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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D12
Full Name:
TBC1 domain family member 12
Alias:
KIAA0608; TBC1 domain family, member 12; TBC12
Type:
GTPase activating protein, Rab
Mass (Da):
85626
Number AA:
775
UniProt ID:
O60347
International Prot ID:
IPI00479688
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
P
E
D
A
G
A
C
S
G
R
N
P
K
L
L
Site 2
T36
D
R
K
V
I
R
A
T
G
G
F
G
G
G
V
Site 3
T64
E
A
D
E
E
E
E
T
P
P
R
Q
L
L
Q
Site 4
Y73
P
R
Q
L
L
Q
R
Y
L
A
A
A
G
E
Q
Site 5
S101
Q
A
G
A
P
P
P
S
A
A
P
R
S
D
A
Site 6
S106
P
P
S
A
A
P
R
S
D
A
C
L
L
G
S
Site 7
S113
S
D
A
C
L
L
G
S
G
S
K
H
R
G
A
Site 8
S115
A
C
L
L
G
S
G
S
K
H
R
G
A
E
V
Site 9
T134
A
P
R
H
E
G
M
T
N
G
D
S
G
F
L
Site 10
S138
E
G
M
T
N
G
D
S
G
F
L
P
G
R
D
Site 11
S163
A
R
A
G
G
R
E
S
R
R
R
R
P
Y
G
Site 12
Y169
E
S
R
R
R
R
P
Y
G
R
L
R
L
E
G
Site 13
S187
E
D
A
D
G
A
G
S
P
S
D
W
A
S
P
Site 14
S189
A
D
G
A
G
S
P
S
D
W
A
S
P
L
E
Site 15
S193
G
S
P
S
D
W
A
S
P
L
E
D
P
L
R
Site 16
S217
Q
E
P
E
G
A
G
S
D
S
G
D
S
P
A
Site 17
S219
P
E
G
A
G
S
D
S
G
D
S
P
A
S
S
Site 18
S222
A
G
S
D
S
G
D
S
P
A
S
S
C
S
S
Site 19
S225
D
S
G
D
S
P
A
S
S
C
S
S
S
E
D
Site 20
S226
S
G
D
S
P
A
S
S
C
S
S
S
E
D
S
Site 21
S228
D
S
P
A
S
S
C
S
S
S
E
D
S
E
Q
Site 22
S229
S
P
A
S
S
C
S
S
S
E
D
S
E
Q
R
Site 23
S230
P
A
S
S
C
S
S
S
E
D
S
E
Q
R
G
Site 24
S233
S
C
S
S
S
E
D
S
E
Q
R
G
V
G
A
Site 25
S252
E
G
A
P
P
A
T
S
A
E
R
T
N
G
G
Site 26
T256
P
A
T
S
A
E
R
T
N
G
G
A
E
P
R
Site 27
S267
A
E
P
R
L
G
F
S
D
I
H
F
N
S
R
Site 28
T276
I
H
F
N
S
R
N
T
F
Q
V
S
R
G
Q
Site 29
S280
S
R
N
T
F
Q
V
S
R
G
Q
S
A
R
D
Site 30
S284
F
Q
V
S
R
G
Q
S
A
R
D
H
L
P
P
Site 31
S309
E
Q
G
P
A
G
A
S
A
R
A
R
R
S
G
Site 32
S315
A
S
A
R
A
R
R
S
G
G
F
A
D
F
F
Site 33
T323
G
G
F
A
D
F
F
T
R
N
L
F
P
K
R
Site 34
T331
R
N
L
F
P
K
R
T
K
E
L
K
S
V
V
Site 35
S336
K
R
T
K
E
L
K
S
V
V
H
S
A
P
G
Site 36
S340
E
L
K
S
V
V
H
S
A
P
G
W
K
L
F
Site 37
Y367
S
K
I
I
Q
Q
E
Y
E
A
R
T
G
R
T
Site 38
S381
T
C
K
P
P
P
Q
S
S
R
R
K
N
F
E
Site 39
S382
C
K
P
P
P
Q
S
S
R
R
K
N
F
E
F
Site 40
S404
L
I
L
E
D
R
P
S
N
L
P
A
K
S
V
Site 41
S410
P
S
N
L
P
A
K
S
V
E
E
A
L
R
H
Site 42
Y421
A
L
R
H
R
Q
E
Y
D
E
M
V
A
E
A
Site 43
S473
P
N
W
E
V
M
R
S
T
R
R
V
R
E
L
Site 44
S514
E
L
Y
E
I
F
L
S
R
A
K
E
R
W
K
Site 45
S522
R
A
K
E
R
W
K
S
F
S
E
T
S
S
E
Site 46
S524
K
E
R
W
K
S
F
S
E
T
S
S
E
N
D
Site 47
T526
R
W
K
S
F
S
E
T
S
S
E
N
D
T
E
Site 48
S528
K
S
F
S
E
T
S
S
E
N
D
T
E
G
V
Site 49
T532
E
T
S
S
E
N
D
T
E
G
V
S
V
A
D
Site 50
S536
E
N
D
T
E
G
V
S
V
A
D
R
E
A
S
Site 51
S543
S
V
A
D
R
E
A
S
L
E
L
I
K
L
D
Site 52
S557
D
I
S
R
T
F
P
S
L
Y
I
F
Q
K
G
Site 53
Y559
S
R
T
F
P
S
L
Y
I
F
Q
K
G
G
P
Site 54
Y567
I
F
Q
K
G
G
P
Y
H
D
V
L
H
S
I
Site 55
S655
K
L
F
L
H
F
K
S
Y
S
L
T
P
D
I
Site 56
T659
H
F
K
S
Y
S
L
T
P
D
I
Y
L
I
D
Site 57
Y707
G
L
G
I
L
R
L
Y
E
D
I
L
L
Q
M
Site 58
T731
T
K
L
P
E
D
I
T
S
E
K
L
F
S
C
Site 59
S732
K
L
P
E
D
I
T
S
E
K
L
F
S
C
I
Site 60
S747
A
A
I
Q
M
Q
N
S
T
K
K
W
T
Q
V
Site 61
T748
A
I
Q
M
Q
N
S
T
K
K
W
T
Q
V
F
Site 62
S769
I
K
E
G
D
K
N
S
S
P
A
L
K
S
_
Site 63
S770
K
E
G
D
K
N
S
S
P
A
L
K
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation