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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HCN1
Full Name:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Alias:
BCNG1; BCNG-1; Brain cyclic nucleotide-gated channel 1
Type:
Axon, Membrane, Dendrite, Integral membrane protein
Mass (Da):
98796
Number AA:
890
UniProt ID:
O60741
International Prot ID:
IPI00031506
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0016021
GO:0030424
Uniprot
OncoNet
Molecular Function:
GO:0030552
GO:0030955
GO:0005272
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
G
G
G
K
P
N
S
S
S
N
S
R
D
D
Site 2
S10
G
G
G
K
P
N
S
S
S
N
S
R
D
D
G
Site 3
S11
G
G
K
P
N
S
S
S
N
S
R
D
D
G
N
Site 4
S13
K
P
N
S
S
S
N
S
R
D
D
G
N
S
V
Site 5
S19
N
S
R
D
D
G
N
S
V
F
P
A
K
A
S
Site 6
T41
A
A
E
K
R
L
G
T
P
P
G
G
G
G
A
Site 7
S56
G
A
K
E
H
G
N
S
V
C
F
K
V
D
G
Site 8
Y91
A
E
G
P
R
R
Q
Y
G
F
M
Q
R
Q
F
Site 9
T99
G
F
M
Q
R
Q
F
T
S
M
L
Q
P
G
V
Site 10
S110
Q
P
G
V
N
K
F
S
L
R
M
F
G
S
Q
Site 11
S116
F
S
L
R
M
F
G
S
Q
K
A
V
E
K
E
Site 12
T129
K
E
Q
E
R
V
K
T
A
G
F
W
I
I
H
Site 13
T198
I
M
N
F
R
T
G
T
V
N
E
D
S
S
E
Site 14
S203
T
G
T
V
N
E
D
S
S
E
I
I
L
D
P
Site 15
Y217
P
K
V
I
K
M
N
Y
L
K
S
W
F
V
V
Site 16
S245
I
V
E
K
G
M
D
S
E
V
Y
K
T
A
R
Site 17
Y248
K
G
M
D
S
E
V
Y
K
T
A
R
A
L
R
Site 18
T250
M
D
S
E
V
Y
K
T
A
R
A
L
R
I
V
Site 19
Y345
N
D
S
W
G
K
Q
Y
S
Y
A
L
F
K
A
Site 20
Y347
S
W
G
K
Q
Y
S
Y
A
L
F
K
A
M
S
Site 21
S354
Y
A
L
F
K
A
M
S
H
M
L
C
I
G
Y
Site 22
S399
H
A
T
A
L
I
Q
S
L
D
S
S
R
R
Q
Site 23
S402
A
L
I
Q
S
L
D
S
S
R
R
Q
Y
Q
E
Site 24
S403
L
I
Q
S
L
D
S
S
R
R
Q
Y
Q
E
K
Site 25
Y407
L
D
S
S
R
R
Q
Y
Q
E
K
Y
K
Q
V
Site 26
Y411
R
R
Q
Y
Q
E
K
Y
K
Q
V
E
Q
Y
M
Site 27
Y417
K
Y
K
Q
V
E
Q
Y
M
S
F
H
K
L
P
Site 28
S419
K
Q
V
E
Q
Y
M
S
F
H
K
L
P
A
D
Site 29
Y434
M
R
Q
K
I
H
D
Y
Y
E
H
R
Y
Q
G
Site 30
Y435
R
Q
K
I
H
D
Y
Y
E
H
R
Y
Q
G
K
Site 31
Y501
E
V
F
Q
P
G
D
Y
I
I
R
E
G
A
V
Site 32
S526
V
A
G
V
I
T
K
S
S
K
E
M
K
L
T
Site 33
T533
S
S
K
E
M
K
L
T
D
G
S
Y
F
G
E
Site 34
T545
F
G
E
I
C
L
L
T
K
G
R
R
T
A
S
Site 35
T550
L
L
T
K
G
R
R
T
A
S
V
R
A
D
T
Site 36
S552
T
K
G
R
R
T
A
S
V
R
A
D
T
Y
C
Site 37
T557
T
A
S
V
R
A
D
T
Y
C
R
L
Y
S
L
Site 38
Y558
A
S
V
R
A
D
T
Y
C
R
L
Y
S
L
S
Site 39
Y562
A
D
T
Y
C
R
L
Y
S
L
S
V
D
N
F
Site 40
S563
D
T
Y
C
R
L
Y
S
L
S
V
D
N
F
N
Site 41
S565
Y
C
R
L
Y
S
L
S
V
D
N
F
N
E
V
Site 42
Y576
F
N
E
V
L
E
E
Y
P
M
M
R
R
A
F
Site 43
T585
M
M
R
R
A
F
E
T
V
A
I
D
R
L
D
Site 44
Y641
Q
A
I
A
P
I
N
Y
P
Q
M
T
T
L
N
Site 45
T645
P
I
N
Y
P
Q
M
T
T
L
N
S
T
S
S
Site 46
T646
I
N
Y
P
Q
M
T
T
L
N
S
T
S
S
T
Site 47
S649
P
Q
M
T
T
L
N
S
T
S
S
T
T
T
P
Site 48
S652
T
T
L
N
S
T
S
S
T
T
T
P
T
S
R
Site 49
T653
T
L
N
S
T
S
S
T
T
T
P
T
S
R
M
Site 50
T655
N
S
T
S
S
T
T
T
P
T
S
R
M
R
T
Site 51
T657
T
S
S
T
T
T
P
T
S
R
M
R
T
Q
S
Site 52
S658
S
S
T
T
T
P
T
S
R
M
R
T
Q
S
P
Site 53
T662
T
P
T
S
R
M
R
T
Q
S
P
P
V
Y
T
Site 54
S664
T
S
R
M
R
T
Q
S
P
P
V
Y
T
A
T
Site 55
Y668
R
T
Q
S
P
P
V
Y
T
A
T
S
L
S
H
Site 56
T669
T
Q
S
P
P
V
Y
T
A
T
S
L
S
H
S
Site 57
T671
S
P
P
V
Y
T
A
T
S
L
S
H
S
N
L
Site 58
S672
P
P
V
Y
T
A
T
S
L
S
H
S
N
L
H
Site 59
S674
V
Y
T
A
T
S
L
S
H
S
N
L
H
S
P
Site 60
S676
T
A
T
S
L
S
H
S
N
L
H
S
P
S
P
Site 61
S680
L
S
H
S
N
L
H
S
P
S
P
S
T
Q
T
Site 62
S682
H
S
N
L
H
S
P
S
P
S
T
Q
T
P
Q
Site 63
S684
N
L
H
S
P
S
P
S
T
Q
T
P
Q
P
S
Site 64
T685
L
H
S
P
S
P
S
T
Q
T
P
Q
P
S
A
Site 65
T687
S
P
S
P
S
T
Q
T
P
Q
P
S
A
I
L
Site 66
S691
S
T
Q
T
P
Q
P
S
A
I
L
S
P
C
S
Site 67
S695
P
Q
P
S
A
I
L
S
P
C
S
Y
T
T
A
Site 68
S710
V
C
S
P
P
V
Q
S
P
L
A
A
R
T
F
Site 69
T716
Q
S
P
L
A
A
R
T
F
H
Y
A
S
P
T
Site 70
Y719
L
A
A
R
T
F
H
Y
A
S
P
T
A
S
Q
Site 71
S721
A
R
T
F
H
Y
A
S
P
T
A
S
Q
L
S
Site 72
T723
T
F
H
Y
A
S
P
T
A
S
Q
L
S
L
M
Site 73
S725
H
Y
A
S
P
T
A
S
Q
L
S
L
M
Q
Q
Site 74
S728
S
P
T
A
S
Q
L
S
L
M
Q
Q
Q
P
Q
Site 75
S741
P
Q
Q
Q
V
Q
Q
S
Q
P
P
Q
T
Q
P
Site 76
T746
Q
Q
S
Q
P
P
Q
T
Q
P
Q
Q
P
S
P
Site 77
S752
Q
T
Q
P
Q
Q
P
S
P
Q
P
Q
T
P
G
Site 78
T757
Q
P
S
P
Q
P
Q
T
P
G
S
S
T
P
K
Site 79
S760
P
Q
P
Q
T
P
G
S
S
T
P
K
N
E
V
Site 80
T762
P
Q
T
P
G
S
S
T
P
K
N
E
V
H
K
Site 81
S770
P
K
N
E
V
H
K
S
T
Q
A
L
H
N
T
Site 82
T780
A
L
H
N
T
N
L
T
R
E
V
R
P
L
S
Site 83
S787
T
R
E
V
R
P
L
S
A
S
Q
P
S
L
P
Site 84
S789
E
V
R
P
L
S
A
S
Q
P
S
L
P
H
E
Site 85
S792
P
L
S
A
S
Q
P
S
L
P
H
E
V
S
T
Site 86
S798
P
S
L
P
H
E
V
S
T
L
I
S
R
P
H
Site 87
T799
S
L
P
H
E
V
S
T
L
I
S
R
P
H
P
Site 88
S802
H
E
V
S
T
L
I
S
R
P
H
P
T
V
G
Site 89
T807
L
I
S
R
P
H
P
T
V
G
E
S
L
A
S
Site 90
S811
P
H
P
T
V
G
E
S
L
A
S
I
P
Q
P
Site 91
T834
L
Q
A
G
G
R
S
T
V
P
Q
R
V
T
L
Site 92
T840
S
T
V
P
Q
R
V
T
L
F
R
Q
M
S
S
Site 93
S846
V
T
L
F
R
Q
M
S
S
G
A
I
P
P
N
Site 94
S847
T
L
F
R
Q
M
S
S
G
A
I
P
P
N
R
Site 95
S871
A
A
A
L
P
R
E
S
S
S
V
L
N
T
D
Site 96
S872
A
A
L
P
R
E
S
S
S
V
L
N
T
D
P
Site 97
S873
A
L
P
R
E
S
S
S
V
L
N
T
D
P
D
Site 98
T877
E
S
S
S
V
L
N
T
D
P
D
A
E
K
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation