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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF4E2
Full Name:
Eukaryotic translation initiation factor 4E type 2
Alias:
EIF4EL3; EIF4E-like protein 4E-LP; Eukaryotic translation initiation factor 4E; mRNA cap-binding protein type 3
Type:
Protein synthesis
Mass (Da):
28362
Number AA:
245
UniProt ID:
O60573
International Prot ID:
IPI00006779
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0000339
GO:0005515
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0006417
GO:0006413
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
D
A
L
K
D
D
D
S
G
D
H
D
Q
N
E
Site 2
T24
D
Q
N
E
E
N
S
T
Q
K
D
G
E
K
E
Site 3
T33
K
D
G
E
K
E
K
T
E
R
D
K
N
Q
S
Site 4
S40
T
E
R
D
K
N
Q
S
S
S
K
R
K
A
V
Site 5
S41
E
R
D
K
N
Q
S
S
S
K
R
K
A
V
V
Site 6
S42
R
D
K
N
Q
S
S
S
K
R
K
A
V
V
P
Site 7
Y58
P
A
E
H
P
L
Q
Y
N
Y
T
F
W
Y
S
Site 8
Y60
E
H
P
L
Q
Y
N
Y
T
F
W
Y
S
R
R
Site 9
Y64
Q
Y
N
Y
T
F
W
Y
S
R
R
T
P
G
R
Site 10
T68
T
F
W
Y
S
R
R
T
P
G
R
P
T
S
S
Site 11
T73
R
R
T
P
G
R
P
T
S
S
Q
S
Y
E
Q
Site 12
S74
R
T
P
G
R
P
T
S
S
Q
S
Y
E
Q
N
Site 13
S75
T
P
G
R
P
T
S
S
Q
S
Y
E
Q
N
I
Site 14
Y78
R
P
T
S
S
Q
S
Y
E
Q
N
I
K
Q
I
Site 15
T87
Q
N
I
K
Q
I
G
T
F
A
S
V
E
Q
F
Site 16
Y98
V
E
Q
F
W
R
F
Y
S
H
M
V
R
P
G
Site 17
T108
M
V
R
P
G
D
L
T
G
H
S
D
F
H
L
Site 18
S111
P
G
D
L
T
G
H
S
D
F
H
L
F
K
E
Site 19
S145
R
L
R
K
G
L
A
S
R
C
W
E
N
L
I
Site 20
S188
S
I
W
N
K
T
A
S
D
Q
A
T
T
A
R
Site 21
T192
K
T
A
S
D
Q
A
T
T
A
R
I
R
D
T
Site 22
T199
T
T
A
R
I
R
D
T
L
R
R
V
L
N
L
Site 23
T216
N
T
I
M
E
Y
K
T
H
T
D
S
I
K
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation