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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIF21B
Full Name:
Kinesin-like protein KIF21B
Alias:
KI21B; KIAA0449
Type:
Microtubule binding protein, Motor protein
Mass (Da):
182662
Number AA:
1637
UniProt ID:
O75037
International Prot ID:
IPI00397809
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0007018
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
V
R
I
R
P
Q
L
S
K
E
K
I
E
G
C
Site 2
S32
E
G
C
H
I
C
T
S
V
T
P
G
E
P
Q
Site 3
Y50
G
K
D
K
A
F
T
Y
D
F
V
F
D
L
D
Site 4
Y64
D
T
W
Q
E
Q
I
Y
S
T
C
V
S
K
L
Site 5
Y95
Q
T
G
A
G
K
T
Y
T
M
G
T
G
F
D
Site 6
T105
G
T
G
F
D
M
A
T
S
E
E
E
Q
G
I
Site 7
S106
T
G
F
D
M
A
T
S
E
E
E
Q
G
I
I
Site 8
Y151
S
A
Q
F
L
E
L
Y
N
E
E
I
L
D
L
Site 9
S161
E
I
L
D
L
F
D
S
T
R
D
P
D
T
R
Site 10
T162
I
L
D
L
F
D
S
T
R
D
P
D
T
R
H
Site 11
T167
D
S
T
R
D
P
D
T
R
H
R
R
S
N
I
Site 12
S172
P
D
T
R
H
R
R
S
N
I
K
I
H
E
D
Site 13
Y185
E
D
A
N
G
G
I
Y
T
T
G
V
T
S
R
Site 14
S196
V
T
S
R
L
I
H
S
Q
E
E
L
I
Q
C
Site 15
T213
Q
G
A
L
S
R
T
T
A
S
T
Q
M
N
V
Site 16
T216
L
S
R
T
T
A
S
T
Q
M
N
V
Q
S
S
Site 17
S222
S
T
Q
M
N
V
Q
S
S
R
S
H
A
I
F
Site 18
T256
V
T
G
L
P
D
G
T
P
P
S
S
E
Y
E
Site 19
S259
L
P
D
G
T
P
P
S
S
E
Y
E
T
L
T
Site 20
S260
P
D
G
T
P
P
S
S
E
Y
E
T
L
T
A
Site 21
T264
P
P
S
S
E
Y
E
T
L
T
A
K
F
H
F
Site 22
S277
H
F
V
D
L
A
G
S
E
R
L
K
R
T
G
Site 23
S325
V
H
V
P
Y
R
D
S
K
L
T
R
L
L
Q
Site 24
T328
P
Y
R
D
S
K
L
T
R
L
L
Q
D
S
L
Site 25
S334
L
T
R
L
L
Q
D
S
L
G
G
N
S
Q
T
Site 26
S339
Q
D
S
L
G
G
N
S
Q
T
I
M
I
A
C
Site 27
S350
M
I
A
C
V
S
P
S
D
R
D
F
M
E
T
Site 28
T357
S
D
R
D
F
M
E
T
L
N
T
L
K
Y
A
Site 29
T360
D
F
M
E
T
L
N
T
L
K
Y
A
N
R
A
Site 30
Y363
E
T
L
N
T
L
K
Y
A
N
R
A
R
N
I
Site 31
T381
V
V
V
N
Q
D
K
T
S
Q
Q
I
S
A
L
Site 32
S382
V
V
N
Q
D
K
T
S
Q
Q
I
S
A
L
R
Site 33
S386
D
K
T
S
Q
Q
I
S
A
L
R
A
E
I
A
Site 34
Y402
L
Q
M
E
L
M
E
Y
K
A
G
K
R
V
I
Site 35
Y417
G
E
D
G
A
E
G
Y
S
D
L
F
R
E
N
Site 36
T453
D
A
I
N
N
R
V
T
Q
L
M
S
Q
E
A
Site 37
S457
N
R
V
T
Q
L
M
S
Q
E
A
N
L
L
L
Site 38
T490
R
E
I
E
E
L
R
T
K
L
L
E
S
E
A
Site 39
S501
E
S
E
A
M
N
E
S
L
R
R
S
L
S
R
Site 40
S505
M
N
E
S
L
R
R
S
L
S
R
A
S
A
R
Site 41
S507
E
S
L
R
R
S
L
S
R
A
S
A
R
S
P
Site 42
S510
R
R
S
L
S
R
A
S
A
R
S
P
Y
S
L
Site 43
S513
L
S
R
A
S
A
R
S
P
Y
S
L
G
A
S
Site 44
Y515
R
A
S
A
R
S
P
Y
S
L
G
A
S
P
A
Site 45
S516
A
S
A
R
S
P
Y
S
L
G
A
S
P
A
A
Site 46
S529
A
A
P
A
F
G
G
S
P
A
S
S
M
E
D
Site 47
S532
A
F
G
G
S
P
A
S
S
M
E
D
A
S
E
Site 48
S533
F
G
G
S
P
A
S
S
M
E
D
A
S
E
V
Site 49
S538
A
S
S
M
E
D
A
S
E
V
I
R
R
A
K
Site 50
S562
E
V
R
Q
R
R
K
S
P
E
K
E
A
F
K
Site 51
S579
A
K
L
Q
Q
E
N
S
E
E
T
D
E
N
E
Site 52
T582
Q
Q
E
N
S
E
E
T
D
E
N
E
A
E
E
Site 53
S597
E
E
E
E
R
D
E
S
G
C
E
E
E
E
G
Site 54
S612
R
E
D
E
D
E
D
S
G
S
E
E
S
L
V
Site 55
S614
D
E
D
E
D
S
G
S
E
E
S
L
V
D
S
Site 56
S617
E
D
S
G
S
E
E
S
L
V
D
S
D
S
D
Site 57
S621
S
E
E
S
L
V
D
S
D
S
D
P
E
E
K
Site 58
S623
E
S
L
V
D
S
D
S
D
P
E
E
K
E
V
Site 59
T640
Q
A
D
L
A
D
L
T
C
E
I
E
I
K
Q
Site 60
S656
L
I
D
E
L
E
N
S
Q
R
R
L
Q
T
L
Site 61
T662
N
S
Q
R
R
L
Q
T
L
K
H
Q
Y
E
E
Site 62
T681
L
Q
N
K
I
R
D
T
Q
L
E
R
D
R
V
Site 63
S693
D
R
V
L
Q
N
L
S
T
M
E
C
Y
T
E
Site 64
Y710
A
N
K
I
K
A
D
Y
E
K
R
L
R
E
M
Site 65
S739
A
R
L
L
K
N
Q
S
R
Y
E
R
E
L
K
Site 66
Y741
L
L
K
N
Q
S
R
Y
E
R
E
L
K
K
L
Site 67
T778
Q
R
R
R
L
V
E
T
K
R
N
R
E
I
A
Site 68
S803
F
Q
I
R
A
L
E
S
Q
K
R
Q
Q
E
M
Site 69
T816
E
M
V
L
R
R
K
T
Q
E
V
S
A
L
R
Site 70
S820
R
R
K
T
Q
E
V
S
A
L
R
R
L
A
K
Site 71
S830
R
R
L
A
K
P
M
S
E
R
V
A
G
R
A
Site 72
S846
L
K
P
P
M
L
D
S
G
A
E
V
S
A
S
Site 73
S851
L
D
S
G
A
E
V
S
A
S
T
T
S
S
E
Site 74
S853
S
G
A
E
V
S
A
S
T
T
S
S
E
A
E
Site 75
T855
A
E
V
S
A
S
T
T
S
S
E
A
E
S
G
Site 76
S857
V
S
A
S
T
T
S
S
E
A
E
S
G
A
R
Site 77
S861
T
T
S
S
E
A
E
S
G
A
R
S
V
S
S
Site 78
S865
E
A
E
S
G
A
R
S
V
S
S
I
V
R
Q
Site 79
S867
E
S
G
A
R
S
V
S
S
I
V
R
Q
W
N
Site 80
S868
S
G
A
R
S
V
S
S
I
V
R
Q
W
N
R
Site 81
T888
L
G
D
H
P
A
P
T
V
N
G
T
R
P
A
Site 82
S905
K
F
Q
K
K
G
A
S
Q
S
F
S
K
A
A
Site 83
S907
Q
K
K
G
A
S
Q
S
F
S
K
A
A
R
L
Site 84
S909
K
G
A
S
Q
S
F
S
K
A
A
R
L
K
W
Site 85
S918
A
A
R
L
K
W
Q
S
L
E
R
R
I
I
D
Site 86
T932
D
I
V
M
Q
R
M
T
I
V
N
L
E
A
D
Site 87
S968
R
E
R
L
Q
A
E
S
P
E
E
E
K
G
L
Site 88
S1015
E
T
K
E
E
L
D
S
T
D
T
S
V
V
I
Site 89
T1016
T
K
E
E
L
D
S
T
D
T
S
V
V
I
S
Site 90
T1018
E
E
L
D
S
T
D
T
S
V
V
I
S
S
C
Site 91
S1019
E
L
D
S
T
D
T
S
V
V
I
S
S
C
S
Site 92
T1065
L
E
G
R
L
R
Q
T
D
M
A
G
S
S
Q
Site 93
S1071
Q
T
D
M
A
G
S
S
Q
N
H
L
L
L
D
Site 94
Y1095
P
E
L
Q
A
L
I
Y
N
V
Q
Q
E
N
G
Site 95
S1111
A
S
T
D
E
E
I
S
E
F
S
E
G
S
F
Site 96
S1114
D
E
E
I
S
E
F
S
E
G
S
F
S
Q
S
Site 97
S1117
I
S
E
F
S
E
G
S
F
S
Q
S
F
T
M
Site 98
S1119
E
F
S
E
G
S
F
S
Q
S
F
T
M
K
G
Site 99
S1121
S
E
G
S
F
S
Q
S
F
T
M
K
G
S
T
Site 100
T1123
G
S
F
S
Q
S
F
T
M
K
G
S
T
S
H
Site 101
S1137
H
D
D
F
K
F
K
S
E
P
K
L
S
A
Q
Site 102
S1142
F
K
S
E
P
K
L
S
A
Q
M
K
A
V
S
Site 103
S1149
S
A
Q
M
K
A
V
S
A
E
C
L
G
P
P
Site 104
S1160
L
G
P
P
L
D
I
S
T
K
N
I
T
K
S
Site 105
T1161
G
P
P
L
D
I
S
T
K
N
I
T
K
S
L
Site 106
S1167
S
T
K
N
I
T
K
S
L
A
S
L
V
E
I
Site 107
S1182
K
E
D
G
V
G
F
S
V
R
D
P
Y
Y
R
Site 108
Y1187
G
F
S
V
R
D
P
Y
Y
R
D
R
V
S
R
Site 109
Y1188
F
S
V
R
D
P
Y
Y
R
D
R
V
S
R
T
Site 110
S1193
P
Y
Y
R
D
R
V
S
R
T
V
S
L
P
T
Site 111
T1195
Y
R
D
R
V
S
R
T
V
S
L
P
T
R
G
Site 112
S1197
D
R
V
S
R
T
V
S
L
P
T
R
G
S
T
Site 113
S1203
V
S
L
P
T
R
G
S
T
F
P
R
Q
S
R
Site 114
T1204
S
L
P
T
R
G
S
T
F
P
R
Q
S
R
A
Site 115
S1209
G
S
T
F
P
R
Q
S
R
A
T
E
T
S
P
Site 116
T1212
F
P
R
Q
S
R
A
T
E
T
S
P
L
T
R
Site 117
S1215
Q
S
R
A
T
E
T
S
P
L
T
R
R
K
S
Site 118
T1218
A
T
E
T
S
P
L
T
R
R
K
S
Y
D
R
Site 119
S1222
S
P
L
T
R
R
K
S
Y
D
R
G
Q
P
I
Site 120
Y1223
P
L
T
R
R
K
S
Y
D
R
G
Q
P
I
R
Site 121
T1232
R
G
Q
P
I
R
S
T
D
V
G
F
T
P
P
Site 122
T1237
R
S
T
D
V
G
F
T
P
P
S
S
P
P
T
Site 123
S1240
D
V
G
F
T
P
P
S
S
P
P
T
R
P
R
Site 124
S1241
V
G
F
T
P
P
S
S
P
P
T
R
P
R
N
Site 125
T1244
T
P
P
S
S
P
P
T
R
P
R
N
D
R
N
Site 126
S1254
R
N
D
R
N
V
F
S
R
L
T
S
N
Q
S
Site 127
T1257
R
N
V
F
S
R
L
T
S
N
Q
S
Q
G
S
Site 128
S1258
N
V
F
S
R
L
T
S
N
Q
S
Q
G
S
A
Site 129
S1261
S
R
L
T
S
N
Q
S
Q
G
S
A
L
D
K
Site 130
S1269
Q
G
S
A
L
D
K
S
D
D
S
D
S
S
L
Site 131
S1272
A
L
D
K
S
D
D
S
D
S
S
L
S
E
V
Site 132
S1274
D
K
S
D
D
S
D
S
S
L
S
E
V
L
R
Site 133
S1275
K
S
D
D
S
D
S
S
L
S
E
V
L
R
G
Site 134
S1277
D
D
S
D
S
S
L
S
E
V
L
R
G
I
I
Site 135
S1302
T
A
P
L
Q
C
V
S
M
A
E
G
H
T
K
Site 136
T1323
A
T
D
E
L
L
F
T
G
S
K
D
R
S
C
Site 137
S1325
D
E
L
L
F
T
G
S
K
D
R
S
C
K
M
Site 138
T1385
D
S
A
K
C
I
R
T
L
T
S
S
G
Q
V
Site 139
T1407
A
T
S
T
R
A
I
T
S
A
Q
G
E
H
Q
Site 140
S1421
Q
I
N
Q
I
A
L
S
P
S
G
T
M
L
Y
Site 141
S1441
A
V
R
I
W
E
L
S
R
F
Q
P
V
G
K
Site 142
T1462
P
V
M
C
L
T
V
T
Q
T
A
S
Q
H
D
Site 143
Y1479
V
T
G
S
K
D
H
Y
V
K
M
F
E
L
G
Site 144
Y1504
H
N
F
E
P
P
H
Y
D
G
I
E
C
L
A
Site 145
S1521
G
D
I
L
F
S
G
S
R
D
N
G
I
K
K
Site 146
T1578
V
W
N
V
D
N
F
T
P
I
G
E
I
K
G
Site 147
S1588
G
E
I
K
G
H
D
S
P
I
N
A
I
C
T
Site 148
T1619
W
N
Y
V
P
G
L
T
P
C
L
P
R
R
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation