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Updated November 2019
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Protein Info
Short Name:
PLCL4
Full Name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2
Alias:
Phosphoinositide phospholipase C-like 4; phospholipase C-eta-2; PLC-eta2; PLCH2
Type:
Enzyme, phospholipid phospholipase
Mass (Da):
154668
Number AA:
1416
UniProt ID:
O75038
International Prot ID:
IPI00409676
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004435
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0016042
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
G
P
W
P
S
P
D
S
R
T
K
G
Site 2
S10
G
P
W
P
S
P
D
S
R
T
K
G
T
V
A
Site 3
S62
M
V
K
L
R
G
G
S
K
G
L
V
R
F
Y
Site 4
Y69
S
K
G
L
V
R
F
Y
Y
L
D
E
H
R
S
Site 5
Y70
K
G
L
V
R
F
Y
Y
L
D
E
H
R
S
C
Site 6
S83
S
C
I
R
W
R
P
S
R
K
N
E
K
A
K
Site 7
S95
K
A
K
I
S
I
D
S
I
Q
E
V
S
E
G
Site 8
S100
I
D
S
I
Q
E
V
S
E
G
R
Q
S
E
V
Site 9
S105
E
V
S
E
G
R
Q
S
E
V
F
Q
R
Y
P
Site 10
Y111
Q
S
E
V
F
Q
R
Y
P
D
G
S
F
D
P
Site 11
Y125
P
N
C
C
F
S
I
Y
H
G
S
H
R
E
S
Site 12
S128
C
F
S
I
Y
H
G
S
H
R
E
S
L
D
L
Site 13
S132
Y
H
G
S
H
R
E
S
L
D
L
V
S
T
S
Site 14
S137
R
E
S
L
D
L
V
S
T
S
S
E
V
A
R
Site 15
T145
T
S
S
E
V
A
R
T
W
V
T
G
L
R
Y
Site 16
S158
R
Y
L
M
A
G
I
S
D
E
D
S
L
A
R
Site 17
S162
A
G
I
S
D
E
D
S
L
A
R
R
Q
R
T
Site 18
T169
S
L
A
R
R
Q
R
T
R
D
Q
W
L
K
Q
Site 19
T177
R
D
Q
W
L
K
Q
T
F
D
E
A
D
K
N
Site 20
S188
A
D
K
N
G
D
G
S
L
S
I
G
E
V
L
Site 21
S190
K
N
G
D
G
S
L
S
I
G
E
V
L
Q
L
Site 22
T219
Q
M
F
R
E
A
D
T
D
D
H
Q
G
T
L
Site 23
Y235
F
E
E
F
C
A
F
Y
K
M
M
S
T
R
R
Site 24
T240
A
F
Y
K
M
M
S
T
R
R
D
L
Y
L
L
Site 25
Y245
M
S
T
R
R
D
L
Y
L
L
M
L
T
Y
S
Site 26
Y251
L
Y
L
L
M
L
T
Y
S
N
H
K
D
H
L
Site 27
S262
K
D
H
L
D
A
A
S
L
Q
R
F
L
Q
V
Site 28
S296
E
P
C
P
E
N
K
S
K
G
L
L
G
I
D
Site 29
Y308
G
I
D
G
F
T
N
Y
T
R
S
P
A
G
D
Site 30
T309
I
D
G
F
T
N
Y
T
R
S
P
A
G
D
I
Site 31
S311
G
F
T
N
Y
T
R
S
P
A
G
D
I
F
N
Site 32
S333
Q
D
M
T
Q
P
L
S
H
Y
F
I
T
S
S
Site 33
Y335
M
T
Q
P
L
S
H
Y
F
I
T
S
S
H
N
Site 34
T343
F
I
T
S
S
H
N
T
Y
L
V
G
D
Q
L
Site 35
Y344
I
T
S
S
H
N
T
Y
L
V
G
D
Q
L
M
Site 36
S352
L
V
G
D
Q
L
M
S
Q
S
R
V
D
M
Y
Site 37
Y359
S
Q
S
R
V
D
M
Y
A
W
V
L
Q
A
G
Site 38
Y406
V
I
E
T
I
N
K
Y
A
F
I
K
N
E
Y
Site 39
Y434
Q
Q
K
K
M
A
Q
Y
L
T
D
I
L
G
D
Site 40
S446
L
G
D
K
L
D
L
S
S
V
S
S
E
D
A
Site 41
S447
G
D
K
L
D
L
S
S
V
S
S
E
D
A
T
Site 42
S450
L
D
L
S
S
V
S
S
E
D
A
T
T
L
P
Site 43
T454
S
V
S
S
E
D
A
T
T
L
P
S
P
Q
M
Site 44
T455
V
S
S
E
D
A
T
T
L
P
S
P
Q
M
L
Site 45
S458
E
D
A
T
T
L
P
S
P
Q
M
L
K
G
K
Site 46
S478
K
K
L
P
A
N
I
S
E
D
A
E
E
G
E
Site 47
S487
D
A
E
E
G
E
V
S
D
E
D
S
A
D
E
Site 48
S491
G
E
V
S
D
E
D
S
A
D
E
I
D
D
D
Site 49
S507
K
L
L
N
G
D
A
S
T
N
R
K
R
V
E
Site 50
T508
L
L
N
G
D
A
S
T
N
R
K
R
V
E
N
Site 51
S523
T
A
K
R
K
L
D
S
L
I
K
E
S
K
I
Site 52
S540
C
E
D
P
N
N
F
S
V
S
T
L
S
P
S
Site 53
S542
D
P
N
N
F
S
V
S
T
L
S
P
S
G
K
Site 54
T543
P
N
N
F
S
V
S
T
L
S
P
S
G
K
L
Site 55
S545
N
F
S
V
S
T
L
S
P
S
G
K
L
G
R
Site 56
S547
S
V
S
T
L
S
P
S
G
K
L
G
R
K
S
Site 57
S554
S
G
K
L
G
R
K
S
K
A
E
E
D
V
E
Site 58
S562
K
A
E
E
D
V
E
S
G
E
D
A
G
A
S
Site 59
S569
S
G
E
D
A
G
A
S
R
R
N
G
R
L
V
Site 60
S579
N
G
R
L
V
V
G
S
F
S
R
R
K
K
K
Site 61
S581
R
L
V
V
G
S
F
S
R
R
K
K
K
G
S
Site 62
S588
S
R
R
K
K
K
G
S
K
L
K
K
A
A
S
Site 63
S595
S
K
L
K
K
A
A
S
V
E
E
G
D
E
G
Site 64
S605
E
G
D
E
G
Q
D
S
P
G
G
Q
S
R
G
Site 65
T614
G
G
Q
S
R
G
A
T
R
Q
K
K
T
M
K
Site 66
T619
G
A
T
R
Q
K
K
T
M
K
L
S
R
A
L
Site 67
S623
Q
K
K
T
M
K
L
S
R
A
L
S
D
L
V
Site 68
S627
M
K
L
S
R
A
L
S
D
L
V
K
Y
T
K
Site 69
Y632
A
L
S
D
L
V
K
Y
T
K
S
V
A
T
H
Site 70
T633
L
S
D
L
V
K
Y
T
K
S
V
A
T
H
D
Site 71
S635
D
L
V
K
Y
T
K
S
V
A
T
H
D
I
E
Site 72
S648
I
E
M
E
A
A
S
S
W
Q
V
S
S
F
S
Site 73
S652
A
A
S
S
W
Q
V
S
S
F
S
E
T
K
A
Site 74
S653
A
S
S
W
Q
V
S
S
F
S
E
T
K
A
H
Site 75
S655
S
W
Q
V
S
S
F
S
E
T
K
A
H
Q
I
Site 76
T657
Q
V
S
S
F
S
E
T
K
A
H
Q
I
L
Q
Site 77
Y670
L
Q
Q
K
P
A
Q
Y
L
R
F
N
Q
Q
Q
Site 78
S679
R
F
N
Q
Q
Q
L
S
R
I
Y
P
S
S
Y
Site 79
Y682
Q
Q
Q
L
S
R
I
Y
P
S
S
Y
R
V
D
Site 80
S684
Q
L
S
R
I
Y
P
S
S
Y
R
V
D
S
S
Site 81
S685
L
S
R
I
Y
P
S
S
Y
R
V
D
S
S
N
Site 82
Y686
S
R
I
Y
P
S
S
Y
R
V
D
S
S
N
Y
Site 83
S690
P
S
S
Y
R
V
D
S
S
N
Y
N
P
Q
P
Site 84
S691
S
S
Y
R
V
D
S
S
N
Y
N
P
Q
P
F
Site 85
Y710
C
Q
M
V
A
L
N
Y
Q
S
E
G
R
M
L
Site 86
S725
Q
L
N
R
A
K
F
S
A
N
G
G
C
G
Y
Site 87
S748
Q
G
V
F
N
P
N
S
E
D
P
L
P
G
Q
Site 88
S766
Q
L
V
L
R
I
I
S
G
Q
Q
L
P
K
P
Site 89
S776
Q
L
P
K
P
R
D
S
M
L
G
D
R
G
E
Site 90
S801
I
G
L
P
V
D
C
S
R
E
Q
T
R
V
V
Site 91
T805
V
D
C
S
R
E
Q
T
R
V
V
D
D
N
G
Site 92
T852
R
D
F
I
G
Q
R
T
L
A
F
S
S
M
M
Site 93
S856
G
Q
R
T
L
A
F
S
S
M
M
P
G
Y
R
Site 94
S857
Q
R
T
L
A
F
S
S
M
M
P
G
Y
R
H
Site 95
Y862
F
S
S
M
M
P
G
Y
R
H
V
Y
L
E
G
Site 96
Y866
M
P
G
Y
R
H
V
Y
L
E
G
M
E
E
A
Site 97
S906
L
R
G
P
K
P
G
S
L
D
S
H
A
A
G
Site 98
S909
P
K
P
G
S
L
D
S
H
A
A
G
R
P
P
Site 99
S920
G
R
P
P
A
R
P
S
V
S
Q
R
I
L
R
Site 100
S922
P
P
A
R
P
S
V
S
Q
R
I
L
R
R
T
Site 101
T929
S
Q
R
I
L
R
R
T
A
S
A
P
T
K
S
Site 102
S931
R
I
L
R
R
T
A
S
A
P
T
K
S
Q
K
Site 103
S936
T
A
S
A
P
T
K
S
Q
K
P
G
R
R
G
Site 104
T954
L
V
L
G
T
R
D
T
G
S
K
G
V
A
D
Site 105
S956
L
G
T
R
D
T
G
S
K
G
V
A
D
D
V
Site 106
S982
P
A
Q
E
G
P
G
S
G
S
P
R
D
T
R
Site 107
S984
Q
E
G
P
G
S
G
S
P
R
D
T
R
P
L
Site 108
T988
G
S
G
S
P
R
D
T
R
P
L
S
T
Q
R
Site 109
S992
P
R
D
T
R
P
L
S
T
Q
R
P
L
P
P
Site 110
T993
R
D
T
R
P
L
S
T
Q
R
P
L
P
P
L
Site 111
S1002
R
P
L
P
P
L
C
S
L
E
T
I
A
E
E
Site 112
S1025
P
P
A
A
V
P
T
S
S
S
Q
G
R
P
P
Site 113
S1026
P
A
A
V
P
T
S
S
S
Q
G
R
P
P
Y
Site 114
S1027
A
A
V
P
T
S
S
S
Q
G
R
P
P
Y
P
Site 115
Y1033
S
S
Q
G
R
P
P
Y
P
T
G
P
G
A
N
Site 116
T1035
Q
G
R
P
P
Y
P
T
G
P
G
A
N
V
A
Site 117
S1043
G
P
G
A
N
V
A
S
P
L
E
D
T
E
E
Site 118
T1048
V
A
S
P
L
E
D
T
E
E
P
R
D
S
R
Site 119
S1054
D
T
E
E
P
R
D
S
R
P
R
P
C
N
G
Site 120
Y1068
G
E
G
A
G
G
A
Y
E
R
A
P
G
S
Q
Site 121
S1074
A
Y
E
R
A
P
G
S
Q
T
D
G
R
S
Q
Site 122
T1076
E
R
A
P
G
S
Q
T
D
G
R
S
Q
P
R
Site 123
S1080
G
S
Q
T
D
G
R
S
Q
P
R
T
L
G
H
Site 124
T1084
D
G
R
S
Q
P
R
T
L
G
H
L
P
V
I
Site 125
S1096
P
V
I
R
R
V
K
S
E
G
Q
V
P
T
E
Site 126
Y1121
P
F
P
A
P
A
V
Y
S
D
A
T
G
S
D
Site 127
T1125
P
A
V
Y
S
D
A
T
G
S
D
P
L
W
Q
Site 128
S1142
E
P
C
G
H
R
D
S
V
S
S
S
S
S
M
Site 129
S1144
C
G
H
R
D
S
V
S
S
S
S
S
M
S
S
Site 130
S1145
G
H
R
D
S
V
S
S
S
S
S
M
S
S
S
Site 131
S1146
H
R
D
S
V
S
S
S
S
S
M
S
S
S
D
Site 132
S1147
R
D
S
V
S
S
S
S
S
M
S
S
S
D
T
Site 133
S1148
D
S
V
S
S
S
S
S
M
S
S
S
D
T
V
Site 134
S1150
V
S
S
S
S
S
M
S
S
S
D
T
V
I
D
Site 135
S1151
S
S
S
S
S
M
S
S
S
D
T
V
I
D
L
Site 136
S1152
S
S
S
S
M
S
S
S
D
T
V
I
D
L
S
Site 137
T1154
S
S
M
S
S
S
D
T
V
I
D
L
S
L
P
Site 138
S1168
P
S
L
G
L
G
R
S
R
E
N
L
A
G
A
Site 139
S1186
R
L
P
P
R
P
H
S
A
S
A
A
R
P
D
Site 140
S1188
P
P
R
P
H
S
A
S
A
A
R
P
D
L
P
Site 141
T1198
R
P
D
L
P
P
V
T
K
S
K
S
N
P
N
Site 142
S1200
D
L
P
P
V
T
K
S
K
S
N
P
N
L
R
Site 143
S1202
P
P
V
T
K
S
K
S
N
P
N
L
R
A
T
Site 144
T1209
S
N
P
N
L
R
A
T
G
Q
R
P
P
I
P
Site 145
S1223
P
D
E
L
Q
P
R
S
L
A
P
R
M
A
G
Site 146
S1254
D
C
P
V
A
A
K
S
K
S
L
G
D
L
T
Site 147
S1256
P
V
A
A
K
S
K
S
L
G
D
L
T
A
D
Site 148
T1261
S
K
S
L
G
D
L
T
A
D
D
F
A
P
S
Site 149
S1268
T
A
D
D
F
A
P
S
F
E
G
G
S
R
R
Site 150
S1273
A
P
S
F
E
G
G
S
R
R
L
S
H
S
L
Site 151
S1277
E
G
G
S
R
R
L
S
H
S
L
G
L
P
G
Site 152
S1279
G
S
R
R
L
S
H
S
L
G
L
P
G
G
T
Site 153
T1286
S
L
G
L
P
G
G
T
R
R
V
S
G
P
G
Site 154
S1290
P
G
G
T
R
R
V
S
G
P
G
V
R
R
D
Site 155
T1298
G
P
G
V
R
R
D
T
L
T
E
Q
L
R
W
Site 156
T1300
G
V
R
R
D
T
L
T
E
Q
L
R
W
L
T
Site 157
T1307
T
E
Q
L
R
W
L
T
V
F
Q
Q
A
G
D
Site 158
T1316
F
Q
Q
A
G
D
I
T
S
P
T
S
L
G
P
Site 159
S1317
Q
Q
A
G
D
I
T
S
P
T
S
L
G
P
A
Site 160
S1320
G
D
I
T
S
P
T
S
L
G
P
A
G
E
G
Site 161
S1338
G
P
G
F
V
R
R
S
S
S
R
S
H
S
R
Site 162
S1339
P
G
F
V
R
R
S
S
S
R
S
H
S
R
V
Site 163
S1340
G
F
V
R
R
S
S
S
R
S
H
S
R
V
R
Site 164
S1342
V
R
R
S
S
S
R
S
H
S
R
V
R
A
I
Site 165
S1344
R
S
S
S
R
S
H
S
R
V
R
A
I
A
S
Site 166
S1351
S
R
V
R
A
I
A
S
R
A
R
Q
A
Q
E
Site 167
T1378
P
P
E
E
E
R
G
T
P
E
G
A
C
S
V
Site 168
S1384
G
T
P
E
G
A
C
S
V
G
H
E
G
S
V
Site 169
S1390
C
S
V
G
H
E
G
S
V
D
A
P
A
P
S
Site 170
S1397
S
V
D
A
P
A
P
S
K
G
A
L
G
P
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation