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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAM23
Full Name:
Disintegrin and metalloproteinase domain-containing protein 23
Alias:
ADA23; ADAM metallopeptidase domain 23; MDC3
Type:
Adhesion
Mass (Da):
91926
Number AA:
832
UniProt ID:
O75077
International Prot ID:
IPI00021903
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005178
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0007417
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
K
P
P
G
S
S
S
R
Q
P
P
L
Site 2
S7
_
M
K
P
P
G
S
S
S
R
Q
P
P
L
A
Site 3
S8
M
K
P
P
G
S
S
S
R
Q
P
P
L
A
G
Site 4
S22
G
C
S
L
A
G
A
S
C
G
P
Q
R
G
P
Site 5
S32
P
Q
R
G
P
A
G
S
V
P
A
S
A
P
A
Site 6
S36
P
A
G
S
V
P
A
S
A
P
A
R
T
P
P
Site 7
S59
L
L
P
P
L
A
A
S
S
R
P
R
A
W
G
Site 8
S60
L
P
P
L
A
A
S
S
R
P
R
A
W
G
A
Site 9
T92
V
L
A
D
E
D
N
T
L
Q
Q
N
S
S
S
Site 10
S97
D
N
T
L
Q
Q
N
S
S
S
N
I
S
Y
S
Site 11
S98
N
T
L
Q
Q
N
S
S
S
N
I
S
Y
S
N
Site 12
S99
T
L
Q
Q
N
S
S
S
N
I
S
Y
S
N
A
Site 13
S102
Q
N
S
S
S
N
I
S
Y
S
N
A
M
Q
K
Site 14
S104
S
S
S
N
I
S
Y
S
N
A
M
Q
K
E
I
Site 15
T112
N
A
M
Q
K
E
I
T
L
P
S
R
L
I
Y
Site 16
Y119
T
L
P
S
R
L
I
Y
Y
I
N
Q
D
S
E
Site 17
Y120
L
P
S
R
L
I
Y
Y
I
N
Q
D
S
E
S
Site 18
S127
Y
I
N
Q
D
S
E
S
P
Y
H
V
L
D
T
Site 19
Y129
N
Q
D
S
E
S
P
Y
H
V
L
D
T
K
A
Site 20
T134
S
P
Y
H
V
L
D
T
K
A
R
H
Q
Q
K
Site 21
S175
L
N
N
G
L
L
S
S
D
Y
V
E
I
H
Y
Site 22
Y177
N
G
L
L
S
S
D
Y
V
E
I
H
Y
E
N
Site 23
Y182
S
D
Y
V
E
I
H
Y
E
N
G
K
P
Q
Y
Site 24
Y189
Y
E
N
G
K
P
Q
Y
S
K
G
G
E
H
C
Site 25
Y197
S
K
G
G
E
H
C
Y
Y
H
G
S
I
R
G
Site 26
Y198
K
G
G
E
H
C
Y
Y
H
G
S
I
R
G
V
Site 27
S208
S
I
R
G
V
K
D
S
K
V
A
L
S
T
C
Site 28
S213
K
D
S
K
V
A
L
S
T
C
N
G
L
H
G
Site 29
S242
E
L
V
H
D
E
K
S
T
G
R
P
H
I
I
Site 30
T252
R
P
H
I
I
Q
K
T
L
A
G
Q
Y
S
K
Site 31
S258
K
T
L
A
G
Q
Y
S
K
Q
M
K
N
L
T
Site 32
T265
S
K
Q
M
K
N
L
T
M
E
R
G
D
Q
W
Site 33
Y375
M
L
H
E
F
S
K
Y
R
Q
R
I
K
Q
H
Site 34
Y396
I
S
R
V
T
F
H
Y
K
R
S
S
L
S
Y
Site 35
Y403
Y
K
R
S
S
L
S
Y
F
G
G
V
C
S
R
Site 36
T453
R
K
P
K
C
D
C
T
E
S
W
G
G
C
I
Site 37
S473
V
S
H
S
R
K
F
S
K
C
S
I
L
E
Y
Site 38
Y707
D
D
D
T
D
V
G
Y
V
E
D
G
T
P
C
Site 39
T827
K
K
R
R
F
D
P
T
Q
Q
G
P
I
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation