KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DIAPH2
Full Name:
Protein diaphanous homolog 2
Alias:
DIA; DIA2; DIAP2; diaphanous 2; diaphanous-related formin-2; DRF2; POF; POF2
Type:
Cytoskeletal protein
Mass (Da):
125569
Number AA:
1101
UniProt ID:
O60879
International Prot ID:
IPI00396241
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005829
GO:0005769
Uniprot
OncoNet
Molecular Function:
GO:0017048
GO:0003779
GO:0005102
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0030154
GO:0000910
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
Q
P
G
A
A
A
S
G
A
G
G
G
S
E
Site 2
S15
A
S
G
A
G
G
G
S
E
E
P
G
G
G
R
Site 3
S23
E
E
P
G
G
G
R
S
N
K
R
S
A
G
N
Site 4
S27
G
G
R
S
N
K
R
S
A
G
N
R
A
A
N
Site 5
T50
K
L
N
I
Q
I
K
T
L
A
D
D
V
R
D
Site 6
T60
D
D
V
R
D
R
I
T
S
F
R
K
S
T
V
Site 7
S61
D
V
R
D
R
I
T
S
F
R
K
S
T
V
K
Site 8
S65
R
I
T
S
F
R
K
S
T
V
K
K
E
K
P
Site 9
T66
I
T
S
F
R
K
S
T
V
K
K
E
K
P
L
Site 10
Y94
F
P
A
A
Q
P
L
Y
D
E
R
S
L
N
L
Site 11
S98
Q
P
L
Y
D
E
R
S
L
N
L
S
E
K
E
Site 12
S102
D
E
R
S
L
N
L
S
E
K
E
V
L
D
L
Site 13
T133
P
L
R
N
K
D
F
T
T
K
R
E
M
V
V
Site 14
T134
L
R
N
K
D
F
T
T
K
R
E
M
V
V
Q
Site 15
S149
Y
I
S
A
T
A
K
S
G
G
L
K
N
S
K
Site 16
S155
K
S
G
G
L
K
N
S
K
H
E
C
T
L
S
Site 17
T160
K
N
S
K
H
E
C
T
L
S
S
Q
E
Y
V
Site 18
S162
S
K
H
E
C
T
L
S
S
Q
E
Y
V
H
E
Site 19
S163
K
H
E
C
T
L
S
S
Q
E
Y
V
H
E
L
Site 20
Y166
C
T
L
S
S
Q
E
Y
V
H
E
L
R
S
G
Site 21
S175
H
E
L
R
S
G
I
S
D
E
K
L
L
N
C
Site 22
T191
E
S
L
R
V
S
L
T
S
N
P
V
S
W
V
Site 23
S192
S
L
R
V
S
L
T
S
N
P
V
S
W
V
N
Site 24
S196
S
L
T
S
N
P
V
S
W
V
N
N
F
G
H
Site 25
S311
R
N
N
R
E
R
F
S
P
I
V
E
G
L
E
Site 26
Y341
N
A
L
V
T
S
P
Y
E
L
D
F
R
I
H
Site 27
S356
L
R
N
E
F
L
R
S
G
L
K
T
M
L
P
Site 28
T360
F
L
R
S
G
L
K
T
M
L
P
D
L
K
E
Site 29
T389
E
N
K
E
D
D
L
T
E
L
S
H
R
L
N
Site 30
S392
E
D
D
L
T
E
L
S
H
R
L
N
D
I
R
Site 31
Y424
K
D
T
A
A
E
N
Y
F
L
S
I
L
Q
H
Site 32
Y439
F
L
L
I
R
N
D
Y
Y
I
R
P
Q
Y
Y
Site 33
Y440
L
L
I
R
N
D
Y
Y
I
R
P
Q
Y
Y
K
Site 34
Y445
D
Y
Y
I
R
P
Q
Y
Y
K
I
I
E
E
C
Site 35
Y469
G
M
D
P
D
F
K
Y
R
Q
R
L
D
I
D
Site 36
S543
R
T
Q
A
Q
V
L
S
S
S
S
G
I
P
G
Site 37
S544
T
Q
A
Q
V
L
S
S
S
S
G
I
P
G
P
Site 38
Y632
G
M
K
Q
K
K
M
Y
K
P
E
V
S
M
K
Site 39
T696
E
A
L
E
E
K
K
T
G
P
T
K
K
K
V
Site 40
S718
P
K
T
A
Q
N
L
S
I
F
L
G
S
Y
R
Site 41
S723
N
L
S
I
F
L
G
S
Y
R
M
P
Y
E
D
Site 42
Y728
L
G
S
Y
R
M
P
Y
E
D
I
R
N
V
I
Site 43
S744
E
V
N
E
D
M
L
S
E
A
L
I
Q
N
L
Site 44
T802
S
S
I
L
F
K
L
T
F
E
E
H
I
N
N
Site 45
S827
A
C
E
E
L
K
K
S
E
S
F
N
R
L
L
Site 46
S829
E
E
L
K
K
S
E
S
F
N
R
L
L
E
L
Site 47
S848
G
N
Y
M
N
S
G
S
R
N
A
Q
S
L
G
Site 48
S853
S
G
S
R
N
A
Q
S
L
G
F
K
I
N
F
Site 49
T867
F
L
C
K
I
R
D
T
K
S
A
D
Q
K
T
Site 50
S869
C
K
I
R
D
T
K
S
A
D
Q
K
T
T
L
Site 51
S903
E
E
L
E
H
V
E
S
A
S
K
V
S
A
Q
Site 52
S914
V
S
A
Q
I
L
K
S
N
L
A
S
M
E
Q
Site 53
S918
I
L
K
S
N
L
A
S
M
E
Q
Q
I
V
H
Site 54
S949
K
F
V
E
K
M
T
S
F
T
K
T
A
R
E
Site 55
T953
K
M
T
S
F
T
K
T
A
R
E
Q
Y
E
K
Site 56
Y958
T
K
T
A
R
E
Q
Y
E
K
L
S
T
M
H
Site 57
Y972
H
N
N
M
M
K
L
Y
E
N
L
G
E
Y
F
Site 58
Y978
L
Y
E
N
L
G
E
Y
F
I
F
D
S
K
T
Site 59
S983
G
E
Y
F
I
F
D
S
K
T
V
S
I
E
E
Site 60
S987
I
F
D
S
K
T
V
S
I
E
E
F
F
G
D
Site 61
T1000
G
D
L
N
N
F
R
T
L
F
L
E
A
V
R
Site 62
T1019
R
R
E
M
E
E
K
T
R
R
A
K
L
A
K
Site 63
T1053
I
N
K
E
G
D
E
T
G
V
M
D
N
L
L
Site 64
S1065
N
L
L
E
A
L
Q
S
G
A
A
F
R
D
R
Site 65
S1092
V
P
L
E
R
S
R
S
R
H
N
G
A
I
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation