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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC24A1
Full Name:
Sodium/potassium/calcium exchanger 1
Alias:
Na(+)/K(+)/Ca(2+)-exchange protein 1;Retinal rod Na-Ca+K exchanger
Type:
Mass (Da):
121374
Number AA:
1099
UniProt ID:
O60721
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
Q
E
R
W
L
L
R
T
K
R
L
H
W
S
R
Site 2
S23
R
T
K
R
L
H
W
S
R
L
L
F
L
L
G
Site 3
S48
L
R
R
P
R
G
L
S
S
L
W
A
A
V
S
Site 4
S49
R
R
P
R
G
L
S
S
L
W
A
A
V
S
S
Site 5
S55
S
S
L
W
A
A
V
S
S
H
Q
P
I
K
L
Site 6
S64
H
Q
P
I
K
L
A
S
R
D
L
S
S
E
E
Site 7
S68
K
L
A
S
R
D
L
S
S
E
E
M
M
M
M
Site 8
S69
L
A
S
R
D
L
S
S
E
E
M
M
M
M
S
Site 9
S76
S
E
E
M
M
M
M
S
S
S
P
S
K
P
S
Site 10
S77
E
E
M
M
M
M
S
S
S
P
S
K
P
S
S
Site 11
S78
E
M
M
M
M
S
S
S
P
S
K
P
S
S
E
Site 12
S80
M
M
M
S
S
S
P
S
K
P
S
S
E
M
G
Site 13
S83
S
S
S
P
S
K
P
S
S
E
M
G
G
K
M
Site 14
S84
S
S
P
S
K
P
S
S
E
M
G
G
K
M
L
Site 15
S96
K
M
L
V
P
Q
A
S
V
G
S
D
E
A
T
Site 16
S99
V
P
Q
A
S
V
G
S
D
E
A
T
L
S
M
Site 17
T103
S
V
G
S
D
E
A
T
L
S
M
T
V
E
N
Site 18
S105
G
S
D
E
A
T
L
S
M
T
V
E
N
I
P
Site 19
T107
D
E
A
T
L
S
M
T
V
E
N
I
P
S
M
Site 20
S113
M
T
V
E
N
I
P
S
M
P
K
R
T
A
K
Site 21
S131
T
T
T
K
N
N
Y
S
P
T
A
A
G
T
E
Site 22
T137
Y
S
P
T
A
A
G
T
E
R
R
K
E
D
T
Site 23
T144
T
E
R
R
K
E
D
T
P
T
S
S
R
T
L
Site 24
T146
R
R
K
E
D
T
P
T
S
S
R
T
L
T
Y
Site 25
S147
R
K
E
D
T
P
T
S
S
R
T
L
T
Y
Y
Site 26
S148
K
E
D
T
P
T
S
S
R
T
L
T
Y
Y
T
Site 27
T152
P
T
S
S
R
T
L
T
Y
Y
T
S
T
S
S
Site 28
Y153
T
S
S
R
T
L
T
Y
Y
T
S
T
S
S
R
Site 29
Y154
S
S
R
T
L
T
Y
Y
T
S
T
S
S
R
Q
Site 30
T155
S
R
T
L
T
Y
Y
T
S
T
S
S
R
Q
I
Site 31
S156
R
T
L
T
Y
Y
T
S
T
S
S
R
Q
I
V
Site 32
S158
L
T
Y
Y
T
S
T
S
S
R
Q
I
V
K
K
Site 33
Y166
S
R
Q
I
V
K
K
Y
T
P
T
P
R
G
E
Site 34
T167
R
Q
I
V
K
K
Y
T
P
T
P
R
G
E
M
Site 35
T169
I
V
K
K
Y
T
P
T
P
R
G
E
M
K
S
Site 36
S176
T
P
R
G
E
M
K
S
Y
S
P
T
Q
V
R
Site 37
Y177
P
R
G
E
M
K
S
Y
S
P
T
Q
V
R
E
Site 38
S178
R
G
E
M
K
S
Y
S
P
T
Q
V
R
E
K
Site 39
T180
E
M
K
S
Y
S
P
T
Q
V
R
E
K
V
K
Site 40
Y188
Q
V
R
E
K
V
K
Y
T
P
S
P
R
G
R
Site 41
T189
V
R
E
K
V
K
Y
T
P
S
P
R
G
R
R
Site 42
S191
E
K
V
K
Y
T
P
S
P
R
G
R
R
V
G
Site 43
T199
P
R
G
R
R
V
G
T
Y
V
P
S
T
F
M
Site 44
Y200
R
G
R
R
V
G
T
Y
V
P
S
T
F
M
T
Site 45
T215
M
E
T
S
H
A
I
T
P
R
T
T
V
K
D
Site 46
T218
S
H
A
I
T
P
R
T
T
V
K
D
S
D
I
Site 47
T219
H
A
I
T
P
R
T
T
V
K
D
S
D
I
T
Site 48
S236
Y
K
I
L
E
T
N
S
L
K
R
I
M
E
E
Site 49
T244
L
K
R
I
M
E
E
T
T
P
T
T
L
K
G
Site 50
T245
K
R
I
M
E
E
T
T
P
T
T
L
K
G
M
Site 51
T247
I
M
E
E
T
T
P
T
T
L
K
G
M
F
D
Site 52
S255
T
L
K
G
M
F
D
S
T
P
T
F
L
T
H
Site 53
T256
L
K
G
M
F
D
S
T
P
T
F
L
T
H
E
Site 54
T270
E
V
E
A
N
V
L
T
S
P
R
S
V
M
E
Site 55
S271
V
E
A
N
V
L
T
S
P
R
S
V
M
E
K
Site 56
S274
N
V
L
T
S
P
R
S
V
M
E
K
N
N
L
Site 57
S289
F
P
P
R
R
V
E
S
N
S
S
A
H
P
W
Site 58
S291
P
R
R
V
E
S
N
S
S
A
H
P
W
G
L
Site 59
S292
R
R
V
E
S
N
S
S
A
H
P
W
G
L
V
Site 60
S302
P
W
G
L
V
G
K
S
N
P
K
T
P
Q
G
Site 61
T306
V
G
K
S
N
P
K
T
P
Q
G
T
V
L
L
Site 62
T315
Q
G
T
V
L
L
H
T
P
A
T
S
E
G
Q
Site 63
T324
A
T
S
E
G
Q
V
T
I
S
T
M
T
G
S
Site 64
S326
S
E
G
Q
V
T
I
S
T
M
T
G
S
S
P
Site 65
T327
E
G
Q
V
T
I
S
T
M
T
G
S
S
P
A
Site 66
S332
I
S
T
M
T
G
S
S
P
A
E
T
K
A
F
Site 67
T336
T
G
S
S
P
A
E
T
K
A
F
T
A
A
W
Site 68
T340
P
A
E
T
K
A
F
T
A
A
W
S
L
R
N
Site 69
S344
K
A
F
T
A
A
W
S
L
R
N
P
S
P
R
Site 70
S349
A
W
S
L
R
N
P
S
P
R
T
S
V
S
A
Site 71
S353
R
N
P
S
P
R
T
S
V
S
A
I
K
T
A
Site 72
S355
P
S
P
R
T
S
V
S
A
I
K
T
A
P
A
Site 73
S372
W
R
L
A
K
K
P
S
T
A
P
S
T
S
T
Site 74
T373
R
L
A
K
K
P
S
T
A
P
S
T
S
T
T
Site 75
S376
K
K
P
S
T
A
P
S
T
S
T
T
P
T
V
Site 76
S378
P
S
T
A
P
S
T
S
T
T
P
T
V
R
A
Site 77
T380
T
A
P
S
T
S
T
T
P
T
V
R
A
K
L
Site 78
T382
P
S
T
S
T
T
P
T
V
R
A
K
L
T
M
Site 79
T405
K
P
T
P
A
M
L
T
T
P
S
P
S
L
T
Site 80
T406
P
T
P
A
M
L
T
T
P
S
P
S
L
T
T
Site 81
T412
T
T
P
S
P
S
L
T
T
A
L
L
P
E
E
Site 82
S423
L
P
E
E
L
S
P
S
P
S
V
L
P
P
S
Site 83
S425
E
E
L
S
P
S
P
S
V
L
P
P
S
L
P
Site 84
S430
S
P
S
V
L
P
P
S
L
P
D
L
H
P
K
Site 85
Y440
D
L
H
P
K
G
E
Y
P
P
D
L
F
S
V
Site 86
S446
E
Y
P
P
D
L
F
S
V
E
E
R
R
Q
G
Site 87
S615
V
W
V
K
E
Q
L
S
R
R
P
V
A
K
V
Site 88
S651
N
K
K
L
K
L
P
S
L
L
T
R
G
S
S
Site 89
T654
L
K
L
P
S
L
L
T
R
G
S
S
S
T
S
Site 90
S657
P
S
L
L
T
R
G
S
S
S
T
S
L
H
N
Site 91
S658
S
L
L
T
R
G
S
S
S
T
S
L
H
N
S
Site 92
S659
L
L
T
R
G
S
S
S
T
S
L
H
N
S
T
Site 93
T660
L
T
R
G
S
S
S
T
S
L
H
N
S
T
I
Site 94
S661
T
R
G
S
S
S
T
S
L
H
N
S
T
I
R
Site 95
S665
S
S
T
S
L
H
N
S
T
I
R
S
T
I
Y
Site 96
S695
A
K
E
K
E
E
E
S
L
N
Q
G
A
R
A
Site 97
T724
P
A
K
L
P
A
V
T
V
T
P
A
P
V
P
Site 98
T726
K
L
P
A
V
T
V
T
P
A
P
V
P
D
I
Site 99
T753
D
V
A
E
A
E
S
T
G
E
M
P
G
E
E
Site 100
T769
E
T
A
G
E
G
E
T
E
E
K
S
G
G
E
Site 101
S773
E
G
E
T
E
E
K
S
G
G
E
T
Q
P
E
Site 102
T777
E
E
K
S
G
G
E
T
Q
P
E
G
E
G
E
Site 103
T787
E
G
E
G
E
T
E
T
Q
G
K
G
E
E
C
Site 104
S830
G
N
E
G
E
T
E
S
Q
E
L
S
A
E
N
Site 105
S834
E
T
E
S
Q
E
L
S
A
E
N
H
G
E
A
Site 106
S859
G
G
S
D
G
G
D
S
E
E
E
E
E
E
E
Site 107
S898
K
G
N
E
E
P
L
S
L
D
W
P
E
T
R
Site 108
T904
L
S
L
D
W
P
E
T
R
Q
K
Q
A
I
Y
Site 109
S933
P
D
V
R
R
Q
E
S
R
K
F
F
V
F
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation