
R
G
K
G
L
T
A
I
P
A
N
L
P
Site 18
S330
S
I
P
P
G
A
F
S
P
Y
R
K
L
R
R
Site 19
Y332
P
P
G
A
F
S
P
Y
R
K
L
R
R
I
D
Site 20
S341
K
L
R
R
I
D
L
S
N
N
Q
I
A
E
I
Site 21
S361
Q
G
L
R
S
L
N
S
L
V
L
Y
G
N
K
Site 22
S408
F
Q
D
L
Q
N
L
S
L
L
S
L
Y
D
N
Site 23
S411
L
Q
N
L
S
L
L
S
L
Y
D
N
K
I
Q
Site 24
Y413
N
L
S
L
L
S
L
Y
D
N
K
I
Q
S
L
Site 25
S419
L
Y
D
N
K
I
Q
S
L
A
K
G
T
F
T
Site 26
T456
W
L
A
D
F
L
R
T
N
P
I
E
T
S
G
Site 27
S462
R
T
N
P
I
E
T
S
G
A
R
C
A
S
P
Site 28
S468
T
S
G
A
R
C
A
S
P
R
R
L
A
N
K
Site 29
S482
K
R
I
G
Q
I
K
S
K
K
F
R
C
S
A
Site 30
S488
K
S
K
K
F
R
C
S
A
K
E
Q
Y
F
I
Site 31
Y493
R
C
S
A
K
E
Q
Y
F
I
P
G
T
E
D
Site 32
T498
E
Q
Y
F
I
P
G
T
E
D
Y
Q
L
N
S
Site 33
Y501
F
I
P
G
T
E
D
Y
Q
L
N
S
E
C
N
Site 34
S505
T
E
D
Y
Q
L
N
S
E
C
N
S
D
V
V
Site 35
S509
Q
L
N
S
E
C
N
S
D
V
V
C
P
H
K
Site 36
T532
E
C
S
S
L
K
L
T
K
I
P
E
R
I
P
Site 37
S541
I
P
E
R
I
P
Q
S
T
A
E
L
R
L
N
Site 38
T542
P
E
R
I
P
Q
S
T
A
E
L
R
L
N
N
Site 39
S553
R
L
N
N
N
E
I
S
I
L
E
A
T
G
M
Site 40
T565
T
G
M
F
K
K
L
T
H
L
K
K
I
N
L
Site 41
S573
H
L
K
K
I
N
L
S
N
N
K
V
S
E
I
Site 42
T597
S
V
S
E
L
H
L
T
A
N
Q
L
E
S
I
Site 43
S603
L
T
A
N
Q
L
E
S
I
R
S
G
M
F
R
Site 44
S606
N
Q
L
E
S
I
R
S
G
M
F
R
G
L
D
Site 45
T617
R
G
L
D
G
L
R
T
L
M
L
R
N
N
R
Site 46
S632
I
S
C
I
H
N
D
S
F
T
G
L
R
N
V
Site 47
S643
L
R
N
V
R
L
L
S
L
Y
D
N
Q
I
T
Site 48
T651
L
Y
D
N
Q
I
T
T
V
S
P
G
A
F
D
Site 49
S653
D
N
Q
I
T
T
V
S
P
G
A
F
D
T
L
Site 50
T693
L
R
K
R
K
I
V
T
G
N
P
R
C
Q
N
Site 51
S748
L
D
T
V
V
R
C
S
N
K
H
L
R
A
L
Site 52
Y767
P
K
N
V
T
E
L
Y
L
D
G
N
Q
F
T
Site 53
T774
Y
L
D
G
N
Q
F
T
L
V
P
G
Q
L
S
Site 54
S792
Y
L
Q
L
V
D
L
S
N
N
K
I
S
S
L
Site 55
S797
D
L
S
N
N
K
I
S
S
L
S
N
S
S
F
Site 56
S798
L
S
N
N
K
I
S
S
L
S
N
S
S
F
T
Site 57
S800
N
N
K
I
S
S
L
S
N
S
S
F
T
N
M
Site 58
S802
K
I
S
S
L
S
N
S
S
F
T
N
M
S
Q
Site 59
S803
I
S
S
L
S
N
S
S
F
T
N
M
S
Q
L
Site 60
S838
L
R
S
L
R
L
L
S
L
H
G
N
D
I
S
Site 61
S845
S
L
H
G
N
D
I
S
T
L
Q
E
G
I
F
Site 62
T883
W
L
S
S
W
V
K
T
G
Y
K
E
P
G
I
Site 63
Y885
S
S
W
V
K
T
G
Y
K
E
P
G
I
A
R
Site 64
T907
E
G
K
L
L
L
T
T
P
A
K
K
F
E
C
Site 65
S932
K
C
D
L
C
L
S
S
P
C
Q
N
Q
G
T
Site 66
Y948
H
N
D
P
L
E
V
Y
R
C
A
C
P
S
G
Site 67
S964
K
G
R
D
C
E
V
S
L
D
S
C
S
S
G
Site 68
S967
D
C
E
V
S
L
D
S
C
S
S
G
P
C
E
Site 69
S969
E
V
S
L
D
S
C
S
S
G
P
C
E
N
G
Site 70
S970
V
S
L
D
S
C
S
S
G
P
C
E
N
G
G
Site 71
T990
E
G
E
D
A
P
F
T
C
S
C
P
T
G
F
Site 72
S992
E
D
A
P
F
T
C
S
C
P
T
G
F
E
G
Site 73
S1048
E
Q
L
V
D
L
C
S
P
D
L
N
P
C
Q
Site 74
T1063
H
E
A
Q
C
V
G
T
P
D
G
P
R
C
E
Site 75
Y1075
R
C
E
C
M
P
G
Y
A
G
D
N
C
S
E
Site 76
Y1105
C
M
D
E
V
N
S
Y
S
C
L
C
A
E
G
Site 77
S1129
P
H
L
P
A
P
K
S
P
C
E
G
T
E
C
Site 78
S1167
P
E
C
E
K
L
L
S
V
N
F
V
D
R
D
Site 79
T1175
V
N
F
V
D
R
D
T
Y
L
Q
F
T
D
L
Site 80
Y1176
N
F
V
D
R
D
T
Y
L
Q
F
T
D
L
Q
Site 81
T1191
N
W
P
R
A
N
I
T
L
Q
V
S
T
A
E
Site 82
Y1205
E
D
N
G
I
L
L
Y
N
G
D
N
D
H
I
Site 83
S1224
Y
Q
G
H
V
R
V
S
Y
D
P
G
S
Y
P
Site 84
Y1225
Q
G
H
V
R
V
S
Y
D
P
G
S
Y
P
S
Site 85
S1229
R
V
S
Y
D
P
G
S
Y
P
S
S
A
I
Y
Site 86
Y1230
V
S
Y
D
P
G
S
Y
P
S
S
A
I
Y
S
Site 87
S1233
D
P
G
S
Y
P
S
S
A
I
Y
S
A
E
T
Site 88
Y1236
S
Y
P
S
S
A
I
Y
S
A
E
T
I
N
D
Site 89
S1237
Y
P
S
S
A
I
Y
S
A
E
T
I
N
D
G
Site 90
S1261
F
D
Q
M
V
N
L
S
I
D
G
G
S
P
M
Site 91
S1266
N
L
S
I
D
G
G
S
P
M
T
M
D
N
F
Site 92
T1269
I
D
G
G
S
P
M
T
M
D
N
F
G
K
H
Site 93
S1281
G
K
H
Y
T
L
N
S
E
A
P
L
Y
V
G
Site 94
Y1318
H
G
C
I
R
N
L
Y
I
N
N
E
L
Q
D
Site 95
T1329
E
L
Q
D
F
T
K
T
Q
M
K
P
G
V
V
Site 96
Y1407
S
C
Q
C
Q
D
G
Y
S
G
A
L
C
N
Q
Site 97
S1457
G
E
L
C
E
Q
E
S
E
C
R
G
D
P
V
Site 98
Y1474
F
H
Q
V
Q
R
G
Y
A
I
C
Q
T
T
R
Site 99
S1484
C
Q
T
T
R
P
L
S
W
V
E
C
R
G
S
Site 100
T1509
R
L
K
R
R
K
F
T
F
E
C
S
D
G
T
Site 101
S1513
R
K
F
T
F
E
C
S
D
G
T
S
F
A
E
Site 102
S1517
F
E
C
S
D
G
T
S
F
A
E
E
V
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation