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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMCC2
Full Name:
Transmembrane and coiled-coil domains protein 2
Alias:
Cerebral protein 11
Type:
Membrane, Integral membrane protein
Mass (Da):
77449
Number AA:
709
UniProt ID:
O75069
International Prot ID:
IPI00418557
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
K
R
C
R
S
D
E
L
Q
Q
Q
Q
Site 2
T39
D
L
R
P
G
E
T
T
G
A
N
S
A
G
G
Site 3
S49
N
S
A
G
G
P
T
S
D
A
G
A
A
A
A
Site 4
S63
A
P
N
P
G
P
R
S
K
P
P
D
L
K
K
Site 5
S75
L
K
K
I
Q
Q
L
S
E
G
S
M
F
G
H
Site 6
S90
G
L
K
H
L
F
H
S
R
R
R
S
R
E
R
Site 7
S94
L
F
H
S
R
R
R
S
R
E
R
E
H
Q
T
Site 8
T101
S
R
E
R
E
H
Q
T
S
Q
D
S
Q
Q
H
Site 9
S102
R
E
R
E
H
Q
T
S
Q
D
S
Q
Q
H
Q
Site 10
S105
E
H
Q
T
S
Q
D
S
Q
Q
H
Q
Q
Q
Q
Site 11
S115
H
Q
Q
Q
Q
G
M
S
D
H
D
S
P
D
E
Site 12
S119
Q
G
M
S
D
H
D
S
P
D
E
K
E
R
S
Site 13
S126
S
P
D
E
K
E
R
S
P
E
M
H
R
V
S
Site 14
S133
S
P
E
M
H
R
V
S
Y
A
M
S
L
H
D
Site 15
Y134
P
E
M
H
R
V
S
Y
A
M
S
L
H
D
L
Site 16
S137
H
R
V
S
Y
A
M
S
L
H
D
L
P
A
R
Site 17
T146
H
D
L
P
A
R
P
T
A
F
N
R
V
L
Q
Site 18
S157
R
V
L
Q
Q
I
R
S
R
P
S
I
K
R
G
Site 19
S160
Q
Q
I
R
S
R
P
S
I
K
R
G
A
S
L
Site 20
S166
P
S
I
K
R
G
A
S
L
H
S
S
S
G
G
Site 21
S169
K
R
G
A
S
L
H
S
S
S
G
G
G
S
S
Site 22
S170
R
G
A
S
L
H
S
S
S
G
G
G
S
S
G
Site 23
S171
G
A
S
L
H
S
S
S
G
G
G
S
S
G
S
Site 24
S175
H
S
S
S
G
G
G
S
S
G
S
S
S
R
R
Site 25
S176
S
S
S
G
G
G
S
S
G
S
S
S
R
R
T
Site 26
S178
S
G
G
G
S
S
G
S
S
S
R
R
T
K
S
Site 27
S179
G
G
G
S
S
G
S
S
S
R
R
T
K
S
S
Site 28
S180
G
G
S
S
G
S
S
S
R
R
T
K
S
S
S
Site 29
T183
S
G
S
S
S
R
R
T
K
S
S
S
L
E
P
Site 30
S185
S
S
S
R
R
T
K
S
S
S
L
E
P
Q
R
Site 31
S186
S
S
R
R
T
K
S
S
S
L
E
P
Q
R
G
Site 32
S187
S
R
R
T
K
S
S
S
L
E
P
Q
R
G
S
Site 33
S194
S
L
E
P
Q
R
G
S
P
H
L
L
R
K
A
Site 34
S206
R
K
A
P
Q
D
S
S
L
A
A
I
L
H
Q
Site 35
S220
Q
H
Q
C
R
P
R
S
S
S
T
T
D
T
A
Site 36
S221
H
Q
C
R
P
R
S
S
S
T
T
D
T
A
L
Site 37
S222
Q
C
R
P
R
S
S
S
T
T
D
T
A
L
L
Site 38
T224
R
P
R
S
S
S
T
T
D
T
A
L
L
L
A
Site 39
T226
R
S
S
S
T
T
D
T
A
L
L
L
A
D
G
Site 40
T267
L
P
A
G
H
G
D
T
D
G
P
I
S
L
D
Site 41
S272
G
D
T
D
G
P
I
S
L
D
V
P
D
G
A
Site 42
Y317
R
D
D
N
V
A
E
Y
L
K
L
A
N
N
A
Site 43
S330
N
A
D
K
Q
Q
V
S
R
I
K
Q
V
F
E
Site 44
S343
F
E
K
K
N
Q
K
S
A
Q
T
I
A
Q
L
Site 45
Y357
L
H
K
K
L
E
H
Y
R
R
R
L
K
E
I
Site 46
S411
E
G
V
K
G
S
L
S
G
L
S
Q
A
T
H
Site 47
S414
K
G
S
L
S
G
L
S
Q
A
T
H
T
A
V
Site 48
T419
G
L
S
Q
A
T
H
T
A
V
V
S
K
P
R
Site 49
S423
A
T
H
T
A
V
V
S
K
P
R
E
F
A
S
Site 50
S430
S
K
P
R
E
F
A
S
L
I
R
N
K
F
G
Site 51
S438
L
I
R
N
K
F
G
S
A
D
N
I
A
H
L
Site 52
S462
E
E
A
A
R
A
L
S
G
S
A
T
L
V
S
Site 53
S464
A
A
R
A
L
S
G
S
A
T
L
V
S
S
P
Site 54
T466
R
A
L
S
G
S
A
T
L
V
S
S
P
K
Y
Site 55
S469
S
G
S
A
T
L
V
S
S
P
K
Y
G
S
D
Site 56
S470
G
S
A
T
L
V
S
S
P
K
Y
G
S
D
D
Site 57
Y473
T
L
V
S
S
P
K
Y
G
S
D
D
E
C
S
Site 58
S475
V
S
S
P
K
Y
G
S
D
D
E
C
S
S
A
Site 59
S480
Y
G
S
D
D
E
C
S
S
A
S
A
S
S
A
Site 60
S481
G
S
D
D
E
C
S
S
A
S
A
S
S
A
G
Site 61
S483
D
D
E
C
S
S
A
S
A
S
S
A
G
A
G
Site 62
S485
E
C
S
S
A
S
A
S
S
A
G
A
G
S
N
Site 63
S491
A
S
S
A
G
A
G
S
N
S
G
A
G
P
G
Site 64
S493
S
A
G
A
G
S
N
S
G
A
G
P
G
G
A
Site 65
S503
G
P
G
G
A
L
G
S
P
K
S
N
A
L
Y
Site 66
S506
G
A
L
G
S
P
K
S
N
A
L
Y
G
A
P
Site 67
Y510
S
P
K
S
N
A
L
Y
G
A
P
G
N
L
D
Site 68
S536
G
Q
S
H
L
E
D
S
M
E
D
L
K
T
Q
Site 69
T542
D
S
M
E
D
L
K
T
Q
L
Q
R
D
Y
T
Site 70
Y548
K
T
Q
L
Q
R
D
Y
T
Y
M
T
Q
C
L
Site 71
Y550
Q
L
Q
R
D
Y
T
Y
M
T
Q
C
L
Q
E
Site 72
Y562
L
Q
E
E
R
Y
R
Y
E
R
L
E
E
Q
L
Site 73
T573
E
E
Q
L
N
D
L
T
E
L
H
Q
N
E
M
Site 74
Y596
S
M
E
E
K
V
A
Y
Q
S
Y
E
R
A
R
Site 75
Y599
E
K
V
A
Y
Q
S
Y
E
R
A
R
D
I
Q
Site 76
S611
D
I
Q
E
A
V
E
S
C
L
T
R
V
T
K
Site 77
T617
E
S
C
L
T
R
V
T
K
L
E
L
Q
Q
Q
Site 78
T699
W
K
H
W
D
S
L
T
Y
L
L
E
H
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation